This special issue grew out of the efforts of an expert work group at a Klaus-Grawe Think-Tank Meeting convened by the Klaus-Grawe Foundation October 2010 in Switzerland. The meeting focused on critical aspects of children, adults, and couples in relation to family adjustment, mental health, and well-being. Psychological distress is a frequent experience for many children and adults who are living in a family system, even though such distress does not necessarily lead to a diagnosis implicating above-threshold psychopathology. Much research has focused on psychopathology in the individual. This includes individual adults as well as individual children and adolescents. In fact, this orientation toward the individual in clinical research and services is also supported by a system of clinical training that requires that clinical decisionmaking focus on either adults or children. Moreover, within the adult domain, clinicians when building their competencies to deliver services might have to choose whether to concentrate on individuals or on couples. These separations are at times unfortunate, as illustrated by two brief case examples. In the first example, imagine that you are a child psychologist providing services to a mother who presents one of her two children for assessment and potential treatment. The primary complaint refers to the child’s behavior, conceptualized as oppositional-defiant with some symptoms of conduct disorder. In assessing the child and the family, you become aware of the fact that the parents fight with each other, with the most frequent topic of conflict being the child’s behavior problems. The mother laments that her husband has withdrawn from the family, leaving her to deal with the child problem on her own. She reports symptoms of depression, which at times fulfill criteria for a major depressive episode. She has thought about seeking individual treatment for her low self-esteem and feelings of inadequacy. The child is likely going to be the focus of the intervention because the mother presented the child’s problems as central to her concerns. However, the mother might also receive individual treatment for depression or seek couple counseling. Each intervention might be delivered by a different treatment provider although the dynamics of the problems seem to be interrelated. In a second example, a couple sees a clinician who is in private practice. The couple reports about a generally distressed relationship in which both partners often experience overt and covert conflicts surrounding a number of topics (such as financial expenses, chores, role distribution, and intimacy). During the assessment and evaluation, the woman discloses depressive symptoms, while the man indicates alcohol abuse. The couple has two children, both under the age of 18. The younger child is quite anxious in social situations, and both children on occasion have witnessed couple conflicts. In cases like this, some of this information might not even be uncovered because the effects of other members of the family on the individual patient (and vice versa) might not be considered explicitly during assessment and case conceptualization. NIH T32 Behavioral-Biomedical Interface Program: http://www.sc.edu/bbip/.