Purpose: Mass vaccination campaigns in low-resource settings traditionally rely on ground coordination and post-campaign activities to assess coverage and programmatic performance. However, complex humanitarian crises in highly insecure settings present increased limitations on informational and operational access, suppressing accurate measurement and achievement of target coverage rates. To mitigate these contextual constraints, a real-time monitoring strategy implemented concurrently with immunisation activities may quickly identify and address low coverage causes before the campaign concludes. Methods & Materials: Independent monitoring approaches were implemented during two recent emergency outbreak vaccination campaigns for yellow fever in the Democratic Republic of Congo (DRC) and cholera in Somalia. Enumerators conducted post-vaccination exit interviews and focus group discussions (nDRC = 591, nSomalia = 3025) with children and adults at clinical sites, and a two-stage, stratified clustered community household coverage survey (mDRC = 300, mSomalia = 1684). Daily coverage rates, barriers to uptake, and indicators of community awareness, mobilisation and communications strategies, and service delivery were captured. Results: DRC beneficiaries indicated high levels of service satisfaction while also highlighting a lack of visual communication materials and insufficient instruction from clinical staff. Respondents in Somalia experienced good service delivery and emphasised lower understanding around adverse events reporting. Knowledge of cholera disease and prevention strategies centred around hand washing and clean drinking water, varying by age group. Primary barriers of vaccination were incompatible working hours (DRC) and distance to clinical sites (Somalia). Daily coverage indicators from the household survey identified low coverage areas and demonstrated final rates of 93.1% (DRC) [87.4,98.8] and 99.08% (Somalia) [98.64,99.41]. Conclusion: Collective results from the monitoring activities regularly informed coordinators in real-time, allowing them to refine outreach strategies during the campaign. Changes included identifying new communications and information sources, modifying campaign messaging to correct erroneous community perceptions, and targeting geographical areas. The resultant increasing daily coverage trends demonstrate that this monitoring framework can act as a vital source of independent evaluation during emergency vaccination campaigns. It enables immediate feedback and operational modification to increase coverage. This is crucial when pre-campaign information is incomplete and post-campaign activities may be limited or delayed.
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