Microbiology and ImmunologyVolume 63, Issue 5 p. i-ii COVER IMAGEFree Access Issue Information – Cover First published: 10 June 2019 https://doi.org/10.1111/1348-0421.12615AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Cover photograph: Adherence and invasion properties of ST8/SCCmecIV CA-MRSA on HEp-2 cells. ST8/SCCmecIV community-associated Staphylococcus aureus (CA-MRSA/J), an emerging CA-MRSA lineage identified in 2003 (and reported in 2012) in Japan, showed a distinct mode of infection in a HEp-2 cell assay, depending on its pathotype, as revealed by scanning and transmission electron microscopy. Strains NN3 or NN4, isolated from bullous impetigo, induced elongation of the microvilli and formation of a membranous cup-like projection (pedestal formation), and remained attached to the modified membranes above the cell surface. In contrast, strain SI1, isolated from a fatal, strongly invasive infection (with rapid progression to uncontrollable sepsis and multiple organ abscesses and failure), immediately invaded the cytoplasm of HEp-2 cells. Moreover, CA-MRSA/J had a unique surface layer. Microbiol Immunol: 63:186–193.Article link here. Volume63, Issue5May 2019Pages i-ii RelatedInformation