Aim: to assess the application of leading scientific communities’ recommendations for the patient management with chronic heart failure (CHF) in practical medicine.Patients and Methods: a retrospective analysis of 274 case records of patients (both sexes, over 18 years of age) with cardiovascular pathology, arterial hypertension and/or CHD, hospitalized in a Moscow hospital in 2019, was performed. 89 cases were selected for the study. The incidence and patterns of CHF course were analyzed; the scope of methods usage for diagnosing CHF and the treatment compliance of CHF with the principles reflected in the current recommendations for CHF was evaluated.Results: the study included 89 patients, 28 men and 61 women, with an average age of 59±16 and 70±10 years, respectively. CHF was diagnosed in 62 (70%) patients. At the same time, CHF in combination with a low left ventricular ejection fraction (LVEF) was observed in 7 (11%), with intermediate LVEF indicators — in 3 (5%), and with preserved LVEF — in 52 (84%). The main method for confirming CHF was two-dimensional echocardiography with Doppler ultrasound. Comorbidity was observed in 89% of patients with CHF. It was not possible to conduct the complete analysis of treatment compliance, prescribed in accordance with approved national clinical guidelines due to the small number of patients with CHF.Conclusion: at present, it is necessary to expand the scope of diagnostic measures reflected in current national guidelines, as well as to further study the disease and determine treatment tactics for patients with CHF to verify both systolic and diastolic CHF. KEYWORDS: chronic heart failure, arterial hypertension, coronary heart disease, ejection fraction, comorbidity, recommendations.FOR CITATION: Eremina Yu.N., Fedulayev Yu.N., Lomaichikov V.V. et al. Variants of chronic heart failure course in patients with cardiovascular pathology. Focus on patients with preserved left ventricular ejection fraction. Russian Medical Inquiry. 2020;4(7):406–411. DOI: 10.32364/2587-6821-2020-4-7-406-411.