Coupling Process Research Articles

Copper-Catalyzed Decarboxylation Cross-Coupling Cascade Reaction for Synthesis of Fused Dihydro-benzoxazinones.

A protocol for a tandem copper-catalyzed intermolecular decarboxylation cross-coupling cascade between o-bromobenzoic acids and proline or piperic acid has been disclosed. The developed protocol allows access to a variety of synthetically useful fused benzoxazinones scaffolds with high efficiency and good functional group compatibility. A mechanistically sequential approach for the decarboxylation and dehydration coupling process was presented.

Finite element modeling of thermal‐hydro‐mechanical coupled processes in unsaturated freezing soils considering air‐water capillary pressure and cryosuction

AbstractThis paper presents a comprehensive computational model for analyzing thermo‐hydro‐mechanical coupled processes in unsaturated porous media under frost actions. The model employs the finite element method to simulate multiphase fluid flows, heat transfer, phase change, and deformation behaviors. A new soil freezing characteristic curve model is proposed to consider the suctions from air‐water capillary pressure and water‐ice cryosuction. A total pore pressure with components from liquid water pressure, air pressure, and ice pressure is used in the effective stress law. Vapor and dry air are considered miscible gases, utilizing the ideal gas law and Dalton's law. The governing equations encompass the linear momentum balance equation, the energy balance equation, and mass conservation equations for water species (ice, liquid, and vapor) and dry air. Weak forms are formulated based on primary variables of displacement, water pressure, air pressure, and temperature. The spatial discretization is achieved through the finite element method, while temporal discretization employs the fully implicit finite difference method, resulting in a system of fully coupled nonlinear equations. To verify the proposed computational model, a numerical implementation is developed and validated against a set of experimental data from the literature. The successful verification demonstrates the robustness of the model. A detailed discussion of the contributions from phase change strain and different sources of pore pressure is also addressed.

Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation.

Synaptotagmins (SYTs) are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and hormones. However, few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy (DR) through Ca2+/glucose transporter-1 (GLUT1) and the possible regulatory mechanism of SYTs. To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of DR. DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells (ARPE-19). Bioinformatics analysis, reverse transcriptase-polymerase chain reaction, Western blot, flow cytometry, ELISA, HE staining, and TUNEL staining were used for analysis. Six differentially expressed proteins (SYT2, SYT3, SYT4, SYT7, SYT11, and SYT13) were found between the DR and control groups, and SYT4 was highly expressed. Hyperglycemia induces SYT4 overexpression, manipulates Ca2+ influx to induce GLUT1 fusion with the plasma membrane, promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake, induces ARPE-19 cell apoptosis, and promotes DR progression. Parkin deficiency inhibits the proteasomal degradation of SYT4 in DR, resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane, and these effects were blocked by oe-Parkin treatment. Moreover, dysregulation of the myelin transcription factor 1 (Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process, and this process was inhibited in the oe-MYT1-treated group. Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

Phycocyanin-based rapid fluorometric immunoassay for the determination of aflatoxin B1, deoxynivalenol, and zearalenone in food and feed matrices

This study presents a new multiplex lateral flow immunoassay (LFIA) for the detection of aflatoxin B1 (AFB1), deoxynivalenol (DON), and zearalenone (ZEN). The multi-LFIA utilized phycocyanin (PC), a protein with excellent photophysical properties, as a fluorescent indicator for quantifying the three mycotoxins on a lateral flow strip platform. PC and monoclonal antibodies (mAbs) against AFB1, DON, and ZEN were immobilized onto carboxylated latex nanospheres (LNS) through a one-step coupling process. The resulting conjugates with strong red fluorescence were then used for multiplex sensing of AFB1, DON, and ZEN in wheat, corn, and animal feed. The visual results of the assay were obtained using LED UV lights coupled with a smartphone in less than 25 min. Under the optimal conditions, the new multi-LFIA achieved minimum detection limits of 1.04, 1.6, and 2.08 ng/mL for AFB1, 2.2, 6.45, and 2.9 ng/mL for DON, and 1.74, 1.67, and 2.11 ng/mL for ZEN in wheat, corn, and feed, respectively. The proposed method demonstrated high selectivity for AFB1, DON, and ZEN and showed strong correlation with LC-MS/MS results in spiked samples. In summary, the proposed method is feasible, rapid, and could serve as a highly sensitive platform for detecting AFB1, DON, and ZEN and other analytes in a single format.

Ultrafine Cu-Pd bimetallic clusters enhance asymmetric electron distribution to boost C-C coupling in photothermal CO2-to-ethanol conversion

Converting CO2 to ethanol through photothermal catalysis faces significant challenges due to it involves multi-electron reduction and kinetically sluggish C-C coupling process. Here, copper and a minor quantity of palladium are encapsulated within the cage of UiO-66 using a dual-solvent-sonication method to form ultrafine Cu2O/Cu-Pd clusters. The Cu-Cu2O serves as an electron center to enhance CO2 uptake and activation, while the incorporation of Pd accelerates H2 activation. Due to differences in electronegativity, electrons tend to transfer from Cu to Pd, which reduces the electrostatic repulsion between intermediates and facilitates the coupling of *CO and *CHO. The photothermal ethanol yield of Cu6Pd@UiO-66 reached 1077.69 μmol·gcat–1·mL–1 with a selectivity of 94.62%, representing an 11.64-fold increase over the non-illumination, and a 3.11-fold enhancement compared with Cu6@UiO-66. This study offers evidence supporting the promotion of C-C coupling through an asymmetric electron distribution, potentially advancing the conversion of CO2 to liquid products.

The structure, magnetism and mechanical properties of L21-type full-Heusler alloy Cr2ZrSi: A first-principles study

Heusler alloy is a widely studied spintronic material in recent years, which has played a huge role in the field of spintronic devices due to its high spin polarization and high Curie temperature. Using first-principles calculation to predict the basic properties of Heusler alloy can not only save experimental costs and time but also provide a reliable theoretical basis for experimental research. This study used a first-principles calculation to study the magnetic and mechanical properties of full-Heusler alloy Cr2ZrSi with an L21-type structure. The research results indicate that the alloy is a half-metallic ferromagnetic material with a theoretical value of 100% spin polarization. The magnetism mainly comes from the asymmetric spin contribution of d-orbital electrons of transition metal atoms and their hybridization. At the same time, this complex hybridization coupling process is also a possible reason for the half-metallic band gaps. In terms of mechanical properties, the Cr2ZrSi alloy exhibits good ductility and anisotropy, with a Debye temperature of 303.848K. Our theoretical research results provide more choices and theoretical basis for subsequent experimental research.

Bioinspired core-shell nanofiber drug-delivery system modulates osteogenic and osteoclast activity for bone tissue regeneration

Osteogenic-osteoclast coupling processes play a crucial role in bone regeneration. Recently, strategies that focus on multi-functionalized implant surfaces to enhance the healing of bone defects through the synergistic regulation of osteogenesis and osteoclastogenesis is still a challenging task in the field of bone tissue engineering. The aim of this study was to create a dual-drug release-based core-shell nanofibers with the intent of achieving a time-controlled release to facilitate bone regeneration. We fabricated core-shell P/PCL nanofibers using coaxial electrospinning, where alendronate (ALN) was incorporated into the core layer and hydroxyapatite (HA) into shell. The surface of the nanofiber construct was further modified with mussel-derived polydopamine (PDA) to induce hydrophilicity and enhance cell interactions. Surface characterizations confirmed the successful synthesis of PDA@PHA/PCL-ALN nanofibers endowed with excellent mechanical strength (20.02 ± 0.13 MPa) and hydrophilicity (22.56°), as well as the sustained sequential release of ALN and Ca ions. In vitro experiments demonstrated that PDA-functionalized core-shell PHA/PCL-ALN scaffolds possessed excellent cytocompatibility, enhanced cell adhesion and proliferation, alkaline phosphatase activity and osteogenesis-related genes. In addition to osteogenesis, the engineered scaffolds also significantly reduced osteoclastogenesis, such as tartrate-resistant acid phosphatase activity and osteoclastogenesis-related gene expression. After 12-week of implantation, it was observed that PDA@PHA/PCL-ALN nanofiber scaffolds, in a rat cranial defect model, significantly promoted bone repair and regeneration. Microcomputed tomography, histological examination, and immunohistochemical analysis collectively demonstrated that the PDA-functionalized core-shell PHA/PCL-ALN scaffolds exhibited exceptional osteogenesis-inducing and osteoclastogenesis-inhibiting effects. Finally, it may be concluded from our results that the bio-inspired surface-functionalized multifunctional, biomimetic and controlled release core-shell nanofiber provides a promising strategy to facilitate bone healing.

Comparative numerical analysis between butt and lap joints of Mg alloy friction stir welding with considering tilted tool effect

Magnesium (Mg) alloy, as an important lightweight structural metal, can be effectively joined by the friction stir welding (FSW) method. Understanding FSW temperature and material flow coupling process in butt and lap welding configurations has important theoretical significance. In this study, the tilted tool induced incomplete contact distance is calculated by process parameters and slip rate, and the deflection of the contact interface is related to the tool torque. The non-uniform boundary conditions are considered. The numerical model is proposed and experimentally validated by using the measured temperatures and thermo-mechanically affected zone (TMAZ) profiles. The comparative numerical analysis between butt and lap welding with three levels of process parameters is further conducted. The peak temperature and material flow velocity along the specified circumferences in FSBW are more than 10 K and 4 mm/s higher than these in FSLW, respectively. When the rotation rate increases from 600 rpm to 800 rpm, the peak temperature and material flow velocity along the specified circumferences increase about 20 K and 9 mm/s, respectively. When the welding speed decreases from 150 mm/min to 30 mm/min, the temperature and material flow velocity fluctuations along the specified circumference decreases about 25 K and 14 mm/s, respectively.

Efficient nitrogen removal by microalgal-bacterial granular sludge-marimo coupling process

Current biological wastewater treatment processes usually have a drawback of insufficient nitrogen (N) removal, contributing to the ubiquitous eutrophication of aquatic ecosystems globally. To address such a challenging situation, this study explored an innovative microalgal-bacterial granular sludge-marimo (MBGS-MA) coupling process. The process removed 83.4 % of N with the effluent N concentration of 4.0 mg/L. With the growth of MBGS, there was a shift towards genes associated with nitrification and denitrification, and away from ammonia assimilation genes, revealing internal mechanism of the shift of N removal pathway. Contrarily, MA could use gaseous N2 with the N fixing genes in MA enriched, and the genes abundance related to assimilatory nitrate reduction were also raised under the mutualistic interactions between Proteobacteria and Cyanobacteria, which was beneficial to achieve efficient N removal. These findings may open a new horizon for developing innovative hybrid microalgal-bacterial processes aimed at high-efficiency N removal from wastewater.

Rationally Designed Carbon‐Based Catalysts for Electrochemical C‐N Coupling

AbstractThe electrochemical C‐N coupling process, facilitating the production of organic nitrogen substances (such as urea, methylamine, formamide, and ethylamine) via the simultaneous reduction of carbon dioxide (CO2) and small nitrogen‐based substances, stands at the forefront of advancing carbon neutrality and the artificial nitrogen cycle. This method has garnered substantial interest due to its potential economic and environmental benefits. Although considerable progress has been achieved in this emerging field, it still faces challenges, including slow reactant adsorption, competing side reactions, and complex multi‐step pathways, resulting in low yields and selectivity. Strategically designing and developing low‐cost and exceptionally performant catalysts is crucial for cost‐effective and precise electrochemical C─N bonding. This article offers an in‐depth review of the electrosynthesis of valuable organic nitrogen compounds at ambient conditions from earth‐abundant resources/wastes, such as CO2 and small nitrogenous molecules (nitrogen: N2, nitrite: NO2−, nitrate: NO3−, ammonia: NH3, etc.), via electrochemical C─N bond formation reactions, especially using carbon‐based catalysts. The relevant electrochemical C─N bond formation mechanisms, the design principles of advanced carbon‐based electrocatalysts, and the impact of different electrolyser designs are discussed, along with the present obstacles and upcoming prospects in this dynamic field.

Multi-objective optimization of a hydrogen production process for polymer membrane coupled with electrochemical hydrogen pump from hydrogen-doped natural gas by NSGA-II

In this work, a novel process of polymer membrane coupled with electrochemical hydrogen pump (EHP) was proposed to achieve efficient hydrogen production from hydrogen-doped natural gas (HDNG), and was simulated by UniSim Design. A hydrogen separation unit of two-stage polymer membrane was used for achieving hydrogen enrichment from low H2 concentration HDNG. Due to the hydrogen upgrade, EHP was operated at a H2 concentration much higher than HDNG, resulting in low energy consumption. Benefiting from the synergy between hydrogen upgrade and purification, the coupling process brought substantial effect while improving the hydrogen purity and recovery rate and reducing the hydrogen separation cost. The real natural gas components were considered into HDNG to ensure the effectiveness of process simulation. An optimization strategy considering both product yield and production cost was proposed to achieve the trade-off between hydrogen recovery rate and separation cost. However, the impact of process parameters on the objectives is nonlinear and difficult to describe with mathematical expressions. Therefore, an agent model of the proposed process was established based on back propagation neural network (BPNN), and multi-objective optimization of H2 recovery rate and total annual cost (TAC) of hydrogen separation unit was achieved using non-dominated sorting genetic algorithm-II (NSGA-II). Investigations with HDNG under various operating conditions (feed pressure of 8–40 bar and feed H2 concentration of 5–25 mol%) were performed, which proved that 90 % overall H2 recovery rate and 99.99 mol% H2 purity of hydrogen product can be achieved at low cost, with the lowest hydrogen separation cost of 1.00 $/kg H2 achievable at 40 bar feed pressure and 25 mol% feed H2 concentration. In summary, this coupling process can provide engineering solutions for efficient hydrogen production from HDNG and promote the development of green hydrogen.

Packaging of WGM resonator coupled with tapered fiber for various application scenarios

In this study, we proposed a packaging that couples light from a tapered fiber to a whispering gallery mode resonator. The packaging is suitable for a wide range of resonators, such as quartz rods and crystal microdisks. The device uses a self-designed brass base with a special flexible structure to realize the three-dimensional precision adjustment of the relative position of the resonator and the tapered fiber. This structural is different from the packaging proposed in previous studies. It can adjust the coupling state of the resonator by adjusting the relative position between the resonator and the tapered fiber. We demonstrated the coupling process using a crystal resonator as an example and demonstrated three typical coupling states of the WGM system. The packaging also has the advantages of high stability, small size, low cost, and high portability. In addition, we tested the long-term robustness of the packaging and verified the application of the packaging for magnetic field sensing and temperature tuning.

Coupled processes involving ammonium inputs, microbial nitrification, and calcite dissolution control riverine nitrate pollution in the piedmont zone (Qingshui River, China)

Rivers in agricultural countries widely suffer from diffuse nitrate (NO3−) pollution. Although pollution sources and fates of riverine NO3− have been reported worldwide, the driving mechanisms of riverine NO3− pollution associated with mineral dissolution in piedmont zones remain unclear. This study combined hydrogeochemical compositions, stable isotopes (δ18O–NO3−, δ15N–NO3−, δ18O–H2O, and δ2H–H2O), and molecular bioinformation to determine the pollution sources, biogeochemical evolution, and natural attenuation of riverine NO3− in a typical piedmont zone (Qingshui River). High NO3− concentration (37.5 ± 9.44 mg/L) was mainly observed in the agricultural reaches of the river, with ~15.38 % of the samples exceeding the acceptable limit for drinking purpose (44 mg/L as NO3−) set by the World Health Organization. Ammonium inputs, microbial nitrification, and HNO3-induced calcite dissolution were the dominant driving factors that control riverine NO3− contamination in the piedmont zone. Approximately 99.4 % of riverine NO3− contents were derived from NH4+-containing pollutants, consisted of manure & domestic sewage (74.0 % ± 13.0 %), NH4+-synthetic fertilizer (16.1 % ± 8.99 %), and soil organic nitrogen (9.35 % ± 4.49 %). These NH4+-containing pollutants were converted to HNO3 (37.2 ± 9.38 mg/L) by nitrifying bacteria, and then the produced HNO3 preferentially participated in the carbonate (mainly calcite) dissolution, which accounted for 40.0 % ± 12.1 % of the total riverine Ca2+ + Mg2+, also resulting in the rapid release of NO3− into the river water. Thus, microbial nitrification could be a new and non-negligible contributor of riverine NO3− pollution, whereas the involvement of HNO3 in calcite dissolution acted as an accelerator of riverine NO3− pollution. However, denitrification had lesser contribution to natural attenuation for high NO3− pollution. The obtained results indicated that the mitigation of riverine NO3− pollution should focus on the management of ammonium discharges, and the HNO3-induced carbonate dissolution needs to be considered in comprehensively understanding riverine NO3− pollution in piedmont zones.

Numerical simulation of fluid-thermal-structural coupling characteristics of stratospheric non-rigid airship

The voluminous stratospheric non-rigid airship is very sensitive to the external thermal environment. The temperature change of internal gas caused by the variation in the external thermal environment and wind speed will lead to a change in the shape and buoyancy of the airship, thereby affecting its flight control. The traditional static analysis method is difficult to accurately reflect this fluid-thermal-structural coupling process. In this paper, the iterative analysis method was established for the fluid-thermal-structural coupling effect of stratospheric non-rigid airship based on the models of fluid, thermal, and structural deformation. Considering the load such as the internal thermal effect and external flow field of the airship, the simulation of the thermo-induced structural deformation effect was conducted using Fluent and Abaqus software. The influence of local time and external wind speed on the structural deformation, volume, and equilibrium altitude of the airship was analyzed. The results demonstrate that, at low wind speed, the influence of aerodynamic pressure on the deformation of the airship is negligible. However, a great amount of heat is carried away by the wind, then the structural deformation caused by internal and external pressure difference is alleviated and the equilibrium altitude of the airship change obviously. This can serve as a guideline for the design and flight test of the long-endurance stratospheric non-rigid airship.

Large‐Scale Wave‐Driven Interactions and Plasma‐Neutral Coupling in the Low‐Latitude Ionosphere‐Thermosphere

AbstractThe plasma and neutral density variations, interactions and coupling processes within ±30° latitudes are examined concurrently by the DMSP‐F18 and Swarm‐C satellite during geomagnetically quiet years in 2020–2021. The wavenumber (WN) patterns are computed in the form of neutral and electron density for two altitudes and their latitudinal profiles are analyzed. We observe that the WN1 structure of the electron density has a significant seasonal dependence in the topside ionosphere and dominates all other structures but WN2 neutral density amplitude dominates all other structures in the middle thermosphere (∼440 km). Additionally, we analyze vertical‐temporal‐latitudinal tidal structures from the Climatological Tidal Model of the Thermosphere (CTMT) to find evidence for the modulation of the large‐scale waves (LSWs) neutral density structures. Through the examination of the in situ observational and modeling approaches, we show that the tidal contributors of WN structures obtained from CTMT can capture the influence of terrestrial sources on the WN structures of plasma‐neutral density and imprint the corresponding vertical coupling in the IT system. Correlation analysis reveals that the amplitudes of the WN1 and WN3 structures of electron density in topside ionosphere and those of neutral density in the middle thermosphere show intermittent but significant correlations with each other, unlike the WN2 and WN4 structures. This study provides new insights into the topside ionospheric response to wave driving in the lower atmosphere, which ultimately improves our capability to understand the interaction and vertical coupling of large‐scale structures, thereby advancing our predictive capabilities of space weather critical for satellite operations.

Formulation and numerical realization of anisotropic permeability coefficient for fluid-solid coupling in underground engineering

Underground engineering soil functions as a typical porous medium wherein groundwater flow and alterations in pore water pressure can influence the medium’s porosity, thereby affecting soil permeability. Moreover, changes in porosity (volumetric strain) result in anisotropy in the permeability coefficient, complicating the accurate depiction of the entire fluid-solid coupling process using a uniform permeability coefficient. Fluid–solid coupling is achieved by establishing a connection between soil and fluid parameters in response to changes in the permeability coefficient during soil deformation. Considering the limitations of the deformation mode described by volumetric strain, this paper proposes different influencing factors of anisotropic principal strains (εx, εy , and εz ) on the anisotropic permeability coefficient k i, based on the Kozeny–Carman semi-empirical equation for the permeability of porous media. Additionally, a numerical simulation method for the fluid-solid interaction effect in underground engineering is implemented by incorporating variations in the permeability coefficient with strain, using a fish-parameterized programming language within the FLAC 3D software. The coupling effect of the seepage field with the strain-dependent permeability coefficient on the mechanical field is validated using a specific calculation example. This methodology presents a novel approach for expressing fluid-solid coupling processes.

Rapid degradation of high-concentration antibiotic via heterogeneous photocatalysis coupling Fenton-like oxidation with MIL-53(Fe) under visible light irradiation

The photocatalytic technology based on Metal-Organic Frameworks (MOFs) has shown promising applications in the field of antibiotic pollution control. However, it still faces challenges in efficiently removing high-concentration antibiotic wastewater. A typical Fe-containing MOF, MIL-53(Fe), was successfully synthesized and demonstrated efficient photocatalytic activity under visible light irradiation for high-concentrations of tetracycline hydrochloride (TCH). However, the bare MIL-53(Fe) exhibited unsatisfactory photocatalytic performance. To overcome the low degradation efficiency resulting from the rapid recombination of light-induced electron-hole pairs, H2O2 was introduced as an external electron acceptor to establish a synergistic Fenton-like system to couple with the photocatalysis process. The results showed that in the MIL-53(Fe)/H2O2/Vis system, 99% of 1 g/L TCH was degraded within 80 min, while the degradation efficiency of the MIL-53(Fe)/Vis process was only 4.89% under identical conditions. The degradation mechanism of the coupling system was performed by radical scavenging experiments and Electron Spin Resonance characterization. The results indicated that ·OH was the dominant radical in the coupled reaction, and ·O2- and h+ also played a role in this system. The significant improvement in TCH degradation efficiency during the coupling process was attributed to the following three factors: (1) In the coupling reaction process, photo-generated electrons can stimulate H2O2 to form ·OH radicals, inhibiting the recombination of photo-generated electrons and holes, improving the efficiency of the photocatalytic reaction. (2) FeIII in MIL-53(Fe) can be excited by photo-generated electrons and converted to FeII, which then stimulates H2O2 to form ·OH radicals. (3) FeIII in MIL-53(Fe) can convert with FeII, stimulate H2O2 to form ·OH radicals, and participate in the degradation reaction. In addition, the reusability and stability of the MIL-53(Fe) photocatalyst in the coupled system, as well as the impact of operational parameters, were systematically studied. This work demonstrates a feasible strategy for environmental remediation by enhancing the efficiency of MIL-53(Fe) in photocatalytic Fenton-like systems, thereby providing a viable approach for the treatment of high-concentration antibiotic wastewater.

A novel mode coupling mechanism for predicting low-frequency chatter in robotic milling by providing a vibration feedback perspective

The low-frequency chatter (LFC) of the robot body during milling severely constrains the machining efficiency. Taking the classical mode coupling mechanism as the underlying foundation, previous studies have developed various stability models to predict the LFC in robotic milling. However, the classical mode coupling mechanism has recently been proven to be applicable only to operations such as threading and boring, showing significant deviations in robotic milling. In response, this paper proposes a novel vibration feedback-based mode coupling (VF-MC) mechanism applicable to robotic milling based on robotic modal directionality, which describes the coupling and feedback process of modal vibration among multiple modes through dynamic cutting forces. The feedback process is modeled considering the time delay effect. The LFC can be judged by the trend of the amplitudes of the feedback vibrations. The effectiveness and efficiency of the VF-MC model for predicting the LFC are verified by comparing with the milling experiment results and the traditional mode coupling chatter model. Furthermore, the dynamical conditions for the LFC are investigated based on the VF-MC mechanism with the experimental evidence. The core contribution of this paper is to quantitatively reveal the feedback mechanism of low-frequency self-excited vibration among modes in robotic milling, and further develop the VF-MC model to efficiently predict the LFC. The code for the VF-MC model is available at https://github.com/Dr-JwWu/VF-MC__A-chatter-model-for-robotic-milling.

Evaluation of the urban industrial coupling strategy based on the global production networks theory: A case study of the smart phone industry in the Guangdong-Hong Kong-Macao Greater Bay Area.

In the context of uncertain economic environments urban agglomerations play a crucial role in economic development, reshaping industrial chains and fostering inter-city cooperation. This study employs the Global Production Network (GPN) theory to enhance our understanding of how cities integrate into regions, emphasizing the often-overlooked governmental influence in strategic coupling processes. In examining the evolution of China's smartphone industry within the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) this research categorizes 19,599 smartphone companies into five distinct groups. Through analyzing their spatial distribution and geographical linkage the study identifies four strategic coupling modes based on the localization of assets, considering spatial influence and technological complexity along horizontal and vertical dimensions. Structural and institutional elements within these modes are also explored. The research uncovers unique integration patterns among nine cities in the GBA's mobile industry, revealing distinct spatial clusters rooted in technological, resource and innovation factors. Crucially, local policies play a pivotal role. Cities such as Shenzhen and Dongguan emerge as technology hubs, contrasting with Foshan and Zhongshan, which leverage resource advantages. The spatial impact, contingent on specific assets, underscores the necessity for nuanced top-down coupling methods in regional development. Moreover, the study emphasizes the significance of nurturing innovation links, not only between leading companies but also among midstream and downstream enterprises, enhancing cities' strategic coupling capabilities.

Adverse effects of crushed seafloor massive sulphide deposits on the boreal deep-sea sponge Geodia barretti Bowerbank, 1858 and its associated fauna

Abundant mineral resources in the deep sea are prospected for mining for the global metal market. Seafloor massive sulphide (SMS) deposits along the Mid-Atlantic Ridge are one of the potential sources for these metals. The extraction of SMS deposits will expose adjacent marine ecosystems to suspended particle plumes charged with elevated concentrations of heavy metals and other potentially toxic compounds. Up to date there is no information about the impact of mining activities on deep-sea benthic ecosystems such as abundant deep-sea sponge grounds in the North Atlantic Ocean. Sponge grounds play a major role in benthic-pelagic coupling and represent an important habitat for a diversity of vertebrates, invertebrates and microorganisms. To simulate the effects of mining plumes on benthic life in the deep sea, we exposed Geodia barretti, a dominant sponge species in the North Atlantic Ocean, and an associated brittle star species from the genus Ophiura spp. to a field-relevant concentration of 30 mg L−1 suspended particles of crushed SMS deposits. Three weeks of exposure to suspended particles of crushed SMS resulted in a tenfold higher rate of tissue necrosis in sponges. All brittle stars in the experiment perished within ten days of exposure. SMS particles were evidently accumulated in the sponge's mesohyl and concentrations of iron and copper were 10 times elevated in SMS exposed individuals. Oxygen consumption and clearance rates were significantly retarded after the exposure to SMS particles, hampering the physiological performance of G. barretti. These adverse effects of crushed SMS deposits on G. barretti and its associated brittle star species potentially cascade in disruptions of benthic-pelagic coupling processes in the deep sea. More elaborate studies are advisable to identify threshold levels, management concepts and mitigation measures to minimize the impact of deep-sea mining plumes on benthic life.