Count Rate Research Articles

Nondestructive and active interrogation system for special nuclear material: proof of principle and initial results

Herein, we employ the threshold energy neutron analysis (TENA) technique to introduce the world's first active interrogation system to detect special nuclear materials (SNMs), including U-235 and Pu-239. The system utilizes a DD neutron generator based on inertial electrostatic confinement (IEC) to interrogate suspicious objects. To detect secondary neutrons produced during fission reactions induced in SNMs, a tensioned metastable fluid detector (TMFD) is employed. The current status of the system's development is reported in this paper, accompanied by the results from experiments conducted to detect 10 g of highly enriched uranium (HEU). Notably, the experimental findings demonstrate a distinct difference in the count rates of measurements with and without HEU. This difference in count rates surpasses two times the standard deviation, indicating a confidence level of more than 96% for identifying the presence of HEU. The paper presents and extensively discusses the proof-of-principle experimental results, along with the system's planned trajectory.

Design of multi-channel electronic prototype for 101Sn energy level lifetime measurement

In this study, a 32-channel front-end data acquisition unit (DAQU) with high temporal resolution and count rate was developed at the Heavy Ion Research Facility in Lanzhou (HIRFL), China, to measure the lifetime of 101Sn on the Spectrometer for Heavy Atoms and Nuclear Structure. The DAQU data analysis module uses a field programmable gate array (FPGA) to implement and time stamp extraction through an FPGA-based tapped delay line (TDL) time-to-digital converter. The energy measurements were implemented using a trapezoidal algorithm and a sliding baseline averaging method. The DAQU was tested and calibrated using a pulse generator and cosmic rays. The results show that the system had a dead time of less than 500 ns, a dynamic range of “0” to “500” mV, and an energy resolution of better than 4.8‰ (full width at the half-maximum, FWHM). In addition, the single-channel temporal resolution under multi-channel settings surpasses 111.2 ps (FWHM), satisfying the experiment's requirements for the electronics system.

Periodic sampling and count rate correction of the low energy X-ray telescope on board the Insight- Hard X-ray modulation telescope

The Low Energy X-ray Telescope (LE) is an important instrument of the Insight-Hard X-ray Modulation Telescope (Insight-HXMT), which performs scanning and point observation in the soft X-ray energy band (0.7–13 keV). Since its launch in 2017, it has conducted a large number of scientific observations and achieved significant astronomical discoveries. LE is composed of three detector boxes and an electronic control box. The data acquisition system of LE is designed to use periodic sampling, which solves the problem of unstable noise peaks. Data loss may occur when observing X-ray bursts, and periodic sampling provides a method of correcting light curves. In addition, in the South Atlantic Anomaly (SAA) or where the count rate of the particle monitor on the Insight-HXMT is very high, LE automatically switches into SAA operating mode, and only a small number of events are recorded. After data correction, the light curves can be estimated to expand the astronomical achievements of LE.

Cosmic Ray Jump Detection for the Roman Wide Field Instrument

We investigate algorithms for detecting and correcting for jumps due to cosmic rays in infrared detectors, with emphasis on Roman telescope’s Wide Field Instrument. We use a statistic S based on the excess difference between adjacent resultants (average over a group of reads) normalized to the square root of the expected variance that accommodates the uneven resultants of Roman. We show that it is important to account for the covariance of excess difference with that of the estimated count rate. Due to averaging of reads, the ability to detect jumps is reduced, specially if the jump is in the first or the last resultant. Having the first and last resultants as a single-read resultants improves the ability to detect cosmic rays. The signal due to a jump is split across two resultant differences and this motivates small adjustments to the basic algorithm which improves the jump detection. Bias and false negative rate are investigated using Monte Carlo simulations for a few readout patterns. In order to investigate other scenarios approximate formulas for predicting the bias and the misclassification rate are presented. Using cosmic ray properties based on JWST darks, we show that for high count rates (1000 e−1 s−1) most of the cosmic rays remain undetected, with 65% missed identifications. When averaging over multiple exposures, due to low event rates of cosmic rays, the overall bias in estimated count rate due to undetected cosmic rays is negligible. However, for a single exposure with an undetected cosmic ray, one can have a bias of a few percent. This will manifest as abrupt changes in brightness of targets. Fortunately, the bias ranges between 1 and 5 the measurement uncertainty, and this fact can be used to screen out cosmic rays for scientific applications that seek to detect short duration time domain events.

Comparison of the Efficacy of Clascoterone, Trifarotene, and Tazarotene for the Treatment of Acne: A Systematic Literature Review and Meta-Analysis.

Acne vulgaris, a chronic inflammatory condition, is associated with significant physical and psychosocial burden. Since 2019, three new topical agents for acne vulgaris have been approved in the USA and Canada. We performed a systematic review and meta-analysis to compare the efficacy between twice-daily clascoterone cream 1%, once-daily trifarotene 0.005% cream, and once-daily tazarotene 0.045% lotion for acne treatment. Randomized controlled trials (RCTs) comparing clascoterone, trifarotene, or tazarotene with vehicle in patients with moderate-to-severe acne were identified from a systematic literature review and included in a meta-analysis. Primary outcomes were percentage reduction in inflammatory and noninflammatory lesion count (ILC and NILC, respectively) and treatment success rate (≥ 2-grade improvement in Investigator's Global Assessment or Evaluator's Global Severity Score and a rating of clear or almost clear) at week 12. DerSimonian and Laird random-effects models with the inverse variance method were used to calculate the mean difference (MD) for percentage reduction in ILC and NILC, and odds ratios (ORs) for the rate of treatment success. Six Phase 3 RCTs were included in the meta-analysis. The analyses showed robust differences favoring the interventions for ILC (MD: - 11.5; 95% confidence interval [CI]: - 14.39, - 8.62), NILC (MD: - 12.25; 95% CI: - 15.21, - 9.29), and treatment success rate (OR: 2.14; 95% CI: 1.81, 2.53). No differences were observed between clascoterone, trifarotene, and tazarotene for ILC (MD: - 12.8, - 11.2, and - 10.1, respectively), NILC (MD: - 11.6, - 13.9, and - 12.8, respectively), or treatment success rate (OR: 2.9, 1.9, and 2.1, respectively (all P > 0.05). No significant differences in efficacy were observed between clascoterone, trifarotene, and tazarotene after 12weeks of treatment in patients with moderate-to-severe acne. Differences in application frequency and safety profile should also be taken into consideration when making treatment decisions.

Cells expressing POLG loss-of-function variants can decrease mtDNA copy number and increased growth rates in neighbouring A7r5 and HeLa cells

Mitochondrial disfunction promotes vascular disease, and mitochondrial diseases offer valuable insights into the pathological mechanisms of mitochondrial dysfunction. We previously described a patient cohort with variants in the mitochondrial DNA gamma polymerase (POLG) that were prone hypertension. We hypothesized that the POLG variants promote hypertrophy or hyperplasia of vascular smooth muscle cells in a way that stiffens or thickens blood vessels to explain the high rate of resistant hypertension in this cohort. The objective of this study was to assess the cellular phenotype of cells over-expressing POLG variants: pathogenic Y955C and variants of unknown significance; R964C, I1098N, Y1138C. We transiently expressed human FLAG-tagged POLG variants in rat A7r5 and HeLa cells for 2-4 days. Transfection effciency ranged from 20-30% in A7r5 and >60% in HeLa cells. POLG variants increased cell density by nuclear counting (20-60%) and growth rates measured by 48-72 h of live-cell imaging (Y955C > R964C > I1089N » Y1138C). Compared to wild-type, Y955C and R964C reduced mtDNA copy number (mCN) measured by droplet digital PCR by 10-20%. Imaging mtDNA nucleoids (anti-dsDNA) and the FLAG-tag showed that reduced mCN was not restricted to transfected cells. Addition of a P2A-T2A-nuclear-EGFP to the POLG constructs demonstrated that faster growth rates were not specific to transfected cells. Resting and oligomycin-stimulated mitochondrial membrane potential imaged with TMRM were unaffected by Y955C and R964C. Mitochondrial ROS (mitoSox) was similar between cultures transfected with Wild-type versus POLG variants and lower than levels stimulated by antimycin-A’s inhibition of complex III. Notably, we found a linear relationship between mCN and cell density that was not simply due to smaller cell size at higher densities. Using Hoescht-33342 staining to assess cell cycle, no clear difference in cell-cycle distribution was evident in unsynchronized cultures. We conclude that modest reduction of mCN induces a mitogenic effect, likely via a diffusible messenger that further reduces mCN in a cell population. The signalling mechanism of this phenomenon remains to be identified, but our results confirm that POLG malfunction can alter smooth muscle physiology in a way that could support pathogenic vascular remodelling and could promote enhanced growth in cancerous cells. Funded by the Natural Sciences and Research Council of Canada. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Combination of Abiraterone Acetate, Prostate Bed Radiotherapy, and Luteinizing Hormone-releasing Hormone Agonists in Biochemically Relapsing Patients After Prostatectomy (CARLHA): A Phase 2 Clinical Trial

BackgroundThe relevance of next-generation hormone therapies and circulating tumor cells (CTCs) are not elucidated in biochemical recurrence after prostatectomy. ObjectiveTo evaluate the combination of abiraterone acetate plus prednisone (AAP), prostate bed radiotherapy (PBRT), and goserelin in biochemically relapsing men after prostatectomy, and to investigate the utility of CTCs. Design, setting, and participantsIn this single-arm multicenter phase 2 trial, 46 biochemically relapsing men were enrolled between December 2012 and January 2019. The median follow-up was 47 mo. InterventionAll patients received AAP 1000 mg daily (but 750 mg during PBRT), salvage PBRT, and goserelin. Outcome measurements and statistical analysisThe primary outcome was 3-yr biochemical recurrence-free survival (bRFS) when prostate-specific antigen (PSA) levels were ≥0.2 ng/ml. The secondary outcomes included alternative bRFS (alt-bRFS) when PSA levels were ≥0.5 ng/ml and safety assessment. CTC count was assessed. Results and limitationsThe 3-yr bRFS and alt-bRFS were 81.5% (95% confidence interval or CI [66.4–90.3%]) and 95.6% (95% CI [83.5-98.9%]), respectively. The most common acute radiotherapy-related adverse effect (AE; all grades was pollakiuria (41.3%). The most common late AE (all grades) was urinary incontinence (15.2%). Grade 3-4 acute or late radiotherapy-related AEs were scarce. Most frequent AEs nonrelated to radiotherapy were hot flashes (76%), hypertension (63%), and hepatic cytolysis (50%, of which 20% were of grades 3-4). Of the patients, 11% had a CTC count of ≥5, which was correlated with poorer bRFS (p = 0.042) and alt-bRFS (p = 0.008). The association between CTC count and higher rates of relapse was independent of the baseline PSA level and PSA doubling time (p = 0.42 and p = 0.09, respectively). This study was nonrandomized with a limited number of patients, and few clinical events were reported. ConclusionsAdding AAP to salvage radiation therapy and goserelin resulted in high bRFS and alt-bRFS. AEs remained manageable, although a close liver surveillance is advised. CTC count appears as a promising biomarker for prognosis and predicting response to treatment. Patient summaryOur study was a phase 2 clinical trial that exhibited the efficacy and tolerance of a novel androgen-receptor targeting agent (abiraterone acetate plus prednisone) in patients with prostate cancer who experienced rising prostate-specific antigen after radical prostatectomy, in combination with prostate bed radiotherapy. The results also indicated the feasibility and potential value of circulating tumor cell detection, which constitutes a possible advance in managing prostate cancers.

Photon-pair generation using inverse-designed thin-film lithium niobate mode converters

Spontaneous parametric down-conversion (SPDC) has become a key method for generating entangled photon pairs. Periodically poled thin-film lithium niobate (TFLN) waveguides induce strong SPDC but require complex fabrication processes. In this work, we experimentally demonstrate efficient SPDC and second harmonic generation using modal phase matching methods. This is achieved with inverse-designed optical mode converters and low-loss optical waveguides in a single nanofabrication process. Inverse design methods provide enhanced functionalities and compact footprints for the converter. Despite the extensive achievements in inverse-designed photonic integrated circuits, the potential of inverse-designed TFLN quantum photonic devices has been seldom explored. The device shows an on-chip conversion efficiency of 3.95% W−1 cm−2 in second harmonic generation measurements and a coincidence count rate up to 21.2 kHz in SPDC experiments. This work highlights the potential of the inverse-designed TFLN photonic devices and paves the way for their applications in on-chip nonlinear or quantum optics.

Study on the Damage Evolution of Weathered Granite under Different Confining Pressure Based on Hoek-Brown Failure Criterion and Acoustic Emission Parameters

Abstract The stability of the mine construction is significantly impacted by weathered granite (WG), which presents a significant risk to the security of workers and equipment. In order to investigate the strength characteristics of WG under different confining pressures, acoustic emission (AE) and scanning electron microscopy (SEM) tests were performed on WG under triaxial compression. The relationship between strength evolution and different confining pressures of WG is studied. Under various confining pressures, the variation regularity of the AE parameters of rock samples was examined. Additionally, the microscopic morphology of rock samples is investigated using SEM. The results show that increased confining pressure suppresses WG damage development before the stress peak and switches to promoting damage development following the stress peak. The axial strength is quantitatively analyzed before the WG stress peak using the Hoek-Brown failure criterion, and the axial damage threshold stress under different confining pressures is obtained. Furthermore, the axial damage threshold stress point is clearly increased in the AE ring count rate and energy rate curves of WG at various confining pressures. The last effect of water on WG is microstructural weakening, which manifests itself in the swelling and erosion of the structure by water.

Pulse pile-up correction by auto-regression on linear operations (ARLO) method: A comparison with integration-based algorithms

Radiation detection at high count rate suffers from pulse pile-up, where the counting data and energy information of the system are affected by the overlapping of the system output pulses. There exist various pile-up correction strategies to recover the true information of the pulses, among which pulse-tail extrapolation is a well-known method focused on in this study.Present work aims to use a mono-exponential model for extrapolating the pileup-distorted trailing edge of a pulse, to provide a reference line for calculating the true amplitude of its subsequent overlapping pulse. To this goal, the auto-regression on linear operations (ARLO) method is examined and compared with two integration-based methods (the Foss and the Matheson methods), as well as the non-linear least squares (NLS) method.Despite a higher sensitivity to noise, the ARLO method was able to provide a simple, non-iterative solution with a performance over 400 times faster than the NLS algorithm, according to the analysis of a high count rate set of experimental pulses from a NaI(Tl) detection system. Foss and Matheson methods also provided solutions reasonably faster than NLS (but not surpassing ARLO), performing exactly the same as each other with results very close to NLS, benefiting from their non-iterative nature.

Performance of the mass testing setup for arrays of silicon photomultipliers in the TAO experiment.

Modern neutrino physics detectors often employ thousands, and sometimes even hundreds of thousands, of Silicon Photomultipliers (SiPMs). The TAO experiment [1] is a notable example that utilizes a spherical scintillator barrel with a diameter of 1.8 meters, housing approximately 130,000 SiPMs organized into 4,100 tiles. Each tile with size of 5×5 cm2 consists of a 32-SiPM array functioning as a single detector unit. To achieve an unparalleled energy resolution of 2% at 1 MeV within this volume, the SiPMs must possess cutting-edge parameters, including a photon detection efficiency (PDE) exceeding 50%, cross-talk of approximately 10%, and an extremely low dark count rate (DCR) below 50 Hz/mm2. Maintaining the setup at a negative temperature of -50°C is necessary to achieve the desired DCR. This article presents the setup and methods employed to individually characterize the mass of SiPMs across all 4,100 tiles at the specified negative temperature.

Optimal Leveraging of a Gifford-McMahon Cryocooler’s Regenerative Cooling Power for SNSPD Applications

Superconducting nanowire single photon detectors (SNSPDs) offer unparalleled efficiency, minimal dark count rates, and picosecond jitter, making them ideal for single photon detector applications across the visible to mid-IR spectrum. A common cryogenic system used to reach these detectors’ optimal operating temperatures (>1 K) consists of Sumitomo’s compact RDK101 Gifford McMahon Cryocooler (GMC) running on an Zephyr air cooled compressor, coupled with a helium four (4He) adsorption stage. In this work, our aim is to provide measurements of the RDK101 GMC second stage regenerator tube cooling power at several locations along its length. We then characterise the performance of the adsorption cooler with heat loads applied to the regenerator tube. Our measurements demonstrate that heat loads of 1.2 W can be intercepted at the tube’s section near the GMC’s first cooling stage, with a negligible effect on the performance of the adsorption cooler. The thermal conductivity of yellow brass coaxial was characterised from 4 K to 40 K. Here we show that the heat load from 64 coaxial cable can be optimally intercepted with the defined regenerator cooling power. These results indicate that a 1024-pixel SNSPD array using a 32x32 row column multiplexing architecture could be successfully implemented in this cryogenic platform.

Examination of Magnetic Field Signatures and Local Plasma Distribution Variations in Jupiter's Magnetosphere

AbstractSpinning disk of plasma results in deformation of Jupiter's magnetic field from a dipole to a magnetodisc configuration with significant radial and azimuthal components. Polar orbit of the Juno spacecraft enables a comprehensive in situ observation of Jupiter's plasmadisc at different latitudes. Observations from magnetometer and plasma distribution instruments on Juno mission were used to examine interaction of magnetic field and heavy ions in Jupiter's nightside magnetosphere. Power spectrum analysis was used to evaluate magnetic fluctuations inside and outside of the plasmadisc. Extensive radial maps of magnetic activity in Jupiter's nightside magnetosphere are presented. Comprehensive examination of magnetic fluctuations enable to identify local plasma density variations that correlate with plasma distribution count rate fluctuations. Observations of magnetic signatures together with examination of plasma distribution are used to detect features that point to plasma transport inside and outside of Jupiter's plasmadisc. This work shows that plasma in Jupiter's magnetosphere is contained near centrifugal equator and is not a subject to curvature drift that could generate ring currents. Signatures described as current sheet crossings were investigated. On close inspection these signatures show attributes that belong to stand alone formations rather than a single current sheet structure. This work shows that current flow is not an adequate mechanism to explain deformation of Jupiter's magnetic field.

A compact start time counter using plastic scintillators readout with MPPC arrays for the WASA-FRS HypHI experiment

We have developed a compact detector for measuring beam particles using plastic scintillators readout through Multi-Pixel Photon Counters, which is employed for hypernuclear measurements in the WASA-FRS experiment at GSI. The Time-of-Flight resolution of the newly-developed detector has been investigated in relation to the overvoltage with respect to the breakdown voltage, a maximum counting rate of approximately 3×106/s per segment, and a maximum beam charge of Z = 6. The evaluated Time-of-Flight resolutions between the neighboring segments of the detector range from 44.6±1.3 ps to 100.3±3.6 ps (σ) depending on the segment, overvoltage values, and beam intensity. It is also observed that the Time-of-Flight resolution is inversely correlated to the beam atomic charge (Z).

Use of a commercial neutron counting module to validate neutron-particle transport code simulation of a new cosmic radiation neutron monitor design

This paper reports on one of several experiments used to validate MCNP models and processes employed to define a cosmic radiation (CR) neutron source and benchmark to optimise a new ground level neutron monitor (NM) design. The new NM design aims to be more compact, non-toxic and capable of producing comparable counting efficiencies to the NM-64; a monitor standardised in 1964 and which makes up most of the established global network. A broad-energy neutron monitor, the N50L, originally designed for nuclear material accountancy and safeguards, is used to provide primary data in support of our new NM design. Ambient count rate data from the N50L were acquired from it bare and inside a lead (Pb) sarcophagus to boost the neutron signal. Measured data were compared with calculations made using a Monte Carlo N-Particle (MCNP) transport code model of the setup. The calculated compared to the measured count rate for the monitor inside the Pb sarcophagus are in good agreement with a ratio close to one. However, overpredictions (by almost a factor of two) of the calculated rate for the bare monitor suggest inadequacies of the model for high-energy physics. Pressure corrected count rate data were also compared with data from several existing NM-64s over the same period. Our data are in good agreement with variations observed by these existing monitors on the global network. The N50L uses helium-3 (3He) counters and roughly equates to about 1/17th of the proposed final NM design in terms of detector volume. Scaled count rates from the N50L are within 73% of the rates derived from an NM-64 for a similar latitude, geomagnetic cutoff rigidity and altitude, and differs by <8% of the MCNP simulated response of the proposed design.

Examination of cardiac functions during acute attack and remission period in children with familial Mediterranean fever

Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterized by recurring serosal inflammation. Cardiac involvement in FMF commonly manifests as pericarditis and pericardial effusion; however, there is limited research on myocardial function. This study aimed to assess cardiac functions during active inflammation and remission periods of FMF patients and investigate the cardiac effects of inflammation during the attack period. Thirty-eight FMF patients without additional cardiac diseases were included in the study. Demographic characteristics, clinical symptoms, family history, and MEFV gene analysis results were obtained retrospectively. Blood tests, blood pressure measurements, electrocardiogram evaluations, conventional echocardiography, and speckle tracking echocardiography were performed during the attack and remission periods. Disease severity was assessed using the Pras scoring system. During the attack period, FMF patients exhibited significantly higher leukocyte count, neutrophil count, C-reactive protein, and erythrocyte sedimentation rate compared to the remission period (p < 0.005). Speckle tracking echocardiography revealed decreased function in the inferior segments of the left ventricle during the attack period (p < 0.005). Right ventricular function was more affected in the moderate disease group. FMF patients with lymphopenia during the attack demonstrated more impaired right ventricular function compared to those with normal lymphocyte count. Conclusions: FMF patients experience cardiac abnormalities during active inflammation, highlighting the importance of monitoring cardiac functions in these patients. Speckle tracking echocardiography can provide valuable insights into cardiac involvement in FMF. These findings emphasize the cardiac impact of FMF inflammation and the significance of long-term cardiac function monitoring in the management of FMF patients.What is Known:• The current literature lacks studies investigating myocardial function in the pediatric population during the attack period of this particular disease.• Our objective was to assess the alterations in cardiac function during the attack and remission periods, considering clinical manifestations, disease severity, acute phase reactant levels, and mutation type. We also evaluated the pattern of cardiac involvement and the affected cardiac areas by comparing remission and attack periods.What is New:• Several studies have demonstrated a rise in the prevalence of ischemic cardiac disease and mortality among individuals with FMF.• Investigating cardiac involvement during the attack period in FMF patients can provide valuable insights for the prevention of long-term complications.

Pushing the high count rate limits of scintillation detectors for challenging neutron-capture experiments

One of the critical aspects for the accurate determination of neutron capture cross sections when combining time-of-flight and total energy detector techniques is the characterization and control of systematic uncertainties associated to the measuring devices. In this work we explore the most conspicuous effects associated to harsh count rate conditions: dead-time and pile-up effects. Both effects, when not properly treated, can lead to large systematic uncertainties and bias in the determination of neutron cross sections. In the majority of neutron capture measurements carried out at the CERN n_TOF facility, the detectors of choice are the C6D6 liquid-based either in form of large-volume cells or recently commissioned sTED detector array, consisting of much smaller-volume modules. To account for the aforementioned effects, we introduce a Monte Carlo model for these detectors mimicking harsh count rate conditions similar to those happening at the CERN n_TOF 20 m flight path vertical measuring station. The model parameters are extracted by comparison with the experimental data taken at the same facility during 2022 experimental campaign. We propose a novel methodology to consider both, dead-time and pile-up effects simultaneously for these fast detectors and check the applicability to experimental data from 197Au(n, γ), including the saturated 4.9 eV resonance which is an important component of normalization for neutron cross section measurements.

Edge computing based real-time Nephrops (Nephrops norvegicus) catch estimation in demersal trawls using object detection models

In demersal trawl fisheries, the unavailability of the catch information until the end of the catching process is a drawback, leading to seabed impacts, bycatches and reducing the economic performance of the fisheries. The emergence of in-trawl cameras to observe catches in real-time can provide such information. This data needs to be processed in real-time to determine the catch compositions and rates, eventually improving sustainability and economic performance of the fisheries. In this study, a real-time underwater video processing system counting the Nephrops individuals entering the trawl has been developed using object detection and tracking methods on an edge device (NVIDIA Jetson AGX Orin). Seven state-of-the-art YOLO models were tested to discover the appropriate training settings and YOLO model. To achieve real-time processing and accurate counting simultaneously, four frame skipping ideas were evaluated. It has been shown that adaptive frame skipping approach, together with YOLOv8s model, can increase the processing speed up to 97.47 FPS while achieving correct count rate and F-score of 82.57% and 0.86, respectively. In conclusion, this system can improve the sustainability of the Nephrops directed trawl fishery by providing catch information in real-time.

Modelization of extended axial field-of-view PET scanners to analyze the performance improvement

Positron Emission Tomography (PET) offers non-invasive insights into physiological processes. However, in clinical practice conventional PET scanners face limitations in comprehensive imaging due to their restricted axial field of view (FOV).This study explores the benefits and challenges of extending PET scanner AFOV using Monte Carlo simulation with GATE 9.1. The Biograph Vision Quadra scanner is a novel system based on the Digital Biograph Vision 600 scanner. Both devices use silicon photomultipliers and 3.2 x 3.2 × 20 mm Lutetium Oxyorthosilicate crystals (LSO). However, the 32 detector rings of the Quadra scanner enable a four-fold expansion in the Axial Field Of View (FOV) compared to Vision. As a result, higher sensitivity, and an enhancement of noise equivalent count rate and image quality are achieved. The purpose of this study is to analyze the effect of increasing the number of detector rings and the axial FOV on the scanner performance. To accomplish this, four different geometries are modeled using GATE (GEANT4 Application for Tomographic Emission). Based on the Biograph Vision 600 model, the length and the number of detector rings are gradually extended to reach the length of the Quadra scanner. Thus, four geometries with 8 (25.6 cm), 16 (51.2 cm), 24 (76.8 cm) and 32 (102.4 cm) detector rings are simulated, keeping the crystal configuration and the dimensions in the transaxial plane. The study evaluates sensitivity, Noise Equivalent Count Rate (NECR), and image quality parameters. Results indicate a significant increase in sensitivity and NECR with FOV extension, underscoring enhanced performance. However, artifact occurrence, particularly concentric circular patterns and background homogeneity changes, accentuates with extended AFOV. Normalization algorithms, particularly component-based normalization, mitigate these artifacts. This study contributes to the understanding of the advantages and limitations of extending PET scanner AFOV, offering insights into the effectiveness of component-based normalization for improving PET image quality.

Parallel-plate avalanche counters for heavy-ion beam tracking: History and mysteries

Despite being an old detector concept, position-sensitive parallel-plate avalanche counters (PPACs) remain widely used today for heavy-ion position and timing measurements. In modern rare isotope beam facilities and large-acceptance fragment separators, PPACs are used to characterize beam properties (diagnostics), facilitate beam delivery (tuning), and provide event-by-event beam tracking for particle identification (PID). Most popular particle localization methods in PPAC detectors are based on strip electrodes electrically connected to resistive-chain circuits or delay lines. More exotic systems include optical readouts based on recording electroluminescence light with high-granularity photodetector arrays or high-resolution resistive anode electrodes. PPACs with conventional resistive-chain or delay-line readouts achieve typical position and time resolutions of below 1 mm (σ) and around 150 ps (σ), respectively. In addition, delay-line systems are capable of counting rates above several hundred kHz for beam areas of a few millimeters square, and around 1 MHz for larger beam sizes. Resistive-chain readouts have limited rates of a few tens of kHz. A review of the operation principles and performance of PPAC detectors is presented in this paper. We will discuss decades-long experience building and operating PPACs developed at the National Superconducting Cyclotron Laboratory, and then refined at the Facility for Rare Isotope Beams (FRIB), mostly focusing on the delay-line readout technique (DLPPAC). We will also discuss problems that arise due to electric discharges at high rates and briefly describe ongoing developments at FRIB. Published by the American Physical Society 2024