AVIAN INFLUENZA![Figure][1] Isolated. Indonesia has had the world's greatest number of H5N1 deaths, even while the country flip-flops on sharing flu samples with the World Health Organization. CREDIT: TRISNADI/AP PHOTO A battle between Indonesia and the World Health Organization (WHO) is escalating. Indonesia's health minister, Siti Fadilah Supari, has claimed that WHO is refusing to return dozens of H5N1 influenza viruses isolated from Indonesian samples. WHO calls the claims baseless and says Indonesia can get back the viruses once it shows it can handle them safely. The clash promised to complicate what was already expected to be a difficult international meeting about pandemic preparedness, slated to start in Geneva, Switzerland, this week, after Science went to press. At issue are 56 specimens from human H5N1 victims that Indonesia has shared with WHO as part of the Global Influenza Surveillance Network over the past few years. As usual, the samples have gone to WHO's four Collaborating Centres in London, Atlanta, Tokyo, and Melbourne, where researchers isolate and study the virus. Their analysis helps WHO monitor virus evolution, drug resistance, and pandemic risk, as well as aiding vaccine development. Indonesia, by far the most heavily afflicted country with 113 human cases and 91 deaths, has protested the scheme; the country worries that even if it collaborates, it will not have access to vaccines if a pandemic occurs. So far in 2007, Indonesia has shared only two samples, says David Heymann, who heads WHO's pandemic influenza efforts. Heymann says that at Supari's request, on 31 October WHO sent Indonesia a list of the 56 specimens the country had submitted to the network prior to 2007. He says the four labs had isolated H5N1 virus from 40 of them. But according to a report in the Jakarta Post , Supari said at a press conference in Jakarta on 8 November that WHO refuses to send the samples back. “We keep asking [WHO] to return the samples because they belong to us. This is for the sake of our country's sovereignty,” the newspaper quoted Supari as saying. Health ministry officials could not be reached to confirm the report. Heymann claims Supari is trying to cast WHO in a bad light. “She has always said she doesn't trust WHO, and she's finding new reasons not to trust us,” he says. Masato Tashiro, director of the WHO Collaborating Centre for Reference and Research on Influenza in Tokyo, says he believes Indonesia did not retain part of the samples, as countries usually do, because it previously did not have the biosafety level 3 (BSL-3) laboratories recommended for handling dangerous pathogens. Indonesia had cooperated with WHO's flu-sharing network until early this year when it learned that an Australian company had developed a vaccine using an Indonesian H5N1 strain. Fearing that such a vaccine made outside the country would be out of reach financially, Indonesia started developing its own research and development capabilities while withholding specimens and demanding capacity-building assistance from the international community. Tashiro says that when the institutions requesting viruses can certify that their planned BSL-3 labs are up and running, getting viruses returned from Japan—and probably other countries—would be routine. Although Indonesia is the only country that has stopped sending samples, it is reportedly trying to persuade others to follow course. Widjaja Lukito, a physician at the University of Indonesia in Jakarta and a member of Indonesia's delegation to the Geneva meeting, says Indonesia would “clarify everything” in Geneva. Heymann and others say any interruption of the 55-year-old sharing system would create a huge risk for global health. [1]: pending:yes