Letters7 July 2020Estimation of Coronavirus Disease 2019 Burden and Potential for International Dissemination of Infection From IranFREEAshleigh R. Tuite, PhD, MPH, Isaac I. Bogoch, MD, and David Fisman, MD, MPHAshleigh R. Tuite, PhD, MPHUniversity of Toronto, Toronto, Ontario, Canada (A.R.T., D.F.)Search for more papers by this author, Isaac I. Bogoch, MDUniversity of Toronto and University Health Network, Toronto, Ontario, Canada (I.I.B.)Search for more papers by this author, and David Fisman, MD, MPHUniversity of Toronto, Toronto, Ontario, Canada (A.R.T., D.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-0593 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Sharifi and colleagues' thoughtful comments and concerns. We agree that models are simplified representations of reality and are limited by the data used to parameterize them. In our analysis, we assumed that COVID-19 had been circulating in Iran for 1.5 months at the time of our analysis in late February, which would be consistent with an initial case introduction in early to mid-January. In support of this assumption, data now suggest that there was rapid global dissemination of COVID-19 cases in January (before travel restrictions were implemented on 23 January) that was undetected because of the high prevalence of mildly symptomatic or asymptomatic infections (1). The use of data on average tourist behaviors was a required simplification and represented the best available data. We conducted multiple sensitivity analyses, and even our highly conservative estimate of the epidemic size in Iran—which assumed no undetected exported COVID-19 cases among all outbound air passengers—was more than 40 times the officially reported numbers at that time.Dr. Sharifi and colleagues mistakenly assert that we used the Infectious Disease Vulnerability Index to estimate Iran's outbreak response capacity. We actually used this index to highlight other countries with high connectivity to Iran via air travel that would benefit from heightened surveillance. We concur that such a metric may not fully capture a country's capacity to respond to public health threats, especially in the midst of a public health emergency. However, we contend that it is useful for stratifying risk and identifying particularly vulnerable countries when used in conjunction with other data, as was done in our analysis.In conclusion, we recognize the limitations associated with our analysis, which mainly relate to simplifying assumptions. Despite these limitations, the key finding of our study has been validated by abundant observations consistent with a large COVID-19 epidemic in Iran (2, 3), including the appearance of new large burial sites there that became visible on satellite imagery after the epidemic began in that country (4). Our model results are one further piece of evidence lending support to this conclusion.