Countries Bordering Research Articles

Review of Lyme Borreliosis in Africa—An Emerging Threat in Africa

Lyme borreliosis (LB) is more common in the Northern Hemisphere. It is endemic mainly in North America, where the vectors are Ixodes scapularis and Ixodes pacificus, and in Eurasia, where the vectors are Ixodes ricinus and Ixodes persulcatus. Both tick-borne diseases and LB are influenced by climate change. Africa and South America are crossed by the equator and are situated in both the Northern and Southern Hemispheres. In Africa, the LB is present on the Mediterranean and the Indian Ocean coasts. Borrelia lusitaniae is prevalent in countries bordering the Mediterranean Sea, such as Tunisia, Morocco, Algeria, and Egypt. Ticks were detected in the Ixodes Ricinus, which are carried by migratory birds and the Ixodes inopinatus and captured by the Psammodromus algirus lizards. The Borreliae Lyme Group (LG) and, in particular, Borrelia garinii, have been reported in countries bordering the Indian Ocean, such as Kenya, Tanzania, and Mozambique, transported by migratory birds from North African countries, where the vector was identified as Hyalomma rufipes ticks. This review aims to document the presence of Borreliae LG and LB in Africa.

Climate-related risk to maize crops in China from Fall Armyworm, Spodoptera frugiperda

AbstractThe Fall Armyworm, Spodoptera frugiperda, invaded China late in 2018 and was responsible for substantial crop losses, especially to maize. This work focuses on the suitability of climate across China for Fall Armyworm survival and spread. It uses climate metrics derived with guidance from experts to enable assessment of the risks posed by Fall Armyworm on maize production in different regions of China. The locations and time of year when temperature conditions are within a viable range for Fall Armyworm survival (minimum temperature higher than 9.7$$^\circ$$ ∘ C and maximum temperature lower than 39.2$$^\circ$$ ∘ C) are used to estimate the spatial distribution of winter breeding and overwintering zones, which helps understand the regions and timing of Fall Armyworm migration risk into northern maize production regions. In addition, meridional wind conditions across the Yangtze River basin area are assessed, and a metric of migration potential from the winter breeding and overwintering regions in the south towards northern regions with maize production is established. Results show that temperature during the winter months currently limits Fall Armyworm winter breeding populations to the very southern regions of China (and bordering countries to the south). However, due to the consistent timing and direction of the East Asian Summer Monsoon winds, the Fall Armyworm could easily be directed northwards to the Yangtze River basin during summer months with a peak in July. For this reason, pest management actions against the Fall Armyworm on summer maize should be taken.

The mental health toll of the Russian-Ukraine war across 11 countries: Cross-sectional data on war-related stressors, PTSD and CPTSD symptoms

Exposure to war is a severe traumatic experience with disastrous mental health effects. This study examined the mental health among 5,560 residents in 11 countries worldwide at different geographic distances from the epicenter of the Russian-Ukrainian War (RUW). An online questionnaire assessed war-related variables (e.g., personal experiences with RUW, perceived concern and threat), previous life stress experiences, and mental health (i.e., resilience, anxiety, depression, perceived stress, ICD-11 PTSD, and CPTSD). Results showed regional differences. Ukrainians had the worst mental health indices, followed by participants in the bordering countries, and then by those in the distal ones. War-related variables were associated with worse mental health. The common predictors for PTSD and CPTSD were previous mental disorder, anxiety, and perceived stress, whereas unique predictors were also found (PTSD: female gender and impact of news on mental health; CPTSD: being single, overall impact of war on mental health, sum of lifetime traumatic experiences, resilience (inversely), and depression). Given the continuing uncertainty about the threat of war for many of the nations in this study, findings suggest the need for practitioners to support concerned populations.

Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study

Monkeypox virus clade I is endemic in several central African countries and characterised by an increase in disease severity and mortality. Since October, 2023, a large-scale mpox outbreak has emerged in DR Congo, and in March, 2024, the first individuals with mpox were reported outside the endemic areas in Republic of the Congo. We aimed to provide insight into the epidemic by sequencing samples obtained from individuals with mpox in Republic of the Congo. In this cross-sectional, descriptive study, samples were collected from individuals with suspected mpox between Jan 15 and April 8, 2024, in Brazzaville, Pointe-Noire, Likouala, Cuvette-Centrale, and Plateaux (Republic of the Congo). Blood samples, skin or oropharyngeal swabs, or skin crusts were obtained for molecular diagnosis via real-time PCR. Monkeypox virus sequences were obtained and analysed using newly established nanopore sequencing methodology and bioinformatic pipeline. The sequences obtained were aligned and used to construct a maximum likelihood phylogenetic tree using IG-TREE. 61 samples were collected from individuals with suspected mpox, 31 of which were positive for monkeypox virus and were included in our analysis (four positive samples were excluded due to unavailability of epidemiological data or insufficient biological material). Individuals who tested positive for monkeypox virus were from Cuvette-Centrale (19 [61%] of 31), Likouala (eight [26%]), and Pointe-Noire (four [13%]). 20 (65%) were male and 11 (35%) were female. Phylogenetic analysis of sequences showed two major clusters within clade Ia. One cluster was made up of four sequences from this study clustering with two monkeypox virus sequences from the current DR Congo outbreak, three older sequences from Central African Republic sequenced between 2017 and 2018, and seven sequences from DR Congo sequenced in 2006-07 and 2022. The second cluster was made up of 16 sequences from this study clustering with sequences from the current DR Congo outbreak. In addition, sequences from Republic of the Congo show multiple phylogenetic positioning suggesting the occurrence of multiple co-circulating strains in the human population. Our findings suggest that multiple monkeypox virus strains are co-circulating in the human population, highlighting the need for implementation of expanded mpox surveillance, especially in countries bordering DR Congo and Republic of the Congo, in combination with control measures focused on containing the current outbreaks in these countries to prevent escalation into a larger-scale epidemic. Intramural Research Program of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.

POSSIBILITIES OF CREATING CROSS-BORDER TOURIST DESTINATIONS IN EAST-CENTRAL EUROPE

Tourism development is one of today's popular tools for mitigating regional inequalities, thus many regions see tourism as an opportunity to break out. This is no different in the case of border regions, where development in this direction is also supported by cross-border, EU-financed or (co-)financed programs. The aim of the paper is to investigate whether there is a real possibility of connecting the areas along the national borders for tourism purposes and creating sustainable tourism in these regions. The study examines the possibility of creating cross-border tourist destinations in three pre-selected areas in the Hungarian-Croatian, Hungarian-Slovenian and North-Western Hungarian-Slovakian border regions during the last two, already closed programming periods. Results of the research show, that cooperation between border countries for real tourism purposes is still possible today, and it only really aimed at creating uniform reception areas that ignore borders in a few cases. After the implementation of the programs, cross-border destinations as sellable tourist products were not created. The study shows that, in the case of two regions, the potential is given and the initiatives aimed at creating cross-border destinations are promising.

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020.

Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7464 specimens (oropharyngeal (OP) and cloacal specimens) from poultry and 6531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n = 292) of specimens collected from poultry and 0.2% (n = 10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A-positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as a low-pathogenicity avian influenza H5N2 virus of the Eurasian lineage, and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP and nasal specimens from poultry workers with acute respiratory illness (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low-pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for the introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

A Short Review on Zika Virus

The Zika disease, a mosquito-borne flavivirus, has procured basic thought of late. This disease has been standing apart as genuinely newsworthy in view of its constant pandemic and general prosperity emergency, particularly in southern America and Asia. The episode, what began in December 2015, incited the World Prosperity Relationship to articulate it an overall prosperity emergency in February 2016. While most occasions of Zika disease pollution are depicted by subclinical or delicate influenza like affliction, there have been reports of extra outrageous signs. A couple of youngsters have made Guillain-Barré problem, while newborn children brought into the world to corrupted mothers have been believed to have Microcephaly. The contamination has even spread to bordering countries, transforming into a serious concern for the Indian people. This intensive review article intends to outfit perusers with a blueprint of the contamination, its finding, clinical features, and the leaders. By diving into these perspectives, we want to uncover understanding into the greater consequences of the Zika contamination and its impact on broad prosperity.

An enlightened aristocrat at the crossroads of countries and languages

This paper focuses on the personality of an important aristocrat from the Age of Enlightenment, Ignác Dominik Chorynský, as a person living and acting on the border of countries and languages, creating an extensive network of social and intellectual contacts around him. The vast personal archive of this nobleman conserved in Opava still awaits closer examination. Ignác Dominik Chorynský, a member of an old Moravian family, settled after 1750 in Velké Hoštice under Prussian domination, due to his marriage to Countess Barbora Hodic, while also being active in Opava, on Austrian territory. This paper examines the “frontier” position of Ignác Dominik from several aspects. The first is from the political aspect: the count was a subject of the King of Prussia and, at the same time, a regional governor in the Prussian and Austrian parts of Opava, still subordinate to the House of Habsburg. Moreover, his brother Jan Nepomuk fell in the Seven Years’ War against Prussia. Obviously, the position on the border also played a role in the representation of the count, as evidenced by the “Banquet Hall of Three Lands”, which he had built in Velké Hoštice. In the following portion, this paper presents Ignác Dominik’s wide network of contacts: amongst the local nobility in Silesia, amongst actors on the Prussian side (Frederick II, the nobles and intellectuals of Wrocław), and in Moravia (his brothers Matyáš and František Jan, Count Mittrowsky, etc.). This paper then delves into the theme of artistic transfers, as Ignác Dominik contributed to the cultural development of his region with his activities (building the castle in Velké Hoštice, rebuilding the so-called “Blücher Palace” in Opava, collecting works of art, etc.). Finally, this paper focuses on the possible role of Silesian and Prussian milieu on Ignác Dominik’s cultural activities. This paper also demonstrates the unique position of the Opava and Hlučín regions after the Wars of Austrian Succession and the imminent role of Ignác Dominik and his close friends in the cultural development of the region.

Employment and Poverty under Neoliberal Capitalism

ABSTRACT: Neoliberal capitalism, characterized by freer movement of goods and services and capital, including finance, across country borders, keeps down real wages everywhere even as labor productivity increases. This raises income inequalities, creating an ex ante tendency toward overproduction, which underlies the current stagnation and growing unemployment in the world economy. This crisis cannot be overcome within neoliberalism, since globalized finance opposes larger state expenditure financed through heavier taxation of the rich or a larger fiscal deficit. This underlies the current pervasive tendency toward neofascism. Overcoming neofascism requires transcending neoliberalism by mobilizing working people around a rights-based welfare state.

The Impact of Geopolitical Risks on Global Supply Chains - The Example of the Palestinian-Israeli Conflict

Geopolitical risk is an international risk that transcends the borders of a single country, and in response to the diversity and suddenness of the types of geopolitical risk-causing indices, there are all kinds of uncertainties in the process of global supply chain management affected by geopolitical risk, which makes the main body of the supply chain affected by the risk. With the development of globalisation, more and more enterprises extend their production and supply chains to all parts of the world, which makes geopolitical risk one of the important challenges that they must pay attention to and deal with. Factors such as regional political instability caused by the Israeli-Palestinian conflict, disruptions in the transport of goods, the impact on regional supply chains, and volatility in financial markets all pose challenges to the stability and reliability of global supply chains.

Analysis of lithium trade patterns and influencing factors in the regions along the "Belt and Road".

Lithium has broad applications in several emerging industries and fields, including high energy batteries, energy storage, aerospace, and controlled nuclear reactions. Currently, the discrepancy between the supply and demand for lithium resources increases, and its distribution is uneven. Within the framework of the "Belt and Road" Initiative, the lithium trade pattern evolves constantly. However, the trade pattern of lithium in the nations along the "Belt and Road" is likely to face substantial repercussions in modern world of unilateral protectionism and geopolitical conflicts. Taking the social network analysis approach as a tool, this study first examines the characteristics of the lithium trade network structure as it has evolved over the years in the Belt and Road countries, from 2000 to 2022. Additionally, this study uses the quadratic assignment problem approach to analyze the factors influencing the evolution of the lithium trade network. The study shows that: (1) The spatial patterns of import and export trade network of lithium in countries along the route has a certain path dependence. And the market is mainly concentrated in East Asia, Central and Eastern Europe, South America and Southeast Asia. (2) The network density of the countries along the route has increased year after year, but it remains low. And the fluctuation of the network's reciprocity has increased, with a huge magnitude of variation. The number of core countries in the network has decreased over time, but the core-periphery structure has stayed largely steady. China, Chile, and South Korea are the network's main node countries. (3) Regarding the influencing factors, the differences in economic and technological development between these countries have a beneficial impact on the formation of lithium trade; whether or not regional trade agreements have been signed, the differences about average tax rates for mineral products, bordering countries, and similar languages and cultures are all conducive to the establishment of close trade links. The contribution of this essay is of paramount importance for understanding different countries' role along the Belt and Road in the lithium trade network pattern, and promoting regional trade cooperation.

Convergence in European Cross-Border Structures: The Case of Spanish Euroregions

ABSTRACT European border regions are considered to be laboratories of the European integration. However, it is not clear whether that integration is an indicator of convergence between the regions, since it can result from similarities as well as from existing differences between border regions. This paper studies the processes of σ, β and spatial convergence in the particular case of the Euroregions, mixed territories with (international) border and non-border regions, with the aim of determining whether the intense cooperation relationships that occur in these particular structures stimulate the convergence as well as contribute to the levelling of the economic inequalities within the Euroregion. Specifically, we focus on the Spanish Euroregions, to analyze how the inherent differences between the border countries could determine the presence or absence of convergence in the Euroregions. The results show that convergence is achieved in the Spanish Euroregions that share a border with Portugal but not in those bordering France.

Epidemiological and environmental investigation of the 'big four' Vibrio species, 1994 to 2021: a Baltic Sea retrospective study.

BackgroundThe Vibrio genus comprises several bacterial species present in the Baltic Sea region (BSR), which are known to cause human infections.AimTo provide a comprehensive retrospective analysis of Vibrio-induced infections in the BSR from 1994 to 2021, focusing on the 'big four' Vibrio species - V. alginolyticus, V. cholerae non-O1/O139, V. parahaemolyticus and V. vulnificus - in eight European countries (Denmark, Estonia, Finland, Germany, Latvia, Lithuania, Poland and Sweden) bordering the Baltic Sea.MethodsOur analysis includes data on infections, Vibrio species distribution in coastal waters and environmental data received from national health agencies or extracted from scientific literature and online databases. A redundancy analysis was performed to determine the potential impact of several independent variables, such as sea surface temperature, salinity, the number of designated coastal beaches and year, on the Vibrio infection rate.ResultsFor BSR countries conducting surveillance, we observed an exponential increase in total Vibrio infections (n = 1,553) across the region over time. In Sweden and Germany, total numbers of Vibrio spp. and infections caused by V. alginolyticus and V. parahaemolyticus positively correlate with increasing sea surface temperature. Salinity emerged as a critical driver of Vibrio spp. distribution and abundance. Furthermore, our proposed statistical model reveals 12 to 20 unreported cases in Lithuania and Poland, respectively, countries with no surveillance.ConclusionsThere are discrepancies in Vibrio surveillance and monitoring among countries, emphasising the need for comprehensive monitoring programmes of these pathogens to protect human health, particularly in the context of climate change.

From not knowing, to knowing more needs to be done: health care providers describe the education they need to care for sex trafficked patients

BackgroundSex trafficking is highly prevalent, pernicious, and under-recognized. When an individual is trafficked for the purpose of sexual exploitation within the borders of a single country, it is termed domestic sex trafficking. Sex trafficked persons can experience severe physical and mental health outcomes requiring medical attention and treatment. However, health care providers often fail to identify sex trafficked patients, missing opportunities to provide needed care and support.MethodsIn this qualitative study, we interviewed 31 health care providers (physicians, nurses, and social workers) working in Ontario, Canada to learn what they identified as their specific education and training needs to recognize and care for sex trafficked persons. Interviews were conducted over Zoom, recorded, and transcribed. Coding of the transcripts followed a standard framework for qualitative studies. Codes related to the education and training needs of providers were identified as a core issue suited to further analysis.ResultsThree themes related to providers’ education and training needs emerged. These acknowledge basic (Foundational knowledge), as well as more specific learning needs (Navigating the encounter). The final theme, (“It just seems so much bigger than me”) suggests that even with some knowledge of domestic sex trafficking, participants still experienced considerable distress and multiple challenges due to gaps in the broader system impacting the provision of appropriate care.ConclusionsParticipants voiced their need for specialized sex trafficking education as well as role specific training to combat their sense of inadequacy and provide better care for their patients. Participants’ education needs ranged from requiring the definition of domestic sex trafficking and the frequency of its occurrence, to the various circumstances associated with increased risk of recruitment into sex trafficking. In terms of desired training and specific skills, participants wanted to learn how to identify a person being sex trafficked, broach the subject with a patient, know what to do next including access to local resources and referrals, as well as connections to other critical services, such as legal and housing. The results can be used to inform the design and content of education and training on sex trafficking for health care providers.

Applying Spectroscopies, Imaging Analyses, and Other Non-Destructive Techniques to Olives and Extra Virgin Olive Oil: A Systematic Review of Current Knowledge and Future Applications

Given its huge economic, nutritional, and social value, extra virgin olive oil (EVOO) is an essential food. This flagship product of the countries bordering the Mediterranean basin is one of the most frauded products worldwide. Although traditional chemical analyses have demonstrated to be reliable tools for olive drupes and EVOO quality assessment, they present several drawbacks; the urgent need for fast and non-destructive techniques thus motivated this review. Given the lack of comprehensive reviews in the literature, our first aim was to summarize the current knowledge regarding applying spectroscopies, imaging analyses, and other non-destructive techniques to olives and EVOO. The second aim was to highlight the most innovative and futuristic applications and outline the future research prospects within this strategic production chain. With respect to olive drupes, the most interesting results were obtained using RGB imaging and NIR spectroscopy, particularly using portable NIR devices and specific digital cameras for in-field or in-mill monitoring. Nevertheless, it is important to highlight that RGB imaging and NIR spectroscopy need to be integrated with flesh hardness measurements, given the higher reliability of this parameter compared to olive skin color. Finally, with respect to EVOO, although several useful applications of visible imagining, UV–Visible, NIR, and Mid-Infrared spectroscopies have been found, the online monitoring of EVOO quality using NIR spectroscopy strikes us as being the most interesting technique for improving the EVOO production chain in the near future.

Tobacco Taxation in Spain: A tax laggard with a brighter possible future.

In recent years tobacco taxation in Spain has regressed, with its Tobacconomics tax scorecard falling from 3.9 points (out of 5) in 2014, to only 2.625 in 2020. The objective of this research is to provide a detailed analysis of the causes behind this deterioration and identify possible ways forward for reversing this trend. A retrospective 2014-2022 analysis of manufactured cigarettes (FM) and roll-your-own tobacco (RYO) markets including tax structure/rates, affordability, retail price gaps across products, and price differentials with bordering countries. A market level simulation model to 2028 studied the impact of various tax policy scenarios on smoking prevalence, premature deaths averted, smoking intensity, product substitution, government revenue, sales, and industry profit. A lack of tax increases in a context of inflation and income growth during the past 8 years means FM and RYO have become 13% more affordable, with a constant differential of €2 between 20 FM and RYO sticks, and the price gap between Spain and neighbouring France increased. Modelling of two realistic reform scenarios that reduce/eliminate the price gap between FM and RYO suggest substantial increases in government revenues and up to 700,000 fewer smokers and 210,000 fewer premature deaths. Current European Union legislation on tobacco taxes leaves ample room for much needed tobacco tax reform. For the sake of both public health and the economy, Spain should increase its Minimum Excise Tax. This would not only save lives, but also bring much needed revenue for the government. The stance of Spain on tobacco taxes has deteriorated recently. This study argues that the failure of successive governments to raise minimum taxes in an inflationary context has made tobacco products more affordable, and quantifies the improvements in smoking prevalence and excise revenue that would accrue if the authorities act urgently increasing rates within realistic limits.Spain is representative of European countries where government inaction has rendered minimum tobacco taxes obsolete. Given the postponement of the revision of the European Union Tobacco Tax Directive, this study highlights the need to act unilaterally within the existing legal framework.

Serosurvey of canine leishmaniasis in five departments near an identified human clinical case in Marseille (France)

Leishmania infantum is a protozoan parasite of the family Trypanosomatidae, transmitted by the bite of phlebotomine sand flies (Diptera: Psychodidae). It is responsible for human and canine leishmaniasis in countries bordering the Mediterranean basin. Here we describe a clinical case of human cutaneous leishmaniasis in a 76-year-old female patient living in Marseille. Upon interrogation, the patient had no history of recent travel or contact with animals. The study involved clinical, serological, and molecular investigation of the occurrence of Leishmania infection in 718 dogs from five departments within a 130 km radius perimeter around Marseille. Five dogs showed signs of moderate leishmaniasis. Additionally, the serological survey of dogs revealed a global seroprevalence of 5.1%, with a significantly different prevalence in the Vaucluse department. Molecular analysis and phylogenetic studies highlighted the close relatedness of Leishmania strains between human and canine hosts with 99.6% of identity, indicating local transmission. The findings underscore the importance of serological surveillance in dogs and human. In a One Health approach, it is necessary to continue investigating Leishmania infection in all potential reservoirs, especially for zoonotic L. infantum in wildlife (red foxes, leporids, rodents, etc.) but also in dogs, cats, and equids.

A methodological approach for enhancing visualization of country data representation in the presence of significant spatial disparity

In this article, we present a methodological approach to address spatial disparity in global data representation, introducing an algorithm called Flexible Mapping to Understand Spatial Analysis (FLEMUSA). We utilize world maps to depict various data points across countries, revealing substantial variation among them. However, conventional choropleth maps often fail to effectively represent regions with sparse data, obscuring valuable insights. To mitigate this issue, we propose interactive graphical methods in both two and three dimensions, implemented through open-source Python code accessible via Google Colab. Our approach includes several contributions such as excluding countries without data from the representation, scaling magnitudes within country borders, focusing on regional analysis, and using logarithmic scales for bubble maps proportional to country sizes. Additionally, we offer interactive 2D and 3D representations, rotatable 3D representations, and zoomable options, facilitating enhanced visualization of regional similarities amidst data heterogeneity. Through this algorithm, we aim to improve the clarity and interpretability of spatial data analysis, integrating solutions for extreme data overdispersion, all programmed with open-source code.-Utilization of world maps for visual representation of data across countries mitigating the overdispersion step by step.-Implementation of graphical methods, including interactive 2D and 3D maps, to address spatial disparity.-Provision of open-source code for customizable graphical representations, facilitating implementation in online journals as interactive code snippets.

The Geopolitics of EU Enlargement: From Club to Commons

Russia’s full-scale invasion of Ukraine changed the European Union’s attitude towards enlargement. Whereas five years previously European leaders had suggested that any expansion of the EU should be put on hold, suddenly they embraced potential membership for Ukraine, Georgia, Moldova and the Western Balkans. Enlargement is the strongest instrument that the EU has to bring stability to and foster reform in bordering countries. But that strategy invites risk. Countries might join before their democracies are stable and before European institutions are ready to accommodate a wider and more diverse membership. Nevertheless, enlargement is better than the alternative. Russian victory over Ukraine would threaten not only the security of the EU but also the functioning of the single market, efforts to fight inflation and the stability of the financial system. The EU needs enlargement to protect the European commons.

Caspian Sea as a continuation of the history of determining the border of the Republic of Kazakhstan

The article examines the aspirations of our sovereign state to strengthen its foreign policy since 1991 and the process of demarcation of the border, maintaining good neighborly relations with neighboring countries. One of the most important achievements in solving the problem was the decision in August 2018 to demarcate the Caspian Sea border, which is of strategic importance in strengthening the state border of Kazakhstan, preserving the territorial integrity and independence of the country, ensuring national security. The main purpose of our scientific article is to reveal the historical significance of the actions taken on the Caspian Sea, the latest milestone in the actions of the Republic of Kazakhstan to strengthen the country's borders. The scientific novelty of the work is a comprehensive, concise analysis of the measures taken in the Republic of Kazakhstan to clarify the borders of the country since 1991 and the optimal use of the existing experience of Kazakh diplomacy in defining the status of the Caspian Sea. We believe that some of the results of our research can be applied to the study of this topic.