Counting Function Research Articles

On the Primorial Counting Function

Let Nk denote the kth primorial and let K(x) be the primorial counting function, the function that counts the number of primorials not exceeding x. In this note, we examine the sign of the functions K ( x ) − π ( log x ) and K ( x ) − li ( log x ) and find a new necessary and sufficient criterion for the truth of the Riemann hypothesis.

To Study on Number of Subgroups of Finite Abelian Group Zm ⊗ Zn

In this paper, we determine the number of subgroups of group Z_(p^m ) ⊗ Z_(p^n ) which may be cyclic or non –cyclic by using simple number –theoretic formulae. We describe the subgroups of the group and derive a simple formula for the total number s(m,n ) of the subgroups where m, n are arbitrary positive integers. We point out that certain multiplicative properties of related counting functions for finite. Abelian groups are immediate consequences of these formula.

Effect of recombinant human thrombopoietin on platelets in rats with D-galactosamine salt-induced acute liver failure

To evaluate the effects of recombinant human thrombopoietin (rhTPO) on platelet count (PLT) and liver function in acute liver failure (ALF) rats by observing the dynamic changes of PLT, thrombopoietin (TPO) and liver function during ALF. Twenty-four male Sprague-Dawley (SD) rats were divided into model group, TPO group and interleukin-11 (IL-11) group using a random number table method, with eight rats in each group. All rats were intraperitoneally injected with D-galactosamine (D-GalN, 1 500 mg/kg, dosed within 72 hours) to induce the ALF model. After modeling, rats in TPO group was received subcutaneous injection of 15 μg/kg of rhTPO for 5 days, and rats in IL-11 group was received subcutaneous injection of 0.45 mg/kg of IL-11 for 5 days. Venous blood samples were collected before and at 1, 3, 5, 7 and 12 days after molding for whole blood cell detection. The level of TPO in serum was detected by enzyme-linked immunosorbent assay (ELISA). Liver function indexes including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil) and albumin (ALB) were measured before and at 1, 3 and 5 days after modeling. The rats were sacrificed 12 days after the modeling, and the pathological changes of liver tissue were observed by hematoxylin-eosin (HE) staining. Two rats in each group died within 24-48 hours after modeling. HE staining showed that all three groups of ALF rats showed large flake necrosis of hepatocytes, disorder of hepatic lobular structure, mesh scaffold collapse, hepatic sinus congestion and hemorrhage, and flake infiltration of inflammatory cells on day 12 after modeling. The levels of serum ALT, AST and TBil of rats in each group were significantly increased 1 day after modeling and then decreased. The level of ALB decreased significantly on the first day after modeling and then increased, but there was no significant difference in the trend of liver function indexes among the three groups. PLT in the three groups decreased rapidly on day 1 after modeling, and then recovered gradually with the improvement of liver function. The PLT of the TPO group rose to the peak value 7 days after molding and was significantly higher than that of the model group [PLT (×109/L): 1 673.3±347.5 vs. 855.3±447.0, P < 0.05], while there was no significant difference between the IL-11 group and the model group [PLT (×109/L): 1 350.3±386.6 vs. 855.3±447.0, P > 0.05]. The level of serum TPO of the three groups increased significantly on day 1 after modeling, then decreased, and dropped to the lowest value on day 5, but there was no significant difference in the trend of serum TPO level among the three groups. PLT in ALF rats decreased rapidly in the early stage and recovered gradually with the improvement of liver function, and the serum TPO level increased first and then decreased. Injection of rhTPO can significantly increase PLT in ALF rats, but has no significant effect on liver function and survival rate.

Countability in Kaingang

This paper is the first investigation of nominal countability in Kaingang, a Jê language spoken in Brazil. The main claim of this paper is that all Kaingang nouns are lexically count. This hypothesis is supported by a number of morphosyntactic and semantic properties of nouns in the language. Among them two crucial properties emerge: (i) Kaingang allows numerals and other count quantity expressions to combine directly with individual and substance nouns, and (ii) in quantity judgement tasks (Barner &amp;amp; Snedeker 2005) comparisons with both types of nouns are cardinality-based. I analyze this generalized counting strategy as a direct effect of the lexical semantics of nouns. Building on Krifka’s approach (1989; 2007; 2008), I argue that all Kaingang nouns are born quantized, i.e., they are lexically equipped with a context-sensitive built-in counting function that measures quantities in terms of individual- or portion-units. This paper contributes with additional crosslinguistic evidence to two claims: (i) that the mass/count distinction in the nominal domain isn’t a language universal (Wiltschko 2012), and (ii) that the defining property of count nouns is quantization, rather than atomicity (Krifka 1989; 2007).

Feasibility of Simultaneous Bilateral Endoscopic Surgery in Prone Split-Leg Position for Bilateral Upper Urinary Tract Calculi: A Pilot Study

Introduction: We explored the viability of simultaneous bilateral endoscopic surgery (SBES) in the prone split-leg position for managing bilateral calculi. Methods: We retrospectively reviewed 72 patients who underwent SBES, with procedures involving ureteroscopy (URS) and contralateral percutaneous nephrolithotomy (PNL) simultaneously, in prone split-leg position. Results: Operative times averaged 109.38 ± 30.76 min, with an average hospital stay of 7.79 ± 3.78 days. The bilateral stone-free rate (SFR) was 70.83%, while URS and PNL demonstrated comparable unilateral SFR (83.33% and 79.17%, respectively). Receiver operating characteristics curves for predicting unilateral residual fragments yielded an area under the curve of 0.84 (URS) and 0.81 (PNL) with respective cutoff values of stone diameter of 11.55 mm and 23.52 mm. Fifty-seven (79.17%) and 15 (20.83%) patients encountered grade 0–1/2 complications, with no severe complications (grade 3–5) recorded. No significant changes in blood count or renal function were observed post-SBES. Conclusions: SBES in the prone split-leg position is a viable option for managing bilateral upper tract urolithiasis. Larger scale studies are needed to further assess safety and efficacy in various positions.

Analytic Ax–Schanuel for semi-abelian varieties and Nevanlinna theory

Let $A$ be a semi-abelian variety with an exponential map $\exp : \mathop{\mathrm{Lie}}(A) \to A$. The purpose of this paper is to explore Nevanlinna theory of the entire curve $\hskip1pt{\widehat{\mathrm{exp}}}\hskip2pt f := (\exp f, f) : \mathbf{C} \to A \times \mathop{\mathrm{Lie}}(A)$ associated with an entire curve $f : \mathbf{C} \to \mathop{\mathrm{Lie}}(A)$. Firstly we give a Nevanlinna theoretic proof to the analytic Ax–Schanuel Theorem for semi-abelian varieties, which was proved by J. Ax 1972 in the case of formal power series (Ax–Schanuel Theorem). We assume some non-degeneracy condition for $f$ such that the elements of the vector-valued function $f(z) - f(0) \in \mathop{\mathrm{Lie}}(A) \cong \mathbf{C}^n$ are $\mathbf{Q}$-linearly independent in the case of $A = (\mathbf{C}^{*})^{n}$. Our proof is based on the Log Bloch–Ochiai Theorem and a key estimate which we show. Our next aim is to establish a Second Main Theorem for $\hskip1pt{\widehat{\mathrm{exp}}}\hskip2pt f$ and its $k$-jet lifts with truncated counting functions at level one. We give some applications to a problem of a type raised by S. Lang and the unicity. The results clarify a relationship between the problems of Ax–Schanuel type and Nevanlinna theory.

On the gap probability of the tacnode process

The tacnode process is a universal determinantal point process arising from non-intersecting particle systems and tiling problems. It is the aim of this work to explore the integrable structure and large gap asymptotics for the gap probability of the thinned/unthinned tacnode process over (−s,s). We establish an integral representation of the gap probability in terms of the Hamiltonian associated with a system of differential equations. With the aids of some remarkable differential identities for the Hamiltonian, we also compute large gap asymptotics, up to and including the constant term in the thinned case. As direct applications, we obtain expectation, variance and a central limit theorem for the associated counting function.

An analogy between effective potential representing prime numbers and Schwarzschild black hole

The effective two body interaction is derived using the single particle Schrödinger equation for the prime numbers with probability density based on the prime counting function (which is the number of primes below a certain x). Though the speculative connection of primes to Schwarzschild spacetime or black hole has been there for a long time, here for the first time our derived potential serendipitously shows the unique similarity with the effective potential derived from general theory of relativity (GTR) for Schwarzschild spacetime. Also, we report the existence of ISCO and photon sphere in prime potential and compare with GTR. It is found that when the prime numbers are represented by a quantum system, the two-body interactions mimic the effective general relativistic gravitational interaction in black hole with the four-acceleration diverging. We also establish an analogy between Einstein's static universe and the universe of primes. The question is: “Who ordered that?”

The effects of ambient particulate matter air pollution on platelets and hemostasis.

Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with the balance of hemostatic system remain unclear. This study investigates PM-mediated hemostatic changes in individuals across unique seasonal variations of ambient pollution. This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters. Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values. Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health.

Hop count, ETX and energy selection-based objective function for image data transmission over 6LoWPAN in Internet of Things

Hop count, ETX and energy selection-based objective function for image data transmission over 6LoWPAN in Internet of Things

Effect of poor glycemic control on the prevalence and determinants of anemia and chronic kidney disease among type 2 diabetes mellitus patients in Jordan: An observational cross-sectional study.

Anemia and chronic kidney disease (CKD) are common findings in diabetic patients. Lack of glycemic control is associated with increased risk of diabetic complications. This study aimed to determine the effect of poor glycemic control on the prevalence and determinants of anemia and CKD among type 2 diabetes mellitus (T2DM) patients in Jordan. A cross-sectional study design was used in this research. T2DM patients with controlled diabetes (HbA1c ≤7.0%, n = 120) and age-, gender- and body mass index-matched uncontrolled diabetic patients (HbA1c >7.0%, n = 120) were recruited. Blood sample for HbA1c and serum insulin measurement were obtained. Complete blood count and kidney function test results were obtained from the patient's medical records. Anemia was determined according to World Health Organization criteria. A binomial logistic regression was performed to ascertain the effects of age, gender, CKD and glycemic control on the likelihood that participants have anemia. The prevalence of anemia was significantly higher in the uncontrolled T2DM compared to controlled T2DM patients (40% vs 27.5%, OR: 2.14, 95% CI: 1.23, 3.71, P = 0.006). Female patients with uncontrolled T2DM had significantly greater prevalence of anemia compared to male patients with uncontrolled T2DM. The binomial logistic regression analysis showed that age, female gender, and CKD were positively associated with anemia in the multivariate model, while in the univariate model, lack of glycemic control increases the odds of anemia by 1.74 (95% CI: 1.01, 2.99, P = 0.046). Anemia is commonly present among T2DM patients in Jordan and is associated with poor glycemic control especially in females. These results emphasize the necessity of including anemia screening in standard diabetes care to enable early detection and treatment of anemia and to enhance the overall care of diabetic patients.

Hop count, ETX and energy selection-based objective function for image data transmission over 6LoWPAN in Internet of Things

Hop count, ETX and energy selection-based objective function for image data transmission over 6LoWPAN in Internet of Things

Towards automating stocktaking in warehouses: Challenges, trends, and reliable approaches

Stocktaking refers to the examination or counting over of materials, supplies, goods or products inside a stockroom, store, warehouse. There are many challenges concerning this important business function, which are even more demanding inside an unstructured large warehouse. Huge variance in size, volume, shape of the stock-keeping units that are stored in bulk without packaging, leads to many emerging problems that necessitate significant research endeavors so as to develop solutions that can automate this process. Nowadays, there are many approaches related to computer vision-based stocktaking in unstructured warehouses with products stored in bulk, which employ several existing technologies namely Deep Learning, Optical Character Recognition, and 3D model retrieval. The paper at hand aims at presenting the i-Count Air concept which outlines the utilization of Unmanned Aerial Vehicles, endowed with cognitive hardware sensors, active vision and an innovative perception and stocktaking software, that will push the boundaries of robotic perception and help automate the inventory counting function in a Warehouse 5.0 environment.

Moments of ideal class counting functions

We consider the counting function of ideals in a given ideal class of a number field of degree d. This describes, at least conjecturally, the Fourier coefficients of an automorphic form on GL(d), typically not a Hecke eigenform and not cuspidal. We compute its moments, and also investigate the moments of the corresponding cuspidal projection.

Anaemia-based screening for resistance to thyroid hormone alpha in children.

The hypothyroid phenotype associated with resistance to thyroid hormone alpha (RTH-α) is associated with a diverse clinical picture. On the other hand, thyroid-stimulating hormone (TSH) levels are normal. Free triiodothyronine (fT3) and free thyroxine (fT4) levels can also be normal; however, normo- or macrocytic anaemia is usually present in reported cases. Diagnosis is challenging and there is limited data regarding screening methods. The study aimed to assess the efficiency of a screening strategy for RTH-α. Out of a total of 6540 children evaluated at the outpatient clinics of paediatric neurology over 2 years and who underwent complete blood count and thyroid function tests, 432 were found to have anaemia. Within this group, we identified 42 children without an underlying specific neurological aetiology who exhibited normo- or macrocytic anaemia, normal TSH levels, fT3 levels in the upper half of the normal range or high, and fT4 levels in the lower half of the normal range or low. We excluded one patient who had already been diagnosed with RTH-α and nine patients could not be reached. Subsequently, clinical evaluation, biochemical assessment, and THRA sequencing analysis were conducted on 32 children. The findings were compared with those of the known RTH-α patients in our unit. The median age of the patients was 5.7 (5.1-7.4) years, and 22 of them were males (69%). The main reasons for assessment in paediatric neurology clinics were autism spectrum disorder (n = 12, 38%), epilepsy (n = 11, 34%), and delay in developmental stages (n = 8, 25%). Constipation was present in five of the cases (16%), while the closure of the anterior fontanelle and tooth eruption were delayed in two cases (6%) and one case (3%), respectively. The median length/height and weight standard deviation (SD) scores were 0.3 [(-0.8)-(1.1)] and -0.1 [(-0.8)-(0.3)], respectively. The median fT3, fT4, and TSH levels were 4.6 (4.2-5.0) pg/mL, 0.9 (0.8-1.0) ng/dL, and 2.2 (1.8-3.1) uIU/mL, respectively. Thirteen of the patients (41%) had high fT3 levels, while none of them had low fT4 levels. The normo- or macrocytic anaemia rate was 47% (normocytic/macrocytic, n = 8/7) at the time of reassessment. Serum creatine kinase (CK) was elevated in five patients (16%; one had anaemia). None of the subjects had a pathological variant in THRA. Known RTH-α patients had significantly lower median height SD score, higher rates of delayed tooth eruption and closure of the anterior fontanelle, lower haemoglobin levels, and higher mean corpuscular volume (MCV) and CK levels as compared to those found without RTH-α. This approach found one known patient with RTH-α but did not reveal any new cases. Notably, normo- or macrocytic anaemia did not persist in nearly half of the screened patients. A screening strategy that takes clinical findings and prominent laboratory features suggestive of RTH-α into account could lower unnecessary genetic analysis of THRA in patients presenting with neurological problems.

Comparison of Long-Term Effectiveness and Safety ofUpadacitinibfor Atopic Dermatitis Between Dupilumab-Exposed and Dupilumab-Naïve Patients.

Upadacitinib is an oral selective Janus kinase-1 inhibitor approved for the treatment of moderate-to-severe atopic dermatitis (AD) in patients [Formula: see text] 12 years of age. In real life, upadacitinib currently represents a valid therapeutic option for patients failing available systemic therapies, in particular patients who discontinued dupilumab because of lack of efficacy or occurrence of adverse events. The objectives of the present study were to compare the effectiveness and safety of upadacitinib in patients affected by AD who had previously failed dupilumab therapy versus biologic naïve patients. A retrospective, multi-centre, observational, real-life study was conducted in four Italian dermatological referral centres (Milan, Perugia, Naples and Vicenza). Baseline characteristics included age, sex, AD history and severity, prior treatments, comorbidities and concomitant therapies. AD severity was assessed at baseline and at week 4 (W4), W16, W24 and W52, using Eczema Area Severity Index (EASI), Dermatology Life Quality Index (DLQI) and Pruritus Numerical Rating Scale (P-NRS) scores. Full blood count, hepatic and renal function, lipid panel, and muscle enzymes [lactate dehydrogenase (LDH) and creatine phosphokinase (CPK)] were assessed at baseline and at each follow-up visit. A total of 113 patients (72 males, 63.7%; mean age: 37.22 ± 16.8 years) were included in the analysis, all patients were in treatment and underwent follow-up period until W16, whilst 91 (80.5%) and 75 (66.4%) patients were in treatment and in follow-up period until W24 and W52, respectively. Mean EASI score significantly changed from 24.30 ± 10.27 to 1.28 ± 4.34, 0.74 ± 2.31 and 0.25 ± 1.34 at W16, W24 and W52, respectively (p < 0.0001). Specifically, at W16 the percentage of patients achieving EASI-75, EASI-90 and EASI-100 was 85.21, 76.35 and 66.11%, respectively. At W24, EASI-75, EASI-90 and EASI-100 were reached by 88.54, 85.42, and 78.37% of patients, respectively. Finally, 90.1% of patients achieved EASI-75, 88.3% achieved EASI-90 and 83.0% achieved EASI-100 at W52. This study confirmed the clinical effectiveness of upadacitinib treatment in adult patients in a real-world setting with moderate-to-severe AD who had discontinued dupilumab due to poor effectiveness or adverse events and who were biologic naïve; therefore, previous treatments do not seem to affect the response to upadacitinib treatment.

Effects of 4G mobile phone radiation exposure on reproductive, hepatic, renal, and hematological parameters of male Wistar rat.

Mobile phones have become a vital part of human life. Due to drastic increase in the number of mobile phone subscribers, exposure to radiofrequency radiation (RFR) emitted from these phones has increased dramatically. Hence, the effect of RFR on humans is an area of concern. This study was performed to determine the impact of 4G mobile phone radiation on the male reproductive system, liver, kidney, and hematological parameters. Seventy-day-old Wistar rats were exposed to 4G radiation (2350MHz for 2h/day for 56days). Sperm parameters such as sperm count, viability, sperm head morphology, mitochondrial activity, total antioxidant activity, and lipid peroxidation of sperm were evaluated. Histopathology of the testis, prostate, epididymis, seminal vesicle, liver, and kidney was carried out. Complete blood count, liver and kidney function tests, and testosterone hormone analysis were done. At the end of the experiment, results showed a significant (p < 0.05) decrease in sperm viability with alterations in the histology of the liver, kidney, testis, and other reproductive organs in the exposed group of rats. A reduced level of testosterone, total antioxidant capacity, and decreased sperm mitochondrial function were also observed in the exposed rats. Moreover, the exposed rats showed an increase in sperm lipid peroxidation and sperm abnormality. Hematological parameters like hemoglobin, red blood cells (RBC), and packed cell volume (PCV) showed a significant (p < 0.05) increase in the exposed rats. The results indicate that chronic exposure to 4G radiation may affect the male reproductive system, hematological system, liver, and kidney of rats.

Some General Theorems About a Class of Sets of Numbers

Abstract We prove a theorem which unifies some formulas, for example the counting function, of some sets of numbers including all positive integers, h-free numbers, h-full numbers, etc. We also establish a conjecture and give some examples where the conjecture holds.

Real-Life Experience in the Efficacy and Safety of COVID-19 Vaccination in Patients with Advanced Cirrhosis.

COVID-19 infections accelerate liver decompensation and serious liver-related co-morbidities. The aim is to evaluate the safety and impact of COVID vaccines on hepatic disease progression in patients with advanced liver disease and to identify parameters that predict the occurrence of complications. The study involved 70 patients with advanced liver disease who were vaccinated with different COVID vaccines from January 2021 to April 2022. They were evaluated clinically. The laboratory investigation included a complete blood count, liver and kidney function tests, calculation of CTP and MELD scores, plasma levels of ammonia, abdominal ultrasound, and upper GI endoscopy. Twenty patients had experienced complications 64 ± 12 days from the last dose of a vaccination. Twenty patients (28.6%) developed hepatic decompensation and hypothyroidism (n = 11, 15.7%), and five (7.14%) patients developed splanchnic thrombosis. There were no COVID-19 reinfections except for two patients who received Sinopharm and developed vaccine-associated enhanced disease (2.9%). Complications after COVID vaccinations were correlated with ALT (r = 0.279, p = 0.019), serum sodium (r = -0.30, p = 0.005), creatinine (r = 0.303, p = 0.011), liver volume (LV) (r = -0.640, p = 0.000), and MELD score (r = 0.439, p = 0.000). Multivariate logistic regression revealed that LV is the only independent predictor (p = 0.001). LV ≤ 682.3 has a sensitivity of 95.24% and a specificity of 85.71% in predicting complications with an AUC of 0.935, p < 0.001. In conclusion, the hepatic reserve and prognosis in liver cirrhosis should be evaluated prior to COVID vaccinations using the MELD score and liver volume as promising risk stratification criteria. In summary, the research proposes a novel triaging strategy that involves utilizing the MELD score and liver volume as risk stratification parameters of the hepatic reserve and prognosis of advanced liver cirrhosis prior to COVID immunization to determine who should not receive a COVID vaccination.

Evaluation of Efficacy and Safety of Nivolumab in Treatment of Relapsed/Refractory Classical Hodgkin Lymphoma at King Abdulaziz Medical City-Jeddah/the Kingdom of Saudi Arabia Experience

Introduction: Hodgkin's lymphoma (HL) is one of the most common lymphoid cancers. Preclinical studies suggest that Reed-Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase the abundance of the PD-1 ligands, PD-L1 and PD-L2, and promote their induction through Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. Nivolumab, an immune checkpoint inhibitor, which has shown great efficacy in relapsed/refractory cHL (R/R cHL) in multiple clinical trials. The aim of this study is to evaluate the efficacy and safety of Nivolumab in R/R cHL patients treated at King Abdulaziz Medical City in Jeddah-Kingdome of Saudi Arabia Methods: We conducted a retrospective analysis on all patients received nivolumab for R/R cHL at King Abdulaziz Medical City, Jeddah, Saudi Arabia. From introduction of nivolumab in our center till the present time, it was used in a total of 21 patients, all of them were included in our analysis. Data of these patients were entered into an Excel sheet, and analyzed using SPSS software version 25.0. Statistical significance was determined as (P&amp;lt;0.05). Results: Total of 21 patient were included in this analysis. The average age of the participants was 26 years, almost equal gender distribution, 63% were advanced stage, 72% were nodular sclerosis subtype. Patients had received a median of 5 prior regimens (range 4-7). 12 patients received Nivolumab as post-ASCT salvage and 9 patients did not undergo ASCT prior Nivolumab treatment. The number of treatment cycles with Nivolumab ranged between 3 and 121, with an average of 31 cycles. Overall response rate (ORR) was 84.2% includes 52.6% of patients has achieved complete response (CR). In the patients who received the Nivolumab as post-ASCT salvage, 40% had CR, 20% had PR, 10% had stable disease and 30% had disease progression. ORR was 60% and 40% of those patients had disease progression later. 28.6% of the patients studied were still on Nivolumab, and the main reason for stopping the Nivolumab was the disease progression. Nine patients still required treatment after Nivolumab. Our study showed that neutropenia and hypothyroidism were the most common adverse effects of Nivolumab therapy, 33.3%, and 19.0%, respectively, whereas fatigue, tachycardia, fever, itching, pneumonitis and cough were less common, 4.8% for each. Conclusion: Nivolumab is a safe drug and could be given to patients with HL. However, neutropenia and hypothyroidism were the most common adverse effects; therefore, routine complete blood count and thyroid function tests should be obtained. Regarding the efficacy of Nivolumab, our results revealed relatively low survival and response rates.