Count Score Research Articles

The (Mis)Information Game: A social media simulator

Given the potential negative impact reliance on misinformation can have, substantial effort has gone into understanding the factors that influence misinformation belief and propagation. However, despite the rise of social media often being cited as a fundamental driver of misinformation exposure and false beliefs, how people process misinformation on social media platforms has been under-investigated. This is partially due to a lack of adaptable and ecologically valid social media testing paradigms, resulting in an over-reliance on survey software and questionnaire-based measures. To provide researchers with a flexible tool to investigate the processing and sharing of misinformation on social media, this paper presents The Misinformation Game—an easily adaptable, open-source online testing platform that simulates key characteristics of social media. Researchers can customize posts (e.g., headlines, images), source information (e.g., handles, avatars, credibility), and engagement information (e.g., a post’s number of likes and dislikes). The platform allows a range of response options for participants (like, share, dislike, flag) and supports comments. The simulator can also present posts on individual pages or in a scrollable feed, and can provide customized dynamic feedback to participants via changes to their follower count and credibility score, based on how they interact with each post. Notably, no specific programming skills are required to create studies using the simulator. Here, we outline the key features of the simulator and provide a non-technical guide for use by researchers. We also present results from two validation studies. All the source code and instructions are freely available online at https://misinfogame.com.

Comparative Evaluation of Breast Ductal Carcinoma Grading: A Deep-Learning Model and General Pathologists' Assessment Approach.

Breast cancer is the most prevalent neoplasia among women, with early and accurate diagnosis critical for effective treatment. In clinical practice, however, the subjective nature of histological grading of infiltrating ductal adenocarcinoma of the breast (DAC-NOS) often leads to inconsistencies among pathologists, posing a significant challenge to achieving optimal patient outcomes. Our study aimed to address this reproducibility problem by leveraging artificial intelligence (AI). We trained a deep-learning model using a convolutional neural network-based algorithm (CNN-bA) on 100 whole slide images (WSIs) of DAC-NOS from the Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) dataset. Our model demonstrated high precision, sensitivity, and F1 score across different grading components in about 17.5 h with 19,000 iterations. However, the agreement between the model's grading and that of general pathologists varied, showing the highest agreement for the mitotic count score. These findings suggest that AI has the potential to enhance the accuracy and reproducibility of breast cancer grading, warranting further refinement and validation of this approach.

Effect of adding of sabah snake grass (clinacanthus nutans) on the antioxidant and sensory properties of chocolate

This research was carried out to identify the effect of drying methods on the antioxidant activity of Sabah snake grass leaves as well as the addition of Sabah snake grass powder on the antioxidant and sensory properties of chocolate. Antioxidant properties of chocolate samples were determined through total phenolic content and DPPH radical scavenging activity tests. The best formulation of chocolate filled with Sabah snake grass was determined based on sensory and antioxidant test. Nutrient content of chocolate was determined through AOAC methods whereas water activity and hardness of chocolate shell were determined using water activity meter and Texture Analyzer. Changes of chocolate during storage was reviewed through the aspect of moisture content, water activity, hardness, melting point, microorganism count and sensory score. Results showed that chocolate F2, chocolate filled with 100g of Sabah snake grass powder was the best formulation with satisfaction by panels and higher antioxidant activity. This sample contain 7.25% moisture, 2.19% ash, 30.61% fat, 5.41% protein, 1.94% crude fibre and 52.61% carbohydrate. The storage sample showed significantly difference (p<0.05) in moisture content, water activity, hardness and melting property after kept for eight weeks but still safe to be consumed.

Emotional and Behavioral Problems among Preschool Children

It is essential to recognize the rapid pace of growth and maturation from birth to age 5, which has multiple implications for assessment and treatment. For the primary types of problem behaviour discussed in this chapter (i.e., disruptive and emotional problems), identification and diagnosis based purely on child behaviour have been shown to have limited stability and prognostic implications until at least 24 months of age. Objectives To assess psychological issues (behaviour and psychological problems) among preschool children and To find out the relationship between psychological issues with child and parent personal characteristics (age, gender, father life, mother live, father job, mother job, level of education, residence area, and monthly income). Methodology A descriptive design cross-sectional study was carried out throughout the present study to identify psychological issues among preschool children, starting from 1st February 2018 to 1st May 2018 in Najaf city. A non-probability purposive sample of (269) children with psychological issues among preschool children, who were children of the schools of education directorate at Najaf. The data are collected through the use utilization of the developed questionnaire and utilizing a checklist technique, which consists of two parts (1) A socio-demographic characteristics form that consists of 10 items (2) Child Symptom Inventory-4 (CSI-4) is a DSM-IV-referenced rating scale that screens for emotional and behavioural symptoms of childhood disorders. Parent (97 items) and teacher versions (77 items). The CSI-4: Parent Checklist contains screens for 15 emotional and behavioural disorders, and the CSI-4: Teacher Checklist contains screens for 13 emotional and behavioural disorders. The CSI-4 can be scored to derive Symptom Count Scores or Symptom Severity scores. The reliability of the questionnaire is determined through a pilot study and the validity through a panel of (15) experts. Results The findings of the present study indicate that preschool children's socio-characteristics affect the emotional and behavioural problems domains. The maximal effect is presented by the father and mother characteristics domains. There is a significant relationship between a live father, alive mother, father job, and mother job with emotional and behavioural symptoms of childhood disorders domains. There is a non-significant relationship between the age of the child, gender, class number, and sequence of a child with emotional and behavioural symptoms of childhood disorders domains. Conclusion: The study concludes that the emotional and behavioural symptoms of childhood disorders most commonly occurs among preschool children in male than in the female child. Emotional and behavioural problems in children most occur at the age of five years. Behavioural problems in children do not affect a child's age, gender, and sequence. Also, the study confirmed that the behavioral problems of children affect negatively the parent's jobs. Recommendations The study recommends providing support for families of children with emotional and behavioural problems, especially psychological ones, and working on introducing caregivers to know wide information about the early detection of emotional and behavioural problems in children to prevent them and ways to deal with behaviours of odd and Family to Family Education Programs to existing services in community mental health programs. And health-oriented mass media approach should be employed by the Ministry of Health and Ministry of Education to increase population knowledge and awareness about emotional and behavioural problems among preschool children.

Clinical estimation of anticaries effect of probiotic toothpaste among 18-25 years old young adults- A double blinded randomized controlled trial

Aim & Objectives: The aim and objective of the study was to estimate the anticaries effect of probiotic toothpaste by assessing the Streptococcus mutans and Lactobacillus levels and by recording indices before and after intervention among 18-25 years old young adults. Materials and Methods : A double blinded, randomized controlled trial was carried out among thirty healthy volunteers of young adults in the city of Madurai. The subjects were randomly divided into two equal groups of A and B. At baseline, samples of saliva were collected to check Streptococcus mutans and Lactobacillus levels and indices like Oral Hygiene Index (1960), Modified Turesky Plaque Index (1970), Stain Index (1968) and Gingival Index (1963) were recoded. Group A received Conventional toothpastes (Colgate cavity protection) and Group B received Probiotic toothpastes (Purexa). For the next 15 days, they were instructed to brush using only the allotted toothpastes. The saliva sample collection and recording of indices were repeated after 15 days post intervention. Results : Gingival and oral hygiene indices showed significant differences of mean in Group B (0.14, 0.28; p<0.05 respectively). A significant difference of means was noted between Group A and B in the case of Plaque, Stain, Oral Hygiene indices and the bacterial count (Lactobacilli and Streptococcus mutans) (A :0.10, -0.12, 0.01; B :0.06, 0.09, 0.28 and -12.8, -14.8 ; p<0.05 respectively). Conclusion : The probiotic toothpastes illustrated a significant reduction of Lactobacillus, Streptococcus mutans bacterial count, Stain, Plaque and Oral Hygiene index scores compared to conventional toothpastes.

Efficiency Ranking of Journals in Turkey with DEA and DR/DEA Methods

Today, all countries publish many scientific studies in order to make progress in a scientific sense and plan for the future. Many criteria, such as impact factor, citation count, and article impact score, have been developed to measure, compare, and rank the quality of journals in which these studies are published. These criteria are used for purposes such as academic promotion, hiring, publication support, project support, and scholarships. It is extremely important to evaluate the quality standards of journals published in any field objectively in order to determine their quality and improve their standards. In this study, effective analysis was performed on certain journals published in Turkey using suitable input and output variables selected from these criteria. The efficiency scores of the journals were calculated using the Data Envelopment Analysis method and Discriminant Ratio Data Envelopment Analysis was applied. The journals were ranked according to the efficiency scores obtained. The efficiency scores obtained using Discriminant Ratio Data Envelopment Analysis were found to give better results in evaluating the performance of journals. In addition, the obtained efficiency scores were compared with the journal rankings given by Journal Citation Reports. As a result of this study, the importance of evaluating the performance of journals using objective criteria has once again been emphasized.

Understanding multimorbidity requires sign-disease networks and higher-order interactions, a perspective.

Count scores, disease clustering, and pairwise associations between diseases remain ubiquitous in multimorbidity research despite two major shortcomings: they yield no insight into plausible mechanisms underlying multimorbidity, and they ignore higher-order interactions such as effect modification. We argue that two components are currently missing but vital to develop novel multimorbidity metrics. Firstly, networks should be constructed which consists simultaneously of signs, symptoms, and diseases, since only then could they yield insight into plausible shared biological mechanisms underlying diseases.Secondly, learning pairwise associations is insufficient to fully characterize the correlations in a system. That is, synergistic (e.g., cooperative or antagonistic) effects are widespread in complex systems, where two or more elements combined give a larger or smaller effect than the sum of their individual effects. It can even occur that pairs of symptoms have no pairwise associations whatsoever, but in combination have a significant association. Therefore, higher-order interactions should be included in networks used to study multimorbidity, resulting in so-called hypergraphs. We illustrate our argument using a synthetic Bayesian Network model of symptoms, signs and diseases, composed of pairwise and higher-order interactions. We simulate network interventions on both individual and population levels and compare the ground-truth outcomes with the predictions from pairwise associations. We find that, when judged purely from the pairwise associations, interventions can have unexpected 'side-effects' or the most opportune intervention could be missed. The hypergraph uncovers links missed in pairwise networks, giving a more complete overview of sign and disease associations.

Leucocyte volume, conductivity, and scatter at presentation in COVID-19 patients.

In COVID-19 patients, besides changes in leucocyte count, morphological abnormalities of circulating blood cells have been reported. This study aims to investigate the relationship between the morphological and functional properties of leucocytes and the severity of the disease in COVID-19 patients. Blood samples were collected from COVID-19 patients (n = 130) at the time of admission. The patients were stratified according to the comorbidity, age, LDH, lymhocyte count score as mild, moderate, and severe. Complete blood count and the cell population data were analyzed by the Volume, conductivity, scatter (VCS) technology on Beckman Coulter LH-780 hematology analyzer. Kruskal-Wal'lis test was used to assess the differences between the groups with subsequent Bonferroni correction. Neutrophil count was increased, and lymphocyte count was decreased in severe patients compared to mild patients. The increase in the percent of neutrophils and the neutrophil/lymphocyte ratio in the severe patient group was significant in comparison to both the moderate and the mild group. The dispersion of the neutrophil volume and conductivity showed significant changes depending on the severity of the disease. The lymphocyte volume, lymphocyte-volume-SD and lymphocyte-conductivity as well as the monocyte-volume and monocyte-volume-SD were significantly increased in severe patients in comparison to mild patients. The increase of lymphocyte and monocyte volume in severe patients was also significant in comparison to moderate patients. COVID-19 infection leads to important changes in cell population data of leucocytes. The volumetric changes in lymphocytes and monocytes are related to the severity of the disease.

Effectiveness of tumor necrosis factor inhibitors in children with enthesitis-related arthritis: a single-center retrospective analysis.

In children with enthesitis-related arthritis (ERA), the hip and sacroiliac joint function might be impaired if not properly treated. We sought to evaluate the effectiveness of anti-tumor necrosis factor-α (TNF-α) therapy using the inflammatory indicators, Juvenile Arthritis Disease Activity Score 27 (JADAS27) and magnetic resonance imaging (MRI). We conducted a single-center retrospective study of 134 patients with ERA. We evaluated the effect of anti-TNF therapy on the inflammatory indicators, active joint count, MRI quantitative score, and JADAS27 over 18 months. We used the Spondyloarthritis Research Consortium of Canada (SPARCC) and the Hip Inflammation MRI Scoring System (HIMRISS) scoring systems for hip and sacroiliac joints scoring. The average age of onset of children with ERA was 11.62 ± 1.95 years, and they were treated with disease-modifying antirheumatic drugs (DMARDs) combined with biologics (n = 87, 64.93%). There were no differences in HLA-B27 positivity between the biologics and non-biologics treatment groups [66 (49.25%) vs. 68 (50.75%), P > 0.05]. Children who received anti-TNF (71 received etanercept, 13 adalimumab, 2 golimumab, and 1 infliximab) therapy improved significantly. Children with ERA used DMARDs and biologics at baseline (Group A) were followed up to 18 months, and their active joint count (4.29 ± 1.99 vs. 0.76 ± 1.33, P = 0.000), JADAS27 (13.70 ± 4.80 vs. 4.53 ± 4.52, P = 0.000) and MRI quantitative scores (P = 0.001) were significantly lower than those at baseline. Some of the patients (n = 13, 9.70%) were treated with DMARDs at the onset of the disease, but did not show significant improvement (Group B). After 6-18 months of switching to anti-TNF therapy, related indicators of the children were significantly lower than at baseline and 1 month (P < 0.013). At 18 months, a total of 33 patients (n = 74, 44.59%) in Group A and 7 (n = 13, 53.85%) in Group B reached inactive state. Eighteen months after diagnosis, anti-TNF therapy was found to be effective in children diagnosed with ERA. MRI is important for the early diagnosis of juvenile idiopathic arthritis. TNF-α inhibitors can significantly improve the clinical manifestations of sacroiliac joint and hip involvement in patients with ERA. Overall, the real-world study provides more evidence for precision diagnosis and treatment for other hospitals, families and patients.

Construction of recombinant SAG22 Bacillus subtilis and its effect on immune protection of coccidia

Avian coccidiosis causes huge economic losses to the global poultry industry. Vaccine is an important means to prevent and control coccidiosis. In this study, Bacillus subtilis was selected as the expression host strain to express anti Eimeria tenella surface protein SAG22. The synthesized surface protein SAG22 gene fragment of E. tenella was ligated with Escherichia coli-bacillus shuttle vector GJ148 to construct the recombinant vector SAG22-GJ148. And then the recombinant Bacillus strain SAG22-DH61 was obtained by electrotransfer. The results of SDS-PAGE and Western Blot showed that the recombinant protein SAG22 was successfully expressed intracellularly. The immunoprotective effect of recombinant Bacillus strain SAG22-DH61 on broiler chickens was evaluated in 3 identically designed animal experiments. The birds were infected with E. tenella on d 14, 21, and 28, respectively. Each batch of experiments was divided into 4 groups: blank control group (NC), blank control group+infected E. tenella (CON), addition of recombinant SAG22-DH61 strain+infected with E. tenella (SAG22-DH61), addition of recombinant empty vector GJ148-DH61 strain+infected with E. tenella (GJ148-DH61). The animal experiments results showed that the average weight gain of the SAG22-DH61 group was higher than that of the infected control group, and the difference was significant in the d 14 and 28 attack tests (P < 0.05); the oocyst reduction rate of the SAG22-DH61 group was much higher than that of the GJ148-DH61 group (P < 0.05); the intestinal lesion count score of the SAG22-DH61 group was much lower than that of the GJ148-DH61 group (P < 0.05). In addition, the SAG22-DH61 group achieved highly effective coccidia resistance in the d 14 attack test and moderately effective coccidia resistance in both the d 21 and 28 attack tests. In summary, recombinant SAG22 B. subtilis has the potential to become one of the technological reserves in the prevention and control of coccidiosis in chickens in production.

301 Youtube as a Source of Information for Skin Graft Procedures

Abstract Introduction YouTube, one of the most popular sites on the internet, has become a primary source of healthcare information for patients. Although YouTube videos about skin graft procedures have accrued millions of views, there lacks a publication defining their educational quality. With recent articles revealing the misleading nature of healthcare information on YouTube, this study aims to evaluate the quality of videos pertaining to skin graft procedures. Methods YouTube was searched for various terms such as “Skin Graft Procedures” and “Skin Graft Surgery” with content stratified by total view count. After applying exclusion criteria, the top 84 most viewed videos were assessed, 24 of which implicating burn injuries. Four independent reviewers rated the material with the Global Quality Scale (GQS; 5 = highest quality, 1 = lowest quality) to judge educational value based upon factors such as publisher credibility, delivery of accurate information, and presence of biases. Viewership, source, educational modality, and date of upload were also collected from each video and compiled for further analysis. Results The mean GQS score of all videos was 2.60. Videos uploaded by physicians (80.1%) had a significantly higher average GQS score than those not uploaded by physicians (p &amp;lt; 0.01). When grouped by modality, patient-friendly delivery methods (animations, news reports, etc.) contained the lowest quality information, while physician-led presentations provided the highest educational value (p &amp;lt; 0.01). Assessment of videos split into cohorts based on viewership noted a significantly higher GQS in videos with lower view counts (p &amp;lt; 0.05). There was no correlation between upload date and quality. Conclusions Overall, skin graft videos found on YouTube provide low quality information. This is especially true for the “popular” videos, where an inverse correlation was found between view count and GQS score. Likewise, patient-friendly videos received the lowest GQS scores amongst the cohorts. Alternatively, videos performed by physicians, most notably physician-led presentations, significantly improved the educational quality of videos pertaining to skin graft procedures. As such, further analysis of skin graft videos found on YouTube could poise physician involvement in producing videos of high educational quality while potentially bridging the gap spanning quality content and video popularity. Applicability of Research to Practice With online platforms such as YouTube evolving into conventional sources of healthcare information, physicians must act to improve the quality of online content to better guide patients in navigating treatment options and making healthcare decisions.

Are dietary intake and nutritional status of specific polyunsaturated fatty acids correlated with sarcopenia outcomes in community-dwelling older adults with sarcopenia? – Exploratory results from ENHANce

AimsTo explore the relationship between dietary polyunsaturated fatty acids (PUFAs) intake, nutritional PUFAs status and sarcopenia outcomes in sarcopenic older adults.MethodsThe Exercise and Nutrition for Healthy AgeiNg (ENHANce) is an ongoing 5-armed triple blinded randomized controlled trial, in sarcopenic older adults (> 65y) aiming to assess the effect of combined anabolic interventions (protein, omega-3 supplement and exercise) on physical performance in these adults, compared to single/placebo interventions. Baseline data were used for a secondary, exploratory, cross-sectional analysis. Dietary PUFAs intake was assessed with 4-day food records, status with RBC membrane fatty acids profiles. Spearman’s rho(ρ) correlation coefficients were calculated to explore associations of PUFAs intake and status with sarcopenia-defining parameters (muscle strength, mass and physical performance), physical activity (step count) and quality of life (SF-36, SarQoL).ResultsIn total, 29 subjects (9♂/20♀, mean age 76.3 ± 5.4y) were included. Total omega-3 intake of participants (1.99 ± 0.99 g/d) was below the recommended intake (♂:2.8–5.6 g/d; ♀:2.2–4.4 g/d). Intake and status of PUFAs were not correlated. Regarding correlations with outcomes, α-linolenic acid status was inversely associated with appendicular lean mass (aLM) (ρ:-0.439; p = 0.017), whereas docosahexaenoic acid status was positively associated with aLM (ρ:0.388; p = 0.038). Some omega-3 PUFAs intake and status markers were positively associated with step count, SF-36 and SarQoL scores, whereas gamma-linolenic acid status was inversely associated with SF-36 physical component summary score (ρ = -0.426; p = 0.024).ConclusionsAlthough intake of omega-3 and omega-6 was low, the present exploratory study generated new hypotheses for potential correlations of PUFAs intake and status with sarcopenia outcomes in older adults with sarcopenia.

Characteristics, level of evidence, and impact of clinical studies on peri-implantitis: 2017 to 2021.

The level of evidence (LOE) is an important tool in current evidence-based practice and clinical research. However, in clinical studies on peri-implantitis, the present status of the LOE and its association with research impact remains to be determined. The present study aimed to gather the characteristics and LOE of clinical studies on peri-implantitis conducted from 2017 to 2021 and assess the association of the LOE with social and scientific impact. The PubMed database was searched to retrieve clinical studies that evaluated peri-implantitis-related healthcare interventions and were published between 2017 and 2021. A 4-level modified Oxford 2011 LOE tool was used to determine the LOE of these studies. Citation count and Altmetric Attention Scores (AAS) were derived from the Web of Science and Altmetric Explorer, respectively. Multivariate generalized estimation equation (GEE) analysis was conducted to explore relationships between the LOE and citation count, and between the LOE and AAS; the publication year was considered the grouping factor for adjusting for potential clustering effects. Two hundred and thirty-five studies were considered eligible. The percentages by level from Level-1 to Level-4 were 9.8%, 35.7%, 28.9%, and 25.5%. Multivariable GEE analyses revealed that studies with higher LOE ratings had significantly greater citation counts (p=0.008). However, no significant association (p=0.872) was observed between the LOE and AAS. From 2017 to 2021, more than 40% of studies published on peri-implantitis each year had high-LOE ratings. High-LOE studies showed a tendency to have greater scientific impact.

Counting tournament score sequences

The score sequence of a tournament is the sequence of the out-degrees of its vertices arranged in nondecreasing order. The problem of counting score sequences of a tournament with n n vertices is more than 100 years old [Quart. J. Math. 49 (1920), pp. 1–36]. In 2013 Hanna conjectured a surprising and elegant recursion for these numbers. We settle this conjecture in the affirmative by showing that it is a corollary to our main theorem, which is a factorization of the generating function for score sequences with a distinguished index. We also derive a closed formula and a quadratic time algorithm for counting score sequences.

Ovine PAPPA2 gene coding variants are linked to decreased fecal egg shedding in native Turkish sheep naturally infected with gastrointestinal nematodes

In this study, the association between PAPPA2 coding variants and gastrointestinal (GI) nematode fecal egg count (FEC) score in adult Turkish sheep was investigated. For this purpose, the FEC score was determined in adult sheep from six breeds: Karacabey Merino (n = 137), Kivircik (n = 116), Cine capari (n = 109), Karakacan (n = 102), Imroz (n = 73), and Chios (n = 50). Sheep were classified as shedders or non-shedders within breeds and flocks. The first group was the fecal egg shedders (> 50 per gram of feces), and the second group was the no fecal egg shedders (≤ 50 per gram of feces). The exon 1, exon 2, exon 5, exon 7, and a part of 5'UTR of the ovine PAPPA2 gene were genotyped by Sanger sequencing of these two groups. Fourteen synonymous and three non-synonymous single-nucleotide polymorphisms (SNPs) were found. The non-synonymous SNPs, D109N, D391H, and L409R variants, are reported for the first time. Two haplotype blocks were constructed on exon 2 and exon 7. The specific haplotype, C391G424G449T473C515A542 on the exon 2 that carries the 391H variant, was tested against four other common haplotypes. Our results indicate that C391G424G449T473C515A542 haplotype was significantly associated with fecal egg shedding status in adult Turkish sheep (p-value, 0.044).

Effect of Allium cepa extract on total and differential WBC, TP level, oxidant and antioxidant biomarkers, and lung pathology in ovalbumin-sensitized rats.

Previous studies have shown that Allium cepa (A. cepa) has relaxant and anti-inflammatory effects. In this research, A. cepa extract was examined for its prophylactic effect on lung inflammation and oxidative stress in sensitized rats. Total and differential white blood cell (WBC) count in the blood, serum levels of oxidant and antioxidant biomarkers, total protein (TP) in bronchoalveolar lavage fluid (BALF), and lung pathology were investigated in control group (C), sensitized group (S), and sensitized groups treated with A. cepa and dexamethasone. Total and most differential WBC count, TP, NO2, NO3, MDA (malondialdehyde), and lung pathological scores were increased while lymphocytes, superoxide dismutase (SOD), catalase (CAT), and thiol were decreased in sensitized animals compared to controls (p < 0.01 to p < 0.001). Treatment with all concentrations of extract significantly improved total WBC, TP, NO2, NO3, interstitial fibrosis, and emphysema compared to the S group (p < 0.05 to p < 0.001). Two higher concentrations of the extract significantly decreased neutrophil and monocyte count, malondialdehyde, bleeding and epithelial damage but increased lymphocyte, CAT, and thiol compared to the S group (p < 0.05 to p < 0.001). Dexamethasone treatment also substantially improved most measured parameters (p < 0.05 to p < 0.001), but it did not change eosinophil percentage. It was proposed that A. cepa extract could affect lung inflammation and oxidative stress in sensitized rats.

The Structured Trauma-Related Experiences and Symptoms Screener (STRESS): Assessing factor structure and clinical utility in a juvenile justice sample.

High prevalence of traumatic event exposure and posttraumatic stress disorder (PTSD) among justice-involved adolescents has necessitated the use of trauma screening in juvenile justice settings. The present study explored the psychometric properties, factor structure, and construct validity of a trauma screen, the Structured Trauma-Related Experiences and Symptoms Screener (STRESS), in a detained adolescent sample. Prior to the current study, psychometric characteristics of the STRESS were evaluated only in a child welfare sample (Grasso et al., 2015). The sample consisted of 132 adolescents in secure detention facilities in a southeastern state. Participants were included in the study if they engaged in the mental health screening process at intake and a follow-up assessment process with facility staff psychologists. Data consisted of de-identified, archival records. The STRESS total symptom and 4 criterion symptom count scores demonstrated high internal consistency. Confirmatory factor analysis revealed that the STRESS had excellent fit with the DSM-5 four-factor PTSD model. Equally strong evidence was found for a higher order PTSD model, thus reinforcing the use of both STRESS PTSD total and criterion symptom count scores with justice-involved adolescents. Additionally, preliminary evidence of convergent and discriminant validity was supported. Findings support the STRESS as a reliable and valid trauma screen for use with detained adolescents. Results suggest that both STRESS total symptom and criterion symptom count scores have clinical utility for intake-level mental health decisions in juvenile detention settings. Implications for expanding use of the STRESS to inform appropriate interventions for justice-involved adolescents are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Need for Research Colaboratuion among Librarians of Hussaini Adamu Federal Polytechnic Kazaure and Federal Polytechnic Daura

The study investigated need for research collaboration among librarians of Hussaini Adamu Federal Polytechnic Kazaure and Federal Polytechnic Daura. The goal of research collaboration among the librarians is to come together in conducting research and discover new ideas as a group in order to improve research, knowledge-sharing, effective support, and services among the teeming patron community. Survey research design was used for the study and the target population of the study is the librarians of the two polytechnics who are working in the services library and the department of library and information science. The total number of population is 22 and the entire population of the study was sampled because the number can management to be use. The instruments used for the data collection was questionnaire which consist of three sections. Section A. was sought to obtained information about the demographic data of the respondents. Section B. contain questions related to the variables of the study and section c. covered question related to the challenges associated with the partnership and research collaboration. A descriptive statistics was used to analyze the data such as simple percentage, frequency count and mean score with use of table. The study found that there are shortages of librarians in the two federal polytechnic under study, there is dire need for the research collaboration between the two polytechnics but at present, the collaboration is very low. The followings are some of the recommendation of the studyThe management of the two polytechnics under study should educate librarians on the need for research collaboration.. The management of the two polytechnics under study should create awareness on the benefits of research collaboration with colleagues outside the library

Protective effects of resolvin D1 in Pseudomonas aeruginosa keratitis

PurposeHere, we explored the protective effects of resolvin D1 (RvD1) in Pseudomonas aeruginosa (PA) keratitis. MethodsC57BL/6 (B6) mice were used as an animal model of PA keratitis. Plate counting and clinical scores were used to assess the severity of the infection and the therapeutic effects of RvD1 in the model. Myeloperoxidase assay was used to detect neutrophil infiltration and activity. Quantitative PCR (qPCR) was used to examine the expression of proflammatory and anti-inflammatory mediators. Immunofluorescence staining and qPCR were performed to identify macrophage polarization. ResultsRvD1 treatment alleviated PA keratitis severity by decreasing corneal bacterial load and inhibiting neutrophil infiltration in the mouse model. Furthermore, RvD1 treatment decreased mRNA levels of TNF-α, IFN-γ, IL-1β, CXCL1, and S100A8/9 while increasing those of IL-1RA, IL-10, and TGF-β1. RvD1 treatment also reduced the aggregation of M1 macrophages and increased that of M2 macrophages. RvD1 provided an auxiliary effect in gatifloxacin-treated mice with PA keratitis. ConclusionBased on these findings, RvD1 may improve the prognosis of PA keratitis by inhibiting neutrophil recruitment and activity, dampening the inflammatory response, and promoting M2 macrophage polarization. Thus, RvD1 may be a potential complementary therapy for PA keratitis.

The impact of fibromyalgia syndrome on obstructive sleep apnea syndrome in terms of pain threshold, daytime symptoms, anxiety, depression, disease severity, and sleep quality: a polysomnographic study.

Current studies have focused on the association of fibromyalgia syndrome (FMS) and obsctructive sleep apnea syndrome (OSAS). Results of these studies on the effect of this association have been inconsistent. The current study aimed to investigate the effect of FMS on OSAS regarding sleep quality, pressure pain threshold, fatigue, daytime symptoms, anxiety, and depression, and also to determine the relationship between OSAS severity and FMS. In a cross-sectional design, patients diagnosed with OSAS were evaluated in two groups comparing those with and those without FMS. Data on demographics, headache, morning fatigue, and chronic pain duration were collected. Questionnaires including the Fatigue Severity Scale (FSS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were completed. Pressure pain threshold, tender points, and polysomnographic data were recorded. Of 69 patients, 27 were diagnosed with FMS + OSAS and 42 were diagnosed as OSAS only. Statistically significant differences were found between the two groups in VAS, pain duration, morning fatigue, headache, BAI, tender point count, FIQ and FSS scores, and algometer measurements. All polysomnografic data were compared, and no statistically significant differences were found between the two groups. There were no statistically significant differences in the algometer, BDI, BAI, FIQ, and FSS scores when analyzed according to the severity of OSAS. The findings suggest that FMS has no effect on polysomnographic parameters of OSAS. Headache, daytime fatigue, anxiety, depression, pain duration, and pain intensity are higher while the pressure pain threshold is lower when FMS is present. No correlation was found between OSAS severity and FMS, fatigue, pressure pain threshold, depression, and anxiety. NCT05367167/date: April 8, 2022.