The main objective of this study was to eliminate harmful synthetic ingredient from herbal cough syrup. Formulation and substitute them with safe natural ingredient. Asthmatic patients are increasing day by day in India due to various environmental reasons. It is beneficial for people suffering from chest congestion. The study aim to formulate a pure herbal syrup and to evaluate and compare its physicochemical properties with the marketed synthetic and herbal syrup. There are wide range of synthetic cough syrup available in the market with different functions, But there synthetic cough syrup show harmful effect on the body. Such as confusions, hallucinations, trouble urinating. Due to there reasons cough syrup has evolved as an alternative to synthetic cough syrup because of the safe and traditionally used ingredients. The natural herbal syrup was formulated by adding the extracts of Adhatoda vasica nees. Syzygium aromaticum,Vasicine,Vasicol, and Vasinone, Sugar, Alcohol,Orange peel Constituents. It may also act as a bronchodilators nad as an expectorant. Adhatoda Vasica Nees, Leaves extract is a traditional medicine and reported to use in the management of cough. The vasaca plant may have properties such as antimicrobial, antibacterial, anti inflammatory, antiasthmatic, anticancer, antituberculars, antioxidants. Vasaka leaves have the potential to provide compounds with strong antitussive efficacy and little side effectsAllowing for treatment of expectorants,particularly dose and monitoring of unwanted effects. Hence, the results of the present study indicted the Cooperative effect of vasaca leaves in the management of cough aversions.