Couch Angles Research Articles

Deep learning–based statistical robustness evaluation of intensity-modulated proton therapy for head and neck cancer

A dense, dilated 3D U-net was trained to predict the 5th and 95th percentile distributions of planning dose plan using the nominal dose and planning CT images. The data set comprised proton therapy plans for 582 H&N cancer patients. Ground truth percentile values were estimated for each patient through 600 dose recalculations, representing randomly sampled uncertainty scenarios. The comprehensive comparisons of different models were conducted for H&N cancer patients, considering those with and without a beam mask (BM) and diverse beam configurations, including varying beam angles, couch angles, and beam numbers. The performance of our model trained based on a mixture of patients with H&N and prostate cancer was also assessed in contrast with models trained based on data specific for patients with cancer at either site. The DL-based model's predictions of percentile dose distributions exhibited excellent agreement with the ground truth dose distributions. The average gamma index with 2 mm/2%, consistently exceeded 97% for both 5th and 95th percentile dose volumes. Mean dose-volume histogram error analysis revealed that predictions from the combined training set yielded mean errors and standard deviations that were generally similar to those in the specific patient training data sets. Our proposed DL-based method for evaluation of the robustness of proton therapy plans provides precise, rapid predictions of percentile dose for a given confidence level regardless of the beam arrangement and cancer site. This versatility positions our model as a valuable tool for evaluating the robustness of proton therapy across various cancer sites.

Non-coplanar CBCT image reconstruction using a generative adversarial network for non-coplanar radiotherapy.

To develop a non-coplanar cone-beam computed tomography (CBCT) image reconstruction method using projections within a limited angle range for non-coplanar radiotherapy. A generative adversarial network (GAN) was utilized to reconstruct non-coplanar CBCT images. Data from 40 patients with brain tumors and two head phantoms were used in this study. In the training stage, the generator of the GAN used coplanar CBCT and non-coplanar projections as the input, and an encoder with a dual-branch structure was utilized to extract features from the coplanar CBCT and non-coplanar projections separately. Non-coplanar CBCT images were then reconstructed using a decoder by combining the extracted features. To improve the reconstruction accuracy of the image details, the generator was adversarially trained using a patch-based convolutional neural network as the discriminator. A newly designed joint loss was used to improve the global structure consistency rather than the conventional GAN loss. The proposed model was evaluated using data from eight patients and two phantoms at four couch angles (±45°,±90°) that are most commonly used for brain non-coplanar radiotherapy in our department. The reconstructed accuracy was evaluated by calculating the root mean square error (RMSE) and an overall registration error ε, computed by integrating the rigid transformation parameters. In both patient data and phantom data studies, the qualitative and quantitative metrics results indicated that±45° couch angle models performed better than±90° couch angle models and had statistical differences. In the patient data study, the mean RMSE and ε values of couch angle at 45°, -45°, 90°, and -90° were 58.5 HU and 0.42mm, 56.8 HU and 0.41mm, 73.6 HU and 0.48mm, and 65.3 HU and 0.46mm, respectively. In the phantom data study, the mean RMSE and ε values of couch angle at 45°, -45°, 90°, and -90° were 91.2 HU and 0.46mm, 95.0 HU and 0.45mm, 114.6 HU and 0.58mm, and 102.9 HU and 0.52mm, respectively. The results show that the reconstructed non-coplanar CBCT images can potentially enable intra-treatment three-dimensional position verification for non-coplanar radiotherapy.

Off-iso Winston-Lutz test on seven linear accelerators.

The aim of this study is to find optimal gantry, collimator, and couch angles for performing single isocenter, multiple target stereotactic radiosurgery (SIMT-SRS). Nineteen angle sets were tested across seven linear accelerators for radiation-isocenter coincidence and off-isocenter coincidence. The off-isocenter Winston-Lutz test was performed to evaluate the accuracy of isocenter alignment for each angle set, and optimal angle sets as well as maximum off-isocenter distance to target for each angle set was determined. The influence of simulated patient weight on off-iso Winston-Lutz test accuracy was also inspected. The SNC MultiMet-WL phantom and MultiMet-WL QA Software v2.1 were used for the direct measurement and analysis of the off-iso Winston-Lutz test (also referred to as Winston-Lutz-Gao test). A two-step method was developed to ensure precise initial placement of the target. Nineteen beams were delivered at 6X energy and 2×2cm field size to each of six targets on the MultiMet Cube with couch kicks at five cardinal angles (90°, 45°, 0°, 315°, and 270°). To reduce imaging uncertainty, only EPID was used in target alignment and test image acquisition. A total of 200Ibs (90.7kg) of weight was also used to mimic patient weight. All tests were performed on both the free table and the weighted table. For two new TrueBeam machines, the maximum offset was within the 1mm tolerance when the off-iso distance is less than 7cm. Two older VitalBeam machines exhibited unfavorable gantry, couch, and collimator (GCC) angle sets: Linac No. 3 at (0,90,0), (0,270,0) and Linac No. 4 at (0,45,45) and (0,90,0). The C-Series Linacs failed in the majority of GCC angle sets, with Linac No. 5 exhibiting a maximum offset of 1.53mm. Four of seven machines show a clear trend that offset increases with off-isocenter distance. Additionally, the IGRT table was less susceptible to the addition of simulated patient weight than the ExactCouch. Among the seven linear accelerators addressed, newer model machines such as the Varian TrueBeam were more precise than older models, especially in comparison to the C-Series Linacs. The newer machines are more suitable for delivering SIMT-SRS procedures in all GCC angle sets, and the results indicate that newer TrueBeams are capable of performing SIMT-SRS procedures at all angle sets for targets of off-iso distances up to 7cm. The trend that offset between the target center and radiation field center increases with off-iso distance, however, does not always hold true across machines. This may be comprised by the EPID's severe off-axis horn effect. Lastly, the IGRT couch was less susceptible to patient weight compared to ExactCouch in the off-isocenter Winston-Lutz test.

1124: Feasibility of AI chosen automated couch and gantry beam angles for brain tumors treated with IMPT

1124: Feasibility of AI chosen automated couch and gantry beam angles for brain tumors treated with IMPT

Assessment of stereotactic high-resolution detectors for stereotactic body radiotherapy: comparative analysis between myQA® SRS and Gafchromic EBT-XD films.

The study aimed to evaluate dosimetry systems used for stereotactic body radiotherapy (SBRT), specifically 2D array dosimetry and film dosimetry systems, for exploring their characteristics and clinical suitability. For this, high-resolution myQA SRS detectors and Gafchromic EBT-XD films were employed. Film analysis included net optical density (OD) values depending on energy, dose rate, scanner orientation, scanning side, and post-exposure growth. For myQA SRS, signal values were evaluated in terms of dose rate (400-1400 MU/min) and angular dependence (0-180° at 30° intervals) along with couch angles of 0°, 45°, and 90°. Pre-treatment verification included 32 SBRT patients for whom myQA SRS results were compared with those obtained with Gafchromic EBT-XD films. Analysis revealed less than 1% deviation in net OD for energy and dose rate dependence. Scanner orientation caused 2.5% net OD variation, with minimal differences between film front and back scan orientations (variance < 1.0%). A rapid OD rise occurred within six hours post-exposure, followed by gradual increase. The myQA SRS detector showed -3.7% dose rate dependence (400 MU/min), while the angular dependence at 90° was -26.7%. A correction factor effectively reduced these differences to < 1%. For myQA SRS, gamma passing rates were-93.6% (2%/1mm), while those for EBT-XD films were-92.8%. Improved rates were observed with 3%/1mm: for myQA SRS-97.9%, and for EBT-XD film-98.16%. In contrast, for 2%/2mm with 10% threshold, for myQA SRS-97.7% and for EBT-XD film-98.97% were obtained. It is concluded that both myQA SRS detectors and EBT-XD films are suitable for SBRT pre-treatment verification, ensuring accuracy and reliability. However, myQA SRS detectors are preferred over EBT-XD film due to the fact that they offer real-time measurements and user-friendly features.

A grayscale compression method to segment bone structures for 2D-3D registration of setup images in non-coplanar radiotherapy

Purpose. To evaluate the performance of an automated 2D-3D bone registration algorithm incorporating a grayscale compression method for quantifying patient position errors in non-coplanar radiotherapy. Methods. An automated 2D-3D registration incorporating a grayscale compression method to segment bone structures was proposed. Portal images containing only bone structures ( Portalbone ) and digitally reconstructed radiographs containing only bone structures ( DRRbone ) were used for registration. First, the portal image was filtered by a high-pass finite impulse response (FIR) filter. Then the grayscale range of the filtered portal image was compressed. Thresholds were determined based on the difference in gray values of bone structures in the filtered and compressed portal image to obtain Portalbone. Another threshold was applied to generate DRRbone when the CT image uses the ray-casting algorithm to generate DRR images. The compression performance was assessed by registering the DRRbone with the Portalbone obtained by compressing the portal image into various grayscale ranges. The proposed registration method was quantitatively and visually validated using (1) a CT image of an anthropomorphic head phantom and its portal images obtained in different poses and (2) CT images and pre-treatment portal images of 20 patients treated with non-coplanar radiotherapy. Results. Mean absolute registration errors for the best compression grayscale range test were 0.642 mm, 0.574 mm, and 0.643 mm, with calculation times of 50.6 min, 42.2 min, and 49.6 min for grayscale ranges of 0–127, 0–63 and 0–31, respectively. For the accuracy validation (1), the mean absolute registration errors for couch angles 0°, 45°, 90°, 270°, and 315° were 0.694 mm, 0.839 mm, 0.726 mm, 0.833 mm, and 0.873 mm, respectively. Among the six transformation parameters, the translation error in the vertical direction contributed the most to the registration errors. Visual inspection of the patient registration results revealed success in every instance. Conclusions. The implemented grayscale compression method successfully enhances and segments bone structures in portal images, allowing for accurate determination of patient setup errors in non-coplanar radiotherapy.

Insights into the dosimetric and geometric characteristics of stereotactic radiosurgery for multiple brain metastases: A systematic review.

GammaKnife (GK) and CyberKnife (CK) have been the mainstay stereotactic radiosurgery (SRS) solution for multiple brain metastases (MBM) for several years. Recent technological advancement has seen an increase in single-isocentre C-arm linac-based SRS. This systematic review focuses on dosimetric and geometric insights into contemporary MBM SRS and thereby establish if linac-based SRS has matured to match the mainstay SRS delivery systems. The PubMed, Web of Science and Scopus databases were interrogated which yielded 891 relevant articles that narrowed to 20 articles after removing duplicates and applying the inclusion and exclusion criteria. Primary studies which reported the use of SRS for treatment of MBM SRS and reported the technical aspects including dosimetry were included. The review was limited to English language publications from January 2015 to August 2023. Only full-length papers were included in the final analysis. Opinion papers, commentary pieces, letters to the editor, abstracts, conference proceedings and editorials were excluded. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. The reporting of conformity indices (CI) and gradient indices, V12Gy, monitor units and the impact of translational and rotational shifts were extracted and analysed. The single-isocentre technique for MBM dominated recent SRS studies and the most studied delivery platforms were Varian. The C-arm linac-based SRS plan quality and normal brain tissue sparing was comparable to GK and CK and in some cases better. The most used nominal beam energy was 6FFF, and optimised couch and collimator angles could reduce mean normal brain dose by 11.3%. Reduction in volume of the healthy brain receiving a certain dose was dependent on the number and size of the metastases and the relative geometric location. GK and CK required 4.5-8.4 times treatment time compared with linac-based SRS. Rotational shifts caused larger changes in CI in C-arm linac-based single-isocentre SRS. C-arm linac-based SRS produced comparable MBM plan quality and the delivery is notably shorter compared to GK and CK SRS.

Going from 3D/3D to 2D/3D registration for noncoplanar setup verification in intracranial single-isocenter multiple-target hypofractionated stereotactic radiotherapy: comparison between kilo-voltage/mega-voltage image pairs and noncoplanar cone-beam computed tomography.

Single-isocenter (SI) noncoplanar volumetric modulated arc therapy (NC-VMAT) has been widely used in stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (HSRT) for multiple brain metastases (BMs). However, it is critical to verify patient positioning at a noncoplanar couch angle. This study aimed to compare the noncoplanar setup discrepancies between kilo-voltage/mega-voltage image (kV/MV) orthogonal image pairs with a 2-dimensional/3-dimensional (2D/3D) matching mode and noncoplanar cone-beam computed tomography (NC-CBCT) with a 3D/3D matching mode in SI NC-VMAT HSRT for multiple BMs. Twenty patients with multiple BMs [2-5] who underwent SI NC-VMAT HSRT were enrolled in this study. Prior to each noncoplanar field delivery, both kV/MV orthogonal image pairs and NC-CBCT were used to determine setup errors. The setup error values reported by NC-CBCT were defined as the gold standard and compared to those reported by kV/MV orthogonal image pairs. The Bland-Altman analysis method was utilized to assess the agreement of the two positioning modalities. In total, 104 kV/MV image pairs and NC-CBCT scans were acquired. The mean setup error differences (SEDs; absolute values) between the two positioning systems were 0.17 mm, 0.21 mm, 0.16 mm, 0.22°, 0.18°, and 0.17° in the vertical, longitudinal, lateral, yaw, pitch, and roll directions, respectively. The maximum SEDs regarding translation and rotation occurred in the longitudinal and yaw directions at 0.60 mm and 0.8°, respectively. Bland-Altman analysis showed excellent agreement between the two positioning modalities, and the 95% limits of agreement (LOAs) never exceeded 0.6 mm and 0.6° in the translational and rotational directions, respectively. Only 4.80% of SEDs exceeded the tolerance of 0.5 mm/0.5°. Orthogonal kV/MV image pairs with 2D/3D matching mode could provide comparable accuracy for noncoplanar positioning as NC-CBCT with 3D/3D matching mode.

Feasibility of MPC enhanced couch as SRS/SBRT Pretreatment QA

Purpose: The purpose of this study was to investigate the feasibility of using the Winston-Lutz (WL) interchangeability with a Machine Performance Check-enhanced couch for pretreatment quality assurance (QA) of stereotactic radiotherapy (SRS) and stereotactic body radiation therapy (SBRT). The study employed the MPC with an electronic portal imaging device (EPID) to carry out geometric checks and verify the radiation isocenter. The isocenter size was assessed using the MultiMet cube and the MPC-enhanced couch module for SRS/SBRT pretreatment QA. Methods: The isocenter size of the MPC-enhanced couch module was compared to the WL measurements of the MultiMet cube. Measurements were taken at various gantry, collimator, and couch angles over a period of one month. The data from the cube were evaluated using PIPSRO and MultiMet (MMWL), including the offset targets. Various statistical tests were performed to evaluate the agreement, normality, separability, sensitivity, and specificity between the two methods. Results: The results showed isocenter sizes of 0.273 ± 0.065 mm, 0.293 ± 0.010 mm, and 0.209 ± 0.070 mm for PIPSPRO, MPC, and MMWL, respectively. The average bias was -0.0639 ± 0.1061 mm between MMWL and PIPSPRO, -0.0837 ± 0.0688 mm between MMWL and MPC, and 0.0198 ± 0.0696 mm between MPC and PIPSPRO. A Shapiro-Wilk test revealed no significant departure from normality for all tests and showed satisfactory discrimination through the area under the curve (AUC). A paired t-test analysis revealed a statistically significant difference between the mean isocenter size of the MPC and WL (MMPWL: t = 5.654, df = 29, p &lt; 0.001; PIPSPRO: t = -1.483, DF = 29, p = 0.1488), and there was no significant difference within the WL test (t = 3.008, DF = 29, p = 0.0054). Conclusion: Despite the statistical test results, there was agreement between the MPC and WL radiation isocenter size that was within the requirement of the AAPM TG 142 tolerance (±1.0 mm). The MPC proved to be accurate, reproducible, and consistent throughout the measurements, making it an appropriate and effective pretreatment QA tool for SRS/SBRT.

Comparison of patient setup accuracy for optical surface-guided andX-ray-guided imaging with respect to the impact on intracranial stereotactic radiotherapy.

The objective of this work is to estimate the patient positioning accuracy of asurface-guided radiation therapy (SGRT) system using an optical surface scanner compared to an X‑ray-based imaging system (IGRT) with respect to their impact on intracranial stereotactic radiotherapy (SRT) and intracranial stereotactic radiosurgery (SRS). Patient positioning data, both acquired with SGRT and IGRT systems at the same linacs, serve as abasis for determination of positioning accuracy. Atotal of 35patients with two different open face masks (578 datasets) were positioned using X‑ray stereoscopic imaging and the patient position inside the open face mask was recorded using SGRT. The measurement accuracy of the SGRT system (in a"standard" and an SRS mode with higher resolution) was evaluated using both IGRT and SGRT patient positioning datasets taking into account the measurement errors of the X‑ray system. Based on these clinically measured datasets, the positioning accuracy was estimated using Monte Carlo (MC) simulations. The relevant evaluation criterion, as standard of practice in cranial SRT, was the 95th percentile. The interfractional measurement displacement vector of the SGRT system, σSGRT, in high resolution mode was estimated at 2.5 mm (68th percentile) and 5 mm (95th percentile). If the standard resolution was used, σSGRT increased by about 20%. The standard deviation of the axis-related σSGRT of the SGRT system ranged between 1.5 and 1.8 mm interfractionally and 0.5 and 1.0 mm intrafractionally. The magnitude of σSGRT is mainly due to the principle of patient surface scanning and not due to technical limitations or vendor-specific issues in software or hardware. Based on the resulting σSGRT, MC simulations served as ameasure for the positioning accuracy for non-coplanar couch rotations. If an SGRT system is used as the only patient positioning device in non-coplanar fields, interfractional positioning errors of up to 6 mm and intrafractional errors of up to 5mm cannot be ruled out. In contrast, MC simulations resulted in apositioning error of 1.6 mm (95th percentile) using the IGRT system. The cause of positioning errors in the SGRT system is mainly achange in the facial surface relative to adefined point in the brain. In order to achieve the necessary geometric accuracy in cranial stereotactic radiotherapy, use of an X‑ray-based IGRT system, especially when treating with non-coplanar couch angles, is highly recommended.

Functional lung avoidance in radiotherapy using optimisation of biologically effective dose with non-coplanar beam orientations

Background and purposeIn external beam radiotherapy for non-small cell lung cancer, dose to functioning lung should be minimised to reduce lung morbidity. This study aimed to develop a method for avoiding beam delivery through functional lung and to quantify the possible benefit to the patients. Materials and methodsTwelve patients that were treated as part of a clinical trial of single photon emission computed tomography (SPECT) functional lung avoidance were retrospectively studied. During treatment planning, the dose in the lung was weighted by the relative intensity of the functional image. A single conformal beam was scanned systematically around the planning target volume to find optimum orientations and the resulting map of functional dose variation with gantry and couch angle was used to select five non-coplanar intensity-modulated beams, taking into account directions prohibited due to collision risk. Expected reduction in pneumonitis risk was calculated using a logistic model. ResultsThe volume of lung irradiated to a functionally weighted dose of 5 Gy was 11.8 % (range 3.5 %–22.0 %) for functional plans, versus 20.9 % (range 4.9 %–33.3 %) for conventional plans (p = 0.002). Mean functionally weighted dose was 4.1 Gy (range 1.3 Gy-7.2 Gy) for functional plans, versus 4.5 Gy (range 1.5 Gy-8.3 Gy) for conventional plans (p = 0.002). Predicted pneumonitis risk was reduced by 4.3 % (range 0.4 %-15.6 %) (p = 0.002). ConclusionsBy seeking the optimum non-coplanar beam orientations, it is possible to reduce dose/volume lung parameters by 10% or more, consistently in all patients, regardless of the pattern of lung perfusion. A prediction model indicates that this will improve radiation-associated lung injury.

Data Driven Approach to Exactrac Setup Parameters after CBCT for Cranial Radiotherapy

The purpose of this study is to 1) Determine the congruence of shifts derived from Cone-Beam CT (CBCT) and from Exactrac dynamic KV X-rays 2) To setup action levels for Exactrac imaging to determine if patient potentially moved between CBCT and Exactrac acquisition and 3) To analyze if Exactrac alone can be reliably used for cranial setup forgoing the CBCT step MATERIALS/METHODS: Exactrac dynamic, uses in-room KV X-ray imaging that is mounted on the floor to monitor patient positioning during treatment. The congruence of imaging and radiation isocenter for the LINAC and Exactrac system was verified using the Winston-Lutz (WL) test over a period of one year. The WL pointer was set up and its coincidence with imaging and radiation isocenter was confirmed. Exactrac images were then acquired at various couch angles and the pointer deviation from Exactrac imaging isocenter is noted. Secondly, translation and rotation shifts for 175 consecutive cranial cases were examined to determine the deviation between shifts as denoted by CBCT and Exactrac. These patients were initially set up using CBCT and then once in treatment position, Exactrac KV images were acquired to check for any deviation. The deviation between the two systems was collected and a Kolomogorov-Smirnov (KS) test was performed on the data to check for the normality of the distribution. Statistical Process Control (SPC) was performed to derive action levels for Exactrac based shifts after CBCT. Based on repeated Winston-Lutz tests over a period of one year, the maximum deviation between radiation and imaging isocenters and Exactrac isocenter was 0.3mm and 0.3 deg over all couch angles. This number remained stable over the entire time period without necessitating any recalibration of Exactrac isocenter. Based on patient data for cranial cases, the mean and standard deviations for the largest shifts were (0.45 mm, 0.40 mm) for translations (range 0 - 2.03mm) and (0.44 deg and 0.32 deg) for rotations (range 0 - 2.21 degree). Using SPC, it was decided that the action level for translations and rotations could be set to 0.8mm and 0.5 deg respectively. Any deviation beyond this action level necessitates re-imaging to verify that the patient did not move in between the CBCT and Exactrac imaging acquisitions CONCLUSION: Exactrac system derived shifts show excellent agreement with CBCT. The isocentricity of the systems is maintained over a long period of time and shows no drift. Either system can be reliably used to set up cranial patients. With the added advantage of speed of acquisition, matching and shifts, the Exactrac system could replace CBCT for daily setup of patients undergoing cranial radiotherapy.

Hippocampal Sparing Whole Brain Radiation Therapy: 2 Arc Coplanar and 4 Arc Noncoplanar Planning Comparison

Whole brain radiation therapy (WBRT) has been shown to provide palliation but with negative neurocognitive effects associated with radiation-induced damage to the hippocampus. Sparing of the hippocampus has been shown to reduce the risk of neurocognitive deficit. Hippocampal sparing WBRT plan optimization is commonly done using 2 arc coplanar technique. The purpose of this work is to show that 4 arc noncoplanar plans will improve hippocampal sparing without compromising PTV coverage. Retrospective WBRT with hippocampal sparing using 2 arc coplanar and 4 arc noncoplanar VMAT technique were done on 10 patients previously treated for intracranial lesions. CT and MRI fused images were used to delineate the whole brain and hippocampus. Strictly following RTOG 0933 atlas guidelines, the hippocampus was manually delineated by a single Radiation Oncologist. Plans with prescription dose of 30 Gy in 10 fractions were generated using the 2 techniques. The 4 arc noncoplanar plan included 2 partial field arcs with couch angle at 90 degrees and 2 coplanar arcs. The 2 noncoplanar partial arcs consisted of a clockwise arc and a counterclockwise arc with gantry angles between 5 and 179 degrees. Lens were kept to < 7 Gy and pituitary gland to < 30 Gy. Dosimetric parameters from both techniques were compared by paired t-test. Radiation dose to the hippocampus was significantly reduced using 4 arc noncoplanar plan when compared to 2 arc coplanar plan. While hippocampus D100% were similar (7.25 Gy vs 7.32 Gy, p = 0.557), the mean dose (9.46 Gy vs 9.87 Gy, p = 0.003) and D0.03cc (12.48 Gy vs 12.94 Gy, p < 0.001) were significantly reduced with 4 arc noncoplanar plans. Whole brain PTV coverage remained at V100% = 95% for both techniques. However, the 4 arc noncoplanar plans showed significantly improved D2% (32.56 Gy vs 32.97 Gy, P = 0.003), D98% (28.11 Gy vs 27.91 Gy, P = 0.01), and homogeneity index (0.141 vs 0.159, P < 0.001). The 4 arc noncoplanar plans improved hippocampal sparing without compromising PTV coverage or compromise to other nearby organs at risk.

Can Optical Surface Imaging Replace Non-coplanar Cone-beam Computed Tomography for Non-coplanar Set-up Verification in Single-isocentre Non-coplanar Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy for Single and Multiple Brain Metastases?

AimsTo conduct a direct comparison regarding the non-coplanar positioning accuracy between the optical surface imaging system Catalyst HDTM and non-coplanar cone-beam computed tomography (NC-CBCT) in intracranial single-isocentre non-coplanar stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (HSRT). Materials and methodsTwenty patients with between one and five brain metastases who underwent single-isocentre non-coplanar volumetric modulated arc therapy (NC-VMAT) SRS or HSRT were enrolled in this study. For each non-zero couch angle, both Catalyst HDTM and NC-CBCT were used for set-up verification prior to beam delivery. The set-up error reported by Catalyst HDTM was compared with the set-up error derived from NC-CBCT, which was defined as the gold standard. Additionally, the dose delivery accuracy of each non-coplanar field after using Catalyst HDTM and NC-CBCT for set-up correction was measured with SRS MapCHECKTM. ResultsThe median set-up error differences (absolute values) between the two positioning methods were 0.30 mm, 0.40 mm, 0.50 mm, 0.15°, 0.10° and 0.10° in the vertical, longitudinal, lateral, yaw, pitch and roll directions, respectively. The largest absolute set-up error differences regarding translation and rotation were 1.5 mm and 1.1°, which occurred in the longitudinal and yaw directions, respectively. Only 35.71% of the pairs of measurements were within the tolerance of 0.5 mm and 0.5° simultaneously. In addition, the non-coplanar field with NC-CBCT correction yielded a higher gamma passing rate than that with Catalyst HDTM correction (P < 0.05), especially for evaluation criteria of 1%/1 mm with a median increase of 12.8%. ConclusionsCatalyst HDTM may not replace NC-CBCT for non-coplanar set-up corrections in single-isocentre NC-VMAT SRS and HSRT for single and multiple brain metastases. The potential role of Catalyst HDTM in intracranial SRS/HSRT needs to be further studied in the future.

Dosimetric analysis of beam arrangement for intensity-modulated radiation therapy in the postoperative irradiation of thymoma

This study aimed to investigate the dosimetric effect of various beam arrangements (BAs), for intensity-modulated radiotherapy (IMRT) in female thymoma patients. Six-field IMRT plans with three different BAs, named IMRTCA, IMRTCS, and IMRTNC were created for each patient. The couch angles of all fields were selected at 0°, which made the fields coplanar in the axial plane in IMRTCA plans. The couch angles of all fields were selected to be 90°, which makes the fields coplanar in the sagittal plane in IMRTCS plans. The couch angles of the four fields and two fields were selected as 90° and 0°, respectively in IMRTNC plans. Plans were compared in terms of dose homogeneity, conformity, and OAR doses. IMRTCS plans created with coplanar beams in the sagittal plane could offer significant advantages in terms of breast and lung sparing. IMRTCS may be useful for young female thymoma patients to reduce the risk of developing a second cancer in the breast. In addition, it should be considered that IMRTCS contributes approximately 1 Gy to the mean heart dose.

Commissioning and clinical evaluation of the IDENTIFYTM surface imaging system for frameless stereotactic radiosurgery.

To commission and assess the clinical performance of a new commercial surface imaging (SI) system by analyzing intra-fraction motion from the initial cohort of patients treated with frameless stereotactic radiosurgery (fSRS). The IDENTIFYTM SI system was commissioned for clinical use on an Edge (Varian Medical Systems, Palo Alto, CA) linear accelerator. All patients who received intracranial radiotherapy with HyperArcTM (Varian Medical Systems, Palo Alto, CA) were immobilized with the EncompassTM (Qfix, Avondale, PA) thermoplastic mask and monitored for intra-fraction motion with SI. IDENTIFYTM log files were correlated with trajectory log files to correlate treatment parameters with SI-reported offsets. IDENTIFYTM reported offsets were correlated with gantry and couch angles to assess system performance for obstructed and clear camera field of view. Data were stratified by race to evaluate performance differences due to skin tone. All commissioning data were found to meet recommended tolerances. IDENTIFYTM was used to monitor intra-fraction motion on 1164 fractions from 386 patients. The median magnitude of translational SI reported offsets at the end of treatment was 0.27mm. SI reported offsets were shown to increase when camera pods are blocked by the gantry with larger increases seen at non-zero couch angles. With camera obstruction, the median magnitude of the SI reported offset was 0.50 and 0.80mm for White and Black patients, respectively. IDENTIFYTM performance during fSRS is comparable to other commercially available SI systems where offsets are shown to increase at non-zero couch angles and during camera pod blockage.

Technical note: Comprehensive evaluations of gantry and couch rotation isocentricities for implementing proton stereotactic radiosurgery.

Mechanical accuracy should be verified before implementing a proton stereotactic radiosurgery (SRS) program. Linear accelerator (Linac)-based SRS systems often use electronic portal imaging devices (EPIDs) to verify beam isocentricity. Because proton therapy systems do not have EPID, beam isocentricity tests of proton SRS may still rely on films, which are not efficient. To validate that our proton SRS system meets mechanical precision requirements and to present an efficient method to evaluate the couch and gantry's rotational isocentricity for our proton SRS system. A dedicated applicator to hold brass aperture for proton SRS system was designed. The mechanical precision of the system was tested using a metal ball and film for 11 combinations of gantry and couch angles. A more efficient quality assurance (QA) procedure was developed, which used a scintillator device to replace the film. The couch rotational isocentricity tests were performed using orthogonal kV x-rays with the couch rotated isocentrically to five positions (0°, 315°, 270°, 225°, and 180°). At each couch position, the distance between the metal ball in kV images and the imaging isocenter was measured. The gantry isocentricity tests were performed using a cone-shaped scintillator and proton beams at five gantry angles (0°, 45°, 90°, 135°, and 180°), and the isocenter position and the distance of each beam path to the isocenter were obtained. Daily QA procedure was performed for 1month to test the robustness and reproducibility of the procedure. The gantry and couch rotational isocentricity exhibited sub-mm precision, with most measurements within ±0.5mm. The 1-month QA results showed that the procedure was robust and highly reproducible to within ±0.2mm. The gantry isocentricity test using the cone-shaped scintillator was accurate and sensitive to variations of ±0.2mm. The QA procedure was efficient enough to be completed within 30min. The 1-month isocentricity position variations were within 0.5mm, which demonstrating that the overall proton SRS system was stable and precise. The proton SRS Winston-Lutz QA procedure using a cone-shaped scintillator was efficient and robust. We were able to verify radiation delivery could be performed with sub-mm mechanical precision.

Cross-irradiation in multiple isocenter frameless treatment for limited number of multiple brain metastases with volumetric modulated arc therapy

PurposeTo evaluate cross-irradiation among targets in multiple isocenter (multiISO) plans with simultaneous optimization for multiple brain metastases in frameless stereotactic radiotherapy. MethodsThree spherical targets separated by 3 cm were drawn on a brain CT image set. Volumetric modulated arc therapy (VMAT) plans consisting of single or two-arc beams were created using the multiISO method, in which partial arcs and selective couch angles were included to avoid cross-irradiation among the targets. Plans were evaluated using conformity index, dose volumes, and beam weight from cross-irradiation. Single isocenter (singleISO) plans were also produced and compared. The entire simulation was repeated for targets separated by 5 cm. A single patient case with two targets was also simulated for application. ResultsFor target distance of 3 cm, both the multiISO and singleISO plans with two beams were equivalent and favored based on the conformity index and dose volumes. The cross-irradiation was considerable and was not reduced effectively by partial arc or selective couch angles. With a 5- cm target distance, multiISO two-arc plans made of full or partial arc and selective couch angles were equivalent and adequate for treatment. The cross-irradiation was small and made negligible by partial arc or selective couch angles. The two-arc singleISO plan was acceptable but slightly inferior with respect to conformity index and low-dose volumes. ConclusionsMultiISO radiation treatment for multiple brain metastases was prone to cross-irradiation among targets, which led to target undercoverage from potential rotational error, though it was less than with the singleISO method. For the multiISO VMAT plan to be robust to rotational error, the plan should be designed with beams minimizing cross irradiation by incorporating a partial arc or selective couch angle to avoid irradiating neighboring targets, which is more effective for targets with greater separation.

Effect of angular dependence for small-field dosimetry using seven different detectors.

Small-field dosimetry is challenging for radiotherapy dosimetry because of the loss of lateral charged equilibrium, partial occlusion of the primary photon source by the collimating devices, perturbation effects caused by the detector materials and their design, and the detector size relative to the radiation field size, which leads to a volume averaging effect. Therefore, a suitable tool for small-field dosimetry requires high spatial resolution, tissue equivalence, angular independence, and energy and dose rate independence to achieve sufficient accuracy. Recently, with the increasing use of combinations of coplanar and non-coplanar beams for small-field dosimetry, there is a need to clarify angular dependence for dosimetry where the detector is oriented at various angles to the incident beam. However, the effect of angular dependence on small-field dosimetry with coplanar and non-coplanar beams has not been fully clarified. This study clarified the effect of angular dependence on small-field dosimetry with coplanar and non-coplanar beams using various detectors. Seven different detectors were used: CC01, RAZOR, RAZOR Nano, Pinpoint 3D, stereotactic field diode (SFD), microSilicon, and microDiamond. All measurements were taken using a TrueBeam STx with 6MV and 10MV flattening filter-free (FFF) energies using a water-equivalent spherical phantom with a source-to-axis distance of 100cm. The detector was inserted in a perpendicular orientation, and the gantry was rotated at 15° increments from the incidence beam angle. A multi-leaf collimator (MLC) with four field sizes of 0.5 × 0.5, 1 × 1, 2 × 2, and 3 × 3cm2 , and four couch angles from 0°, 30°, 60°, and 90° (coplanar and non-coplanar) were adopted. The angular dependence response (AR) was defined as the ratio of the detector response at a given irradiation gantry angle normalized to the detector response at 0°. The maximum AR differences were calculated between the maximum and minimum AR values for each detector, field size, energy, and couch angle. The maximum AR difference for the coplanar beam was within 3.3% for all conditions, excluding the maximum AR differences in 0.5 × 0.5cm2 field for CC01 and RAZOR. The maximum AR difference for non-coplanar beams was within 2.5% for fields larger than 1 × 1cm2 , excluding the maximum AR differences for RAZOR Nano, SFD, and microSilicon. The Pinpoint 3D demonstrated stable AR tendencies compared to other detectors. The maximum difference was within 2.0%, except for the 0.5 × 0.5cm2 field and couch angle at 90°. The tendencies of AR values for each detector were similar when using different energies. This study clarified the inherent angular dependence of seven detectors that were suitable for small-field dosimetry. The Pinpoint 3D chamber had the smallest angular dependence of all detectors for the coplanar and non-coplanar beams. The findings of this study can contribute to the calculation of the AR correction factor, and it may be possible to adapt detectors with a large angular dependence on coplanar and non-coplanar beams. However, note that the gantry sag and detector-specific uncertainties increase as the field size decreases.

Noncoplanar Volumetric Modulated Arc Therapy for Hepatocellular Carcinoma Based on a Cage-Like Radiotherapy System: A Simulation Study.

The incorporation of noncoplanar beam arrangements has been proposed in liver radiotherapy modalities, which can reduce the dose in normal tissues compared to coplanar techniques. Noncoplanar radiotherapy techniques for hepatocellular carcinoma treatment based on the Linac design have a limited effective arc angle to avoid collisions. To propose a novel noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system and investigate its performance in hepatocellular carcinoma patients. The computed tomography was deflected 90° to meet the structure of a cage-like radiotherapy system and design the noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system plan in the Pinnacle3 planning system. An noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system plan was customized for each of 10 included hepatocellular carcinoma patients, with 6 dual arcs ranging from -30° to 30°. Six couch angles were set with an interval of 36° and distributed along with the longest diameter of planning target volume. The dosimetric parameters of noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system plan were compared with the noncoplanar volumetric modulated arc therapy and volumetric modulated arc therapy plan. The 3 radiotherapy techniques regarding planning target volume were statistically different for D98%, D2%, conformity index, and homogeneity index with χ2 = 9.692, 14.600, 8.600, and 12.600, and P = .008, .001, .014, and .002, respectively. Further multiple comparisons revealed that noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system significantly reduced the mean dose (P = .005) and V5 (P = .005) of the normal liver, the mean dose (P = .005) of the stomach, and V30 (P = .028) of the lung compared to noncoplanar volumetric modulated arc therapy. Noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system significantly reduced the mean dose (P = .005) and V5 (P = .005) of the normal liver, the mean dose (P = .017) of the spinal cord, V50 (P = .043) of the duodenum, the maximum dose (P = .007) of the esophagus, and V30 (P = .047) of the whole lung compared to volumetric modulated arc therapy. The results indicate that noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system protects the normal liver, stomach, and lung better than noncoplanar volumetric modulated arc therapy and protects the normal liver, spinal cord, duodenum, esophagus, and lung better than volumetric modulated arc therapy. The noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system technique with the arrangement of noncoplanar arcs provided optimal dosimetric gains compared with noncoplanar volumetric modulated arc therapy and volumetric modulated arc therapy, except for the heart. Noncoplanar volumetric modulated arc therapy technique based on a cage-like radiotherapy system should be considered in more clinically challenging cases.