Intercropping of wheat and cotton is practiced at a large scale in northern China, but the productivity of intercrops, compared to monoculture, and the productivity and growth patterns of different alternative intercropping patterns have not been quantitatively documented. In this study, four typical wheat–cotton intercropping patterns were examined as to their growth and productivity in field experiments over three growing seasons in Anyang, Henan Province, China. The systems varied in the number of wheat and cotton rows in the alternating strips of either crop, and were labeled accordingly as 3:1, 3:2, 4:2 and 6:2. Dry matter accumulation, yield, land equivalence ratio (LER) and lint quality were determined. Grain yield of wheat, averaged over three seasons, ranged from 4600 to 5200 kg ha −1 in intercropping, corresponding to 70–79% of the yield in the monoculture (6550 kg ha −1). The 3:1 system gave the highest wheat yield (79% of monoculture), followed by the 6:2 (73%), 3:2 (70%) and 4:2 (70%) systems. Cotton lint yield, averaged over three seasons, ranged from 590 to 740 kg ha −1 in intercropping, corresponding to 54–69% of the yield in cotton monoculture (1085 kg ha −1). The 3:2 and 4:2 systems gave the highest lint yields (69% and 68% of monoculture, respectively), which was significantly lower than in monoculture but significantly higher than in the 3:1 (58%) and 6:2 (54%) systems. The land equivalent ratio was 1.39 in the 3:1, 3:2 and 4:2 systems, and significantly lower, 1.28, in the 6:2 system. All systems provide a substantial land use advantage. Cotton growth patterns in monocultures and intercrops were characterized by fitting expolinear growth equations to periodic harvest data. Fitted parameters indicate a growth delay, compared to cotton monoculture, of 11.8 d in the 3:1 system, 6.3 d in the 3:2 system, 6.9 d in the 4:2 system and 5.6 d in the 6:2 system. Estimated growth rate during the linear growth phase was lowest in the 6:2 system (5.9 g m −2 d −1), significantly greater in the 3:1 (7.0 g m −2 d −1), 4:2 (7.7 g m −2 d −1) and 3:2 (8.4 g m −2 d −1) systems, and greatest, but not significantly different from 3:2 and 4:2 systems, in the monoculture (8.9 g m −2 d −1). These results are interpreted in terms of the competitive effect of wheat during the seedling phase of cotton, which is strongest in the 3:1 system, causing a comparatively long growth delay, and the ability of the cotton leaf canopy to intercept radiation after wheat harvest, which is diminished in the 6:2 system due to the large distance between cotton rows, resulting in a comparatively low rate of linear growth. Effects of intercropping on the quality of cotton were minor and mostly below detection threshold.