The cotton bollworm (Helicoverpa armigera) (Lepidoptera: Noctuidae) is a highly destructive insect pest that feeds on more than 200 plants including cotton. Diamide insecticides are typically preferred to combat H. armigera. However, many reports of resistance to diamide insecticides such as chlorantraniliprole have been reported. Tetraniliprole is a novel diamide insecticide, but little is known about its resistance risk in H. armigera. After ten generations of treating H. armigera with tetraniliprole, neither the G4946 nor I4775 mutations were detected and no resistance to tetraniliprole was observed. The realized heritability (h2) was 0.094 after ten generations of selection with tetraniliprole, suggesting a low risk of resistance in H. armigera. Additionally, we found that the LD50 of tetraniliprole (4.01 μg/g) was lower than the LD50 of chlorantraniliprole (5.79 μg/g) in the susceptible strain. Molecular docking analysis also found a difference between the ryanodine receptor (RyR) binding sites of tetraniliprole and chlorantraniliprole, the tetraniliprole free binding energy to RyR was −6.9 kcal/mol, which was smaller than for chlorantraniliprole (−6.4 kcal/mol). Our study reveals that there is a low resistance risk to tetraniliprole in H. armigera, thus suggesting that tetraniliprole can be used as a substitute for other insecticides for this pest control.