S-7 DIABETES MELLITUS is a serious metabolic disorder that places patients at increased risk of coronary and vascular disease, as well as debilitating conditions such as retinopathy, nephropathy, and neuropathy (Table 1).1–3 The attainment of tight glucose control can reduce the occurrence of deleterious long-term complications associated with the progression of both type 1 and type 2 diabetes mellitus.4–9 This relationship has been most convincingly demonstrated with microvascular complications (i.e., retinopathy, neuropathy, and nephropathy). In the Diabetes Control and Complications Trial (DCCT), intensive therapy reduced the risk of developing retinopathy by 76% in patients with type 1 diabetes mellitus.4 The United Kingdom Prospective Diabetes Study (UKPDS) showed a 25% risk reduction in microvascular endpoints with intensive therapy for type 2 diabetes,8 and every 1% decrease in HbA1C correlated with a 37% reduction in the risk of microvascular complications.10 Data are less definitive for macrovascular complications such as coronary heart disease and peripheral vascular disease, but current evidence suggests that hyperglycemia is associated with negative cardiovascular outcomes.10–12 In turn, improved control of blood glucose can reduce the costs associated with the treatment and long-term management of the common complications of diabetes. In the DCCT, the annual cost of therapy aimed at intensive control was $4,000–5,800 per patient—approximately threefold the cost of conventional therapy—but it was estimated that intensive treatment would begin to show savings within 5–7 years by decreasing the incidence of future complications.13 A retrospective study of a large HMO population determined that patients with either type 1 or type 2 diabetes (n 5 8,905) experienced higher incidence rates of various complications than ageand sex-matched controls without diabetes (n 5 36,520), which translated into excess costs (Fig. 1a,b).14 Similarly, a retrospective analysis of a large type 2 diabetes population (n 5 11,768) enrolled in an HMO found that per-person costs increased above baseline by 360% after a major cardiovascular event, by 195% for those with advanced renal disease, and by 771% for those with end-stage renal disease.15 In essence, long-term intensive treatment is cost-effective, a particularly important point given the size of the patient population and the clinical magnitude of the disease. Approximately 16 million Americans—or 5.9% of the U.S. population—have diabetes. However, 5.4 million are unaware that they have the disease.1 The economic impact of diabetes is staggering. For 1997, the direct and indirect costs of diabetes care were estimated to be $98 billion.16 The direct costs were $44 billion, including $27.5 billion for inpatient hospital care and $5.5 billion for nursing home care. The indirect costs were $54 billion, including $37.1 billion for disability and $16.9 billion attributed to mortality.