Introduction Operating rooms (ORs) are associated with high waste generation that contribute significantly to the overall hospital waste production, costs, and environmental impact. Hence, this study sought to explore the impact of the revision of single-use surgical packs in waste reduction and hospital cost savings. Methods A systematic review with meta-analysis was conducted to assess waste reduction strategies in operating rooms. A search was conducted on databases to evaluate the impacts of interventions on anesthesia waste reduction and cost savings. The search was limited to studies conducted between 2014 and 2024. Results The findings of the systematic review indicate that the revision of single-use surgical packs was associated with significant reductions in OR and anesthesia waste production and hospital costs. Conclusion The findings show that waste reduction initiatives could be effective in enhancing the sustainability of surgical procedures. The study underscores the role of simple but sustainable practices in addressing persistent environmental and financial challenges in the healthcare sector.
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