Fish is an important dietary element and a major source of animal protein in human diet for many Nigerians. The demand for fish has been on the increase because of geometrical increase in human population, this has resulted to a significant gap created between fish demand and supply. It is obvious given the importance of fish production that efforts must be made to encourage entrepreneurs to go into the business. However, many have shown doubts on the productivity and profitability of fish production, particularly on a smallholder level. This study therefore, examines the profitability of catfish production in Kano metropolis, Nigeria. Two stage sampling procedure was employed to select respondents for the study. Primary data were collected with the use of well-structured questionnaire administered to 120 catfish producers. The tools of analysis employed were descriptive statistics, gross margin and net farm income. The study revealed that Majority of the producers (69%) are male. Furthermore, 85percent of the fish producers have attained post primary education. The gross margin (GM) was ₦657,420, while the enterprise profit which is the net farm income was estimated at ₦598,128 and 0.33 return to capital for the farmers. Some of the challenges confronting the respondents in their business includes high cost of feed, lack of government support and lack of training. Thus, there is a need for provision of training for higher level of productivity, subsidizing of inputs such as feed by the government and participation in cooperative societies by the fish farmers for financial and inputs assistance by relevant Non-Governmental Organizations.