Piezo-ceramics with low sintering temperature (<1000 °C), enhanced strain (>0.1 %), low degree of hysteresis (<10 %), fatigue resistance (>106 cycles) with better thermal stability are extremely important characteristics for the development of high performance and cost-effective actuators. In this study, temperature (−50 to 250 °C) and fatigue (100 to 106) dependence of ferro/piezoelectric (P-E/S-E) characteristics of low temperature sintered (950 °C) (0.4[Pb(Zn1/3Nb2/3)O3-0.6Pb(Zr0.49Ti0.51)O3]) ceramics was investigated. A thermally stable strain response with a maximum of 0.17 % and degree of strain hysteresis (ηhys) of < 10 % was observed till 250 °C. The fatigue studies revealed a robust unipolar strain stability till 106 cycles even up to 200 °C. Interestingly, a very minimal strain asymmetry (γS) was observed only after 104 cycles till 200 °C, unlike PZT-5A, PIC151 and PMN-PT. This study demonstrates an exceptional thermal and fatigue resistant strain response even close to the Curie transition temperature (TC ∼ 280 °C) and suggests that the low temperature sintered 0.4PZN-0.6PZT ceramics could be a promising material, exclusively for high-precision actuator applications over a wide temperature range with a cost-effective solution.