Cosmological Concepts Research Articles

Insights into Metabolic Reprogramming in Tumor Evolution and Therapy.

Background: Cancer remains a global health challenge, characterized not just by uncontrolled cell proliferation but also by the complex metabolic reprogramming that underlies its development and progression. Objectives: This review delves into the intricate relationship between cancer and its metabolic alterations, drawing an innovative comparison with the cosmological concepts of dark matter and dark energy to highlight the pivotal yet often overlooked role of metabolic reprogramming in tumor evolution. Methods: It scrutinizes the Warburg effect and other metabolic adaptations, such as shifts in lipid synthesis, amino acid turnover, and mitochondrial function, driven by mutations in key regulatory genes. Results: This review emphasizes the significance of targeting these metabolic pathways for therapeutic intervention, outlining the potential to disrupt cancer's energy supply and signaling mechanisms. It calls for an interdisciplinary research approach to fully understand and exploit the intricacies of cancer metabolism, pointing toward metabolic reprogramming as a promising frontier for developing more effective cancer treatments. Conclusion: By equating cancer's metabolic complexity with the enigmatic nature of dark matter and energy, this review underscores the critical need for innovative strategies in oncology, highlighting the importance of unveiling and targeting the "dark energy" within cancer cells to revolutionize future therapy and research.

Comparative Analysis of the "H"-shaped Symbol from Göbekli Tepe and the Ritual "Binocular-shaped" Ceramics of the Trypillia Culture in Light of Ancient Farmers' Cosmological Beliefs

This article is dedicated to a comprehensive analysis and interpretation of the sacred "H"-shaped symbolism, which originates from the ancient temple complex of hunter-gatherers and early farmers of the Near East – Göbekli Tepe. The research identifies and analyzes a similar symbol found in the religious complex of ancient farmers in the territory of modern Ukraine, specifically in the Trypillia culture and its ceramic artifacts known as "Trypillia binoculars." A comparative analysis of these symbols is conducted within the context of the cosmological beliefs of early farming societies in Asia and Europe. Special attention is given to interpreting this symbolism as a reflection of complex religious and philosophical concepts related to the cyclicality of nature, the movement of celestial bodies, and the unity of heaven and earth. The research examines the architectural features of Göbekli Tepe, particularly the arrangement of the T-shaped columns, and their potential astronomical purpose. The author hypothesizes a connection between the physical structure of the temple complex, its T-shaped columns, and the formation of abstract "H"-type symbols. Parallels are drawn between the symbolism of Göbekli Tepe and the ritual artifacts of the Trypillia culture, allowing the hypothesis of shared cosmological concepts between various early farming cultures, despite significant geographical and temporal distances. This article offers a new perspective on the development of religious thought in ancient societies, highlighting the depth and complexity of their spiritual ideas. The findings contribute to a better understanding of the cultural connections and exchange of ideas between ancient civilizations of the Near East and Europe.

Modeling and validation of purification of pharmaceutical compounds via hybrid processing of vacuum membrane distillation

This study provides an in-depth examination of forecasting the concentration of pharmaceutical compounds utilizing the input features (coordinates) r and z through a range of machine learning models. Purification of pharmaceuticals via vacuum membrane distillation process was carried out and the model was developed for prediction of separation efficiency based on hybrid approach. Dataset was collected from mass transfer analysis of process to obtain concentration distribution in the feed side of membrane distillation and used it for machine learning models. The dataset has undergone preprocessing, which includes outlier detection using the Isolation Forest algorithm. Three regression models were used including polynomial regression (PR), k-nearest neighbors (KNN), and Tweedie regression (TWR). These models were further enhanced using the Bagging ensemble technique to improve prediction accuracy and reduce variance. Hyper-parameter optimization was conducted using the Multi-Verse Optimizer algorithm, which draws inspiration from cosmological concepts. The Bagging-KNN model had the highest predictive accuracy (R2 = 0.99923) on the test set, indicating exceptional precision. The Bagging-PR model displayed satisfactory performance, with a slightly reduced level of accuracy. In contrast, the Bagging-TWR model showcased the least accuracy among the three models. This research illustrates the effectiveness of incorporating bagging and advanced optimization methods for precise and dependable predictive modeling in complex datasets.

Integrated study of dark matter and dark energy models

Dark matter and dark energy are used as two important concepts in cosmology to explain some of the observed phenomena in the universe. Dark matter is one of the most dominant constituents of the Universe, and it influences the structural formation of the Universe through gravity, including the formation and evolution of galaxies, clusters, and the large-scale structure of the Universe. Dark energy is believed to be one of the causes of the accelerated expansion of the Universe, and its presence explains the observed phenomenon of the accelerating rate of expansion of the Universe. Although their existence has not been directly observed, people understand through the study of the structure and evolution of the universe that they play an important role in the universe. This paper first introduces the background knowledge of dark matter and its related properties and explains the reasons why three types of models, namely WIMP, axion, and sterile neutrino, are candidates for dark matter in the light of existing observations. The paper then discusses the relevant properties of dark energy and analyses the mainstream dark energy models. For the cosmological constant mode, the fine-tuning problem and cosmic coincidence problem it faces are analysed in detail. The evolution of the dark energy equation of state from the past >-1 to the present <-1 is then explained, and this is used to introduce the scalar field model involving dynamic, the Chaplygin gas model, the holographic dark energy model, and the interacting dark energy model.

The End of the World in the Quran and Physic

This paper delves into the exploration of eschatological themes present in the Quran, the sacred text of Islam, and their intersection with scientific theories in physics regarding the ultimate fate of the universe. Through a comparative analysis of Quranic verses and principles of physics, this study aims to elucidate the parallels, divergences, and potential synergies between religious and scientific perspectives on the end of the world. The research employs an interdisciplinary approach, drawing upon insights from Islamic studies and physics to unravel the symbolic language and metaphorical descriptions used in both domains to depict complex cosmological concepts. Through critical analysis and scholarly discourse, the paper endeavors to foster a deeper understanding of the complexities inherent in contemplating the end of the world, thereby contributing to the ongoing dialogue between faith and science. The scientific facts of science fully confirm the verses of the Quran that refer to the death of the world, which is called the Resurrection, and after that the life of another world begins.

MANUSIA PELAKU DARI ANTROPOSENTRISME MANUSIA DAN ALAM SEMESTA

Humans are creatures that are the center of the earth and mangula is often referred to in environmentalethical theory as humans are positioned tobe the central being son earth, but sometimes in anthropocentrism thinking it gives preservation to the universe but humans can also destroy or dissolve all universes with their advantages so that human needs and desires which is fulfilled without looking at the damaged environment, but humans can also preserve the universe as a whole, in Hindu religious teachings which are included in the teachings of the Hinducosmological concept interms of the creation of the entire universe.Cosmology is one of the important knowledge in Hinduism, because cosmology not only provides knowledge about the creation of the universe, further more cosmology can explain the true nature of human beings,which has so far been difficult to understand.Cosmological teachings in Bali are written down in local theology. In particular, lontars or Shivaistic texts always put forward the teachings or knowledge of God (Stwa)and knowledge of the path to attaining Himand the creation of the universe,be it bhuana agung or bhuana alit.For this reason, true knowledge and proper implementation of concepts are also needed it is especially important to put forward the concept of Hindu cosmology in the Bhuana Kosa text on the correct understanding in everyday life burning a harmonious life and increasing devotion to God.

Cosmic Emotions; or, Why Is the Universe Joyful according to Plato’s Timaeus and Empedocles?

Plato and Empedocles depict a universe that manifests beauty, goodness, reason, and bliss. This article aims to investigate why both philosophers felt it important to describe a cosmos that participates in a human emotion such as happiness. First, it will be shown how both Plato and Empedocles could not dispense with embodied human experience, including emotional experience, in the formation of cosmological concepts. Indeed, their respective cosmoi are constructed through notions derived from the conceptual domain of human agency. Second, attention will also be paid to Plato and Empedocles’ reconstruction of the notion of the happy life. The main argument advanced here is that both Plato and Empedocles conceive of their (macro)cosmos as a paradigm of behavior, so that the conception of a happy universe has a significant ethical function at the level of the microcosm, ultimately demonstrating the centrality of the concept of happiness in the doctrines of both authors. byChiara FerellaJohannes Gutenberg University, Mainzferella@unimainz.de

Ricoeur on the Problem of Archaism in the Augustinian Concept of Time

Abstract This article will explore the role of what Ricoeur calls ‘archaism’ in his work on the third aporia of time in Time and Narrative. Presented in some detail in the conclusion of the third volume, the concept remains undeveloped. In this article we will identify the three characteristics, two forms and three dispositional states (praise, lamentation and hope) that help us to understand it, specifically in the Augustinian context. We have two main goals. We need to see whether there is a problem of origins in the Aristotelian cosmological conception of time as movement and succession and in the Augustinian psychological conception of time in respect of past, present and future against the limit of the Eternal.

KAJIAN FILOLOGI DAN KEARIFAN BUDAYA LOKAL DALAM TEKS MANUSKRIP KEISLAMAN LAYANG IMAN SUJANA KOLEKSI ANUT EKOWIYONO

This research describes the Islamic manuscript text Layang Iman Sujana with philological studies and local cultural wisdom. Layang Iman Sujana is a collection of Islamic manuscript texts collected by Anut Ekowiyono which contains the journey of the figure Iman Sujana from the country of Ngesam to spread the religion of Islam. This research aims to determine the study of philology and the study of local cultural wisdom in the Islamic manuscript text Layang Iman Sujana. This research is research using philological methods and is linked to local knowledge theory with the Tri Hita Karana cosmological concept. The results of the research show that Layang Iman Sujana generally tells the story of the character Iman Sujana who spread Islam on the orders of his father, Abdur Asfar. The local cultural wisdom contained in Layang Iman Sujana consists of two categories, namely harmonizing the relationship between people and God and harmonizing the relationship between people and each other. Harmonization of people with God in the form of sahadat, sharia, dhikr, surrender, torekot, prayer, quran, eling, piwales, titah, sukur, nugraha, and compassion. Meanwhile, the harmonization of humans with fellow humans takes the form of urmat, panuwun, ngabekti, tumindak becik, uluk salam, ngajeni, bale homestead, manners, nyenengke others, confident, combing anger, empan plank, and compassion.

Singularidade e a disputa por uma ideologia transhumanista

Abstract We understand Singularism, a stream of transhumanist thought, to be an ideology associated with Silicon Valley and the political right-wing (Hughes 2002). Taking this as our object of study, the present article conducts an anthropological discussion around the concepts of culture, ideology, and cosmology as proposed by Eric Wolf (1999). Cosmology provides a basis for ideology so as to offer elements for criteria such as truth and the inevitability of a given project for power. We point out how cybernetics works as a cosmology for Singularism and we explore political and philosophical differences between exponents of Singularism, which -- to a large extent - express different appropriations of cybernetics in their construction of the concept of Singularity.

We Need to Talk about the Penis

Abstract: What does epistemic decolonization mean for contemporary rethinking of the body, gender/sexuality, and knowledge in feminist and queer scholarship? Through a close reading of Chinese medicine's classical text Huang Di Nei Jing ( Yellow Emperor's Inner Canon ), this essay proposes a "body-of-orifices" in which the penis like the vagina and the anus is but another orifice among other more visible bodily openings. In feminist and queer theorization, the penis has been almost only accounted for as something else, as the metaphoric pen, the psychoanalytic phallus, as anything other than the organ itself. Meanwhile, in pornographic, cinematic, and other visual representations, the Asian man's member(ship) is largely denied, nowhere to be seen. This invisibility mirrors the overrepresentation of white male philosophers in much of queer theory's theoretical foundation. Engaging closely with feminist and queer re-readings of Freudian and Lacanian psychoanalysis while delving deeply into the philosophical and cosmological concepts of Chinese medicine, the essay also argues that the body-of-orifices entails a different heuristic model for a less hegemonic practice of knowing based on cultivation of passivity and receptiveness, which is very different from the colonial/modern model of knowledge-acquisition as mastery, penetration, and possession.

The transformation of Tuban Batik colors: perception and value in modern society

This article discusses the philosophical meanings represented by the dominant color in the background of traditional batik cloth in Tuban, East Java, Indonesia. These meanings have provided values and appreciation for the people of Tuban throughout their lives, reflecting a way of life connected to the concept of cosmology from birth to death. However, the current wave of development trends and modernity has impacted how the people of Tuban attribute value and adhere to these philosophical meanings within batik. This research employs an ethnographic approach involving direct data collection at the research location. We immersed ourselves in the local community, engaging in random interactions to gain insight into their thoughts and behaviors. Additionally, to uncover hidden philosophical values, data was collected through oral traditions involving one community leader, two entrepreneurs, and batik craftsmen knowledgeable about these values due to hereditary teachings. Subsequently, the data was analyzed using a phenomenological approach to elucidate the relationship between the philosophical meanings inherent in the traditional Tuban batik color and the daily behavioral patterns of the current population. This exploration illustrates the enduring significance of these philosophical meanings to the Tuban people. These meanings serve as a foundation for contemplating actions that preserve the tradition's continuity in the face of evolving innovations. It is imperative to assess how these values within the tradition are treated—whether maintenance, development, or elimination is appropriate—based on contemporary conditions.

Jagad Raya: Representation of Flora and Fauna in Wooden Craft From A Cosmological Perspective

The art of teak wood carving was one of the leading export commodities, especially wood carvings with flora and fauna motifs. Javanese culture and Hindu mythology influenced the flora and fauna motifs, so they had their meanings. This research aimed to develop carvings of flora and fauna motifs inspired by classic batik motifs using wood media. The results showed that the media used was teak wood with a finishing process without painting to produce a natural color. It was adjusted to its function and use in creating teak wood carvings. Wood carving did not only function to be enjoyed for its aesthetic value but as a decorative and sacred medium where each motif influences one's beliefs when creating artwork. In addition, teak wood carvings were used as symbols of a culture, and the designed motifs often contained the meaning of teachings to humans in carrying out life. Based on the economic aspect, the teak woodcarving industry strategically improved the community's income, especially for craftsmen in tourism centers. By making woodcarving crafts with flora and fauna motifs, it hoped that woodcarving crafts would not only use as decorative objects, but it used as an educational media for fine art, history, and Javanese culture, which were full of meaning to the broader community so that they could increase knowledge and encourage people to behave following the concept of cosmology.

The Cosmology of Tana Toa: Local Knowledge, Traditions, and Experiences of Forest Preservation in South Sulawesi, Indonesia

The study aims to explore the traditions of the Kajang people in nature/forest management based on their local knowledge and experience. In specific, this research describes the concept of cosmology of the Kajang tribe and the nature management system based on the prevalent social system in the Kajang tribe community. The research methods used in the study were interviews, observations, and documentation. Key leaders in the Kajang tribe community were the primary sources in this research. The collected data were analyzed and validated through focused group discussion sessions, discussions with peers, and discussions with experts. In this study, it was discovered that the Kajang people believe that nature comes from God and sent someone from the sky to lead the Kajang people with the aim of protecting and preserving nature. Pasang Ri Kajang is a spiritual message passed down through oral tradition to preserve nature in the Kajang community system.

Подборка драгоценных камней: элементы акбарийской космологии

The author notes that the Sufi theological tradition of Akbariya was formed on the basis of the works by Muhyiddin ibn Arabi. Part of this tradition is the doctrine of the nature of the world and its creation, i.e. cosmology. The purpose of the article is to reveal some elements of Akbarian cosmology. The semantic content of the concepts of Akbarian cosmology, creation and approved incarnations is determined. The author maintains that, although things exist eternally, from time immemorial and without beginning in divine knowledge precisely in the form of approved incarnations, at the same time they do not exist. The shortcomings of the (neo)platonic interpretation of the approved incarnations are demonstrated. The difference between Akbariya and the Academy of Plato lies in the fact that the teaching of the first concerns a person and his heart as an organ of self-integrity and connection with God, while the teaching of the second concerns the rational part of the soul. Also, several aspects of the cosmological concept of the Divine Names are revealed, the problem of the pantheistic interpretation of this theory is discussed and it is proved that it is not justified by the texts of Ibn Arabi. The cosmologi-cal meaning of the image of the mirror and the epistemological meaning of the image of “the silence of those who know” are also revealed. The last “gem” – the Perfect Man – is the beginning, the end and the preservation of creation. Various aspects of the concept of the Perfect Man (ethical and cosmologi-cal), its identification with Adam, with humanity in general and with Muhammad (the reality of Mu-hammad) are considered, the question of the “hypostasy” of the Perfect Man is identified and discussed

Simulating gravitational motion, gas dynamics, and structure in the cosmos

We provide introductory explanations and illustrations of the N-body hydrodynamics code Charm N-body GrAvity solver (ChaNGa). ChaNGa simulates the gravitational motion and gas dynamics of matter in space with the goal of modeling galactic and/or cosmological structure and evolution. We discuss the algorithm for leapfrog integration and smoothed particle hydrodynamics and computer science concepts used by the program, including the binary data structure for the particle positions. Our presentation borrows from the doctoral dissertation of J. Stadel, U. Washington, 2001. Problems are provided in order to use ChaNGa to learn or solidify some cosmological concepts.

Reading Cosmology in Establishment of The Noble Settlement in Puyung Village, Central Lombok District

This paper is intended to explain the reading of cosmological concepts set as the foundation of dwelling in Puyung village, Central Lombok. The questions answered and explained are about who the Puyung really are. What is the universe and how do Puyung people see it? And, how do their knowledges of the universe applied in constructing and organize their environment. In answering those questions, cosmological concepts were reviewed. Historical reference related to their ancestors was used to find out who the Puyung people really were in the larger context of Sasak People. The research method used is the historical method consisting of heuristics, source criticism, interpretation and historiography. Whereas in reading cosmology using hermeneutic and semiotic methods, in addition to using descriptive methods in analyzing in order to find cosmological connectedness with their settlements which make the concept in the formation of their own settlements while collecting data using observation and in-depth interviews with local communities.

Alienation in Ntshavheni Alfred Milubi’s poetry

In this article, I analyse the thematization of alienation in the poetry of the Muvenḓa poet, playwright, and scholar Ntshavheni Alfred Milubi. Milubi ascribes people’s abandonment of moral values to their perpetual frustrations, herein described as alienation. Reference is made to the crumbling African traditional institutions, which, in the past, seemingly functioned as havens for the rehabilitation of alienated individuals in African communities. These institutions are shown to be triggering alienation in the modernising and globalising space, seemingly with no room for recuperation unless one heeds the poet’s clarion calls. I restrict my analysis of Milubi’s poetry only to social and cosmic alienation, guided by a fixed set of themes, namely, from society, a romantic lover, and God, respectively. The article represents the idea that African-language literatures provide insights into how the indigenes have grappled with the interface between tradition and modernity. The three forms of alienation as treated by Milubi serve as a representative sample of how Tshivenḓa poetry in particular and African-language literatures in general often register subaltern voices and the ways in which they inscribe their experiences to explain their relationship with God or god(s), society, and intimate partners, among others. This trifocal relationship is essential to the Vhavenḓa and other African communities because it reveals their concept of cosmology, community, and intimacy.

Cesare Cremonini's non-theological cosmology: a contribution to Padua's secular culture in times of wars of religion.

This essay deals with the cultural-political motivations behind the cosmological conceptions of the Padua Aristotelian Cesare Cremonini (1550-1631). A defender of the interests of the university against Jesuit teachings, and one of the philosophers who was most frequently scrutinized by the Inquisition, he was an important actor in Venetian cultural politics during the years of European religious conflict that culminated in the Thirty Years War. In those years, he was officially titled 'protector' of the multi-confessional German Nation of Artists, one of the largest groups of foreign students at the University of Padua, and had to act as mediator in cases of conflict. His efforts to keep teaching free from religious concerns is reflected by his commitment to pursue philosophical and cosmological inquiries without engaging in revealed theology. In particular, his strict adherence to Aristotelian cosmology proved to be at odds with central Christian dogmas as it relinquished, among other concepts, the ideas of Creation and divine Providence. I argue that this position of Cremonini's fostered a tolerant and universalistic attitude in line with a secular programme that could enable cross-confessional coexistence in a cosmopolitan institution like Padua.

Arthur E. Haas, from the Atom to the Cosmos—Struggles for a Scientific Career in the Early 20th Century

Arthur E. Haas, from the Atom to the Cosmos—Struggles for a Scientific Career in the Early 20th Century