I discuss cosmological particle production in spaces with spectral asymmetry. A change in the amount of spectral symmetry sufficient to produce a level crossing will result in the creation of neutrino pairs rather than neutrino, antineutrino pairs; the net excess of fermions being given by the number of level crossing. A symmetric Bianchi IX model is treated in detail and for large initial anisotropy the number of neutrinos produced is ( 1 256 ) exp 12 β + where β + is a measure of the initial anisotropy. The relation of this phenomenon to chiral anomalies and to the Atiyah-Patodi-Singer index theorem for manifolds with boundary is described. The effect of spectral asymmetry on photons is discussed and it is shewn that no level crossing can occur.