Cosmetic Effect Research Articles

Clinical analysis of breast reconstruction with endoscopic-assisted harvesting of latissimus dorsi muscle flap for breast cancer

To investigate the benefits and drawbacks of breast reconstruction with endoscopic-assisted harvesting of the latissimus dorsi muscle flap for breast cancer and treatment experience of postoperative operation-related complications. A retrospective analysis was performed on clinical data of 26 female patients with breast cancer who met the selection criteria between September 2021 and March 2023 aging 48.7 years (range, 26-69 years). All tumors were unilateral, with 17 on the left side and 9 on the right side. The tumor size ranged from 1.0 to 7.0 cm, with an average of 2.7 cm. The pathological staging included T 1 in 11 cases, T 2 in 14 cases, and T 3 in 1 case; N 0 in 10 cases, N 1 in 11 cases, N 2 in 2 cases, and N 3 in 3 cases; no distant metastasis (M 0) occurred when first diagnosed. Among them, 10 cases underwent breast conserving surgery, and 16 cases underwent nipple-sparing mastectomy. All patients underwent breast reconstruction with endoscopic-assisted harvesting of the latissimus dorsi muscle flap. The operation time, incision length, and postoperative drainage volume in 3 days were recorded. Breast-Q "Satisfaction with back" scale was conducted to evaluate patients' satisfaction with back at 6 months after operation. The operation time was 280-480 minutes (mean, 376.7 minutes), the incision length was 10-15 cm (mean, 12.2 cm), the postoperative drainage volume in 3 days was 500-1 600 mL (mean, 930.2 mL). There were 4 cases of postoperative seroma, 1 case of incision rupture, 1 case of paresthesia of the thoracic wall, and 1 case of edema of the ipsilateral upper limb. All patients were followed up 12-30 months (mean, 20.1 months). No latissimus dorsi muscle flap necrosis, latissimus dorsi muscle atrophy, or shoulder joint dysfunction occurred during follow-up; 2 patients had recurrence of lymph nodes in the ipsilateral axilla after operation, but no distant metastasis occurred. Breast-Q score at 6 months after operation was 64-100 (mean, 79.5). The average score was 78.6 (range, 64-100) in patients underwent nipple-sparing mastectomy and 81.0 (range, 78-100) in patients underwent breast conserving surgery. Breast reconstruction with endoscopic-assisted harvesting of the latissimus dorsi muscle flap for breast cancer is proven to be a surgical approach with safety and cosmetic effects with mild postoperative operation-related complications and considerable patient satisfaction.

Apple Pomace Extract Induces Cell Proliferation and Increases Type I Collagen and Hyaluronan Production in Human Skin Fibroblasts In Vitro.

Apple pomace is the residue left after apples are squeezed. The majority of pomace produced worldwide is produced by the apple manufacturing industry, however, most of the pomace produced by the industry is discarded. Apple pomace contains functional ingredients, such as polyphenols and triterpenoids, and exerts several beneficial effects on human health; however, studies on its cosmetic effects on the skin are lacking. Therefore, herein, we investigated the effects of apple pomace extract (APE) on human skin fibroblasts (HSFs) in vitro. When HSFs were cultured with the extract for 72h, the number of HSFs increased at concentrations of 10 and 20µg/mL. Transcriptome analysis and reverse transcription-quantitative PCR results revealed that the extract upregulated the expression of hyaluronan synthase (HAS) 1, HAS2, and HAS3 and downregulated the expression of HYAL1, a gene encoding the hyaluronan-degrading enzyme, in HSFs. Additionally, enzyme-linked immunosorbent assay revealed increased amounts of factors related to skin extracellular matrix, such as type I collagen and hyaluronic acid, secreted in the culture supernatant. The western blotting results suggested that the extract induced extracellular signal-regulated kinase and protein kinase B phosphorylation in HSFs. Additionally, several GO_Terms related to mitosis were detected in the Gene Ontology analysis. This is the first study to show that APE induces the proliferation of HSFs and production of factors related to skin anti-aging.

Is the duration and effectiveness of cosmetic effects from botulinum toxin decreasing? results from a survey of 400 healthcare professionals

Is the duration and effectiveness of cosmetic effects from botulinum toxin decreasing? results from a survey of 400 healthcare professionals

Tips and tricks for transluminal specimen extraction and extra-abdominal sigmoid colon resection.

The purpose of this video is to demonstrate how to achieve adequate length and blood supply of the proximal colon for a perineal pull-through procedure, without splenic flexure mobilization during natural orifice specimen extraction. Key steps of the procedure include lateral mobilization of the colon, D3 lymph node dissection, preservation of the left colic artery, low ligation of the inferior mesenteric vein, ligation and washout of the distal bowel lumen, extra-abdominally proximal resection of sigmoid colon, purse-string sutures on the distal sigmoid colon, and an air leak test. Transluminal specimen extraction with extra-abdominal resection was found to be a cost-effective procedure with good cosmetic effects. Tension-free anastomosis was achieved by preservation of the left colic artery and low ligation of the inferior mesenteric vein. The purse-string sutures were placed on the proximal and distal bowel to avoid crossing the staples line. Transluminal specimen extraction with extra-abdominal resection required minimal manipulation intra-abdominally in comparison with other natural orifice specimen extraction techniques.

Antimicrobial Therapy in Dentistry: An Evidence-based Review of Pomegranate Fruit Properties

Background: Phytotherapy is characterized by the use of medicinal plants in their different dosage forms. Currently, the use of this alternative medicine has increased. The raw material of herbal medicines consists of organs from medicinal plants (leaves, stems, fruits, peels, flowers and roots) with pharmacological, food, technical or cosmetic adjuvant effects. In addition, the side effects of its use appear to be reduced compared to synthetic and conventional medication. Objective: The aim of this mini-review is to present the scientific evidence involving the properties of the pomegranate fruit for future antimicrobial applications in dentistry. Methods: Literature searches included randomized clinical trials and in vitro studies [2000-2023] filtered mainly by the following terms [Punica granatum L.], [Pomegranate], [Dentistry], [Antimicrobial activity] and [Candida albicans]. Results: Studies have shown that Punica granatum Linn. has considerable antimicrobial activity, in addition to other pharmacological effects such as anti-cancer, antioxidant and antiinflammatory action. The use of herbal medicines, as potent antimicrobial agents against oral pathogens, has been widely reported. Conclusion: The use of P. granatum has proven its effectiveness, as a potent antimicrobial agent against oral pathogens, especially against the fungus Candida albicans, future studies need to focus on the development of a biocompatible formulation directed to the treatment of patients with oral candidiasis.

Natural orifice trans-oral, trans-vestibular endoscopic thyroidectomy: Surgical steps and technique.

Natural orifice scarless cosmetic surgeries are becoming a reality with increasing experience of advanced laparoscopic surgeries and availability of modern energy sources. Many techniques of minimally invasive video-assisted thyroidectomy through cervical and extra-cervical routes such as chest wall, trans-axillary, sub-mental, post-auricular and trans-luminal approach have been attempted. However, trans-oral trans-vestibular endoscopic thyroidectomy with its excellent cosmetic effect has become the more popular option among the surgical community with advantages such as decreased hospital stay and minimal complications. In this case report, we describe natural orifice trans-oral, trans-vestibular endoscopic thyroidectomy approach (NO-TOTVET) and add to literature the technique in which NO-TOTVET can be utilised, thus adding to the repertoire of the operating surgeon.

Antioxidant, Anti-photoaging, and Anti-wrinkle Effects of Cosmetics Containing Low-molecular-weight Peptide Complexes

Purpose: This study aimed to confirm the skin improvement effects of cosmetics containing low-molecular-weight peptide complexes using <i>in vitro</i> and human application tests.Methods: An <i>in vitro</i> test was conducted to confirm the cytotoxicity, antioxidant, and anti-photoaging effects of cosmetics comprising low-molecular-weight peptide complexes. The protective effect on HacaT cells subjected to oxidative stress and collagen production in CCD-986sk cells irradiated with UV-B (Ultraviolet B) were confirmed. Moreover, to validate skin improvement effects, a human application test was performed on 20 adults aged 30–59 years. The wrinkles depth and the indentation index around the forehead, eyes, cheeks, and mouth were evaluated using ANTERA 3D CS.Results: The test material demonstrated excellent cell viability, confirming its safety on the skin. At a concentration of 0.1%, it exhibited a removal rate of reactive oxygen species (ROS) by 63.39% (<i>p</i><0.001) and an increase in collagen content of 102.14% (<i>p</i><0.01). Furthermore, in the human application test over 4 weeks, skin folds exhibited a decrease in average depth by 20.53% (<i>p</i><0.001), and the indentation index decreased by 17.02% (<i>p</i><0.001).Conclusion: Cosmetics containing low-molecular-weight peptide complexes possess excellent antioxidant, anti-photoaging, and collagen synthesis promotion properties. Their efficacy in reducing skin wrinkles and increasing skin elasticity was also confirmed. Low-molecular-weight peptide complexes could be an excellent active ingredient in cosmeceuticals.

모바일 화장품 앱 활용현황 및 소비자의 구매행동이 구매만족도에 미치는 영향

While the mobile environment is rapidly absorbing new beauty-related information, the information of mobile cosmetics apps is playing an important role in changing women's personality, beautiful appearance, and life. The purpose of this study is to understand the characteristics of mobile cosmetics apps from this point of view, and through this, the effect of cosmetics apps' utilization status and cosmetics consumers' purchasing behavior on purchase satisfaction. This study was conducted as an empirical analysis through theoretical consideration and questionnaire method. Previous studies, academic journals, reports, and presentation data were collected and analyzed to understand the characteristics and current status of the cosmetics market, and cosmetics purchase behavior through mobile cosmetics apps was analyzed. A questionnaire was conducted and empirical analysis was conducted to analyze the cosmetics purchase behavior, satisfaction, and usage status of cosmetics apps by consumers through the app. The results of the study are as follows. The group that uses mobile cosmetics apps the most is office workers under their 20s, and the preference for cosmetics apps is Olive Young, which is rich in product information, because it is well suited to the lifestyle of the 20s. Housewives in their 50s used offline more than apps. Through this, it can be seen that people in their 20s who are familiar with smartphones use mobile cosmetics apps more than those in their 50s who have difficulty using smartphones. As a result of analyzing the factors affecting the satisfaction of purchasing cosmetics through mobile cosmetics apps, acquisition of makeup information and easy purchase channels were found to have a great influence on purchase satisfaction.

Postoperative complications and hernia recurrence after the use of various ventral hernia repair techniques

Prosthetic hernioplasty (HP) for ventral hernias (VH) has a complication rate of up to 27% and a hernia recurrence rate up of to 37%, depending on the chosen technique. The use of laparoscopic HP techniques allows for a shorter hospital stay and a lower risk of wound infection. There is a wide range of data on the superiority of laparoscopy over the open technique in terms of recurrence rates and various types of complications. The results of comparing HP with and without suturing of the hernia defect are controversial. Objective — to study the structure and incidence of postoperative complications, as well as the frequency of hernia recurrences after the use of open and laparoscopic HP for VH. Materials and methods. A multicenter prospective study, which included 482 patients diagnosed with VH, was conducted at the clinical base of the Department of General Surgery No. 2 at Bogomolets National Medical University. A total of 279 (57.9%) patients had primary VH, while 203 (42.1%) had incisional VH. The patients were divided into two groups, comparable in terms of age, sex, and hernia size distribution. Group 1 included 250 (51.9%) patients who underwent open HP with suturing of the hernia defect: subgroup 1a — open sublay (n=243; 50.4%), and subgroup 1b — open intraperitoneal onlay mesh technique (IPOM) (n=7; 1.5%). Group 2 included 232 (48.1%) patients who underwent laparoscopic HP using the IPOM technique: subgroup 2a — IPOM without suturing of the aponeurosis defect (n=81; 16.8%), subgroup 2b — IPOM with suturing of the aponeurosis defect (n=108; 22.4%), and subgroup 2c — IPOM+ with open aponeurosis defect suturing (n=43; 8.9%). Follow‑up evaluations were carried out at intervals of 2 weeks, 1 month, 6 months, and 1 year to assess the presence of complications, recurrence, and satisfaction with the cosmetic effect of the operation. Results. The overall frequency of complications after HP was 15.6%, while after open sublay it was 21.2%, and after laparoscopic IPOM it was 9.9%. All cases of complications belonged to Grades I—IIIb according to the Clavien‑Dindo classification. In both groups, there were no fatalities. In group 1, the frequency of seroma was 11.6% and hematoma was 5.6%, and in group 2, it was 7.3% and 0.9%, respectively. A statistically significant increase in the frequency of hematoma development was observed after open HP techniques compared to laparoscopic ones (p=0.004), while the frequency of seroma detection was comparable (p=0.148). Non‑suturing of the aponeurosis defect after laparoscopic IPOM in patients with VH did not result in an increase in the total number of complications or the percentage of recurrence (p >0.05). Laparoscopic IPOM with hernia suturing demonstrated significantly higher patient satisfaction with the appearance of the anterior abdominal wall compared to other HP techniques (р <0.05). Conclusions. The open sublay and laparoscopic IPOM HP procedures have a comparable recurrence rate of VH (p >0.05). The incidence of infectious complications and hematomas is significantly higher after open operations compared to laparoscopic ones (p=0.041 and p=0.004, respectively).

The benefit and clinical value of CT scan as preoperative assessment for structural functional septorhinoplasty

<b>Introduction:</b> Structural functional septorhinolplasty is an operation designed to achieve both aesthetic and functionalgoals, which were the most important success parameters for patient satisfaction. Different preoperative examination toolsare available for assessment.<b>Aim:</b> To evaluate the diagnostic benefit and clinical value of a CT scan, and compare it with other examination tools, such as nasal endoscopy and anterior rhinoscopy for structural functional septorhinoplasty<b>Material and Methods:</b> A prospective randomized controlled study of 148 consecutive patients seeking for a solution to their primary problem of nasal obstruction, and also for a cosmetic effect within the same operation (structural functional septorhinoplaty). They were divided into 3 groups; CT scan group, endoscopic group, and control group (anterior rhinoscopy). The subjective postoperative assessment was carried out with the Nasal Obstruction Symptom Evaluation scale (NOSE), Rhinoplasty Outcome Evaluation scale (ROE), Visual Analogue Scale (VAS), and SNOT-22 score. Those outcomes at 12-month follow-up were compared to preoperative values.<b>Results:</b> Among 148 patients, there were 77 males (52.02%) and 71 females (47.97%), age range between 19 to 52 years (mean age 23.4 2.7 SD). In all 3 groups, there was a significant clinical improvement in nasal symptoms and structural functional septorhinoplasty outcomes, as well as better ROE, NOSE, VAS, and SNOT-22 scores in the CT scan group when compared to the other two groups, with the P-values being 0.01, 0.01, 0.03, and 0.04, respectively.<b>Conclusions:</b>CT scan is of greater benefit than nasal endoscopy and anterior rhinoscopy and constitutes the method of choice as a part of preoperative assessment in detecting any nasal pathology and assessing nasal anatomical structures prior to structural functional septorhinoplasty.

The first experience of applying microwave ablation in primary hyperparathyroidism

The OBJECTIVE of this article was to present a clinical demonstration of the successful experience of using minimally invasive surgical treatment of a patient with primary hyperparathyroidism (PHPT) by percutaneous microwave ablation (MWA) of parathyroid adenoma, under ultrasound guidance. This method provides maximum effectiveness with minimal invasiveness, a shorter recovery period after surgery, and a better cosmetic effect. After the minimally invasive intervention, the patient had complaints related to hypocalcemia, which develops practically after any form of radical PHPT treatment. No other complications were observed. Further dynamic observation was carried out by an endocrinologist at the place of residence. The obtained positive results demonstrated a good perspective of PHPT treatment by using MWA.

The possibilities of minimally invasive approach in aortic root surgery

The trend towards minimally invasive and excellent cosmetic effect has affected the most difficult section of cardiac surgery – the aortic root. To date, there are various minimally invasive approach for the correction of aortic root pathol ogy, which are used in single clinics in the world. The objective of this literature review was to study the current state of minimally invasive aortic root surgery and critically evaluate methods of correcting its pathology from different types of minimally invasive approach. The minimally invasive approach to these operations is presented in this review of the literature. A mutual comparison of minimally invasive approaches was carried out, their advantages over the traditional approach were determined. Despite the attractiveness of the technique, there are serious limitations of its wide appli cation, such as a long learning curve, an extremely low number of long-term results and the absence of multicenter, randomized comparison studies with traditional approach.

Adverse effects of nail cosmetics and how to prevent them

Nail cosmetics are being used world over for nail enhancement, and their list is an ever expanding one. However, due to their widespread usage, there are an increasing number of adverse effects also being reported. These have been reported both in the users as well as service providers (nail salon workers/technicians). Adverse effects to nail cosmetics usually present to dermatologists, who need to be equipped to suspect, diagnose, and manage them. A whole range of newer nail cosmetic products are available now, which can lead to a variety of adverse reactions. These may be early and hence easy to temporally correlate with cosmetic usage; or have a delayed onset making it difficult to correlate with the nail cosmetic used. Varying presentations include onycholysis, infections, allergic dermatitis, psoriasiform nail changes, and systemic adverse effects. The range of clinical manifestations, prevention, and management of nail cosmetic-related adverse effects are detailed in this review.

Serpentine supravenous hyperpigmentation (SSH) in nasopharyngeal carcinoma patient on docetaxel and carboplatin chemotherapy: a case report

Serpentine supravenous hyperpigmentation (SSH) is a rare but unique side effect of intravenous anticancer. It manifests as linear hyperpigmentation eruption on the skin that radiates along the superficial vein accompanied by mild pain and/or itch. This SSH does not cause systemic alterations, however, most patients complained about its cosmetic effects. The diagnosis of SSH can be made clinically, although histopathological examinations can aid in excluding differential diagnoses. We reported a case of SSH found in a nasopharyngeal cancer patient during docetaxel and carboplatin chemotherapy. It is a potentially alarming interface dermatitis that is not lot reported in the literature. It was reported, the patient tolerated the second and third cycles well with less severe side effects when premedicated with 250 mL NaCl 0.9% bolus intravenously before and after chemotherapy sessions, 10 mg cetirizine every 24 hr orally, and desoximetasone cream 0.25% every 12 hr topically added.

ИЗМЕНЕНИЕ БИОТИПА ДЕСНЫ В ПРОЕКЦИИ ДЕНТАЛЬНЫХ ИМПЛАНТАТОВ

Deficiency of keratinized gum in the peri-implant zone contributes to bone recession and visualization of implant necks and abutments through its thin layer. To develop clinically effective and scientifically based protocols for the prevention and treatment of pathology of tissues surrounding implants, it is necessary to study the risk factors for the occurrence of mucositis and peri-implantitis, one of which is the deficiency or complete absence of attached keratinized gum in the implant area, as a result of which the mobile mucous membrane is constantly displaced during eating, talking, performing hygiene procedures. The gums are easily injured, which leads to rapid colonization of pathogenic microflora and the development of initial inflammation in the form of mucositis. The inflammatory process is launched, which in turn leads to an increase in the activity of osteoclasts. It should be noted that the rate of development of the inflammatory process in the area of implants is much higher than in the area of teeth. Due to the absence of the periodontal ligament, the inflammatory infiltrate directly spreads to the alveolar bone and penetrates into the medullary spaces. The gum contour in the area of installed implants must be aesthetic, stable and dense. This together will not only provide a cosmetic effect, but will also prevent the development of early and late complications of dental implantation. The paper provides an analysis of various methods of mucogingival surgery in the field of dental implants using an allogeneic graft of the “Alloplant” series. Engraftment of mucosal autografts from the tubercle of the upper jaw after surgery is accompanied by severe inflammation, which can lead to scarring of the mucosa or exposure of the bone. Allografts transplanted to patients to thicken the gums in the area of implantation are completely replaced after 6 months without signs of rejection or inflammatory processes by a full-fledged connective tissue regenerate covered with stratified squamous keratinizing epithelium. In the surgical area, gum tissue is formed in thickness, which can be classified as a “thick” gum phenotype.

Transoral robotic thyroidectomy via vestibular approach: a retrospective study of 107 cases in a single center

Objective: To investigate the short-term outcome of transoral robotic thyroidectomy. Methods: This is a retrospective case series study. The clinicopathologic characteristics and postoperative results of 107 patients who underwent transoral robotic thyroidectomies in the Department of Thyroid and Breast Surgery of the 960th Hospital of People's Liberation Army from May 2020 to August 2023 were retrospectively analyzed. There were 12 males and 95 females, with an age of (31.8±9.4) years (range: 11 to 55 years), including 20 benign tumors and 87 thyroid papillary carcinoma. Postoperative follow-up was carried out through returning visit and telephone, mainly to observe the recovery of postoperative complications, cosmetic effects and recurrence results. Results: All transoral robotic thyroidectomy was successfully completed without conversion to open surgery. The tumor size of thyroid papillary carcinoma patients was (5.6±2.7) mm (range: 2 to 15 mm). Furthermore, central cervical lymph node metastasis was found in 45 cases. The number of central cervical lymph nodes retrieved and metastasized (M(IQR)) were 11 (8) (range: 3 to 26) and 1 (3) (range: 0 to 13), respectively. There was no recurrent laryngeal nerve injury and permanent hypoparathyroidism. The transient hypoparathyroidism after surgery was 8 cases. Other complications occurred as follows: postoperative infection (n=1), left submandibular perforation (n=1), skin scald (n=1), and perioral numbness (n=1), oral tear (n=2). The postoperative stay was 6 (2) days (range: 3 to 11 days). No local lymph node recurrence or metastasis occurred after a follow-up of (22.6±10.0) months (range: 1.0 to 37.4 months). All patients were satisfied with the postoperative cosmetic results, the aesthetic effect score was 9.3 (0.2) (range: 8.4 to 9.6) one month after surgery. Conclusion: For highly screened patients with early thyroid cancer, experienced surgeons can perform a transoral robotic thyroidectomy that has excellent cosmetic results.

Clinical application of a novel separated magnetic controlled forceps assisted single-incision laparoscopic cholecystectomy

Objective: To explore the application value of a novel separated magnetic-controlled forceps in transumbilical single-incision laparoscopic cholecystectomy (SILC). Methods: This is a prospective case series study. Data from patients who underwent SILC at the Department of General Surgery, the Second Affiliated Hospital of Air Force Medical University from March to August 2023 were prospectively collected, based on inclusion and exclusion criteria. All patients underwent cholecystectomy assisted by a novel separated magnetic-controlled forceps. Surgical time, intraoperative blood loss, the need for additional incisions during surgery, and the length of hospital stay were recorded to assess surgical difficulty and effectiveness. Postoperative pain scores and complications were documented to evaluate the safety of the procedure. The collaboration experience of the surgeon and assistant was evaluated using a 5-point Likert scale to assess the feasibility of this surgical approach. Informed consent was obtained from all patients in accordance with medical ethical regulations. Patients were followed up through outpatient visits or telephone calls, with follow-up at 7 days and 1 month after surgery, and evaluation of incisional scar healing and completion of satisfaction questionnaires. Follow-up was conducted until September 30, 2023. Results: A total of 45 patients were included in the study,including 19 males and 26 females,aged (42.7±4.2)years(range:32 to 61 years). The difficulty of the operation was evaluated as grade 1 or 2 in 38 cases(84.4%) and grade 3 in 7 cases(15.6%). Operation time was (37.3±5.3) minutes(range: 25 to 80 minutes),and intraoperative blood loss(M(IQR)) was 17.8(35.0) ml (range:10 to 60 ml). All surgical procedures proceeded smoothly without intraoperative incidents, and the overall satisfaction of the surgeon and assistants was high. All patients underwent successful day surgery management and were discharged within 48 hours of hospitalization. The postoperative pain scores at 1, 7, and 30 days were 3 (4), 1 (3), and 0 (2), respectively. The follow-up time was 5.0(2.2) weeks (range: 3 to 7 weeks), with no occurrence of grade 3 to 4 adverse reactions, and the patients were satisfied with the cosmetic effect of the umbilical incision. Conclusions: The novel separated magnetic-controlled forceps can be applied in transumbilical SILC. It has the advantages of convenient operation, and patients are satisfied with the surgical results.

Formulation and Evaluation of Poly Herbal Body Scrub

The research aimed to produce an Polyherbal body scrub. These days, the demand for skin care products and treatments has increased to a larger extend.Having a proper appearance and a beauty standard has gotten a lot of importance. A typical skin care routine consists of a cleanser, a serum, a moisturizer and a sunscreen.Among these, it has been seen that the serums are the new go to when it comes to building an excellent skin routine. Serums come in various types of formulation be it for oily, dry or anything in between type of skin. Facial wrinkles and skin aging are undesirable outcome of photo damage and ultraviolet (UV) rays. Currently no effective strategies are available to delay skin aging process. Aloe Vera, glycerin and honeybee venom face serum is a highly concentrated cosmetic product. When using aloe Vera we get not only a quick cosmetic effects but also psychological satisfactions, serum has a property of rapid absorption and ability to penetrate into deeper layer of the skin. In the present work we have formulated the poly herbal body scrub by using Orange peel powder, SCI powder, SLS powder, Honey, Glycerine, Bees wax, Aloe vera. These formulations are safe to use for skin and found to be satisfied with all required characterizations. The scrub was evaluated by using the parameters like Appearance, Viscosity, pH, Spreadibility, Washability, Grittiness, Foamability, Moisture content, Consistancytest and Irritation.

Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide.

Peptides are a promising skincare ingredient, but due to their inherent instability and the barrier function of the skin's surface, they often have limited skin absorption and penetration, which can significantly hinder their skincare benefits. To address this, a novel technique called NanoGlow has been introduced for encapsulating peptide-based cosmetic raw materials into engineered nanosized plant-derived exosomes (pExo) to achieve the goal of a healthier and more radiant skin state. In this approach, pExo served as carriers for cosmetic peptides across the intact skin barrier, enhancing their biological effectiveness in skin beauty. The NanoGlow strategy combines chemical activation and physical proencapsulation, boasting a high success rate and straightforward and stable operation, making it suitable for large-scale production. Comprehensive analysis using in vitro cellular absorption and skin penetration models has demonstrated that the nanosized pExo carriers significantly improve peptide penetration into the skin compared to free peptides. Furthermore, in vivo tissue slice studies have shown that pExo carriers efficiently deliver acetyl hexapeptide-8 to the skin's dermis, surpassing the performance of free peptides. Cosmetic skincare effect analysis has also indicated that pExo-loaded cosmetic peptides deliver superior results. Therefore, the NanoGlow technique harnesses the natural size and properties of pExo to maximize the bioavailability of cosmetic peptides, holding great promise for developing advanced peptide delivery systems in both the cosmetic and medical drug industries.

Morphometric analysis of the effects of high molecular weight sodium hyaluronate and amino acids mixture on face rejuvenation.

Skin aging can be observed at various levels in the epidermis, dermis, and dermo-epidermal junction. Reducing the cosmetic effects of skin aging in the facial region is a widespread demand due to common aesthetic concerns. Consequently, many injectable products on the market promise antiaging effects and cosmetic improvements. We aimed to evaluate the cosmetic efficacy of a high molecular weight sodium hyaluronate and amino acids mixture for the facial region using morphometric analysis. This study evaluates the morphometric effectiveness of an injectable mixture (high molecular weight sodium hyaluronate, glycine, L-Proline, L-leucine, L-lysine HCL, L-valine, and L-alanine collagen active ingredient) on the mid-face and jawline in women aged 30-55. We used morphological measurements and digital image data to assess changes and determine effectiveness. Various computational methods were applied simultaneously with statistical tests for validation. The hydration assessment showed a significant increase on both sides of the face. A noticeable decrease was observed in gonion angle, bitragion breadth, bigonion breadth, and marionette wrinkle scale. These results suggest combining mechanical and chemical stimulation from the injection and its components (hyaluronic and amino acids) effectively enhances skin quality. The study indicates that the mechanical stimulation of the injection improves skin quality. Combining hyaluronic and amino acids (collagen, elastin, and pro-synthetic) is a safe and effective alternative for antiaging treatments.