The co-seismic and post-seismic deformation field associated with the Mw5.9 Arkalochori main shock that occurred in central Crete (Greece) on 27 September 2021 is analyzed using Copernicus Sentinel-1A & 1B images, GNSS measurements and seismological data. The fault geometry is constrained through the joint inversion of multiple datasets and the slip distribution for the co-seismic and post-seismic period is obtained using a homogeneous half-space elastic model and the Steepest Descent Method. The results indicate a blind normal fault striking 215° with a 55° dip to the northwest and the co-seismic slip model suggests a nearly circular main slip patch (8 × 6 km2) with a maximum slip of 0.98 m. Post-seismic displacements started rapidly after the main shock followed by a gradual decay as highlighted by the calculated InSAR time series. The temporal evolution of post-seismic slip is described by a simple logarithmic function, decaying faster at the southwest part of the fault. The cumulative afterslip model suggests that the maximum post-seismic slip of 0.23 m occurred within a similar depth range compared to the co-seismic one, yet with a shift towards the southwest. Post-seismic slip inside the main shock rupture area is sustained, highlighting the slow recovery of locking in the co-seismic slip region. Afterslip (seismic or aseismic) played a dominant role in the early post-seismic period acting complementarily to the main rupture. Indications suggest that the spatiotemporal evolution of the productive aftershock sequence may be driven afterslip, alongside other potential factors.