Pituitary adenomas are the most common type of pituitary disorder. While prolactinoma and non-functioning pituitary adenomas are the most common pituitary tumour, adrenocorticotropic hormone (ACTH)-secreting tumours are relatively rare. ACTH-secreting tumour arises from corticotroph cells from pituitary gland and generally presents as Cushing's disease. Thirty-one years old female with recent history of multiple admission to acute care hospital got admitted to general medicine ward with complaints of gastro intestinal disturbance. Magnetic resonance imaging and lab studies confirmed the diagnosis of ACTH-secreting pituitary macroadenoma with development of Cushing's disease. The onset of illness was very slow and most of the signs and symptoms remained non-specific until patient developed severe metabolic and hormonal disturbances. Over a period of two years patient had multiple diagnosis like poly cystic ovarian disease, diabetes mellitus, depression and hyperacidity by different medical practitioners and received symptomatic treatment. Patient's condition completely improved after transnasal endoscopic excision of pituitary macroadenoma normalising her hormonal levels with disappearances of bodily changes. Most of her complications were successfully treated except diabetes insipidus which was identified during pre-operative period remained unchanged even after the surgery and patient continued treatment for the same. In this paper the condition of pituitary macroadenoma and the nursing care of the patient with pituitary macroadenoma is elaborated.