Professional ethics of employees is an effective Factor in the growth of spirituality and reducing administrative corruption in organizations. One factor that influences employees on Professional Ethics is personality. The overall goal of this research is to study the link between personalities of employees (Neuroticism, Extroversion, Agreeableness, Conscientiousness, Openness to experience) and their Professional ethics (responsibility, Competitiveness, honestly, respect to others, respect to values, justice, Sympathy to others, Loyalty) in Medical Sciences University of Bushehr. To study the correlation between personality style and Professional ethics of employees, five hypotheses were proposed in this project and the objective was to find the ones that were supported by the collected and analyzed data. Two sets of questionnaires titled “Form NEO five factors personality test” and “Professional ethics” questionnaires were distributed among 270 employees. Population of this research was 690 employees. The sorted data was analyzed using in SPSS and Lisrel software. While designed to test the hypothesis, based on the results, Findings show that, Between personality traits and PE, there is a positive relationship (0.445), Between personality traits and PE, there is a negative relationship(- 0 .251) some recommendations for developing Professional ethics in the organization, as is the end of the study