The aim of the present study is to experimentally investigate the thermal performance and the pressure drop in copper tubes partially filled with open-cell metal foams using MgO nanofluid. The tubes are produced by casting liquid metal around space holder material with the porosity of 70% and bounded by constant heat flux. MgO nanoparticles are added to the base fluid (water and ethylene glycol) to make the working fluid at the volumetric concentrations of 0.0625%, 0.25%, and 0.5%. The experiments are performed in a pipe with steady-state laminar flow. The obtained experimental results are compared with the correlation outputs, where a proper agreement between the results was observed. It is perceived that both pressure drop and Nusselt number are highly dependent on the Reynolds number. The data further shows that using nanofluid and porous media inside the tubes increases the pressure drop and convection heat transfer coefficient, significantly.