Flow boiling heat transfer coefficient, pressure drop, and flow pattern are investigated in the horizontal smooth tube of 6.1 mm inner diameter for CO 2, R410A, and R22. Flow boiling heat transfer coefficients are measured at the constant wall temperature conditions, while pressure drop measurement and flow visualization are carried out at adiabatic conditions. This research is performed at evaporation temperatures of −15 and −30 °C, mass flux from 100 to 400 kg m −2 s −1, and heat flux from 5 to 15 kW m −2 for vapor qualities ranging from 0.1 to 0.8. The measured R410A heat transfer coefficients are compared to other published data. The comparison of heat transfer coefficients for CO 2, R410A, and R22 is presented at various heat fluxes, mass fluxes, and evaporation temperatures. The difference of coefficients for each refrigerant is explained with the Gungor and Winterton [K.E. Gungor, R.H.S. Winterton, A general correlation for flow boiling in tubes and annuli, Int. J. Heat Mass Transfer 29 (1986) 351–358] correlation based on the thermophysical properties of refrigerants. The Wattelet et al. [J.P. Wattelet, J.C. Chato, B.R. Christoffersen, J.A. Gaibel, M. Ponchner, P.J. Kenny, R.L. Shimon, T.C. Villaneuva, N.L. Rhines, K.A. Sweeney, D.G. Allen, T.T. Heshberger, Heat Transfer Flow Regimes of Refrigerants in a Horizontal-tube Evaporator, ACRC TR-55, University of Illinois at Urbana-Champaign, 1994], and Gungor and Winterton [K.E. Gungor, R.H.S. Winterton, A general correlation for flow boiling in tubes and annuli, Int. J. Heat Mass Transfer 29 (1986) 351–358] correlations give the best agreement with the measured heat transfer coefficients for CO 2 and R410A. Pressure drop for CO 2, R410A, and R22 at various mass fluxes, evaporation temperatures and qualities is presented in this paper. The Müller-Steinhagen and Heck [H. Müller-Steinhagen, K. Heck, A simple friction pressure drop correlation for two-phase flow in pipes, Chem. Eng. Process. 20 (1986) 297–308], and Friedel [L. Friedel, Improved friction pressure correlations for horizontal and vertical two-phase pipe flow, in: The European Two-Phase Flow Group Meeting, Ispra, Italy, 1979 (paper E2)] correlation can predict most of the measured pressure drop within the range of ±30%. The relation between pressure drop and properties for each refrigerant is described by applying the Müller-Steinhagen and Heck correlation. The observed two-phase flow patterns for CO 2 and R410A are presented and compared with flow pattern maps. Most of the flow patterns can be determined by the Weisman et al. [J. Weisman, D. Duncan, J. Gibson, T. Crawford, Effect of fluid properties and pipe diameter on two-phase flow patterns in horizontal lines, Int. J. Multiphase Flow 5 (1979) 437–462] flow pattern map.