Correlation Effect Size Research Articles

Psychological Factors Are Associated with Pain at All Time Frames After Breast Cancer Surgery: A Systematic Review with Meta-Analyses.

This systematic review aimed to 1) assess associations between psychological factors and pain after breast cancer (BC) treatment and 2) determine which preoperative psychological factors predicted pain in the acute, subacute, and chronic time frames after BC surgery. A systematic review with meta-analysis. Women with early-stage BC. The Medline, EMBASE, CINAHL, and Web of Science databases were searched between 1990 and January 2019. Studies that evaluated psychological factors and pain after surgery for early-stage BC were included. Associations between psychological factors and pain, from early after surgery to >12 months after surgery, were extracted. Effect size correlations (r equivalents) were calculated and pooled by using random-effects meta-analysis models. Of 4,137 studies, 47 were included (n = 15,987 participants; 26 studies ≤12 months after surgery and 22 studies >12 months after surgery). The majority of the studies had low to moderate risk of bias. Higher preoperative anxiety and depression were weak but significant predictors of pain at all time points up to 12 months (r equivalent: 0.15-0.22). Higher preoperative pain catastrophizing and distress were also weak but significant predictors of pain during the acute (0-7 days) and chronic (3-12 months) periods (r equivalent: 0.10-0.20). For the period >12 months after surgery, weak but significant cross-sectional associations with pain were identified for anxiety, depression, pain catastrophizing, and distress (r equivalents: 0.15, 0.17, 0.25, 0.14, respectively). Significant pooled effect size correlations between psychological factors and pain were identified across all time frames. Though weak, these associations should encourage assessment of key psychological factors during preoperative screening and pain assessments at all postoperative time frames.

Influence of Contextual Factors, Technical Performance, and Movement Demands on the Subjective Task Load Associated With Professional Rugby League Match-Play.

To identify the association between several contextual match factors, technical performance, and external movement demands on the subjective task load of elite rugby league players. Individual subjective task load, quantified using the National Aeronautics and Space Administration Task Load Index (NASA-TLX), was collected from 29 professional rugby league players from one club competing in the European Super League throughout the 2017 season. The sample consisted of 26 matches (441 individual data points). Linear mixed modeling revealed that various combinations of contextual factors, technical performance, and movement demands were associated with subjective task load. Greater number of tackles (effect size correlation ± 90% confidence intervals; η2 = .18 ± .11), errors (η2 = .15 ± .08), decelerations (η2 = .12 ± .08), increased sprint distance (η2 = .13 ± .08), losing matches (η2 = .36 ± .08), and increased perception of effort (η2 = .27 ± .08) led to most likely-very likely increases in subjective total task load. The independent variables included in the final model for subjective mental demand (match outcome, time played, and number of accelerations) were unclear, excluding a likely small correlation with technical errors (η2 = .10 ± .08). These data provide a greater understanding of the subjective task load and their association with several contextual factors, technical performance, and external movement demands during rugby league competition. Practitioners could use this detailed quantification of internal loads to inform recovery sessions and current training practices.

Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology

Recent years have seen an increased understanding of the importance of myelination in healthy brain function and neuropsychiatric diseases. Non-invasive microstructural magnetic resonance imaging (MRI) holds the potential to expand and translate these insights to basic and clinical human research, but the sensitivity and specificity of different MR markers to myelination is a subject of debate. To consolidate current knowledge on the topic, we perform a systematic review and meta-analysis of studies that validate microstructural imaging by combining it with myelin histology. We find meta-analytic evidence for correlations between various myelin histology metrics and markers from different MRI modalities, including fractional anisotropy, radial diffusivity, macromolecular pool, magnetization transfer ratio, susceptibility and longitudinal relaxation rate, but not mean diffusivity. Meta-analytic correlation effect sizes range widely, between R2 = 0.26 and R2 = 0.82. However, formal comparisons between MRI-based myelin markers are limited by methodological variability, inconsistent reporting and potential for publication bias, thus preventing the establishment of a single most sensitive strategy to measure myelin with MRI. To facilitate further progress, we provide a detailed characterisation of the evaluated studies as an online resource. We also share a set of 12 recommendations for future studies validating putative MR-based myelin markers and deploying them in vivo in humans.

Visual N80 latency as a marker of neuropsychological performance in schizophrenia: Evidence for bottom-up cognitive models

ObjectiveCognitive deficits and visual impairment in the magnocellular (M) pathway, have been independently reported in schizophrenia. The current study examined the association between neuropsychological (NPS) performance and visual evoked potentials (VEPs: N80/P1 to M- and P(parvocellular)-biased visual stimuli) in schizophrenia and healthy controls. MethodsNPS performance and VEPs were measured in n = 44 patients and n = 34 matched controls. Standardized NPS-scores were combined into Domains and a PCA (Principal Component Analysis) generated Composite. Group differences were assessed via (M)ANOVAs, association between NPS and VEP parameters via PCA, Pearson’s coefficient and bootstrapping. Logistic regression was employed to assess classification power. ResultsPatients showed general cognitive impairment, whereas group differences for VEP-parameters were non-significant. In patients, N80 latency across conditions loaded onto one factor with cognitive composite, showed significant negative correlations of medium effect sizes with NPS performance for M/P mixed stimuli and classified low and high performance with 70% accuracy. ConclusionThe study provides no evidence for early visual pathway impairment but suggests a heightened association between early visual processing and cognitive performance in schizophrenia. SignificanceOur results lend support to bottom-up models of cognitive function in schizophrenia and implicate visual N80 latency as a potential biomarker of cognitive deficits in schizophrenia.

Validity of the Polar V800 Monitor for Assessing Heart Rate Variability in Elderly Adults under Mental Stress and Dual Task Conditions.

Background: Aging may result in autonomic nervous dysfunction. Heart rate variability (HRV) is a non-invasive method to measure autonomic nervous activities. Many studies have shown that HRV contributes to the risk assessment of diseases. A Polar V800 heart rate monitor is a wearable device that measures R-R intervals, but has only been validated in younger adults under limited testing conditions. There is no validation of the V800 under mental stress or in dual task testing conditions. Therefore, this study investigated the validity of the Polar V800 heart rate monitor for assessing R-R intervals and evaluated if there were differences on HRV parameters under different situations in community-dwelling elderly adults. Methods: Forty community-dwelling elderly adults were recruited. Heart rates were recorded via electrocardiogram (ECG) and the V800 under sitting, during an arithmetic test, during a naming test, a self-selected walking velocity test (SSWV), and dual tasks (SSWV performing mental arithmetic test and SSWV performing naming test). Indices of time and frequency domains of HRV were calculated afterwards. The intra-class correlation coefficient (ICC) analysis and effect size were calculated to examine the concurrent validity between the V800 and the ECG. Results: All HRV indices from the V800 were highly correlated with the ECG under all tested conditions (ICC = 0.995–1.000, p < 0.001) and the effect size of bias was small (<0.1). Conclusion: Overall, the V800 has good validity on the assessment of HRV in community-dwelling elderly adults during sitting, mental arithmetic test, naming test, SSWV, and dual tasks.

First Correlation Study between Family Organizational/ Administrative Functionality Scale Results and School Performance of the Young Human Capital at Public and Private Elementary, Middle and High School of the South/ Center of the US, Territory of Puerto Rico

This quantitative study presents the first correlation between Family Organizational and Administrative Functionality and School Performance. To evaluate Family Organizational and Administrative Functionality is using the FOAF Scale (Vélez-Candelario, S., 2019) and the overall percent of it. This scale has 90% of the overall value. The intern consistency and the Factor Analysis are, .89 (Cronbach's Alpha) and the Factor Analysis shows a .8 KMO (Kaiser-Mayer-Olkin), recognizing each measured area as an independent factor. To analyze the school performance, we are using the General Point Average (GPA) at the school of each one of the participant. The study includes a socio-demographic document and parent consent. The sample is two-hundred-sixty-five (265) children with six (6) to seventeen (18) years old from public and private schools. It was from the south and center zone of Puerto Rico, with an education system based on the American model (Classbase, 2018). The sample is selected by availability from volunteer families and from Puerto Rico's Department of Educationn. The hypothesis investigation (Hi) is: Exist a positive correlation between Family Organizational/Administrative Functionality and school performance. For the statistical analysis, the sample is submitted in the SPSS 26 version and applies a Pearson's correlation formula and a sample descriptive Statistics. The findings show a positive correlation with a significance level of 0.01. The Pearson correlation degree between, FOAF and GPA, is medium, ρ = .341**, (Cohen 1988; in Wuensh 2015). The small correlation effect size is one in which there is a real effect, but one which can only be see-through careful study. A large effect size is an effect which is big enough such that it may be visible to the naked eye (Cohen 1988 in Walker 2007-08). The statistics analysis allowed the acceptance of the Hi confirming the existence of a positive correlation between FOAF Scale results and GPA at School. Keywords: Family, Organizational, Administrative, Functionality, Scale, School, Performance, Correlation.

Is adherence to the Mediterranean diet associated with healthy habits and physical fitness? A systematic review and meta-analysis including 565421 youths.

The relationship between adherence to the Mediterranean diet (MD), physical activity (PA), sedentary behaviour and physical fitness levels has been analysed in several studies; however, there is mixed evidence among youth. Thus, this study aimed to meta-analyse the associations between adherence to the MD, PA, sedentary behaviour and physical fitness among children and adolescents. Three databases were systematically searched, including cross-sectional and prospective designs with a sample of healthy youth aged 3-18 years. Random effects inverse-variance model with the Hartung-Knapp-Sidik-Jonkman adjustment was used to estimate the pooled effect size (correlation coefficient (r)). Thirty-nine studies were included in the meta-analysis, yielding a total of 565421 youth (mean age, 12·4 years). Overall, the MD had a weak-to-moderate positive relationship with PA (r 0·14; 95 % CI 0·11, 0·17), cardiorespiratory fitness (r 0·22; 95 % CI 0·13, 0·31) and muscular fitness (r 0·11; 95 % CI 0·03, 0·18), and a small-to-moderate negative relationship with sedentary behaviour (r -0·15; 95 % CI -0·20, -0·10) and speed-agility (r -0·06; 95 % CI -0·12, -0·01). There was a high level of heterogeneity in all of the models (I2 ≥ 75 %). Overall, results did not remain significant after controlling for sex and age (children or adolescents) except for PA. Improving dietary habits towards those of the MD could be associated with higher physical fitness and PA in youth, lower sedentary behaviours and better health in general.

P.323 Assessing the benefit-risk ratio of approved treatments for bipolar depression using likelihood to be helped or harmed (LHH) analyses

Rapid reduction of suicidal thoughts is critical for treating suicidal patients. Clinical trials evaluating these treatments require appropriate measurement. Key methodological issues include: 1) the use of single or multi-item assessments, and 2) evaluating whether suicidal ideation measures can track rapid change over time. The current study presents data from two randomized, placebo-controlled, crossover clinical trials evaluating ketamine in individuals with treatment-resistant depression (n = 60). Participants were assessed for suicidal thoughts using the Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), Beck Depression Inventory (BDI), and Scale for Suicidal Ideation (SSI) at eight time points over three days. Assessments were compared using correlational analyses and effect sizes at 230 min and three days after ketamine infusion. Linear mixed models evaluated change in ideation across all time points. The HAM-D and MADRS suicide items demonstrated correlations of r > .80 with the first five items of the SSI (SSI5). On linear mixed models, an effect for ketamine was found for the HAM-D, MADRS, BDI items, and SSI5 (p < .001), but not for the full SSI (p = .88), which suggests a limited ability to assess change over time in patients with low levels of suicidal thoughts. Taken together, the results suggest that repeated suicidal assessments over minutes to days appear to detect improvement in suicidal thoughts after ketamine infusion compared to placebo. The MADRS suicide item, BDI suicide item, and SSI5 may be particularly sensitive to rapid changes in suicidal thoughts.

Consequences of multiple imputation of missing standard deviations and sample sizes in meta-analysis.

Meta‐analyses often encounter studies with incompletely reported variance measures (e.g., standard deviation values) or sample sizes, both needed to conduct weighted meta‐analyses. Here, we first present a systematic literature survey on the frequency and treatment of missing data in published ecological meta‐analyses showing that the majority of meta‐analyses encountered incompletely reported studies. We then simulated meta‐analysis data sets to investigate the performance of 14 options to treat or impute missing SDs and/or SSs. Performance was thereby assessed using results from fully informed weighted analyses on (hypothetically) complete data sets. We show that the omission of incompletely reported studies is not a viable solution. Unweighted and sample size‐based variance approximation can yield unbiased grand means if effect sizes are independent of their corresponding SDs and SSs. The performance of different imputation methods depends on the structure of the meta‐analysis data set, especially in the case of correlated effect sizes and standard deviations or sample sizes. In a best‐case scenario, which assumes that SDs and/or SSs are both missing at random and are unrelated to effect sizes, our simulations show that the imputation of up to 90% of missing data still yields grand means and confidence intervals that are similar to those obtained with fully informed weighted analyses. We conclude that multiple imputation of missing variance measures and sample sizes could help overcome the problem of incompletely reported primary studies, not only in the field of ecological meta‐analyses. Still, caution must be exercised in consideration of potential correlations and pattern of missingness.

여가제약과 여가참가의 관계에 대한 종합적 분석

This study was attempted to comprehensively analyze relationship between leisure constraint and leisure participation through meta-analysis. 16 individual studies on relationship between leisure constraint and leisure participation were collected and analysed with coefficient of correlation effect size. To analyze the data, CMA(Comprehensive Meta-Analysis) software program was used. The main findings are as follows: First, the overall average effect size between leisure constraint and leisure participation was. 018. Second, Average effect size between leisure constraint and sub-factor leisure participation, participation frequency was observed to be higher than the others. Third, Average effect size between leisure constraint and leisure participation in participant characteristics, working people were observed to be higher than non-working people. Finally, the limitation of this study and future research orientation were discussed.

Effect of Different Interfaces on FIO2 and CO2 Rebreathing During Noninvasive Ventilation.

Improving [Formula: see text] and reducing CO2 rebreathing ([Formula: see text]) are the key means to improve the therapeutic efficacy of noninvasive ventilation (NIV). This study aimed to investigate the impact of interface design on [Formula: see text] and [Formula: see text] during NIV. A simulated lung model was established to analyze 17 different interfaces. CO2 was injected into the outlet of the simulated lung, and the noninvasive ventilator was connected to the simulated lung to simulate the application of NIV in patients with COPD with hypercapnia. [Formula: see text] and [Formula: see text] were calculated by mathematical integration of synchronously collected data pertaining to real-time pressure, flow, oxygen concentration, and CO2 concentration in the breathing circuit. Comparisons were performed between different types (nasal vs oronasal) and models of interfaces as well as between interfaces with different leak positions. Correlation of [Formula: see text] and [Formula: see text] with inner volume and leakage, respectively, and the correlation between [Formula: see text] and [Formula: see text] were analyzed. [Formula: see text] levels were significantly different with a nasal or an oronasal mask (0.45 ± 0.05% vs 0.41 ± 0.08%, respectively; P < .001). [Formula: see text] levels associated with different models of interfaces varied significantly (all P < .001); [Formula: see text] did not differ significantly among the different interfaces (P = .19). Leak position significantly affected [Formula: see text] and [Formula: see text] (all P < .001). Both inner volume and leakage significantly correlated with [Formula: see text] (r = -0.23, P < .001; r = -0.08, P = .02). There was a significant correlation between [Formula: see text] and [Formula: see text] (r = 0.43, P < .01); the general linear equation was y = 0.17 + 0.02x (r = 0.43, R2 = 0.19). The design of the interface had a significant impact on [Formula: see text] and [Formula: see text] during NIV. [Formula: see text] and [Formula: see text] showed a significant positive correlation, although the effect size of correlation was moderate.

Good News! Communication Findings May be Underestimated: Comparing Effect Sizes with Self-Reported and Logged Smartphone Use Data

Abstract Despite long-standing concerns over self-reported measures of media use, media research has relied heavily on self-reported data. This study not only examined discrepancies between survey and logged smartphone data but assessed whether correlational outcomes using self-reported measures produce greater or smaller effect sizes compared to outcomes using logged measures. College students (n = 294) and MTurk workers (n = 291) provided self-reported and logged data of smartphone use over seven days. The correlations we examined involved four psychosocial contexts, including bridging, bonding, well-being, and problematic use of smartphones. The results showed that the effect sizes of correlations using self-reported data tend to be smaller compared to those using logged data. We believe that this is a hopeful message to the field. This could mean that extant survey results have not erroneously inflated communication findings and that communication researchers still have a lot to reveal with further refined measures.

Efficient and effective control of confounding in eQTL mapping studies through joint differential expression and Mendelian randomization analyses.

Identifying cis-acting genetic variants associated with gene expression levels-an analysis commonly referred to as expression quantitative trait loci (eQTLs) mapping-is an important first step toward understanding the genetic determinant of gene expression variation. Successful eQTL mapping requires effective control of confounding factors. A common method for confounding effects control in eQTL mapping studies is the probabilistic estimation of expression residual (PEER) analysis. PEER analysis extracts PEER factors to serve as surrogates for confounding factors, which is further included in the subsequent eQTL mapping analysis. However, it is computationally challenging to determine the optimal number of PEER factors used for eQTL mapping. In particular, the standard approach to determine the optimal number of PEER factors examines one numberat a time and chooses a number that optimizes eQTLs discovery. Unfortunately, this standard approach involves multiple repetitive eQTL mapping procedures that are computationally expensive, restricting its use in large-scale eQTL mapping studies that being collected today. Here, we present a simple and computationally scalable alternative, Effect size Correlation for COnfounding determination (ECCO), to determine the optimal number of PEER factors used for eQTL mapping studies. Instead of performing repetitive eQTL mapping, ECCO jointly applies differential expression analysis and Mendelian randomization analysis, leading to substantial computational savings. In simulations and real data applications, we show that ECCO identifies a similar number of PEER factors required for eQTL mapping analysis as the standard approach but is two orders of magnitude faster. The computational scalability of ECCO allows for optimized eQTL discovery across 48 GTEx tissues for the first time, yielding an overall 5.89% power gain on the number of eQTL harboring genes (eGenes) discovered as compared to the previous GTEx recommendation that does not attempt to determine tissue-specific optimal number of PEER factors. Our method is implemented in the ECCO software, which, along with its GTEx mapping results, is freely available at www.xzlab.org/software.html. All R scripts used in this study are also available at this site. Supplementary data are available at Bioinformatics online.

E-Cigarette Demand: Impact of Commodity Definitions and Test-Retest Reliability.

Behavioral economic demand provides a multidimensional understanding of reinforcement. Commodity purchase tasks are an efficient method for measuring demand in human participants. One challenge in translating these procedures to electronic nicotine delivery systems (ENDS or e-cigarettes) is defining commodity units given the lack of standardization in the e-cigarette marketplace. The purpose of this study was to directly compare methods of operationalizinge-cigarette purchases, puffs, cartridges, and mLs liquid, using a within-subject design. Participants (N = 132) reporting past week e-cigarette use were recruited using crowdsourcing. Purchase tasks were completed operationalizing e-cigarette units as puffs or cartridges at baseline and puffs or mLs liquid at a 3-month follow-up. Bivariate associations supported convergent and discriminant validity with the largest effect size correlations for intensity and elasticity observed for the puff version. Interaction models suggested that product preferences moderated the relationship between time-to-first use and cartridge demand with larger effect size correlations among persons reporting a preference for JUULs, but weaker relationships among persons reporting other device preferences. Puff intensity (rxx = .61) and elasticity (rxx = .62) showed good test-retest reliability for participants reporting stable consumption, but poor test-retest reliability for individuals with changed consumption levels (intensity rxx = -.08; elasticity rxx = -.10). This study highlights the relevance of commodity definitions in the e-cigarette purchase task. Puffs as an experimental commodity may provide flexibility for studying e-cigarette demand in heterogenous or unknown populations, whereas more tailored or personalized approaches like cartridge or mL-based tasks will likely be helpful when studying known subgroups. The commodity purchase task procedure is widely used for understanding cigarette and e-cigarette demand in nicotine dependence research. This study evaluates the importance of operational definitions of e-cigarette commodities in the purchase task (ie, puffs, cartridges, or mLs liquid). Puffs may provide a more flexible commodity unit when evaluating e-cigarette demand in general or heterogenous populations, whereas device-specific units may prove more valuable when studying populations with consistent and known product use.

Test-retest Reliability Of Cognitive And Neuroimaging Measures In Older Adults

PURPOSE: Exercise is a promising strategy to help maintain brain function during aging. Determining the efficacy of exercise interventions requires reliable clinical outcome measures. In addition to measurement error and biological variability, long-term test-retest values can also be influenced by biasing factors - namely aging and practice effects. The purpose of this study was to determine the 12-week test-retest reliability of cognitive and neuroimaging measures in older adults. METHODS: Twenty healthy older adults (14 females, 60-80 years of age) participated in two sessions of cognitive testing and multimodal 3T MRI scanning (Siemens MAGNETOM Prisma). All tests were performed by a single rater separated by a 12-week control period. The NIH Toolbox Cognition Battery (NIHTB-CB) was used to assess fluid and crystallized cognitive function. T-2 FLAIR images were processed for white matter lesion volume (WMLV, ml) using the Lesion Segmentation Toolbox. T-1 MPRAGE images were processed for gray matter volume (GMV, mm3) in 3 subcortical regions using FreeSurfer cortical segmentation. Statistical analyses were performed in SPSS (v.25) including mean percent difference, effect size, paired t-test, and two-way mixed intraclass correlation coefficient (ICC) with absolute agreement. RESULTS: Results are presented in Table 1. There were no significant t-test values indicating good agreement between the two sessions. As expected, reliability was excellent in crystallized cognition and moderate to good in fluid cognition. Last, all brain segmentations showed good to excellent reliability. CONCLUSIONS: The long-term (12-weeks) test-retest reliability of standard cognitive and neuroimaging measures were within an acceptable tolerance for use in future intervention studies. Although fluid cognition has the greatest implications for and neurobiological link to cognitive aging, investigators should consider the greater variability in these measures.

Loneliness, Depressive Mood and Cyberbullying Victimization in Adolescent Victims of Cyber Dating Violence.

Currently, cyber dating violence (CDV) is a serious health problem among adolescents due to their frequent use of communication technologies in their romantic relationships including the use of these technologies to perpetrate dating violence. However, research on this topic is recent and more studies about victims’ psychosocial adjustment are needed. The objectives of this study were to analyze the prevalence of CDV victimization according to frequency (occasional and frequent) and type (cyber control and cyber-aggression) and to explore their relations with loneliness, depressive mood and cyberbullying victimization. A total of 604 adolescents (M age = 14.32, SD = 1.67) who had a dating relationship at the time or in the past 12 months, participated in this study. The results showed a higher prevalence for cyber-control than cyber-aggression victimization, and positive correlations of CDV victimization with depressive mood and cyberbullying victimization in boys and girls. Positive correlations with loneliness were also observed for girls. The average effect size of the aforementioned correlations was large for girls and medium for boys. Both boys and girls who were frequent victims of CDV also suffered more cyberbullying by peers than those who were never, and occasionally, cyber victimized by their partners. Girls who were frequent victims of CDV also reported higher scores for loneliness and depressive mood, with a small average effect size. All these results highlight close relations between cyberbullying and CDV in adolescents, being necessary to pay greater attention to possible experiences of poly-victimization, and a worse psychosocial adjustment in frequently victimized girls than boys. These findings may be useful for developing more effective intervention programs.

The Role of Family Time Together in Meeting the Recommendation for Physical Activity among Primary School Children.

Family time may have an influence on children’s physical activity (PA) participation or may contribute to increased sedentary behaviour. The aim of this paper was to examine whether spending family time is associated with the PA of children aged 10–11. Cross-sectional data on 158 primary school children (80 girls and 78 boys) with a mean age of 10.6 ± 0.49 years were collected. Weight and height were used to calculate body mass index. The level of moderate-to-vigorous physical activity (MVPA) was determined with a physical activity screening measure. Participants wore a Vivofit® wrist band activity tracker to measure their daily number of steps. The Health Behaviour in School-Aged Children questionnaire was used to obtain information from children about the frequency of activities undertaken by the family. Analyses entailed descriptive statistics of the total sample and by gender, t-test, and the Mann–Whitney U-test to examine the gender differences and Spearman’s correlation coefficients. It was found that 32.3% of the children did not accomplish at least 60 min per day on ≥5 of the seven days and more than 75.9% of them did not accumulate at least 12,000 or more steps daily. More boys than girls tended to be sufficiently active and met the guideline of at least 60 min per day on ≥5 of the seven days (70.5% and 65.0%, respectively) or 12,000 steps per day (25.8% and 10.0%, respectively). The number of steps during the weekday was significantly and inversely associated both in girls and in boys with active family time (r = −0.27 and r = −0.25, respectively), and with total family time (r = −0.28) and non-active family time (r = −0.25) only in boys. Average MVPA was also inversely correlated with active family time (r = −0.31), non-active family time (r = −0.24), and total family time (r = −0.29) in boys. The correlation effect size values ranged between small to medium significant differences for these measures. The findings underscore the need for community-based PA programmes designed for whole families to meet the recommended PA of children and also to develop and promote active leisure activities among families.

Construct Validity of an Instrument for Assessment of Reflective Writing-Based Portfolios of Medical Students.

PurposeAssessment of reflective writing for medical students is challenging, and there is lack of an available instrument with good psychometric properties. The authors developed a new instrument for assessment of reflective writing-based portfolios and examined the construct validity of this instrument.MethodsAfter an extensive literature review and pilot testing of the instrument, two raters assessed the reflective writing-based portfolios from years 2 and 3 medical students (n=135) on three occasions. The instrument consists of three criteria: organization, description of an experience and reflection on the experience. We calculated the reliability of scores using generalizability theory with a fully crossed design and two facets (raters and occasions). In addition, we measured criterion validity by testing correlations with students’ scores using other assessment methods.ResultsThe dependability (Φ) coefficient of the portfolio scores was 0.75 using two raters on three occasions. Students’ portfolio scores represented 46.6% of the total variance across all score comparisons. The variance due to occasions was negligible, while the student–occasion interaction was small. The variance due to student–rater interaction represented 17.7%, and the remaining 27.7% of the variance was due to unexplained sources of error. The decision (D) study suggested that an acceptable dependability (Φ = 0.70 and 0.72) can be achieved by using two raters for one and two occasions, respectively. Finally, we found moderate to large effect-size correlations between students’ scores in reflective writing-based portfolios and communication skills (r = 0.47) and PBL tutorials (r = 0.50).ConclusionWe demonstrated the presence of different sources of evidence that support construct validity of the study instrument. Further studies are warranted before utilizing this instrument for summative assessment of students’ reflective writing-based portfolios in other medical schools.

Adaptation and psychometric evaluation of the simplified Chinese version of the identification of functional ankle instability questionnaire in Chinese-speaking patients with chronic ankle instability disorders

BackgroundThe aims of this study were to adapt the Identification of Functional Ankle Instability (IdFAI) questionnaire into a simplified Chinese version and to assess its reliability, validity, and responsiveness in Chinese-speaking patients with chronic ankle instability (CAI) disorders.MethodsThe simplified Chinese version of the IdFAI (SC-IdFAI) questionnaire was developed with a five-step procedure involving cross-cultural translation and adaptation. Three questionnaires, including the SC-IdFAI, Medical Outcomes Study Short-Form 36 (SF-36), and Foot and Ankle Ability Measure (FAAM), were administered to the recruited patients. Then, the Cronbach’s alpha value, intraclass correlation coefficient (ICC), standard error of measurement (SEM), minimal detectable change (MDC), Spearman’s correlation coefficient (rs), effect size (ES), and standardized response mean (SRM) were calculated to evaluate the reliability, validity, and responsiveness of the SC-IdFAI questionnaire.ResultsA total of 131, 119, and 86 patients with CAI successfully completed the first, second, and third rounds of the questionnaires, respectively. Good or excellent internal consistency and test–retest reliability were found for the overall scale and subscales of the SC-IdFAI questionnaire. The values for the SEM (1.346) and MDC (3.73) were low, indicating that small clinical changes can be detected by the SC-IdFAI questionnaire. The correlations of the SC-IdFAI with FAAM and SF-36 were generally in agreement with the a priori hypotheses (85%, 34/40), suggesting the SC-IdFAI questionnaire has good construct validity. Moreover, the results suggest that the SC-IdFAI (ES = 1.123 and SRM = 1.554) has an acceptable level of responsiveness.ConclusionThe SC-IdFAI scale may be an effective tool, and it is responsive, reliable and valid for the assessment of Chinese patients suffering from CAI.

M156. CORTICAL NEUROANATOMICAL SIGNATURE OF SCHIZOTYPY IN 2,695 INDIVIDUALS ASSESSED IN A WORLDWIDE ENIGMA STUDY

BackgroundCortical neuroanatomical abnormalities have been reported along a continuum between individuals with chronic schizophrenia, first-episode psychosis, clinical high risk for psychosis, and healthy individuals self-reporting subclinical psychotic-like experiences (or schizotypy). Recently, the Schizophrenia Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium provided meta-analytic evidence for robust cortical thickness abnormalities in schizophrenia, while also indicating that these abnormalities are influenced by illness severity and treatment with antipsychotic medications. In this context, schizotypy research allows the investigation of cortical neuroanatomy associated with the expression of subclinical psychotic-like symptoms without the potential influence of a psychotic illness, its severity, or the use of antipsychotics. This study presents the first large-scale imaging meta-analysis of cortical thickness in schizotypy using standardized methods from 23 datasets worldwide.MethodsCortical thickness and surface area were assessed in MRI scans of 2,695 healthy individuals (mean [range] age of 29.1 [17–55.8], 46.3% male) who had also completed validated self-report schizotypy questionnaires. Each site processed their local T1-weighted MRI scans using FreeSurfer and, following the protocol outlined in the ENIGMA Schizophrenia Working Group study, extracted cortical thickness for 70 Desikan-Killiany (DK) atlas regions (34 regions per hemisphere + left and right hemisphere mean thickness). At each site, partial correlation analyses were performed between regional cortical thickness by ROI and total schizotypy scores in R, predicting the left, right and mean cortical thickness, adjusting for sex, age and site. Random-effects meta-analyses of partial correlation effect sizes for each of the DK atlas regions were performed using R’s metafor package. False discovery rate (pFDR < .05) was used to control for multiple comparisons.ResultsWe found significant positive associations between subclinical psychotic-like experiences and mean cortical thickness of the medial orbitofrontal cortex (r = .077; pFDR = .006) and the frontal pole (r = .073; pFDR = .006). When assessed separately by hemisphere, meta-analysis revealed a significant positive association between subclinical psychotic-like experiences and cortical thickness of the left medial orbitofrontal cortex (r = .066; pFDR = .044), and at trend-level with the right medial orbitofrontal cortex (r = .062; pFDR = .053) and the left frontal pole (r = .062; pFDR = .053). No significant associations were observed for surface area.DiscussionWorldwide cooperative analyses of large-scale brain imaging data support a profile of cortical thickness abnormalities involving prefrontal cortical regions positively related to schizotypy in healthy individuals. These findings are not secondary to potential influences of disease chronicity or antipsychotic medication on the neuroanatomical correlates of psychotic-like experiences. The directionality of the observed meta-analytical effects in schizotypy is opposite to those previously reported in patients with schizophrenia (i.e., thinner cortex). The present findings of increased thickness may indicate early microstructural deficits (e.g. in myelination) that contribute to vulnerability for psychosis. Alternatively, these may reflect mechanisms of resilience associated with the expression of subclinical manifestations of psychotic symptoms in otherwise healthy individuals.