Correlation Of Mean Platelet Volume Research Articles

Correlation of Mean Platelet Volume with D-dimer in Patients with COVID-2019

SARS-CoV-2 binds to ACE2 receptors and causes endothelial injury. Endothelial injury causes the release of tissue factors and triggers the activation of the coagulation cascade, which is characterized by an increase in D-dimer levels. The increase in D-dimer levels reflects the activation of coagulation and fibrinolysis. Endothelial injury leads to platelet adhesion and aggregation. Mean platelet volume is a low-cost, routinely performed parameter available in hematology analyzers at various health facilities. This study aimed to determine the correlation between MPV and D-dimer in COVID-19 patients. This study was an analytical study with a cross-sectional design conducted on 88 subjects aged 18-50 years from COVID-19 patients who were admitted at Dr. M. Djamil Central Hospital in May-September 2021. Mean platelet volume levels were measured using the impedance method and D-dimer levels using the ELISA method. Data were analyzed using the Pearson correlation test, significant if p<0.05. The mean age was 33.47 years, range of 18-50 years. Most of the subjects were female, 53 people (62.4%). The mean MPV level was 10.36 (0.87) fL. The mean D-dimer levels were 728.51 (500.99) ng/mL. Correlation analysis showed that mean platelet volume had a weak positive correlation with D-dimer (r=0.269, p=0.013). This study showed an increase in MPV and D-dimer levels in COVID-19 patients. There is a weak correlation between MPV and D-dimer in COVID-19 patients.

The Correlation of Platelet Indices; Platelet Count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet-Large Cell Ratio (P-LCR) with Mortality in Patients Admitted to PICU

Objective: To determine the correlation of platelet indices; platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR) with mortality in patients admitted to PICU.
 Study Design: Comparative cross-sectional study.
 Place and Duration of Study: Pediatric Intensive Care Unit (PICU) of CMH Lahore from Jun 2019 to May 2020.
 Methodology: Cases (mortality group) were the 81 consecutive patients who died in the PICU during the study period and fulfilled inclusion criteria. The control group comprised 81 surviving patients admitted to PICU contemporarily. Both groups' mean values of platelet indices (PC, MPV, PDW and P-LCR) were compared.
 Results: The mortality rate was 10.42%. Infants were the largest sub-group (45.68%) in the mortality group. Mean platelet counts were significantly low, while mean MPV, PDW and P-LCR were significantly higher in children in the mortality group compared to the control group (p-value <0.001). The correlation coefficient 'r' was -0.682,0.598,0.671 and 0.355 for platelet count, PDW, MPV and P-LCR, respectively, showing a negative correlation between platelet count and positive correlation of mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR) with mortality.
 Conclusion: Deranged platelet indices, as manifested by lower platelet count and higher values of MPV, PDW and p-LCR, were significantly correlated with higher mortality in children admitted to PICU and can be used to predict/anticipate the severity of illness.

The Correlation of Mean Platelet Volume and Neutrophil-lymphocyte Ratio Measurements, and the Ishak Fibrosis Score in Our Patients with Chronic Hepatitis B

Background:The ishak score determined by liver biopsy is the most reliable indicator of fibrosis, but biopsy is an invasive procedure. Numerous noninvasive tests have been investigated to determine the hepatic fibrosis score. We aimed to investigate the relationship between the mean platelet volume(MPV) and neutrophillymphocyte ratio (NLR) measurements in patients with chronic hepatitis B virus (CHB) infection, and liver fibrosis stage, which was determined by biopsy and ishak score. Material and Method:CHB patients followed between 2016 and 2020 in our gastroenterology outpatient clinic were included in our study. CHB patients; They were divided into two groups as non-cirrhotic group (ishak fibrosis score in biopsy; F0-F4) and cirrhotic group (F5-F6). Then, 30 healthy control (HC) groups consisting of health personnel who had routine health screenings and blood tests in the same period were formed. MPV, NLR measurements of these two main groups and CHB subgroups and liver biopsy results of CHB patients were evaluated retrospectively, and possible relationships between the groups were investigated. Results:There was no statistically significant difference between the mean age and gender of the cases in the CHB and HC groups. A total of 54 patients with CHB were identified, of which 13 patients were cirrhotic and 41 patients were non-cirrhotic. MPV measurements were found to be significantly higher in the CHB group than in the SC group (11.15±1.77; 10.02±0.92; p=0.002). While there was no significant difference between NLR measurements, it was found to be higher in the CHB group (1.98±0.81; 1.81±0.69). While there was no significant difference between the cirrhotic and non-cirrhotic subgroups of the CHB group in terms of NLR (1.86±0.68; 2.36±1.04) and MPV (11.09±1.89; 11.35±1.36) measurements, NLR and MPV measurements were higher in the cirrhotic group. Conclusion:In our study, MPV values were found to be significantly increased in patients in the CHB group compared to the HC group. In addition, although not statistically significant, NLR and MPV measurements were found to be higher in the cirrhotic group than in the non-cirrhotic group. According to our study, it can be thought that with increasing MPV and NLR measurements in HBV patients, there may be an increase in chronicity and fibrosis scores without an invasive procedure such as biopsy.

Severe Kidney Injury Requiring Continuous Renal Replacement Therapy: Correlation of Mean Platelet Volume with Mortality at Multiple Time Intervals

Severe Kidney Injury Requiring Continuous Renal Replacement Therapy: Correlation of Mean Platelet Volume with Mortality at Multiple Time Intervals

A Comparison of Mean Platelet Volume between Viral Hepatitis and Non-Viral Hepatitis in Liver Cirrhosis

Background: A high level of mean platelet volume (MPV) is associated with platelet activation, which occurs in chronic inflammatory disease. Several studies have demonstrated that a high MPV is associated with chronic viral hepatitis and hepatic fibrosis. However, the role of MPV in patients with cirrhosis is unclear. Objectives: To evaluate the MPV in patients with cirrhosis, and to compare the MPV between viral hepatitis and non-viral hepatitis groups. Moreover, the correlation of MPV and factors was also explored. Materials and Methods: The medical records of 420 cirrhosis outpatients from 2010 to 2017 at Her Royal Highness (HRH) Princess Maha Chakri Sirindhorn Medical center were reviewed and analyzed as a retrospective study. The MPV was expressed as mean±SD. The correlation between MPV values and cirrhosis parameters including mortality outcomes were evaluated. Results: According to retrospective data, the mean age was 56.23 (SD 12.77). Two-hundred and ninety-two patients were males (69.5%), and one-hundred and twenty-eight patients were females (30.5%). Child-Pugh scores A, B, and C were found in 286 (68.1%), 132 (31.4%), and 2 (0.5%) cases, respectively. There was a significant difference of MPV between the group of viral hepatitis and non-viral hepatitis cirrhosis (10.79±1.05 vs. 10.54±1.00; 95% CI, 0.06 to 0.45), respectively. The median time of follow-up in this study was 40.06 months (range, 0.07 to 121.41). The mortality rate was 18.3%. Elevated MPV was found inversely correlated with albumin and platelet counts, and positive correlation with levels of prothrombin time, and INR in all causes of cirrhosis especially chronic viral hepatitis. However, there was no correlation of MPV and long-term mortality outcomes in all causes of cirrhosis (r=-0.066, 95% CI -0.165 to 0.035) and viral hepatitis causes (r=-0.035, 95% CI -0.158 to 0.095). Conclusion: The difference of MPV between viral hepatitis and non-viral hepatitis groups causing liver cirrhosis was identified in our study. The MPV was not correlated with long-term mortality outcomes in cirrhotic patients. Keywords: Platelet volume; Liver cirrhosis; Viral hepatitis; Mortality

Correlation of mean platelet volume (MPV) with blood pressure in smokers and non-smokers: A hospital based study

Introduction and Aim: Smoking and its intensity effect platelet functions and a correlation exists between smoking, inflammation, platelet, and cardiovascular diseases including hypertension. Effects of smoking on platelets were studied in smokers and correlation with blood pressure was analysed. Materials and Methods: 122 male (smokers and non-smoker with 61 subjects each) were studied. Platelet counts, Mean Platelet Volume were analysed using an automated analyser. Systolic and diastolic blood pressure were measured and correlation with MPV was done. Data were analysed using R software and p<0.05 was taken as significant. Results: There was no difference in mean age. Platelet count was non-significantly higher in non-smokers than smokers. MPV and systolic and diastolic blood pressure were significantly (P<0.001) raised in smokers as compared to non-smokers. There was a non-significant (p=0.497) reduction in the platelet counts and a significant increase (p<0.001) in MPV with an increase in smoking intensity. With an increase in the severity of smoking from mild to severe on the basis of pack years a significant increase in systolic (p<0.001) and diastolic (p=0.001), blood pressure were observed. Significant positive correlation of MPV with systolic(r=0.421, p<0.001)) and diastolic blood pressure(r=0.379, p<0.001) was present in all study subjects and significant correlation of MPV with systolic(r=0.506, p<0.001) and diastolic blood pressure(r=0.327, p=0.01) was observed in smokers. Conclusion: Smoking and its intensity effects platelet count and MPV. There appears a correlation between MPV and blood pressure. Keywords: Smoking; hypertension; smoking intensity; platelets; mean platelet volume

A study of the correlation between mean platelet volume and diabetic retinopathy in patients with type 2 diabetes mellitus

Diabetic retinopathy (DR), a kind of micro vascular lesion that is detected on fundus examination, accounts for 40 percent of diabetics over 40 years of age. To determine the correlation of mean platelet volume with diabetic retinopathy. Methodology: Hospital based Case- Control study. 50 patients diagnosed as Type-2 diabetes mellitus with defined diabetic retinopathy. And 50 patients with age and sex matched without the case disease. To all the patients mean platelet volume was done and comparing the significant difference of mean platelet volume between diabetics with retinopathy (cases) and control groups. Results: The mean platelet volume of the diabetic retinopathy and controls were 11.77 + 1.40 and 7.55 + 0.35. Regarding fasting glucose level for diabetic retinopathy and controls were 196.04 + 13.2 and 103.57+12.16 which is significantly higher than the controls (p value + 1.01 which is significantly higher than the control groups 5.48+0.94. (p value Conclusion: Mean platelet volume was reported to be raised in diabetic retinopathy patients compared to the healthy population. Keywords: Diabetic Retinopathy, Mean Platelet Volume, HbA1c, Diabetes Mellitus

Correlation between Pretreatment Hematologic Parameters and Cervical Cancer Patients Undergoing Hysterectomy: a Retrospective Study

The objective of this study is to investigate the correlation of mean platelet volume (MPV), MPV/ platelet count, and monocyte to lymphocyte ratio (MLR) between cervical cancer patients and healthy people and to evaluate the value of those parameters in early diagnosis of cervical cancer. The study population included 137 cervical cancer patients undergoing hysterectomy and 113 healthy controls. The clinical features (age, pathology type, tumor staging, and tumor size) were collected from the hospital information system. The hematology parameters (white blood cell, red blood cell, hemoglobin, platelet count, neutrophil, lymphocyte, monocyte, mean platelet volume, platelet distribution width) are obtained in the laboratory information system. We found that the monocyte count and MLR value are higher in the cervical cancer group. The MPV and MPV/platelet are lower in the cervical cancer group. The receiver operating characteristic (ROC) analysis shows that MPV+MLR can generate a moderate specificity with 71.68%, sensitivity with 65.69%, and AUC with 0.718 to distinguish cervical cancer and healthy people. MPV/platelet and MLR may be helpful for the early diagnosis of cervical cancer. A larger clinical data analysis is necessary to evaluate the diagnostic value of hematologic parameters in cervical cancer.

Use of mean platelet volume as a tool to assess the progression of type 2 diabetes mellitus

Background: Diabetes mellitus (DM) is characterized by chronic hyperglycemia resulting in micro- and macro-vascular complications and is correlated with glycemic control and its duration. The undergoing pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Mean platelet volume (MPV) is a simple economical test in the monitoring of DM. Aims and Objectives: This study aims to determine the activation of platelets in diabetes by measuring the MPV in non-diabetic and diabetic subjects, respectively and to find out the correlation of MPV with blood glucose level. Materials and Methods: It was a cross-sectional study conducted on 70 previously diagnosed diabetic and 130 non-diabetic patients using convenient sampling in SCB Medical College, Odisha. Blood parameters such as body mass index (BMI), fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), and MPV were recorded from complete blood count and compared using independent sample t-test and Pearson correlation test. Results: Mean age of the diabetic population was 53.7 ± 10.63 years. Positive correlation was found between MPV and BMI, FBS, PPBS, and HbA1c. The mean MPV in Group A was significantly lower than that of Group B. Conclusion: MPV in Type 2 DM was significantly elevated and positively correlated to blood glucose level. Thus, strict glycemic control measures should be advised to patients with DM for halting the progression of complications in them.

Immunogenic Heterogeneity of Renal Cell Carcinoma With Venous Tumor Thrombus

ObjectiveTo perform immune-cell enumeration and programmed death-ligand 1 (PD-L1) expression in clear cell renal cell carcinoma (cc-RCC) with tumor thrombus (TT) to guide therapeutic decisions. MethodsAfter obtaining IRB approval and surgical consent, 6 patients underwent radical nephrectomy with venous tumor thrombectomy. We utilized RNA Sequencing to obtain RNAseq expression profiles. Computational calculation and enumeration of immune cells were performed using CIBERSORT, xCell, and ingenuity pathway analysis software. Statistical assessment was conducted using a t test, chi-square, ANOVA and Spearman rank correlations using SPSS v21. ResultsWe observed a higher proportion of M1 macrophages in the primary tumor and tumor thrombus, while we noted no difference in M2 macrophages despite M2 representing a high number in thrombus samples. (ANOVA, P = .032, and P = .89, respectively). Validation with xCell and ingenuity pathway analysis analysis showed a high involvement of macrophages. We observed a higher number of M1 macrophages (CIBERSORT mean 0.11 vs 0.03, P < 0.01) and (nonactivated) resting Natural Killer (NK) cells (0.077 vs 0.017, P = .02) associated PD-L1 high expression of the primary tumor. PDL1 expression was variable without differences in tumor stage, level, or immune cell detection. We observed an inverse correlation of mean platelet volume with PD-L1 expression within the primary tumor (Spearman, −0.89, P = 02) and the TT (Spearman, −0.77, P = 0.07). ConclusionRenal tumor thrombus has higher levels of M1 macrophages that could be utilized as additional targets for future drug development. The PD-L1 expression on clear cell RCC biopsy may not represent its corresponding TT. Future studies are needed to confirm mean platelet volume as a potential blood-based biomarker for PD-L1 expression in RCC.

Is the preoperative MPV value related to early thrombus formation in microvascular anastomosis?

Objective: One of the most common encountered problems in free flap surgeries is anastomotic thrombosis. The mean platelet volume (MPV) may indicate the concentration of intra-platelet proactive substances and the thrombogenic potential of the platelets. MPV is used as a clinical monitoring index in routine blood counts, it has not yet been effectively used in free flap surgery.Methods: This study evaluates the relationship between the preoperative MPV value and anastomotic thrombus formation during the postoperative 48 hours in 32 free flap operations from September 2013 to September 2014. The mean patient age was 36.75 years. The preoperative MPV value, which was obtained from the complete blood count, was recorded and correlation of MPV and postoperative thrombus formation was investigated.Results: Four anastomotic thrombus were encountered in 34 free flaps during the postoperative 48 hours. Two of them were salvaged by performing thrombectomy and/or administration of i.v. heparin. There was no statistical relationship between MPV value and postoperative thrombus formation during 48 hours follow-up (p = 0.925).Conclusion: Even though this study didn’t find a correlation between preoperative MPV value and postoperative early anastomotic thrombus, it would be helpful to validate the results using multi-centre and comprehensive studies with larger patient cohorts.

The relationship of mean platelet volume with microalbuminuriain type 2 diabetic patients.

Activation and size of platelets have been suggested to be involved in the pathogenesis of vascular complications in diabetes mellitus. The purpose of the present study was to investigate the association of mean platelet volume with microalbuminuria in type 2 diabetic patients. Mean platelet volume levels were investigated in healthy participants and type 2 diabetic patients with and without microalbuminuria. After their mean platelet volume values were compared, correlation of mean platelet volume with sex, duration of diabetes, microalbuminuria, fasting blood glucose, hemoglobin A1c, creatinine clearance, and body mass index was examined. Mean platelet volume levels were higher in all diabetic patients than those in controls. Mean platelet volume levels were highest in diabetics with microalbuminuria. The mean platelet volume levels had a positive correlation with microalbuminuria. Mean platelet volume values of diabetic patients were higher than those of nondiabetics, the highest levels being in diabetics with microalbuminuria. Our results suggest that microalbuminuria might be related with mean platelet volume in diabetic patients.

Correlation of mean platelet volume with angiographic severity of coronary artery disease, both stable angina and acute coronary syndrome: A comparative clinical study

Correlation of mean platelet volume with angiographic severity of coronary artery disease, both stable angina and acute coronary syndrome: A comparative clinical study

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

Both of the carotid artery intima-media thickness (IMT) and mean platelet volume (MPV) may add to the risk of atherosclerosis for predicting cardiovascular events. It is not known, however, whether there is an association between them in diabetes patients. The aim of the study was to detect the relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus, and to determine the correlation of MPV with body mass index (BMI), duration of diabetes, glycosylated hemoglobin A1 (HbA1C), fasting blood glucose (FBG), C-reactive protein (CRP), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), serum uric acid (UA), ankle-brachial index (ABI), history of hypertension, and smoking in diabetic patients, respectively. A total of 128 subjects were enrolled into this study, who admitted consecutively to our clinic from January 1, 2013 to January 30, 2014. They were divided into three groups according to their IMT: normal IMT group (A, IMT ≦1.1 mm, n = 26), IMT thickness group (B, IMT >1.1 mm, n = 45), IMT thickening with plaque group (C, n = 57). A significant difference with respect to BMI, HBA1c, TG, HDL-C, CRP, UA, FBG, ABI, and cigarette use between the study groups was not found (P > 0.05). MPV was significantly higher in group A as compared to both group B and group C (7.94 ± 0.97 fl, 7.24 ± 0.71 fl, 7.03 ± 0.79 fl, respectively, P〈0.001), MPV had a high positive correlation with IMT (P〈0.001) and age, as with TC and LDL-C (P〈0.05). The level of MPV content decreased as the diabetic macroangiopathy progressed. Level of MPV was correlated with IMT in diabetic patients. MPV might be a useful marker for detecting atherosclerosis risk in diabetic patients.

Retinopati veya Nöropatisi Olan Tip 2 Diyabetli Hastalarda Ortalama Trombosit Hacmi ve İnflamasyon Belirteçleri Arasında İlişki Var mıdır?

Objective: Patients with diabetes mellitus have an increased risk of developing complications such as retinopathy and neuropathy. Size of platelets and inflammation have been suggested to be involved in the pathogenesis of diabetic complications. The purpose of this study was to find out if there was a correlation of mean platelet volume with inflammatory markers in patients with diabetes and retinopathy or neuropathy. Material and Methods: The study has been carried out on 50 patients with type 2 diabetes without retinopathy or neuropathy, 52 with retinopathy, and 50 with neuropathy, and 50 healthy participants. After comparing all the parameters we seeked correlation of mean platelet volume with inflammation markers in all groups. Results: In diabetic group with retinopathy or neuropathy mean platelet volume levels were higher than patients with diabetes without those complications and the controls. We did not find any correlation between mean platelet volume and leucocyte count, sedimentation rate and high sensitivity C- reactive protein in all the groups. Conclusion: The mean platelet volume values of patients with diabetes were higher than individuals without diabetes, highest levels being in patients with diabetes with retinopathy and neuropathy. We do not think that there is a link between mean platelet volume and inflammation in patients with diabetes with or without retinopathy or neuropathy at least in our patients.

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Related to Inflammation Markers and Anti-CCP in Rheumatoid Arthritis

Background: Various thrombocyte markers and white blood cell levels and their subtypes have recently been investigated in association with inflammation. The purpose of this study was to determine the correlation of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with disease activation and clinical para­meters in rheumatoid arthritis (RA) patients. Methods: 84 RA patients and 60 healthy controls were included. Platelet, MPV, white cell, neutrophil and lymphocyte levels in full blood counts were investigated, and NLR was calculated. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), disease activation score (DAS 28) and a health assessment questionnaire (HAQ) were used in the evaluation of RA. Results: In the present study a total of 144 patients was enrolled, 84 with RA and 60 healthy individuals. 75.2% (n=108) were women and 24.8% (n=36) were men. The patients with RA had lower MPV than control individuals (MPV; 8.52±1.15 fL and 8.92±0.87 fL, respectively) and CRP (r:−0.234, p=0.005). RA patients’ mean NLR was significantly higher than that of the control group (2.74±1.74 and 1.80±0.78, respectively; p Conclusion: In conclusion, MPV and NLR together with acute phase reactants can be a useful index for showing inflammation in RA patients.

Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness

This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population of obese adolescents. Sixty-eight patients and 23 controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, hemoglobin, white blood cell count, platelet count, MPV and insulin resistance by homeostasis model of assessment of insulin resistance were investigated. Furthermore, CCA thickness was measured by high-resolution ultrasound. MPV and the left CCA thickness were significantly higher in obese adolescents than the healthy controls. The association between MPV and left CCA was checked by linear regression analysis. MPV explained 19% of the variation in left CCA (P < 0.001). At multiple regression analysis, MPV maintained a positive association with the left CCA thickness (P = 0.002) independently of fatty liver grade, relative weight, total cholesterol and homeostasis model of assessment of insulin resistance. MPV is significantly correlated with CCA thickness in obese adolescents.

Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B

Many noninvasive tests have been studied for the diagnosis and determining the liver fibrosis score (LFS). In this study, we aimed to research the correlation of mean platelet volume (MPV) and stage of liver fibrosis in patients with chronic hepatitis B (CHB). Fifty-nine patients with CHB were enrolled retrospectively into the study. Age-sex matched 25 healthy subjects were used as control group. The following data were obtained from computerized patient registry database: HBV-DNA level, hepatitis B e-antigen seropositivity, liver enzymes and function tests, white blood cell count, platelet count, hemoglobin, histological activity index, LFS, and MPV. Patients were divided into two groups: patients without significant fibrosis (F0, F1, or F2) (Group 1) and patients with advanced fibrosis (F3, F4) (Group 2). A statistically significant increase in MPV was seen in patients with CHB compared with healthy controls (8.49±0.84 fl vs.7.65±0.42 fl, P<0.001). Receiver operating characteristic curve analysis suggested that the optimum MPV level cut-off points for CHB was 8.0 fl, with sensitivity, specificity, PPV, and NPV of 68, 76, 86, and 50%, respectively. MPV levels were significantly higher in Group 2 (8.91±0.94 fl, P: 0.009) compared with Group 1 (8.32±0.74 fl). ROC curve analysis suggested that the optimum MPV level cut-off points for Group 2 was 8.45 fl, with sensitivity, specificity, positive and negative predictive value of 77, 59, 45, and 85%, respectively. Multivariable logistic regression model, which consisted of HAI, ALT, HBV-DNA, platelet count, and MPV, was performed. We showed that MPV was independently associated with advanced fibrosis (P: 0.031). We suggest that MPV might help in the assessment of fibrosis in CHB. It should not be considered a stand-alone test for this use owing to nonspecificity with other diseases.