Retinopati veya Nöropatisi Olan Tip 2 Diyabetli Hastalarda Ortalama Trombosit Hacmi ve İnflamasyon Belirteçleri Arasında İlişki Var mıdır?

Abstract

Objective: Patients with diabetes mellitus have an increased risk of developing complications such as retinopathy and neuropathy. Size of platelets and inflammation have been suggested to be involved in the pathogenesis of diabetic complications. The purpose of this study was to find out if there was a correlation of mean platelet volume with inflammatory markers in patients with diabetes and retinopathy or neuropathy. Material and Methods: The study has been carried out on 50 patients with type 2 diabetes without retinopathy or neuropathy, 52 with retinopathy, and 50 with neuropathy, and 50 healthy participants. After comparing all the parameters we seeked correlation of mean platelet volume with inflammation markers in all groups. Results: In diabetic group with retinopathy or neuropathy mean platelet volume levels were higher than patients with diabetes without those complications and the controls. We did not find any correlation between mean platelet volume and leucocyte count, sedimentation rate and high sensitivity C- reactive protein in all the groups. Conclusion: The mean platelet volume values of patients with diabetes were higher than individuals without diabetes, highest levels being in patients with diabetes with retinopathy and neuropathy. We do not think that there is a link between mean platelet volume and inflammation in patients with diabetes with or without retinopathy or neuropathy at least in our patients.