We all tell little white lies, but have you ever thought about what is really involved in lying? At the very least, you need to maintain a representation of the truth, while you consciously generate the lie. For longer-term Machiavellian plots, the lie might also need to be maintained, updated and cultivated, certainly requiring large amounts of cognitive effort. Lee and colleagues were interested in finding out the neural correlates of lying and devised two fMRI studies to probe brain activity related to intentionally falsifying a response [1xLie detection by functional magnetic resonance imaging. Lee, T. et al. Hum. Brain Mapp. 2002; 15: 157–164Crossref | PubMed | Scopus (166)See all References[1]. The first made use of a digit memory task in which subjects had to respond by pressing a button if a 3-digit number presented on the screen had been seen in the previous trial. The second study asked an autobiographical question (for example ‘Where were you born?’) followed by a location (e.g. London). In both studies subjects pressed a button for a ‘Yes’ response. Four conditions were used: correct recall, incorrect recall (getting them all wrong deliberately), random recall and feigned memory impairment (i.e. lying). During the lying condition, subjects were instructed to ‘fake skilfully’, with the incentive that a lot of errors without detection (successful lies) would lead to monetary reward. A behavioural study prior to scanning showed that most subjects (about 80%) could manipulate the proportion of correct and incorrect answers in order to fake skilfully. Using this information, activation was predicted in prefrontal regions, responsible for the on-line manipulation of information, and fronto-parietal cortex, responsible for the mental arithmetic required to calculate the proportion of correct versus incorrect responses.Activation from the correct-recall condition was subtracted from that observed during lying, in order to determine the neuroanatomical correlates of deception. Areas of activation common to the digit and autobiographical studies after this subtraction included bilateral prefrontal cortex, frontal, parietal, temporal and subcortical (caudate) regions. Left posterior cingulate activity was also observed. The largest areas of activation were in the lateral regions of the right frontal cortex, areas responsible for processing secondary goals while holding primary goals on-line, and the selection of retrieval strategies. (When lying, it is important to remember the truth in order to be successful in the lie!) Parietal activation represented the calculation of the proportion of ‘lies’ that had been told. The caudate and posterior cingulate activation was attributed to the inhibition of learned rules, in this case, the inhibition of the usual (correct) response, and the monitoring of error performance while lying. Although this study represents an initial attempt to describe the neural activity involved in lying, the lack of specificity of the ‘lying circuitry’ suggests that it will be some time before we hear ‘Are you willing to have an fMRI scan?'in court!
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