Corporate social responsibility (CSR) advertising can differentiate brands and create product value, and an appropriate messaging strategy can help corporations launch persuasive CSR advertisements. This study employed a 2 × 2 mixed experimental design to operate two independent variables—message strategy of CSR advertising (CSR-informational advertising vs. CSR-transformational advertising) and the level of need for cognition (high-NFC vs. low-NFC)—in order to examine the effect of these variables on consumers’ attitudes toward advertising and brands. Three primary conclusions were reached: 1) the message strategy of CSR advertising influenced consumers’ attitudes toward advertising and brands; 2) NFC levels influenced consumers’ attitudes toward advertising and brands; and 3) individuals with high NFC exhibited more positive attitudes toward advertisements and brands in the CSR-informational advertising compared with those in the CSR-transformational advertising. Overall, using advertising to promote CSR activities can strengthen corporate image, promote consumer behavior, and consolidate consumers’ brand loyalty; however, corporations must actively consider how to appropriately design CSR advertising content.