Transmission Of Coronavirus Research Articles

Pelatihan Pembuatan Soal Secara Online Terhadap Guru Kelas Dan Guru bidang Study di SDS PKMI Efesus Aek Batu

The impact of the COVID-19 pandemic has penetrated the world of education, the central and regional governments have issued policies to conduct distance learning as an effort to prevent the spread of the corona virus transmission in Indonesia. schools and campuses implement policies for teaching and learning activities from a distance or online learning or what is often called online learning. Educators/Teachers must ensure that teaching and learning activities and exams continue even though students are at home, learning innovation is a solution that needs to be designed and implemented by teachers by maximizing existing media such as online media such as google form. Google Form or Google Forms is a facility provided by Google that is useful for helping plan events, create questionnaires, send surveys, create quizzes for students and students and collect information in an easy and efficient way. This form can be linked to a spreadsheet, so that responses from respondents can be displayed and downloaded in spreadsheet (excel) format. The method used in community service is training in the form of training and questions and answers, from this activity the teacher is able to understand well the online question-making training.

Association Between Population-Level Factors and Household Secondary Attack Rate of SARS-CoV-2: A Systematic Review and Meta-analysis.

Accurate estimation of household secondary attack rate (SAR) is crucial to understand the transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The impact of population-level factors, such as transmission intensity in the community, on SAR estimates is rarely explored. In this study, we included articles with original data to compute the household SAR. To determine the impact of transmission intensity in the community on household SAR estimates, we explored the association between SAR estimates and the incidence rate of cases by country during the study period. We identified 163 studies to extract data on SARs from 326 031 cases and 2 009 859 household contacts. The correlation between the incidence rate of cases during the study period and SAR estimates was 0.37 (95% CI, 0.24-0.49). We found that doubling the incidence rate of cases during the study period was associated with a 1.2% (95% CI, 0.5%-1.8%) higher household SAR. Our findings suggest that the incidence rate of cases during the study period is associated with higher SAR. Ignoring this factor may overestimate SARs, especially for regions with high incidences, which further impacts control policies and epidemiological characterization of emerging variants.

1926. Risky businesses: Carbon dioxide monitoring to assess ventilation in grocery stores as an indicator of risk for respiratory virus transmission

Abstract Background Poorly ventilated indoor settings pose a risk for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses. Transmission often occurs in community, but limited information is available on the quality of ventilation in community settings. Methods We used carbon dioxide measurements to assess adequacy of ventilation in 6 grocery stores, including large warehouse stores, medium-sized stores, and small neighborhood groceries. Carbon dioxide levels were monitored continuously with values recorded once per minute using a handheld device during multiple shopping trips to each store during both busy (defined as long lines at checkout) and non-busy (defined as no lines at checkout) shopping times. Carbon dioxide readings above 800 parts per million (ppm) were considered an indicator of suboptimal ventilation for the number of people present. Results Carbon dioxide levels remained below 800 ppm in all 6 grocery stores during trips at non-busy shopping times, except for transient rises above 800 ppm (peak = 860 ppm) during check out in 2 stores. In 3 of the 6 stores (50%), carbon dioxide levels rose above 800 ppm for prolonged periods during busy shopping times, with considerable variability in levels in different store locations (ie, increased levels in crowded store locations). The figure shows carbon dioxide levels for 1 medium-sized grocery store during typical shopping trips during busy and non-busy shopping periods. Increase in carbon dioxide levels in parts per million (ppm) in a grocery store during busy and non-busy shopping trips. Peak levels of carbon dioxide above 800 ppm (dotted lines) were considered an indicator of suboptimal ventilation for the number of occupants present. Conclusion Ventilation in grocery stores may be sufficient to minimize the risk for airborne transmission of respiratory pathogens during non-busy shopping periods, but in some stores may be sub-optimal in crowded locations during busy shopping times. There is a need for additional studies to assess the quality of ventilation in a wide range of community settings. Disclosures All Authors: No reported disclosures.

Household secondary attack rate of COVID 19 and its associated housing factors affecting transmission

: Overcrowding and household environments are high-risk settings for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To calculate the household secondary attack rate among household contacts of confirmed case of COVID-19. 2) To elicit the housing factors affecting the transmission of infection. 3) To know the sociodemographic of the discharge patients.A prospective study was conducted among the COVID 19 laboratory-confirmed discharged patients admitted at District Covid Hospital, Designated Covid health centre from period May 2020 to July 2020. Total 94 patients were able to contact telephonically. Sociodemographic details were taken after informed Verbal consent. Those who are not able to contact telephonically or didn't give consent are excluded. Household secondary attack rate is 14.5%. Mean rooms per person were 2.8 with a standard deviation of 1.38. The mean age of the patients was 39 years with a standard deviation of 14.9. A mild negative correlation between the number of positive COVID-19 cases and rooms per person (r= −0.045, p>0.05) and mild negative correlation was seen with the number of family members and proportion of family members (positive COVID-19 cases in family/total members in the family) being infected by COVID-19 (r= −0.20, p>0.05). Infection control and preventive strategies of household transmission such as good ventilation, isolation precautions of infected person at home, household disinfecting procedures, wearing of mask at home, hand hygiene needs to be encouraged at household level to lower the Secondary attack rate before recommendation of home isolation and home quarantine measures.

1911. A Pilot Study to Evaluate the Effectiveness of Nasal and Oral Povidone Iodine in Reducing the Burden of Severe Acute Respiratory Syndrome 2 RNA in Patients with COVID-19

Abstract Background Nasal and oral application of topical antiseptics such as povidone iodine could potentially reduce the risk for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, limited information is available on the efficacy of such agents in reducing the burden of SARS-CoV-2. Methods We conducted a pilot non-blinded, randomized trial to compare the effectiveness of 3 doses of povidone iodine (each dose with 10% intranasal and 1% gargle) administered every 8 hours versus the control with phosphate-buffered saline in reducing the burden of SARS-CoV-2 RNA in the nares and oropharynx of patients with COVID-19. Swabs were used to collect anterior nares and oropharynx samples before the first and second doses and 8 hours after the final dose (24 hours after the initial dose). Real-time polymerase-chain reaction (RT-PCR) was used to assess the burden of viral RNA. Analysis of variance was used to compare cycle threshold values for povidone iodine versus control patients. Subjects were surveyed about adverse reactions to treatment. Results As shown in the figure, SARS-CoV-2 cycle thresholds were similar in the povidone iodine (N=10 subjects) and control (N=8 subjects) groups prior to treatment. After initiation of treatment, there was no significant difference in cycle thresholds for the povidone iodine versus control subjects (P >0.05). No adverse effects of treatment were reported. Effect of intranasal and oral application of povidone iodine versus phosphate-buffered saline on nasal and oropharyngeal SARS-CoV-2 RNA. Error bars show standard error. Conclusion Our findings suggest that that nasal and oral application of povidone iodine have limited effectiveness in reducing the burden of SARS-CoV-2. Future studies are needed to assess for effectiveness of more frequent dosing intervals and to determine if povidone iodine reduces recovery of viable virus by culture. Disclosures All Authors: No reported disclosures.

Molecular modeling of C1-inhibitor as SARS-CoV-2 target identified from the immune signatures of multiple tissues:An integrated bioinformatics study.

The expeditious transmission of the severe acute respiratory coronavirus 2 (SARS-CoV-2), a strain of COVID-19, crumbled the global economic strength and caused a veritable collapse in health infrastructure. The molecular modeling of the novel coronavirus research sounds promising and equips more evidence about the pragmatic therapeutic options. This article proposes a machine-learning framework for identifying potential COVID-19 transcriptomic signatures. The transcriptomics data contains immune-related genes collected from multiple tissues (blood, nasal, and buccal) with accession number: GSE183071. Extensive bioinformatics work was carried out to identify the potential candidate markers, including differential expression analysis, protein interactions, gene ontology, and KEGG (Kyoto Encyclopedia of Genes and Genomes)pathway enrichment studies. The overlapping investigation found SERPING1, the gene that encodes a glycosylated plasma protein C1-INH, in all three datasets. Furthermore, the immuno-informatics study was conducted on the C1-INH protein. 5DU3, the protein identifier of C1-INH, was fetched to identify the antigenicity, major histocompatibility(MHC) Class I and II binding epitopes, allergenicity, toxicity, and immunogenicity. The screening of peptides satisfying the vaccine-design criteria based on the metrics mentioned above is performed. The drug-gene interaction study reported that Rhucin is strongly associated with SERPING1. HSIC-Lasso (Hilbert-Schmidt independence criterion-least absoluteshrinkage and selection operator), a model-free biomarker selection technique, was employed to identify the genes having a nonlinear relationship with the target class. The gene subset is trained with supervised machine learning models by a leave-one-out cross-validation method. Explainable artificial intelligencetechniques perform the model interpretation analysis.

Evaluation of Interventions to Improve Ventilation in Households to Reduce Risk for Transmission of Severe Acute Respiratory Syndrome Coronavirus 2.

Inadequate ventilation may contribute to the high risk for household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluated the effectiveness of several interventions recommended to improve ventilation in households. In 7 residential homes, carbon dioxide monitoring was conducted to assess ventilation in occupied open areas such as family rooms and in bedrooms and/or offices. Carbon dioxide levels above 800 parts per million (ppm) were considered an indicator of suboptimal ventilation for the number of people present. In 1 of the 7 homes, various interventions to improve ventilation or to filter air were assessed in a kitchen area by measuring clearance of aerosol particles produced using an aerosol-based spray system and carbon dioxide generated by cooking with a gas stove. Carbon dioxide levels rose above 800 ppm in bedrooms and offices with 2 occupants when windows and doors were closed and in open areas during gatherings of 5 to 10 people; carbon dioxide levels decreased when windows or doors were opened. Clearance of carbon dioxide and aerosol particles significantly increased with interventions including running fans, operating portable air cleaners, and opening windows, particularly when there was a noticeable breeze or when a window fan was used to blow contaminated air outside. In households, several measures to improve ventilation or air filtration were effective in reducing carbon dioxide accumulation or enhancing clearance of carbon dioxide and aerosol particles. Studies are needed to determine if interventions to improve ventilation can reduce the risk for airborne transmission of SARS-CoV-2 in households.

Overcoming COVID-19 Misinformation: Lessons Learned at the Epicentre of the Outbreak in the USA

THE COVID-19 pandemic has highlighted the dire need to foster increased public confidence in mitigation and prevention strategies through more and better health literacy. More than 2 years into the worst public health crisis of the 21st century, we continue to be consumed by the most basic health questions: should I get tested for COVID-19, should I get vaccinated and boosted against COVID-19, and should I wear a mask? In many countries, the tension between personal freedoms and public good helps to fuel a global threat, with continued transmission of severe acute respiratory syndrome coronavirus 2 and its evolving, more infectious variants. This short essay discusses the negative effects of misinformation and disinformation, and shares recommendations based on lessons learned.

Nosocomial infection and spread of SARS-CoV-2 infection among hospital staff, patients and caregivers.

There are difficulties in diagnosing nosocomial transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hospital settings. Furthermore, mortality of cases of nosocomial infection (NI) with SARS-CoV-2 is higher than that of the general infected population. In the early stage of the pandemic in Taiwan, as patients were not tested for SARS-CoV-2 at admission, NIs often go undetected. Strictly applying the systematic polymerase chain reaction (PCR) screening, as a standard infection control measure was subsequently implemented to reduce NI incidence. However, evidence on risk factors for SARS-CoV-2 NIs among healthcare workers (HCWs) and caregivers is limited. To assess NI incidence of SARS-CoV-2 among hospital staff, hospitalized patients, and caregivers, and the transmission routes of clusters of infection. This descriptive retrospective analysis at our hospital from May 15 to August 15, 2021 included data on 132 SARS-CoV-2 NIs cases among hospital staff, inpatients, and caregivers who previously tested negative but subsequently identified with a positive SARS-CoV-2 reverse transcriptase-PCR (RT-PCR) test results, or a hospital staff who tested positive following routine SARS-CoV-2 RT-PCR test. Chi-square tests were performed to compare the differences between hospital staff and private caregivers, and between clusters and sporadic infections. Overall, 9149 patients and 2005 hospital staff members underwent routine SARS-CoV-2 RT-PCR testing, resulting in 12 confirmed cluster and 23 sporadic infections. Among the index cases of the clusters, three (25%) cases were among hospital staff and nine (75%) cases were among other contacts. Among sporadic infections, 21 (91%) cases were among hospital staff and two (9%) cases were among other contacts (P < 0.001). There was an average of 8.08 infections per cluster. The secondary cases of cluster infection were inpatients (45%), hospital staff (30%), and caregivers (25%). Private caregivers constituted 27% and 4% of the clusters and sporadic infections, respectively (P = 0.024); 92.3% of them were infected in the clusters. The mortality rate was 0.0%. The incidence of SARS-CoV-2 infection was relatively high among private caregivers, indicating a need for infection control education in this group, such as social distancing, frequent hand-washing, and wearing PPE.

Comparison of General Anxiety among Healthcare Professionals before and after COVID-19 Vaccination.

Vaccination plays a crucial role in controlling the rate of coronavirus transmission and infectivity. Healthcare professionals are, in fact, at the greatest risk of contracting coronavirus due to their proximity and prolonged exposure to infected patients; this certitude alone enhances the stress and anxiety among patients and professionals alike. In this study, we aimed to assess the levels of anxiety experienced by healthcare professionals in their practices before and after getting vaccinated. This cross-sectional study was carried out in 2021. An electronic survey was distributed among the non-vaccinated and vaccinated healthcare workers. The survey consisted of the following parts: demographic characteristics, coronavirus-related questions, questions related to the specific field of healthcare professions, general anxiety questions, and working-hour-related questions. The Modified General Anxiety Scale (GAD-7) was used along with the paired t-test, Mann-Whitney U test, and Spearmen's test for comparison. p ≤ 0.05 was considered statistically significant. A total of 798 healthcare professionals participated in the study. In this study, the majority of participants were females, with 598 (74.9%) being between the ages of 21 and 30, and 646 (80.9%) participants were graduates, with the majority being dentists. Non-vaccinated healthcare professionals had severe anxiety (30.9%), whereas, in vaccinated participants, anxiety levels were minimal (56.9%). A statistically significant correlation was discovered when comparing the scores of the vaccinated and non-vaccinated individuals as well as when comparing the professions of vaccinated participants, whereas no association was found with the gender and education level of participants. Vaccination is necessary for all entitled individuals to control the spread of coronavirus. It was discovered that there was an increase in anxiety levels before the vaccination was introduced. The anxiousness was greatly lessened following mass immunizations. Our research will help to raise public awareness of stigmatized mental health disorders in the healthcare industry.

Effectiveness of plexiglass barriers in mitigating spread of aerosolized droplets in a cough

Plexiglass barriers have been prevalently used in the workplace during the Covid-19 pandemic as protective measures against the airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through interactions between potentially infected and uninfected individuals. Doubts have been raised about their effectiveness and concerns have even been expressed about the implications for room ventilation on their overuse. To aid public awareness of the role of such plexiglass barriers, we use flow visualization, aided by particle count measurements, to examine in a laboratory setting the effectiveness of typical workplace barriers in impeding the spread of aerosol-size airborne droplets. Such droplets are emitted in coughs and other respiratory exhalations and serve as modes of transmission for viruses. The visualizations and the supporting particle count measurements indicate that barriers do impede the forward momentum of the droplet-laden airflow jet that result from a cough, but portions of the expelled aerosols can spread around the barriers. Our study suggests that in comparison with the case in the absence of a barrier, a 2.5 ft or higher barrier can reduce the concentration levels of aerosols of size &amp;lt;10 μm on the side of the barrier away from the source by over 90% and those of size &amp;lt;3 μm by over 82%. However, an opening at the bottom of a barrier, for example, representing access for transactions between a worker and customers, can significantly reduce the effectiveness of the barrier. Finally, we illustrate how the aerosol dispersion in this case can be dramatically altered by ambient background airflows.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Vertical Transmission Covid-Positive Mothers in Neonates

An outbreak of Covid-19 occurred in Wuhan, China initially in December 2019. Over the next few months, the wide spread of SARS-CoV-2 had been reported in all continents and the transmission in utero from an infected mother to fetus debating yet was observed.1,9 Objectives: To determine risk of vertical transmission of corona virus in neonates of SARS COVID-2 positive mothers. Study Design: A Cross-Sectional study. Place and Duration of Study: Pediatric department of Pakistan Air Force (PAF) Hospital, Islamabad, Pakistan. The study conducted during 01-03-2020 to 31-08-2020. Methodology: After taking informed consent, Nasopharyngeal swab for PCR for SARS-CoV-2 was taken one week before delivery. Confirmed COVID positive pregnant ladies were included irrespective of symptoms of COVID-19 infection and any other medical illness. Neonates born to COVID-19 positive mothers were admitted in NICU, and Performa was filled for neonates after PCR done 24 and 48 hours respectively. Results: Total 14(87.5%) out of 16 COVID positive mothers were asymptomatic. 16(100%) neonates were negative for Sars-COV-2 at 24 hours and 48 hours. Conclusion: This study concluded with no evidence of transmission of COVID-19 from infected mothers. Keywords: Vertical transmission, COVID-19, neonate, infected mother.

Identification of severe acute respiratory syndrome coronavirus 2 breakthrough infections by anti-nucleocapsid antibody among fully vaccinated non-healthcare workers during the transition from the delta to omicron wave.

Uncontrolled transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the emergence of several variants of concern (VOC). As vaccine-induced neutralizing antibodies against VOC waned over time, breakthrough infections (BTIs) have been reported primarily among healthcare workers or in long-term care facilities. Most BTIs were identified by reverse transcription-polymerase chain reaction (RT-PCR) or antigen test for individuals experiencing symptoms, known as symptomatic BTIs. In this study, we detected seroconversion of anti-nucleocapsid (N) antibody to identify both symptomatic and asymptomatic BTIs in a cohort of COVID-19-naive university employees and students following two or three doses of mRNA vaccines. We reported 4 BTIs among 85 (4.7%) participants caused by the Omicron and Delta VOC during the transition from the Delta to Omicron wave of the pandemic; three were symptomatic and confirmed by RT-PCR test and one asymptomatic. A symptomatic reinfection two and half months after a BTI was found in one participant. Two of three symptomatic BTIs and the reinfection were confirmed by whole genome sequencing. All were supported by a >4-fold increase in neutralizing antibodies against the Delta or Omicron variant. Moreover, we found both symptomatic and asymptomatic BTIs can boost neutralizing antibodies against VOC with variable degrees ranging from 2.5- to 77.4-fold increase in neutralizing antibody titers. As BTIs continue, our findings highlight the application of anti-N antibody test to ongoing studies of immunity induced by spike-based vaccine, and provide new insights into the establishment of herd immunity in the community during the post-vaccination era.

Impact of COVID-19 on urology services at a quaternary referral center in Johannesburg, South Africa

Abstract Background South Africa was placed into a nationwide lockdown on March 26, 2020, to limit the transmission of severe acute respiratory syndrome coronavirus 2. Medical facilities were overwhelmed, and the redeployment of medical staff to deal with coronavirus disease 2019 (COVID-19) cases resulted in the disruption of typical urology services. This has led to the reprioritization of care for urology patients with delays in all elective cases. Materials and methods In this retrospective study, we compared the numbers and types of patients seen in our urology outpatient clinics, ward admissions, and theater cases 90 days before and after the first COVID-19 lockdown. The changes in numbers were calculated as percentages, and Fisher exact test was used to determine p values. Results The number of patients in urology outpatient clinics significantly declined (26.4%) after the lockdown started. Outpatient procedures, which were mostly diagnostic, decreased by 28.6%, with no change observed in therapeutic procedures. A decrease in the total number of theater cases (37.4%) and ward admissions (45.0%) was also observed after the lockdown because of a decrease in elective cases, although the number of emergency and oncology patients was relatively stable. Conclusions Coronavirus disease 2019 and the lockdown forced the urology department to shift the focus to only emergency and oncology cases. This resulted in delays in the treatment of benign elective conditions and a subsequent increase in the backlog of pending surgeries for these conditions, which could potentially lead to future complications. Although COVID-19 is a major problem requiring many resources, ensuring that urological patients still receive adequate care and management is also important.

Dynamical Analysis of COVID-19 Model Incorporating Environmental Factors.

The continuing coronavirus pandemic has come up with considerable questions in front of the world. Presently, India is among concerned countries in Asia. Even though the recovery rate is more than the death rate, it is affecting human lives and experiencing losses to the market. Several methods were employed to study the spread of novel coronavirus. Mathematical modeling is one of the prominent techniques to evaluate the dynamics of novel coronavirus. In this work, we extend the mathematical model SEIAQRDT by incorporating environmental transmission to analyze the transmission of coronavirus in India. The notable aspect of the model incorporates asymptomatic population, quarantine individuals, and environmental transmission factors. These factors have enormous significance in the ongoing COVID-19 outbreak. The basic reproduction number is calculated theoretically. Bifurcation analysis of is also done analytically. The existence and stability analysis of disease-free equilibrium (DFE) and endemic equilibrium (EE) points are established. The impact of environmental factors in spreading COVID-19 pandemic is deliberated. The case study for India and Italy is presented and compared with real data, and the results are in accordance with the real situation.

Impact of Vaccination With the SCB-2019 Coronavirus Disease 2019 Vaccine on Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Household Contact Study in the Philippines.

An exploratory household transmission study was nested in SPECTRA, the phase 2/3 efficacy study of the adjuvanted recombinant protein-based COVID-19 vaccine SCB-2019. We compared the occurrence of confirmed COVID-19 infections between households and household contacts of infected SPECTRA placebo or SCB-2019 recipients. SPECTRA participants at 8 study sites in the Philippines who developed real-time reverse transcriptase-polymerase chain reaction (rRT-PCR)-confirmed COVID-19 were contacted by a study team blinded to assignment of index cases to vaccine or placebo groups to enroll in this household transmission study. Enrolled households and household contacts were monitored for 3 weeks using rRT-PCR and anti-SARS-CoV-2 N-antigen IgG/IgM testing to detect new COVID-19 infections. One hundred fifty-four eligible COVID-19 index cases (51 vaccinees, 103 placebo) were included. The secondary attack rate per household for symptomatic COVID-19 infection was 0.76% (90% CI: .15-3.90%) if the index case was an SCB-2019 vaccinee compared with 5.88% (90% CI: 3.20-10.8%) for placebo index cases, a relative risk reduction (RRR) of 79% (90% CI: -28% to 97%). The RRR of symptomatic COVID-19 per household member was similar: 84% (90% CI: 28-97%). The impact on attack rates in household members if index cases were symptomatic (n = 130; RRR = 80%; 90% CI: 7-96%) or asymptomatic (n = 24; RRR = 100%; 90% CI: -76% to 100%) was measurable but the low numbers undermine the clinical significance. In this prospective household contact study vaccination with SCB-2019 reduced SARS-CoV-2 transmission compared with placebo in households and in household members independently of whether or not index cases were symptomatic.

Automated Physical Distance Estimation and Crowd Monitoring Through Surveillance Video.

The contagious Corona Virus (COVID-19) transmission can be reduced by following and maintaining physical distancing (also known as COVID-19 social distance). The World Health Organisation (WHO) recommends preventing COVID-19 from spreading in public areas. On the other hand, people may not be maintaining the required 2-m physical distance as a mandated safety precaution in shopping malls and public places. The spread of the fatal disease may be slowed by an active monitoring system suitable for identifying distances between people and alerting them. This paper introduced a deep learning-based system for automatically detecting physical distance using video from security cameras. The proposed system introduced the TH-YOLOv5 for object detection and classification and Deepsort for tracking the detected people using bounding boxes from the video. TH-YOLOv5 included another prediction head to identify objects of varying sizes. The original prediction heads are then replaced with Transformer Heads (TH) to investigate the prediction capability of the self-attention mechanism. Then, we include the convolutional block attention model (CBAM) to identify attention areas in settings with dense objects. Pairwise L2 vectorized normalization was utilized to generate a three-dimensional feature space for tracking physical distances and the violation index, determining the number of individuals who follow the distance rules. We use the MS COCO and HumanCrowd, CityPersons, and Oxford Town Centre (OTC) data sets for training and testing. Experimental results demonstrate that the proposed system obtained a weighted mAP score of 89.5% and an FPS score of 29; both are computationally comparable.

COVID-19 vaccinations in pregnancy: Save mother and baby from COVID-19 pandemic.

The current study investigated the immune response of maternal coronavirus disease 2019 (COVID-19) vaccination and vertical transmission of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) and nucleocapsid (N) proteins. This retrospective study included pregnant women in Bahrain Defense Force Hospital from March 2021 to September 2021 who were vaccinated with Sinopharm or Pfizer/BioNTech. Testing of anti-N and -S levels from paired samples of maternal and umbilical cord blood was performed at the time of delivery. The immune response to vaccination, association with maternal and fetal factors, and vertical transmission of antibodies were studied. The current study included 79 pregnant women. The median gestational age for those vaccinated with Sinopharm was 28 weeks and those vaccinated with Pfizer was 31 weeks, with 100% of the vaccinated population generating antibodies and showing vertical transmission. The anti-N and -S titers and interval frequencies varied in both vaccinations. The anti-N and -S and transfer ratio statistically correlated with maternal age, gestational age at delivery, latency period, and birth weight of the neonates differently in both vaccines. In addition, the peak level of antibodies and transfer ratios varied. Although variations are exhibited in both types of vaccination, the vaccinated pregnant population generated a significant level of anti-N and -S and showed vertical transmission.

Tackling COVID-19 Using Antiviral Nanocoating's-Recent Progress and Future Challenges.

In the current situation of the global coronavirus disease 2019 (COVID-19) pandemic, there is a worldwide demand for the protection of regular handling surfaces from viral transmission to restrict the spread of COVID-19 infection. To tackle this challenge, researchers and scientists are continuously working on novel antiviral nanocoatings to make various substrates capable of arresting the spread of such pathogens. These nanocoatings systems include metal/metal oxide nanoparticles, electrospun antiviral polymer nanofibers, antiviral polymer nanoparticles, graphene family nanomaterials, and etched nanostructures. The antiviral mechanism of these systems involves depletion of the spike glycoprotein that anchors to surfaces by the nanocoating and makes the spike glycoprotein and viral nucleotides inactive; however, the nature of the interaction between the spike proteins and virus depends on the type of nanostructure and a surface charge over the coating surface. In this article, the current scenario of COVID-19 and how it can be tackled using antiviral nanocoatings from the further transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with their different mode of action, are discussed. Additionally, it isalso highlighted different types of nanocoatings developed for various substrates to encounter transmission of SARS-CoV-2, future research areas along with the current challenges related to it, and how these challenges can be resolved.

Insights on the possibility of SARS-CoV-2 transmission through the eyes.

A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCOV), causing coronavirus disease 2019 (COVID-19), has rapidly spread to most countries and regions worldwide since it broke out at the end of 2019. Epidemic of the virus produces a tremendous pressure on the global health systems. With progressive insight into SARS-CoV-2, the role of eye tissue has attracted wide attention in the spread of COVID-19. Whether SARS-CoV-2 can enter the human body through eyes and cause infection? The fact that unprotected exposure of the eyes to 2019-nCoV might have allowed the virus to infect the body implies that 2019-nCOV can invade eye tissue and set foot in organism. Facing the severe challenge of preventing spread of the COVID-19, combined with the high-risk environment of ophthalmology, it is crucial to investigate ocular tropism of coronavirus. This paper explores the possibility of coronavirus transmission through the eye from aspects of probable mechanisms, clinical cases, detection of coronavirus; and puts forward precautions for ophthalmologists and nurses. Consequently, this review reveals our understanding of ocular tropism of coronavirus and contributes to determining risk of ocular transmission, raising awareness of necessary eye protection among medical workers and reducing further prevalence of SARS-CoV-2.