Coronavirus Epidemic Research Articles

Homo-harringtonine (HHT) is highly effective against SARS-CoV-2-A potential first-line defense in future coronavirus epidemics

Abstract As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have a treatment scheme in anticipation of a fourth one. We here present a scheme that could clear SARS-CoV-2 in 2-4 days post infection from the upper respiratory tract (URT), where the virions are initially concentrated. The scheme, applicable in large scale by nasal spray, is based on Homo-harringtonine (HHT) that has been approved for treating other diseases. HHT blocked protein elongation and repressed in vitro replication of all 4 coronaviruses (including SARS-CoV-2) tested at the nano-molar concentration, demonstrating its potential of broad effectiveness against coronaviruses. In animal models, HHT cleared SARS-CoV-2 in all treated mice in 3 days by daily nasal dripping of a small dose (40 ug). In December 2022, HHT was administered to 26 cancer patients by nebulization at 1 mg/day. On average, the viral load in the URT was reduced by 3/4 six hours after the nebulization. In the wavelet of May 2023, 11 patients without other medical conditions were administered HHT by repeated liquid nasal spray at the low, total daily-dose of 0.2 mg. Ten of the 11 patients were cleared of the virus in 2-4 days. In comparison, in large-cohort studies of participants in China during the same wave, most patients need 7-9 to turn negative. No adverse effects were detected in any patient in the two clinical trials. A short review of drugs approved for treating COVID-19 shows the many advantages of HHT. With continual development, it could become a first-line defense at the onset of future coronavirus epidemics.

Gentrification of Communities Surrounding Chedi Luang Worawiharn Temple, Sri Phum Subdistrict, Muang District, Chiang Mai Province

Modification of building structure and use by new investors to achieve increased economic returns by pushing former residents out of the areas is the process of gentrification.The purpose of this article is to investigate the gentrification of communities surrounding Chedi Luang Worawiharn Temple, Sri Phum subdistrict, Muang district, Chiang Mai province, and to analyze changes in the gentrification phenomenon during the coronavirus disease 2019 situation. Data collection was composed of physical surveying, interviews, and questionnaires. Three major groups were interviewed including 18 persons from the original community, 15 newcomers, and 10 community leaders and government officials. The 268 questionnaires were sampled in three communities including the Phra Chao Mengrai Samakkhi community, the Chang Taem community, and the Phranon community. The study found that there is mostly commercial land use in all three communities. Most of the new occupants used to live in the central region. The study area has three stages of gentrification. The development process begins with the first stage, early development, and then completes development in the second stage, and lastly to the third stage, which is the community's adaptation to the emergence of the gentrification phenomenon. The study also discovered that, before the emergence of coronavirus disease in 2019, the communities were significantly impacted by the economy due to gentrification, such as increased living costs and rent/land prices. While the rise of commercial and service businesses is a beneficial result of gentrification. During coronavirus epidemics, certain localities witnessed population declines whereas land prices climbed with a stagnant economy, increased speculation, and a drop in commerce and services. However, gentrification improves better relationships between former inhabitants and newcomers for overcoming the 2019 coronavirus disease outbreak.

Phenomenological Models of Three Scenarios of Local SARS-COV-2 Coronavirus Epidemics in New York, Brazil, and Japan

Phenomenological Models of Three Scenarios of Local SARS-COV-2 Coronavirus Epidemics in New York, Brazil, and Japan

A Review of the Coronavirus Epidemic in Nigeria

Nigeria has experienced serious difficulties as a result of the COVID-19 epidemic, which has affected the entire world. With a focus on public health response, socioeconomic effects, and epidemiology, this thorough review aims to offer an in-depth review of the COVID-19 pandemic in Nigeria. The epidemiological overview examines the COVID-19 pandemic's spread in Nigeria. This research aims to provide an in-depth review of Nigeria's techniques and efforts in fighting COVID-19, focusing on what contributes to Nigeria's low COVID-19 mortality toll compared to other nations. In summary, the review concludes with recommendations for future approaches to managing the COVID-19 pandemic in Nigeria, highlighting the significance of ongoing public health initiatives, fair vaccination programs, and international cooperation. It emphasizes how adaptive techniques are necessary to deal with changing issues and guarantee that the nation is ready for future health emergencies. This comprehensive review, in its entirety, provides insightful information about the COVID-19 pandemic in Nigeria, laying the groundwork for well-informed policy development, research projects, and decision-making targeted at halting the pandemic and preserving public health in the country.

Impact of COVID-19 Epidemics on Paediatric and Adult Patients with Haemophilia Treated in a Haemophilia Therapeutic Centre

Abstract Introduction: The pandemic of coronavirus disease 2019 (COVID-19) has posed an unprecedented health crisis for all humans, including people with haemophilia. Aim: To investigate the impacts of COVID-19 pandemic on the infection, symptoms, drug use, and social intercourses of patients with haemophilia. Methods: 265 adults or children with haemophilia followed up in the Haemophilia Diagnosis and Treatment Center of Fujian Medical University Union Hospital during the COVID-19 pandemic were collected and analyzed between January 2022 and January 2023. Results: A total of 265 patients participated in this survey, 30.2% were children and 69.8% were adults. During the COVID-19 pandemic, coagulation factors were not associated with the type and severity of haemophilia, residence, or infection. Compared with adult patients, more children reduced social intercourses and outdoor activities due to the fear of COVID-19 (85.0% vs 66.5%; p = 0.002). The bleeding events were also significantly lower in children than in adult patients (61.2% vs 81.1%; p = 0.001). The SARS-CoV-2 infection rate was significantly higher in patients living in urban areas than in rural areas (74.3% vs 53.6%; p < 0.001). The lasting time of symptoms after infection was not significantly associated with hemorrhage, type and classification of haemophilia, presence of inhibitors, complications, and vaccination. Conclusions: The accompaniment of COVID-19 did not significantly influence the symptoms and treatments in patients with haemophilia. Compared with adults, the number of pediatric patients with bleeding events was significantly lower . Keyword: COVID-19, haemophilia, hemorrhage, infection, symptoms

Vaccination coverage survey of children aged 1–3 years in Beijing, China, 2005–2021

BackgroundThe routine immunization program for children is a primary strategy and a core part of vaccination. Achieving and maintaining high level of vaccination coverage are important to reduce morbidity and mortality caused by vaccine-preventable diseases. In Beijing, annual coverage surveys have been conducted since 2005. It is necessary and possible to assess the level and trend of routine vaccination coverage of children in Beijing as well as the disruption of coronavirus disease 2019 (COVID-19) pandemic and provide the reference for the further improve the vaccination coverage. MethodsThe data of 61,521 children aged 1–3 years in the vaccination coverage surveys during 2005–2021 were analyzed by Beijing Center for Disease Control and Prevention. Descriptive epidemiological method was used to analyze the data and the difference of vaccination coverage within the time period. ResultsMore than 99 % of participants had immunization cards and electronic immunization records. The concordance rate of both records were also over 99 %. During 2011–2019, the rates of on-time and in-time vaccination of each routine vaccine reached 96 % or more and increased significantly (all P values <0.05), compared with that of 2005–2010. All rates of the investigated vaccine, except for Bacillus Calmette-Guérin vaccine (BCG) and the first dose of hepatitis B vaccine (HepB), decreased in 2020–2021 significantly (all P values <0.05). For the causes of failing to vaccinate on time, delayed vaccination accounted for 47.82 %. The top two vaccines to be missed were the first dose of hepatitis A vaccine and the 4th dose of diphtheria-tetanus-acellular pertussis vaccine, accounting for 21.41 % and 20.79 %, respectively. The main reason for zero-dose/drop-out vaccination was “Guardians regarded the immunization service time as inappropriate”, accounting for 72.27 %. ConclusionThe coverage level and service quality of routine immunization in Beijing were relatively high. However, as influenced by COVID-19 epidemics, both on-time and in-time vaccination rates decreased significantly, except for BCG and HepB. Under the background of COVID-19 pandemic, the keys to maintain high level of vaccination coverage include flexible immunization service time to ensure the guardians bringing their children for vaccination timely, and more attention from providers to the doses after children’s first birthday.

ANALYSIS OF COVID-19 IMPACT ON THE STATE OF HEALTH AND CARDIOVASCULAR FUNCTION OF CHILDREN 7-9 YEARS OLD

Influenza and acute respiratory viral infections pose significant challenges in paediatrics, given their high prevalence among children and the potential for severe and complicated cases, particularly in young age groups. Over the past 20 years, there have been three coronavirus epidemics that have caused a substantial number of severe cases, high mortality rates, and global transmission. This review aims to provide a comparative analysis of clinical and epidemiological features of coronavirus infections in children, drawing from the examples of SARS and MERS, and offers essential approaches and recommendations for the diagnosis and treatment of COVID-19. The review covers the etiology, epidemiology, laboratory diagnosis, clinical presentation, and treatment of severe acute respiratory syndrome. It also provides a brief historical overview of the epidemiology, diagnosis, and treatment of this disease. Unlike other respiratory viral infections, COVID-19 can result in persistent symptoms following the acute phase, known as post-infection COVID-19 syndrome, which can last for weeks or even months. The long-term effects of COVID-19 in children are not yet fully understood, and further research is needed to explore its true prevalence, pathogenesis, and lasting impacts. The management of paediatric post-infection COVID-19 syndrome requires a multidisciplinary approach, international collaboration, and consensus to ensure early detection and effective treatment in children.&#x0D; The article presents current scientific insights into the factors contributing to the development of a prolonged post-COVID period, including chronic systemic inflammation, endothelial dysfunction, coagulation disorders, autoimmune reactions, and other immunological changes. The COVID-19 outbreak serves as a reminder of the ongoing threat posed by infectious diseases caused by pathogenic viruses, highlighting the need for global cooperation and preparedness to effectively mitigate their spread.

MEASURING RATIO AND CONVERGENCE OF JURISPRUDENTIAL DOCUMENTATION IN LIGHT OF LOSSES CAUSED BY CORONA TRANSFER

The aim of this study was to assess the civil liability of coronavirus epidemic transmission. The research method is descriptive - analytical and library type. In the realization of the triple elements of the verb or to transmit the coronavirus, the causality and causality relation between them (verbs and harm), the civil liability resulting from the transmission of the coronavirus epidemic is any condition, reason or reason to which the coronavirus epidemic can be attributed. Other laws that can be cited in the area of infection include the Civil Liability Act, "Whoever, as a matter of recklessness, pays compensation to the life or health of the person for any harm, whether moral or physical, is responsible for compensation for his act". In Iranian law, the legal basis of the civil liability of coronavirus epidemic transmission factors is based on negligence theory. But the assumption that the transmission of the coronavirus is carried out by hospitals and health care centers or centers that provide treatment and medical care is a form of responsibility, as they are bound by the rules. The basis of Islamic jurisprudence responsibility is that a dangerous disease transmission is based on the principle of No harm. The research findings indicate that the civil liability territory of coronavirus epidemics is where damage can be assigned. In Iranian law, the agents of the epidemic coronavirus have an obligation to compensate the material damages and any possible loss of benefits. However, there is no doubt that moral damages can be claimed, but there is no doubt that such compensations are due to impact of loss and loss.

A covid-19 világjárvány néhány gazdasági, társadalmi és környezeti következménye földrajzos szemmel

Based on the specifics of the coronavirus epidemics (SARS, MERS) that preceded the COVID-19 pandemic, our study presents the causes and geographical pathways of the spread of the diseases. The global interconnectedness of human societies led almost necessarily to the emergence of the COVID-19 pandemic. We describe the routes of the global spread of the pandemic, including the role of aviation, and then examine the causes of the infection waves of the pandemic, and the methods of effective control. Regarding the effects of the pandemic on the global economy, we found that rich countries recovered from the crisis relatively quickly, while the suffering of the economies of poor countries was prolonged. Among the social impacts, we consider the widening gap between rich and poor and the educational backwardness of poor children to be serious. The beneficial environmental impact of the pandemic was only temporary. In order to avoid another pandemic changes to the urban environment and also in the society are necessary. The imagined green transformation of the world economy has not materialised, nor has the fight against global climate change become more effective.

Health and Economic Impacts of Lockdown Policies in the Early Stage of COVID-19 in the United States

Lockdown policies, such as stay-at-home orders, are known to be effective in controlling the spread of the novel coronavirus disease 2019. However, concerns over economic burdens of these policies rapidly propelled U.S. states to move toward reopening in the early stage of the pandemic. Decision making in most states has been challenging, especially because of a dearth of quantitative evidence on health gains versus economic burdens of different policies. To assist decision makers, we study the health and economic impacts of various lockdown policies across U.S. states and shed light on policies that are most effective. To this end, we make use of detailed data from 50 U.S. states plus the District of Columbia on various factors, including number of tests, positive and negative results, hospitalizations, ICU beds and ventilators used, residents’ mobility obtained from cellphone data, and deaths. Our analyses allow quantifying the total cost versus the total quality-adjusted life year (QALY) associated with various lockdown policies. We utilize a compartmental model with Markov chain Monte Carlo simulation to estimate the spread of disease. To calibrate our model separately for each U.S. state, we make use of empirical data on the intensity of intervention policies, age, ratio of Black/Hispanic populations, per capita income, residents’ mobility, and number of daily tests and feed them to a longitudinal mixed-effect model. Finally, we utilize a microsimulation model to estimate the total cost and total QALY for each state and perform cost-effectiveness analysis to identify policies that would have worked best. Our results show that, compared with no intervention during March–June 2020, the policies undertaken across the United States saved, on average, about 41,284.51 years’ worth of QALY (per 100K capita), incurring $164.01 million (per 100K capita). Had the states undertaken more strict policies during the same time frame than those they adopted, these values would be 44,909.41 years and $117.28 million, respectively. By quantifying the impact of various lockdown policies separately for each state, our results allow federal and state authorities to avoid following a “one size fits all” strategy and instead enact policies that are better suited for each state. Specifically, by studying the trade-offs between health gains and economic impacts, we identify the particular states that would have benefited from implementing more restrictive policies. Finally, in addition to shedding light on the impact of lockdown policies during our study period (March–June 2020), our results have important implications on curbing future fast-spreading variants of the coronavirus or other related potential epidemics.Supplemental Material: The online appendix is available at https://doi.org/10.1287/serv.2023.0321 .

Cognitive and ethical reasons for the dissident movement in epidemiology

The article discusses several fundamental reasons for the emergence of such a significant phenomenon as the anti-vaccination movement. An attempt is made to classify these causes. The theory of the phases of the vaccination cycle by Robert Chen is presented. The theory of cognitive simplicity and the creation of illusory patterns to strengthen psychological control over a stressful situation was developed by Moscow anthropologist Alexandra Arkhipova. The decision to refuse vaccination is often accompanied by an inability to rank the risks and trust in pseudoscientific rumors. The level of distrust of citizens in government and healthcare, and, conversely, excessive trust in populist personalities, is also a significant reason for dissent in epidemiology. The article provides numerous examples from the history of smallpox, cholera and coronavirus epidemics. In conclusion, the article considers the problem of trust and mutual responsibility in society.

Marketing Strategy of Island Tourism Development under Coronavirus Epidemic Marketing Strategy of Island Tourism Development under Coronavirus Epidemic case study of Nan'ao Island in China

Affected by the new coronavirus pneumonia from the year 2019 to 2022, the economic development of the tourism industry was bleak. According to data released by the Ministry of Culture and Tourism, domestic tourism revenue in 2019 was 5.73 trillion yuan. In 2020, under the impact of the epidemic, the domestic tourism market has entered a low stage, with annual domestic tourism revenue of 2.23 trillion yuan, down 61.07 % year-on-year. Judging from the situation of people's travel in recent years, the development of tourism is growing. Under the epidemic, the tourism industry was pressed the pause button and the expected recovery is full of uncertainty. The epidemic has brought great challenges to the tourism industry, but it is not impossible to break through. This will be a good time for transformation and upgrading. If the tourism industry wants to make more stable and better pace of development, more intelligent information construction services need to be created into it in order to achieve breakthrough and develop characteristic products. In the era of marine economy in the 21st century, island tourism is an important part of the marine industry group. It is favored because it gives tourists a psychological feeling of staying away from the hustle and bustle of the city and returning to nature completely. The island has become a popular attraction in the world. In view of this, it is of great significance to summarize the research on island tourism. Taking Nan'ao Island in Guangdong as an example, this paper analyzes the existing problems of island tourism and formulates corresponding marketing strategies, aiming at improving its competitiveness in the travel industry and forming differentiated competitive advantages.

Drawing Parallels between SARS, MERS, and COVID-19: A Comparative Overview of Epidemiology, Pathogenesis, and Pathological Features.

Since November 2019, when the novel coronavirus arose in Wuhan City, over 188 million people worldwide have been infected with COVID-19. It is the third coronavirus outbreak in the twenty-first century. Until now, practically all coronavirus epidemics have occurred due to zoonotic spread from an animal or transitional host or through the consumption of their products. Coronaviruses can infect humans and cause severe illness and even death. This review was designed to help us recognize and harmonize the similarities and differences between these three coronaviridae family members. Measures aimed at containing the epidemic should be emphasized in this circumstance. Prioritizing and planning these activities require an understanding of the particulars of these three viruses. Given the pandemic's enormous death toll and rapid spread, we should be cognizant of the parallels and differences between these three viruses. Additionally, this pandemic warns us to be cautious against the possibility of a future pandemic. We highlight the fundamental characteristics of coronaviruses that are critical for recognizing coronavirus epidemiology, pathogenesis, and pathological features that reveal numerous significant pathological attributes and evolutionary patterns in the viral genome that aid in better understanding and anticipating future epidemics.

The evolutionary view of coronavirus epidemics process

The evolutionary view of coronavirus epidemics process

The Need for Attention and Reoptimization of Preventive Medicine to Deal With the Coronavirus Epidemic Threats.

The Need for Attention and Reoptimization of Preventive Medicine to Deal With the Coronavirus Epidemic Threats.

The outcome of pulmonary function tests and high-resolution computed tomography of chest in post-coronavirus disease 2019-confirmed cases after 3 months of recovery

Background Coronavirus disease (COVID-19) is a recently prevalent infectious disease that is caused by a virus from the coronavirus family and causes acute respiratory syndrome. It is a pandemic catastrophe that has affected more than 60 million people around the world and has caused about 1.5 million deaths, as reported by the WHO. This disease affects the respiratory system and leads to different forms of symptoms and signs. Pneumonia is a common cause for hospitalization, with most patients treated in hospital wards and others requiring ICU. Although the number of complete recoveries from COVID-19 has increased, there is still concern about complications associated with the disease that appear after recovery. The studies that have looked at past types and other forms of coronavirus epidemics, such as SARS have shown that some cases had respiratory complications from the infection after being full recovered, as 36 and 30% of the entire study population had clinical and high-resolution computed tomography (HRCT) changes at 3 and 6 months after recovery, respectively. Mostly, the abnormalities seen in pulmonary function test (PFT) results are sequelae of diffusion capacity defect. In recovered cases of Middle East respiratory syndrome, 36% of patients showed HRCT sequelae at follow-up of 6 weeks, because of fibrosis. Data on COVID-19 indicate that prolonged disease and persistent symptoms show post-PFT affection and follow-up radiographic changes after recovery from COVID-19 as interstitial pulmonary changes and a degree of pulmonary vasculopathy. In recovered cases of COVID-19, capacity of diffusion is the commonest defect in lung function, followed by the restrictive pattern defects on spirometry; both are related to the degree of severity of pneumonic COVID-19. PFTs (involving spirometry as well as diffusion capacity) are considered as routine follow-up examinations for some of the recovered cases, especially severe cases. Rehabilitation programs of the respiratory system are an option strategy that might be considered. This study aims to show changes in pulmonary function and HRCT of chest in post-COVID-19-infected patients to detect long-term effects on the lungs after 3 months as obstructive or restrictive, or both, lung diseases. Patients and methods The study was conducted on 100 confirmed PCR-positive COVID-19 cases that were admitted to Ain Shams University Isolation Hospitals, and the follow-up was performed in the outpatient clinic. PCR samples (Combined nasopharyngeal and oropharyngeal swab) were taken after 3 months from discharge of patients above the age of 18 years who become negative with clinical improvement. PFT [spirometry and diffusion for carbon monoxide (DLCO)] and chest HRCT were done. All patients’ clinical data were recorded, and CT chest imaging data of these patients were correlated with the clinical data. Results A total of 100 patients were included in this study, where males represented 58% and female represented 42%. The mean±SD age of cases in this study was 45.05 ± 11.80 years and ranged from 20 to 79 years. CT chest severity score (SS) of abnormality in COVID-19-infectedd patients based on HRCT chest findings before and after 3 months from treatment showed a highly significant correlation (P=0.000). The results of PFT in the studied group after 3 months of discharge showed restrictive pattern in 14.9%, obstructive pattern in 17.8%, and both obstructive and restrictive patterns in 5.9% of the total number of cases. There was a significant correlation between DLCO abnormality findings and age of studied group (P=0.032), a significant correlation between abnormality findings on PFT and HRCT chest SS after discharge of the studied group (P&lt;0.001). There was a significant correlation between abnormality findings of DLCO and HRCT chest SS after 3 months of the studied group (P=0.000) and before treatment (P=0.001), whereas there was no significant correlation between other findings of PFT and HRCT chest SS after 3 months and before. There was a significant correlation between HRCT chest SS of the studied group and their age after (P=0.003) and before treatment (P=0.000). This cohort study provided the long-term dynamic sequelae and variations of lung function after hospital discharge. Conclusion DLCO-predicted value detected at 3 months is the most important factor associated with severe respiratory COVID-19, which is identified as the cause of impairment of any ordinary basic activity of patients in the stage of postrecovery from COVID-19. The radiological chest findings must be analyzed in conjunction with other functional parameters to provide accurate assessment of the disease. These findings highlight the significance of a comprehensive follow-up after severe and critical COVID-19 infection, with appropriate management of pulmonary consequences. Patients after discharge and on follow-up in outpatient clinics in the post-COVID-19 stage should be strictly followed up with PFTs. Further studies with longer follow-up periods might be needed.

THE COVID-19 PANDEMIC TOWARD BUYING BEHAVIOR FOR E-COMMERCE AMONG HOUSEHOLDS IN MALAYSIA

The COVID-19 epidemic has altered many people's lifestyles and incentives, causing their shopping habits to shift. The current study aims to evaluate these changes. In order to achieve this aim, the study analyzed the influence of the pandemic on Buying Behavior for e-commerce transaction across industries in order to discover household preferences. The present study is intended to respond to research questions of quantitative and qualitative nature. Data collection and analysis techniques from both methods were implemented. Regression analysis was used to study situations in which variables were dependent and simultaneously influenced by several independent variables. The study found that buying behavior is influenced by a number of characteristics, including mental health, isolation, lockdown, price sensitivity, and financial distress. The study also found four factors have a positive association with the dependent variable, whereas the remaining one factor has no relationship with the dependent variable. The world economy, and particularly international trade, have suffered and continue to suffer huge losses as a result of the Coronavirus Epidemic. The uncertainty in which enterprises and end customers have found themselves is exacerbated by a number of issues. These include, to mention a few, income loss, cross-border travel limitations, evolving consumer demand, and changing market actor behavior.

The 60 + Tazelenme University in action: “Projects That Serve Your Hearts" during corona virus epidemics

Thanks to improved living conditions and medical intervention opportunities number of older people is rapidly increasing recently. With the critical structural changes, old age became severed from the profession, feminization, singularization, and impoverished. It is, therefore, crucial to keep this group active and happy to maintain individual and social well-being. 60+ Tazelenme University, the first third-age university of Turkey supports literate older people with third-age education and social support networks. COVID-19 pandemic caused many difficulties threatening the freedom and well-being of older people. 60+ Tazelenme University aims to produce life-saving projects with the understanding of "stay at home but do not stay passive". The purpose of this article is to introduce these projects. Projects such as Fresh Khizir, Fresh English, Fresh Food, Fresh Phone Chain, Fresh Knitting, Fresh Corona Diary, Fresh-Cocoons, Fresh Buddies, ensure that the older people who are at home under COVID-19 restrictions remain active. These projects inspire new concepts to support normalization in the post-pandemic period. Keywords: University of the third age, older adult education, distance education, covid-19, gerontology Resumo Graças a melhores condições de vida e oportunidades de intervenção médica, o número de idosos está aumentando rapidamente recentemente. Com as mudanças estruturais críticas, a velhice foi desvinculada da profissão, feminização, singularização e empobrecimento. É, portanto, crucial manter este grupo ativo e feliz para manter o bem-estar individual e social. 60+ Universidade Tazelenme, a primeira universidade de terceira idade da Turquia apoia idosos alfabetizados com educação de terceira idade e redes de apoio social. A pandemia de COVID-19 causou muitas dificuldades ameaçando a liberdade e o bem-estar dos idosos. 60+ Universidade Tazelenme visa produzir projetos que salvam vidas com o entendimento de "fique em casa, mas não fique passivo". O objetivo deste artigo é apresentar esses projetos. Projetos como Fresh Khizir, Fresh English, Fresh Food, Fresh Phone Chain, Fresh Knitting, Fresh Corona Diary, Fresh-Cocoons, Fresh Buddies, garantem que os idosos que estão em casa sob as restrições do COVID-19 permaneçam ativos. Esses projetos inspiram novos conceitos para apoiar a normalização no período pós-pandemia. Palavras-chave: Universidade da terceira idade, educação de idosos, educação a distância, covid- 19, gerontologia.

Screening and identification of potential MERS-CoV papain-like protease (PLpro) inhibitors; Steady-state kinetic and Molecular dynamic studies

MERS-CoV belongs to the coronavirus group. Recent years have seen a rash of coronavirus epidemics. In June 2012, MERS-CoV was discovered in the Kingdom of Saudi Arabia, with 2,591 MERSA cases confirmed by lab tests by the end of August 2022 and 894 deaths at a case-fatality ratio (CFR) of 34.5% documented worldwide. Saudi Arabia reported the majority of these cases, with 2,184 cases and 813 deaths (CFR: 37.2%), necessitating a thorough understanding of the molecular machinery of MERS-CoV. To develop antiviral medicines, illustrative investigation of the protein in coronavirus subunits are required to increase our understanding of the subject. In this study, recombinant expression and purification of MERS-CoV (PLpro), a primary goal for the development of 22 new inhibitors, were completed using a high throughput screening methodology that employed fragment-based libraries in conjunction with structure-based virtual screening. Compounds 2, 7, and 20, showed significant biological activity. Moreover, a docking analysis revealed that the three compounds had favorable binding mood and binding free energy. Molecular dynamic simulation demonstrated the stability of compound 2 (2-((Benzimidazol-2-yl) thio)-1-arylethan-1-ones) the strongest inhibitory activity against the PLpro enzyme. In addition, disubstitutions at the meta and para locations are the only substitutions that may boost the inhibitory action against PLpro. Compound 2 was chosen as a MERS-CoV PLpro inhibitor after passing absorption, distribution, metabolism, and excretion studies; however, further investigations are required.

General Impacts of Coronavirus on Children

The purpose of this study was to determine whether or not the coronavirus has an impact on the overall health of young people. Investigations of a wide range of affects, including mental, psychological, and systemic impacts, were carried out. Children, in the majority of reported cases, either did not exhibit any clinical signs at all or just had minimal symptoms. Despite this, severe symptoms could still present themselves. Children are a population that need special consideration in order to accomplish the goal of preventing new coronavirus epidemics.