Asthma is characterized as a chronic Th2‐mediated, inflammatory airway disease, with elevated number of eosinophils, and effector cells (CD44+CD62L−). Despite numerous studies aimed at examining the role of fish oil (FO), known for its anti‐inflammatory effects on the asthmatic response, none have considered the impact of age, which is proposed to alter the Th1/Th2 paradigm. We sought to determine how age and diet could alter the asthmatic immune response. Young (4 months) and old (22 months) female Balb/c mice were fed a diet supplemented with 10% corn oil (CO) or 8.8% FO and 1.2% CO for 30 days. Only splenocytes from old asthmatic mice showed decreases in both CD4 (29.4 ± 1.2 vs. 44.1 ± 1.2) and CD8 (13.0 ± 1.0 vs. 25.0 ± 1.3) effector cells in FO compared to CO groups (n=5, p=0.004 and 0.011, respectively). In bronchoalveolar lavage fluid, old asthmatic mice fed FO showed decreased eosinophils compared to old CO fed mice (11.2 ± 1.9 vs. 46.4 ± 7.0 respectively) (p=0.032). Our results indicate a potential mechanism for the therapeutic use of FO in elderly asthmatics. Current work is investigating the role of other pathogenic mediators. Supported by USDA contract # 58‐1950‐7‐707.