An emerging area of research points to an inverse association between social integration and risk for dementia. However, social integration measures in this literature are limited. The current study uses an egocentric network design wherein detailed data are collected on the specific individuals to whom subjects are connected, and on ties between them. The Social Networks in AD (SNAD) protocol was designed to examine associations between social network dynamics (size, density, composition, strength, supportiveness) and disease-associated factors. We administered SNAD to 82 cognitively normal (CN), 23 mild cognitive impairment (MCI), and 16 Alzheimer's disease (AD) subjects from the Indiana Alzheimer's Disease Center. Bivariate statistics were used to identify significant associations. Network characteristics varied significantly across diagnostic groups (df=2; Table 1 and Figure 1). CN individuals reported networks that were larger (p<.05) and less densely-connected (p<.01) than those with MCI or AD, and networks that contained affectively weaker ties (p<.01) and proportionally more friends versus kin (p<.05). Moreover, correlations revealed positive associations of global cognitive performance (MoCA) with network size (r=0.31; p<.001) and with proportion of friends (r=0.23; p<.001). MoCA performance was negatively correlated with network density (r=-0.23; p<.01) and mean tie strength (r=-0.30; p<.001). We observed similar patterns in all cognitive domains except visuospatial. Verbal memory (Craft Story Delayed Recall) was associated with larger (r=0.27; p<.01), less dense (r=-0.20; p<.05), and weaker networks (r=-0.21; p<.05). Executive function (Trail Making Test B) was more impaired in those with smaller networks (r=0.24; p<.01). Finally, subjects with larger networks (r=0.20; p<.05) composed of weaker ties (r=-0.22; p<.05) performed better on an attention task (Digit Span Test). We found more homogenous, insular, and kin-centered networks in MCI and AD relative to CN. Access to social resources through networks may create conditions that are protective of cognitive decline. Alternatively, our data may support a social contraction mechanism, wherein weaker ties to non-kin decay in the context of cognitive decline. Typical core network structure, function*, and composition by clinical cognitive status. *Note: Strength of tie denoted by thickness of black circle.
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