PURPOSE: To determine the influence of directional compression core shorts on self-reported measures of pain and fatigue and maximum driving distance during repeated, maximum-effort golf drives. METHODS: Nine participants with an average PGA handicap of 1.2 (range: 0 to 3) performed 52 drives on an outdoor driving range: 12 practice drives, 20 drives with a driver, 20 drives with a 6 iron. Half of the drives were performed while wearing directional compression core shorts (DCP). Visual analog scores (VAS, 150 mm) for low back pain (LBP), low back muscle fatigue (LBF), quadriceps fatigue (QF) and total fatigue (TotF) were measured at the beginning and end of each 26 trial condition (none, DCP). A launch monitor was used to measure carry distance. Two-way repeated measures ANOVA were computed to contrast the VAS (compression (none, DCP); time (pre, post)) variables. Carry distance was measured with a launch monitor and the maximum carry distance was contrasted with a repeated measures ANOVA between conditions for each club. The coefficient of variation and Cronbach’s Alpha were computed to determine the reliability of carry distance for each club (driver, 6 iron) and condition (none, DCP). RESULTS: Significant time by compression statistical interactions were found for LBF (p=.019), QF (p=.046) and TotF (p=.033). The pre-to-post change in these variables were 57%, 75%, and 57% lower during the DCP condition for LBF (none, 14.6 ± 10.9%; DCP, 6.2 ± 8.0%), QF (none, 7.9 ± 9.6%; DCP, 2.0 ± 4.8%) and TotF (none, 14.9 ± 12.0%; DCP, 6.4 ± 8.7%). Maximum carry distance was not different between conditions for the 6 iron (p=.777; none, 268.6 ± 14.6 yards; DCP, 268.0 ± 17.1 yards) or driver (p=.916; none, 183.0 ± 9.4 yards; DCP, 183.1 ± 9.1 yards). Reliability for the 6 iron drives were .881 and .976 for none and DCP conditions whereas the driver drives were .962 and .975, respectively. The coefficient of variation measurements were 5.6 ± 4.0% and 4.4 ± 1.5% for the 6 iron drives during the none and DCP conditions whereas the variation for the driver drives were 2.8 ± 0.9% and 2.8 ± 1.3%. CONCLUSION: Directional compression core shorts improved self-reported measures of low back, quadriceps and total body muscle fatigue but did not influence carry distance when performing golf drives with a 6 iron or driver.