Copy Scores Research Articles

A - 11 Organizational Strategies and Delayed Recall in Older Adults: Insights from the Rey-Osterrieth Complex Figure Test

Abstract Objective The objective of this study was to investigate the factors that influence older adults’ ability to recall complex figure in the Rey-Osterrieth Complex Figure (ROCF) test. Method 172 participants (50% female; M = 74.64) between the ages of 60 and 100 were recruited through the Israel Interior Ministry. Participants were asked to complete the Rey-Osterrieth Complex Figure Test (ROCF), which involved two tasks: A) participants were first instructed to replicate the complex figure exactly as shown (copy task). Subsequently, they were asked to B) recall and redraw the figure after a 30-minute delay (delayed recall task). The evaluations were conducted at the participants’ homes. The participants were evaluated on three criteria: accuracy, continuation, and the symmetry. To analyze the relationship between participants’ scores on the accuracy, continuation, and symmetry, a linear regression analysis was performed. Results A linear regression model predicting delayed recall score was significant F(3,48) = 9.61, p < 0.001. Among the predictors, continuation (b = 0.75, p = 0.01) and copy scores (b = 0.39, p 0.02) displayed a significant positive relationship with delayed recall score. Conclusion(s) The ROCF test serves as a comprehensive measure of cognitive functions, such as visuospatial memory, executive and organizational abilities, and retrieval. The significant influence of organizational score underscores the important link between planning abilities and declarative memory. This supports previous findings that organizing ROCF into meaningful clusters of units during the copy task improves performance in delayed recall task.

Using Deep Learning Techniques as an Attempt to Create the Most Cost-Effective Screening Tool for Cognitive Decline.

This study aimed to use deep learning (DL) to develop a cost-effective and accessible screening tool to improve the detection of cognitive decline, a precursor of Alzheimer's disease (AD). This study integrating a comprehensive battery of neuropsychological tests adjusted for individual demographic variables such as age, sex, and education level. A total of 2,863 subjects with subjective cognitive complaints who underwent a comprehensive neuropsychological assessment were included. A random forest classifier was used to discern the most predictive test combinations to distinguish between dementia and nondementia cases. The model was trained and validated on this dataset, focusing on feature importance to determine the cognitive tests that were most indicative of decline. Subjects had a mean age of 72.68 years and an average education level of 7.62 years. The DL model achieved an accuracy of 82.42% and an area under the curve of 0.816, effectively classifying dementia. Feature importance analysis identified significant tests across cognitive domains: attention was gauged by the Trail Making Test Part B, language by the Boston Naming Test, memory by the Rey Complex Figure Test delayed recall, visuospatial skills by the Rey Complex Figure Test copy score, and frontal function by the Stroop Test Word reading time. This study showed the potential of DL to improve AD diagnostics, suggesting that a wide range of cognitive assessments could yield a more accurate diagnosis than traditional methods. This research establishes a foundation for future broader studies, which could substantiate the approach and further refine the screening tool.

Chromosomal-level genome assembly of the long-spined sea urchin Diadema setosum (Leske,1778).

The long-spined sea urchin Diadema setosum is an algal and coral feeder widely distributed in the Indo-Pacific that can cause severe bioerosion on the reef community. However, the lack of genomic information has hindered the study of its ecology and evolution. Here, we report the chromosomal-level genome (885.8Mb) of the long-spined sea urchin D. setosum using a combination of PacBio long-read sequencing and Omni-C scaffolding technology. The assembled genome contains a scaffold N50 length of 38.3Mb, 98.1% of complete BUSCO (Geno, metazoa_odb10) genes (the single copy score is 97.8% and the duplication score is 0.3%), and 98.6% of the sequences are anchored to 22 pseudo-molecules/chromosomes. A total of 27,478 gene models have were annotated, reaching a total of 28,414 transcripts, including 5,384 tRNA and 23,030 protein-coding genes. The high-quality genome of D. setosum presented here is a valuable resource for the ecological and evolutionary studies of this coral reef-associated sea urchin.

A cross-sectional study on the effect of altered sleep patterns on working memory among nursing professionals

Background: Sleep is a critical component of existence and vital for the rejuvenation of the body. A minimum of 7 h of sleep is needed for adults for optimal wellness. In the present condition, extended periods of wakefulness are a common occurrence. Such wakefulness can be acute total sleep deprivation or chronic partial sleep restriction. Both forms can negatively impact cognitive abilities. It is prevalent among nursing professionals, who play a vital role in health care, remaining alert during working hours, especially night shifts. Aims and Objectives: This study aims to examine the effects of altered sleep patterns on working memory among nursing personnel working day and night shifts. Materials and Methods: The necessary documents for conducting the study were obtained from the institution and the participants. For this cross-sectional study, 31 nursing staff, age group of 25–40 years, males – six, and females – 25 were chosen according to the selection criteria. They were posted to wards on rotational day and night shifts. Rey–Osterrieth figure copy and recall test (Rey–Osterrieth complex figure test [ROCF]) was used for assessing working memory. The performance was based on a copy score and a recall score. Results: A paired “t” test with one-way repeated within the subject analysis of variance test was applied for analysis. Recall scores of ROCF were significantly less. Copy scores of ROCF were also less but statistically insignificant. Conclusion: The present study showed that the recall scores were significantly less in nursing professionals at the end of the night shift duration indicating poor working memory.

Visuospatial Dysfunction in Alzheimer’s Disease Maps to a Network Centered on the Inferior Parietal Lobule

AbstractBackgroundVisuospatial dysfunction is the predominant symptom in ∼5% of patients with Alzheimer’s disease (AD) and common in amnestic patients. If we can predict which patients are more likely to have trouble with visuospatial functioning, we can intervene earlier to prevent falls and car accidents and improve quality of life.MethodThere were 184 subjects with AD in the Alzheimer’s Disease Neuroimaging Initiative database with MRI scans and clock‐draw and clock‐copy scores ranging from 1‐5. Atrophy was defined as thinner than expected compared to age and sex matched controls. Subject network maps were generated averaging connectivity to each atrophied vertex using the normative connectome. Maps were compared to their behavioral scores generating behavior specific network maps. Atrophy networks were directly compared to a similar network generated from clock‐draw and stroke subjects.ResultAtrophy did not correlate with clock‐draw and ‐copy scores but atrophy networks identified distinct distributed brain networks. Clock‐copy scores directly correlate with atrophy connected to the bilateral angular and visuomotor gyri, which were also hubs of the network derived from stroke and clock‐draw scores.ConclusionThese results suggest that visuospatial dysfunction in AD does not occur due to atrophy in a single brain region but a distributed brain network. The concordance between atrophy in AD and stroke suggest that atrophy network mapping is a valid measure of connectivity underlying visuospatial dysfunction in AD.

Executive function performance depends on hypertension in individuals with sub‐threshold total Hachinski score

AbstractBackgroundThe Hachinski Ischemia Scale (HIS) differentiates AD and vascular dementia and is used to include individuals with minimal vascular risk factors in ADNI i.e., HIS ≤ 4. HIS score includes history of hypertension (HMHYPERT), a known risk for mild cognitive impairment (MCI) and vascular dementia. Cerebrovascular disease affects performance on tasks involving executive function, such as, planning and processing speed more than memory. Here, we determined if HMHYPERT scores influences executive functioning in all ADNI3 participants with normal cognition (CN) and MCI even with minimal vascular risks.MethodWe included a total of 272 participants (102 MCI, age = 74± 8 [42F, 50 HMHYPERT>0], MoCA = 23 ±3 and 170 CN, age = 73 ±6, [109F, 62 HMHYPERT>0], MoCA = 26 ±3), who underwent HIS, Trails Making Test B, Clock Drawing and Copy scores for executive function, and The Rey Auditory Verbal Learning Test (RAVLT) and Logical Memory Test (LOGMEM) scores for memory performance within 12 months. We converted both memory tests into z‐scores and created a composite memory score. Similarly, we created a composite executive function score. To determine if HMHYPERT was associated particularly with executive function, we ran the linear regression analyses twice for the two composite cognitive scores. The following model was used: Composite score ∼ Normalized Age + Sex + Cognitive status * HMHYPERT.Result Executive function: Fig. 1 A shows scores for Trails B, Clock Draw and Clock Copy. The regression analysis showed that executive function was associated with only sex and HYMHYPERT (p<0.05).Memory function Fig. 1 B shows scores for Logical Memory and RAVLT tests in CN and MCI. As expected, MCI groups demonstrate the lowest averages compared to CN groups. As expected, regression analysis showed that memory performance was strongly determined by diagnostic status (p<0.001). Age was significantly associated with memory performance (p<0.05). HMHYPERT was only marginally significantly associated with memory performance (p = 0.08).ConclusionUsing HMHYPERT score as a measure of vascular risk, we observed notable differences in executive function. Although HIS scores ≤ 4 minimize vascular pathology in ADNI3, cognitive performance is still associated with these scores.

Utility of Mini‐Mental State Examination items to detect objective memory impairment in mild cognitive impairment

AbstractBackgroundAlzheimer’s disease (AD) is the main cause of cognitive impairment in late‐life, and the typical early presentation of AD in older adults is amnestic cognitive impairment. Mini‐Mental State Examination (MMSE) is widely used in screening cognitive impairment in elderly. The aim of this study was to examine which MMSE items would be more associated with the verbal memory impairment in individuals with mild cognitive impairment (MCI).Method249 MCI subjects (mean age: 73.67 ± 6.79 years) were included in this study. The participants underwent clinical assessments and completed detailed neuropsychological tests. The participants were divided into two groups according to Seoul Verbal Learning Test Delayed Recall (SVLT DR) scores: normal verbal memory performance (SVLT DR > = ‐1.5 SD) vs low verbal memory performance (SVLT DR < ‐1.5 SD) groups. Group comparisons between normal and low verbal memory performance were performed. In addition, associations between verbal memory performance and MMSE items were analysed.ResultLow verbal memory performance group (n = 91) had more males and a tendency to be older and more educated than normal verbal memory performance group (n = 158). For MMSE items, low verbal memory performance group had lower MMSE time orientation and lower MMSE recall subscores, and a tendency of higher MMSE copy score than normal verbal memory performance group. Multivariable analyses showed that male sex, MMSE time orientation and MMSE recall scores were associated with lower verbal memory performance.ConclusionIn MCI individuals, male sex, and MMSE time orientation and recall subscores among demographics and MMSE items were associated with low verbral memory performance. These results suggest that more consideration for MMSE sub‐items would be helpful for the clinical evaluation of individuals with MCI at first step.

Using digital assessment technology to detect neuropsychological problems in primary care settings.

Screening for neurocognitive impairment and psychological distress in ambulatory primary and specialty care medical settings is an increasing necessity. The Core Cognitive Evaluation™ (CCE) is administered/scored using an iPad, requires approximately 8 min, assesses 3- word free recall and clock drawing to command and copy, asks questions about lifestyle and health, and queries for psychological distress. This information is linked with patients' self- reported concerns about memory and their cardiovascular risks. A total of 199 ambulatory patients were screened with the CCE as part of their routine medical care. The CCE provides several summary indices, and scores on 44 individual digital clock variables across command and copy tests conditions. Subjective memory concerns were endorsed by 41% of participants. Approximately 31% of participants reported psychological distress involving loneliness, anxiety, or depression. Patients with self-reported memory concerns scored lower on a combined delay 3- word/ clock drawing index (p < 0.016), the total summary clock drawing command/ copy score (p < 0.050), and clock drawing to command Drawing Efficiency (p < 0.036) and Simple and Complex Motor (p < 0.029) indices. Patients treated for diabetes and atherosclerotic cardiovascular disease (ASCVD) scored lower on selected CCE outcome measures (p < 0.035). Factor analyses suggest that approximately 10 underlying variables can explain digital clock drawing performance. The CCE is a powerful neurocognitive assessment tool that is sensitive to patient's subjective concerns about possible decline in memory, mood symptoms, possible cognitive impairment, and cardiovascular risk. iPad administration ensures total reliability for test administration and scoring. The CCE is easily deployable in outpatient ambulatory primary care settings.

18 Illustrating Alzheimer's: The Role of Visuospatial Abilities in Figure Copying

Objective:Due to the pathology of Alzheimer's disease (AD), it is not uncommon for patients to struggle with cognitive tasks involving figure copying. However, figure copying requires involvement from multiple other domains, including visuospatial and frontal-executive abilities. Less clear is whether figure copying performance, as measured by the Rey-Osterrieth Complex Figure (ROCF), is more affected by visuospatial or frontal-executive compromise in patients with AD. This study aims to discover whether performance on the ROCF varies more with executive or visuospatial abilities in patients with AD.Participants and Methods:A total of 156 patients (79 women, M age = 77.82, M education = 14.21) diagnosed with Alzheimer's disease (AD) participated in comprehensive neuropsychological assessment as part of outpatient neurology evaluations. In addition to the ROCF Copy trial, participants completed measures of visuospatial function (WAIS-IV Block Design &amp; Picture Completion) and frontalexecutive functioning (Trails B, DKEFS Inhibition, WAIS-IV Similarities).Results:Canonical correlations revealed that ROCF Copy was significantly and positively related to the set of tests measuring visuospatial functioning, p &lt; .001, and frontal-executive functioning, p &lt; .001. Post-hoc bivariate correlations showed significant positive correlations between ROCF Copy and each visuospatial, ps &lt; .01, and each frontalexecutive, ps &lt; .04, measure. The relationship between ROCF Copy and each visuospatial measure was significantly stronger than the relationship between ROCF Copy and every frontal-executive measure except WAIS-IV Similarities, ps &lt; .01. Those with visuospatial impairment (&gt;1.5 SD) performed significantly worse on the ROCF Copy than those without impairment, p &lt;.01. This difference persisted even when the effects of frontal-executive measures were controlled, p &lt; .01. In contrast, those with frontal-executive impairment did not perform significantly worse on the ROCF Copy than those without frontal-executive impairment, p &lt; .01. This did not change when controlling for the effects of visuospatial measures. Finally, the significant difference in ROCF Copy between those with mild cognitive impairment (MCI) and those with dementia (p &lt; .01) disappeared when visuospatial measures were controlled, but it remained when frontal-executive measures were covariates, p &lt; .03.Conclusions:These findings suggest the figure copying of those with AD is significantly related to both their visuospatial and frontal-executive functioning, but the relationship with visuospatial functioning is stronger. Impairment in visuospatial, but not frontal-executive, functions, seems to have a negative impact on the figure copying of those with AD, and performance on visuospatial compared to frontal-executive measures better accounts for the weaker ROCF Copy scores among those with dementia relative to MCI. Therefore, the pathological effects of AD on figure copying appear to occur predominantly through visuospatial rather than frontalexecutive channels, and interventions for offsetting decline in figure copying may be most effective when targeting visuospatial abilities, such as visual perception and visual construction.

84 Using a Combination Score from the Full Rey Complex Figure Test (RCFT) as a Performance Validity Measure (PVT)

Objective:Some RCFT indices are effective Performance Validity Test (PVTs) during neuropsychological evaluations. A combination score that includes the copy score, true positive recognition, and atypical errors has proven to be especially useful (see Lu et al, 2003). However, this score was derived from administration that deviated from protocols outlined by Meyers &amp; Meyers (1995) in that the Recognition trial was administered after the 3-minute delay instead of the 30-minute delay. The current study examined the utility of the RCFT combination score as a performance validity test (PVT) when completing the recognition trial after the 30-minute delay.Participants and Methods:This study utilized archival data from 298 Veterans who presented for a clinical neuropsychological evaluation at a southern Veterans Affairs Medical Center. The evaluation included up to nine PVTs and all trials of the RCFT (per Meyers &amp; Meyers, 1995). Patients were considered credible if all PVT performance fell within normal limits. This resulted in 232 patients in the credible group (Mage = 52.9 years, SDage = 15.2, Medu = SDedu = 2.5, 88% male, 71.2% White, 28.3% Black/African American). Patients were considered non-credible if they failed &gt;2 PVTs. This resulted in 66 patients in the non-credible group (Mage = 51.6, SDage = 13.79, Medu = SDedu = 2.4, 92.4% male, 56.1% White, 43.9% Black/African American). Group assignment was also clinically confirmed. Receiver operating characteristic (ROC) curve analyses were conducted to discriminate between credible and non-credible groups utilizing the established RCFT combination score.Results:RCFT combination scores distinguished groups, with credible participants scoring higher than non-credible participants (F[1, 296]=63.76, p&lt;.001, d=1.11; M = 56.9, SD = 9.3 vs. M = 46.5, SD = 9.5, respectively). A ROC analysis indicated AUC = .800 (95% CI = .73 to .86). When specificity was set at &gt;90%, a cut-score of &lt;46.5 yielded sensitivity at 46.0%. The analogous cut-score from the Lu et al. (2003) study (i.e., &lt;47) was associated with a specificity of 88.7 and sensitivity of 46.0% in the current study.Conclusions:As the Lu et al. (2003) established the combination score of the RCFT with procedures that deviated from the standardized protocol outlined by Meyers and Meyers (1995), clinicians who opted to adhere to Meyers and Meyers’ full protocol may have concerns about using the combination score as a PVT. The current study established a similar cut-off score to what Lu et al., (2003) reported (i.e., &lt;46.5 vs. &lt;47) while following a different administration procedure of the RCFT. Also, the index was moderately sensitive in the current study (i.e., 45.5%) but less so than what Lu et al. reported when using a cut-score that had &gt;90% specificity (i.e., 75.9% sensitivity). This suggests that the index may be robust to deviations in administration procedures. Difference in sensitivity could be related to difference between samples. As the current sample was derived from a clinical, VA setting, current findings extend the generalizability of the index. Future research would benefit exploring if any subgroups would benefit from adjusted cut-scores to reduce the risk of false positive identification.

Melanoma Skin Cancer Detection using Image Processing

Abstract: Early detection of melanoma skin cancer is crucial for effective treatment. Melanoma is considered the most dangerous form of skin cancer due to its higher likelihood of spreading to other parts of the body if not diagnosed and treated promptly. To address this challenge, non-invasive medical computer vision and medical image processing techniques have become increasingly important in clinical diagnosis of various diseases, including melanoma. These techniques offer automated image analysis tools that enable accurate and rapid evaluation of skin lesions.To assess the severity of the lesions, a total dermo copy score was calculated based on the extracted features. Finally, classification was carried out using a convolutional neural network (CNN) model. The results of the study demonstrated a high classification accuracy of 96.5%, indicating the effectiveness of the proposed approach in accurately identifying melanoma skin cancer.

Skin Cancer Detection using Image Processing

Abstract: Early detection of melanoma, the most dangerous form of skin cancer, is crucial for effective treatment. Melanoma has a higher propensity to metastasize to other parts of the body if not identified and treated promptly. In recent years, non-invasive medical computer vision and medical image processing techniques have emerged as valuable tools in clinical diagnosis for various diseases, including melanoma. These techniques enable automatic image analysis, facilitating accurate and efficient evaluation of skin lesions. The study follows a systematic approach, involving the collection of a dermo image database and preprocessing steps such as segmentation using thresholding. Statistical feature extraction methods, including gray level cooccurrence matrix (GLCM), glam asymmetry, border analysis, color assessment, and diameter calculation, are utilized. Principal component analysis (PCA) is employed for feature selection to reduce dimensionality. A total dermo copy score is calculated, followed by classification using a convolutional neural network (CNN). The results indicate an impressive classification accuracy of 92.1%.

Skin Cancer Detection using Image Processing

Abstract: Early detection of melanoma skin cancer is crucial for effective treatment. Among various types of skin cancer, melanoma is considered the most dangerous due to its high likelihood of spreading to other parts of the body if not diagnosed and treated promptly. In recent years, non-invasive medical computer vision and medical image processing techniques have gained significant importance in clinical diagnosis. These techniques offer automated image analysis tools that enable accurate and rapid evaluation of skin lesions. The study involves several steps, including the collection of a dermo image database, preprocessing, segmentation using thresholding, and extraction of statistical features such as gray level co-occurrence matrix (GLCM), asymmetry, border color, and diameter. Feature selection is performed using principal component analysis (PCA), followed by the calculation of a total dermo copy score. The final step involves classification using convolutional neural networks (CNN). The results of the study indicate an impressive classification accuracy of 96.5%.

The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study

ObjectiveSensitive cognitive markers are still needed for frontotemporal dementia (FTD). The Benson Complex Figure Test (BCFT) is an interesting candidate test, as it assesses visuospatial, visual memory, and executive abilities, allowing the detection of multiple mechanisms of cognitive impairment. To investigate differences in BCFT Copy, Recall and Recognition in presymptomatic and symptomatic FTD mutation carriers, and to explore its cognitive and neuroimaging correlates. MethodWe included cross-sectional data from 332 presymptomatic and 136 symptomatic mutation carriers (GRN, MAPT or C9orf72 mutations), and 290 controls in the GENFI consortium. We examined gene-specific differences between mutation carriers (stratified by CDR® NACC-FTLD score) and controls using Quade's / Pearson Χ2 tests. We investigated associations with neuropsychological test scores and grey matter volume using partial correlations and multiple regression models respectively. ResultsNo significant differences were found between groups at CDR® NACC-FTLD 0–0.5. Symptomatic GRN and C9orf72 mutation carriers had lower Copy scores at CDR® NACC-FTLD ≥2. All three groups had lower Recall scores at CDR® NACC-FTLD ≥2, with MAPT mutation carriers starting at CDR® NACC-FTLD ≥1. All three groups had lower Recognition scores at CDR® NACC FTLD ≥2. Performance correlated with tests for visuoconstruction, memory, and executive function. Copy scores correlated with frontal-subcortical grey matter atrophy, while Recall scores correlated with temporal lobe atrophy. ConclusionsIn the symptomatic stage, the BCFT identifies differential mechanisms of cognitive impairment depending on the genetic mutation, corroborated by gene-specific cognitive and neuroimaging correlates. Our findings suggest that impaired performance on the BCFT occurs relatively late in the genetic FTD disease process. Therefore its potential as cognitive biomarker for upcoming clinical trials in presymptomatic to early-stage FTD is most likely limited.

Abstract TMP36: Determining The Association Between Characteristics Of Congestive Heart Failure And Cognition

Introduction: It is not well known if specific measures of congestive heart failure (CHF) severity are associated with cognitive performance. We therefore aim to determine if there is an association between CHF characteristics and cognitive test scores, controlling for risk factors. Methods: 230 CHF outpatients presenting to an outpatient CHF clinic with no dementia, preceding transthoracic echocardiogram (TTE) within 1 year, and ability to provide consent were included. A trained psychometrist administered the Mini Mental State Exam (MMSE), Rey Complex Figure (RCF) Copy and Immediate Recall test, and Letter Number Sequencing (LNS) test. The New York Heart Association (NYHA) heart failure classification and heart failure type (HFpEF vs HFrEF) were collected at time of consent and verified with medical records. Two measures of diastolic function (deceleration time (DT), E/A ratio) were collected from TTEs. Multivariable linear regression models were used to estimate the association between each cardiac function measure and cognitive test (Z scores), adjusted for confounders, in distinct models. Results: Patients were mean age 67 years (SD 13.6), 34% Black, and 49% female. Median time from TTE to cognitive test was 97 days (IQR 31.5 - 198). NYHA class 3-4 patients had on average a worse LNS score when compared to NYHA class 1-2 patients, which remained significant after adjusting for covariates (β: -0.52; 95%CI: -0.87, -0.17). A worse NYHA class was associated with a worse RCF copy score, but only in univariate analysis (Table 1) and not with RCF immediate recall. HFpEF was associated with a worse immediate recall but not after adjustment. Diastolic dysfunction measures had no association with any cognitive test, nor any CHF measure with MMSE. Conclusion: In a cohort of CHF patients, we found an association between a worse stage of heart failure and worse performance on some, but not all cognitive tests. These data suggest that brain health is a critical outcome in CHF care.

A-295 Visuospatial Skills of Adolescents Involved in Prostitution

Abstract Objective: Adolescents involved in prostitution are exposed to traumatic experiences with long-term adverse effects including symptoms of posttraumatic stress disorder (PTSD). Maltreated children tend to perform poorly on tasks of visuospatial orientation. We hypothesized that adolescents who had been involved in prostitution would have weak visuospatial skills and that those with a diagnosis of PTSD would have worse visuospatial skills than those without a diagnosis of PTSD. Method: Due to academic concerns, comprehensive neuropsychological assessment was conducted in a community mental health center with 22 adolescents (21 female and one trans to female) who had been involved in prostitution. Visuospatial skills were measured using the Rey-Osterrieth Complex Figure Test (ROCF). IQ ranged from 72 to 112 (M = 85.4, SD = 13.27). Sixteen out of the 22 participants were diagnosed with PTSD. Results: Adolescents involved in prostitution scored significantly lower on the copying trial of the ROCF (M = 24.2, SD = 7.89) than the normative sample (M = 33.6, SD = 2.98), t = -5.60, p &amp;lt;.001. However, the results revealed no significant difference on ROCF copy scores between participants diagnosed with PTSD (M = 24.69, SD = 6.41) and those not diagnosed with PTSD (M = 22.84, SD = 11.62), F(1, 20) = 0.23, p = 0.64, even controlling for age and intellectual functioning. Conclusion: The findings suggest that adolescents who experienced the trauma of prostitution may have deficiencies in visuospatial functioning, regardless of PTSD diagnosis. Thus they may distort environmental information, leading to poor decision-making.

Qualitative evaluation of the Rey-Osterrieth Complex Figure Test in patients with progressive supranuclear palsy

Objective: In early stages of disease, the differential diagnosis between Parkinson’s Disease (PD) and atypical parkinsonism, such as Progressive Supranuclear Palsy (PSP), could be challenging. Growing attention has recently been dedicated to investigating neuropsychological markers of degenerative parkinsonism. The Rey-Osterrieth Complex Figure Test (ROCFT) copy score was hypothesized able to differentiate PSP from PD. However, ROCFT is a drawing test requiring multiple cognitive abilities and it is still unknown which of them assumes an important role in PSP performance. Using a qualitative scoring system, we investigated which cognitive abilities underpin the PSP performance at the ROCFT copy trial. Moreover, we evaluated usefulness of the BQSS scores in discriminating PSP from PD. Methods: Thirty PSP-Richardson’s Syndrome (PSP-RS) patients, 30 PD patients, and 30 healthy control (HC) comparable for age, education, and gender were enrolled. All subjects underwent a neuropsychological evaluation; ROCFT copy were evaluated with the 36-Point Score and with the Boston Qualitative Scoring System (BQSS). Results: PSP-RS patients performed worse in ROCFT 36-Point Score and in several BQSS scores compared to other groups. Most suitable scores discriminating PSP-RS from PD were “Perseveration” and “Vertical Expansion” of BQSS. A logistic regression model considering “Perseveration” and “Vertical Expansion” showed a diagnostic accuracy of 83,3% for PSP-RS condition. Conclusion: our findings showed that “Perseveration” and “Vertical Expansion” BQSS scores were useful in discriminating PSP-RS from PD. “Perseveration” and “Vertical Expansion” BQSS scores might be included in the cognitive evaluation along with quantitative scores when PSP diagnosis is considered.

Bender-Gestalt II Test: Psychometric Properties with Global Scoring System on a Turkish Standardization Sample

ABSTRACT The present study aims to standardize the Bender-Gestalt II Test by exploring its psychometric properties on a Turkish sample between the ages of 4 and 17 years and to obtain its normative values. The standardization sample consisted of 2691 students aged 4.0–17.11 years/months from low, middle, and high socioeconomic statuses, attending preschool, primary, and high school education. The participants were administered the Bender-Gestalt II Test and other tests, including the Gesell Developmental Schedules test, Colored Progressive Matrices Test, Goodenough Draw-a-Man Test, Test of Nonverbal Intelligence, Raven Standard Progressive Matrices Test, and Visual-Aural Digit Span Test-Revised Form, according to their age groups. The results revealed the absolute agreement values of the Copy items to be between .87 and .98. Thereafter, we calculated the test-retest reliability coefficients of the Copy scores to range from .74 to .67 by age groups, while the split-half reliability coefficients for each age group were between .62 and .87. The results of the exploratory and confirmatory factor analyses suggested its single-factor structure for all age groups. The Copy scores showed significant correlations and predicted the criterion characteristics, which include general cognitive ability, mental development/fine motor skills, short-term memory, and attention. Overall, the present study confirmed that the Bender-Gestalt II Test is a valid, reliable, and standardized measure to evaluate the visual-motor integration ability of those aged 4.0–17.11 years/months.

Comparing and analysing working memory and its adjustments with classical instrumental background music in adolescents of diverse ethical origin – An RCT

Students use variety of music while studying. The aim was to analyse effect of instrumental, background music on working memory in medical students of Indian and Malaysian origin.Age and gender matched 120 1st-year MBBS students (60 Indian and 60 Malaysian), were randomised into music and control groups equally. Music used was non vocal flute, raga malkauns. After 5 min of music/rest, working memory was assessed using Rey-Ostherrieth-complex-figure-test (ROCF). After another concentration task(SDMT) and a gap of 25min, recall of figure was assessed. Copy and recall figures were scored for 36 points.(significant p value&amp;#60;0.05).There was no statistical difference between copy and recall score of ROCF when compared between music and control group of both ethnicities (p=0.223). Malaysian students performed significantly better in copy and recall score compared to Indian students.Instrumental music does not seem to influence working memory, but it does not hamper it too. As a diverse population, Malaysian students are bestowed with efficient working memory than Indian students. Music has no differential influence on the working memory of the two ethnic groups. Students can be advised to use instrumental music, preferably of raga Malkauns, in background while studying which will not hamper their retention.

DETECTION OF SKIN CANCER DISEASE USING DEEP LEARNING ALGORITHM

Early detection of melanoma skin cancer is important for a person effective treatment. Recently, it is well-known that the most dangerous type of skin cancer is other types of skin cancer.Melanoma because it may spread to other are asif you are not diagnosed and treated early. Non-invasive computer vision or medical imaging play an important role in the clinical identification of various diseases. Such techniques that provide an automatic image analysis tool for accurate measurement and quick wound testing. Steps involved in this. The study collects dermos copy image data, preliminary processing, division using threshold, mathematical element domain using Gray Level Cooccurrence Matrix (GLCM), Asymmetry, Border, Color, Scope, (ABCD) etc., feature selection using Principal section (PCA) ), to calculate the value Dermos copy Score then differentiate using Convocation neural network (CNN).the results show that the accuracy of the categories obtained is 92.1