BackgroundParkinson’s disease (PD) is a neurodegenerative disease characterized by tremor, stiffness, and slowness of movement. Many studies showed an abnormality of functional connectivity in different brain regions at rest. In this study, we aimed to investigate the linear and non-linear connectivity of individual regions to differentiate PD from healthy control. Materials and methodsResting-state fMRI data from 25 Parkinson's individuals and 18 healthy individuals were randomly obtained from the PPMI database. Brain regions involved in the movement and basal ganglia were defined as regions of interest. Functional connectivity between these regions was assessed using correlation, and five types of copula family test (linear and non-linear). Discriminative features were selected from different copula parameters and correlation coefficients statistically and used in the discriminant analysis by clustering and classification methods. ResultsWe find non-linear connections, which may be used as the distinguishing characteristics of PD from controls. The strongest of these were related to the non-linear relationship between the left motor cortex and the right prefrontal cortex, which resulted from three non-linear families of the copula (Gumbel, Frank, Clayton). The best result of k-fold classification belonged to Frank copula with 97.67% accuracy in differentiating PD from healthy controls. ConclusionWe found that non-linear copula tests are superior to simple linear correlation calculation in identifying changes of functional connectivity in PD.