Purpose This paper aims to examine the Dufour and Soret combined effects on the study of two-dimensional squeezed flow of copper water nanofluid between parallel plates along with applied (external) magnetic field. Impact of higher order chemical reaction is also considered. Design/methodology/approach The nonlinear partial differential equations (PDEs) are changed into system of ordinary differential equations (ODEs) by employing suitable similarity transformations. These transformed ODEs are then solved by means of a semianalytical method called differential transform method (DTM). Effects of several changing physical parameters on fluid flow, temperature and concentration have been deliberated through graphs. Findings It is observed that Dufour and Soret numbers are directly related to temperature profile and a reverse trend was observed in the concentration profile. Temperature enhancement is perceived for the enhanced Dufour number. Enhancement in Dufour number shows a direct association with Sh and Nu for all values of squeezing parameter. Practical implications The combined Dufour and Soret effects are used in separation of isotopes in mixture of gases, oil reservoirs and binary alloys solidification. The squeeze nanoliquid flow can be used in the field of composite material joining, rheological testing and welding engineering. Social implications This study is mainly useful for geosciences and chemical engineering. Originality/value The uniqueness in this research is the study of the impact of cross diffusion on chemically reacting squeezed nanoliquid flow with the chemical reaction order more than one in the presence of applied magnetic force using a semianalytical procedure, named DTM.