Copper Nanocomposites Research Articles

Duchsnea indica plant extract mediated synthesis of copper oxide nanomaterials for antimicrobial activity and free-radical scavenging assay

Green synthesis of metallic nanoparticles has developed into a key topic in nanotechnology due to its potential in the development of new technologies. The method described in current study is safe for the environment and doesn't include any harmful components. Chitosan and the aromatic medicinal herb Duchsnea indica have been combined to produce environmentally friendly copper oxide nanoparticles and nanocomposites (CuO NPs/NCs). Their synthesis was verified by UV–Visible spectroscopy, FT-IR, X-ray diffraction (XRD), EDX, and TEM analysis. The FTIR spectra of the CuO NPs/NCs showed the presence of functional groups, such as phenolic and flavonoids that may convert Cu2+ ions into CuO NPs/NCs. The XRD pattern indicates that CuO NPs/NCs are crystalline, and have a face-centered cubic (FCC) crystalline structure. TEM analysis revealed that particles are having nearly spherical shape with an average size between 2 and 31 nm. The antibacterial activity of these CuO NPs/NCs against Gram-positive, Gram-negative, and fungal infections has been particularly convincing. The lowest MBC values were 91.24 μg/mL and 99.50 μg/mL, whereas the lowest MIC values were 10.30 μg/mL and 10.84 μg/mL, respectively. According to the DPPH scavenging assay, the antioxidant activity of CuONPs/NCs have shown highest degradation potential of 99.31% at a very low concentration of 50 ppm.

Removal of norfloxacin by combining persulfate with nano zero-valent iron modified by activated carbon and copper nanocomposite

Advanced oxidation process (AORs) is an effective method to remove a wide range of organic contaminants. However, an outstanding catalysis is needed to generate more free radicals. In this work, nano zero-valent iron (nZVI) modified with activated carbon and copper (AC-nZVI/Cu) was synthesized by liquid-phase reduction, and used to catalyze persulfate (PS) to remove norfloxacin (NOR). The effect of various factors, such as diverse adsorbents, pH, temperature, PS dosage, adsorbent dosage, and inorganic anions, on NOR removal efficiency were investigated. The results show that 30 mg/L NOR can be easily removed by 0.5 g/L AC-nZVI/Cu at 313 K through activating 0.5 mM PS, and the removal efficiency is as high as 96.84%. The electron paramagnetic resonance (EPR) analysis proves that numerous sulfate free radicals (·SO<sub>4</sub><sup>-</sup>) appear at the initial stage of the removal process. Furthermore, the quenching experiments manifested that ·SO<sub>4</sub><sup>-</sup> was the predominant radical special in acidic conditions, while adsorption of NOR was predominant under alkaline conditions. Importantly, compared with nZVI, AC-nZVI/Cu has excellent long-term stability because of the introduction of activated carbon and copper. The study laid the groundwork for further development of adsorbent and activator based on nZVI.

Untargeted metabolomics to analyze alterations in two-dimensional graphdiyne–copper nanocomposite on the metabolic reprogramming of prostate cancer

Prostate cancer (PCa) is a common type of cancer in men worldwide. Metabolic reprogramming is an important factor in its pathogenesis. Two-dimensional (2D) nanomaterials have tremendous potential for cancer treatment owing to their unique physicochemical properties. However, very few studies have focused on the metabolic reprogramming mechanisms of PCa using 2D nanomaterials. In this study, for the first time, 2D graphdiyne (GDY) was used as a template to immobilize copper (Cu) ions to form a novel nanocomposite (GDY–Cu). GDY provides a large π-conjugated architecture that spatiotemporally restricts Cu ions spatiotemporally to realize the functional moiety of Cu ions as tumor therapeutics. The GDY–Cu nanocomposite with a 2D morphological structure was characterized using a transmission electron microscopy (TEM) and atomic force microscopy. The distribution of Cu loaded on the GDY was confirmed by high-resolution TEM with energy-dispersive x-ray spectroscopy analysis. In vitro and in vivo, GDY–Cu exhibits a good antitumor effect and is associated with specific metabolic reprogramming characteristics of PCa. In this study, the effect of GDY–Cu on the metabolic reprogramming of PCa cells was analyzed using untargeted metabolomics. Differences in metabolites in DU145 cells treated with GDY–Cu were analyzed by clustering and target analysis using bioinformatics methods. GDY–Cu inhibited the growth of PCa cells by decreasing the expression levels of acetyl-CoA carboxylase and cytoplasmic acetyl-CoA synthase, which inhibits the synthesis of related fatty acids and lipid metabolism. These results indicated that GDY–Cu inhibits the growth of PCa cells mainly via lipid metabolic pathways. At present, combinatory therapeutic modalities based on GDY and Cu are in their infancy. Further exploration is required to promote the development of 2D nanocomposite combinatory therapeutic modalities based on metabolic reprogramming.

Prediction of Tribological Properties of Alumina-Coated, Silver-Reinforced Copper Nanocomposites Using Long Short-Term Model Combined with Golden Jackal Optimization

In this paper, we present a newly modified machine learning model that employs a long short-term memory (LSTM) neural network model with the golden jackal optimization (GJO) algorithm to predict the tribological performance of Cu–Al2O3 nanocomposites. The modified model was applied to predict the wear rates and coefficient of friction of Cu–Al2O3 nanocomposites that were developed in this study. Electroless coating of Al2O3 nanoparticles with Ag was performed to improve the wettability followed by ball milling and compaction to consolidate the composites. The microstructural, mechanical, and wear properties of the produced composites with different Al2O3 content were characterized. The wear rates and coefficient of friction were evaluated using sliding wear tests at different loads and speeds. From a materials point of view, the manufactured composites with 10% Al2O3 content showed huge enhancement in hardness and wear rates compared to pure copper, reaching 170% and 65%, respectively. The improvement of the properties was due to the excellent mechanical properties of Al2O3, grain refinement, and dislocation movement impedance. The developed model using the LSTM-GJO algorithm showed excellent predictability of the wear rate and coefficient of friction for all the considered composites.

An enhanced Dendritic Neural Algorithm to predict the wear behavior of alumina coated silver reinforced copper nanocomposites

Due to the lack of analytical solutions for the wear rates prediction of nanocomposites, we present a modified machine learning method named Dendritic Neural (DN) to predict the wear performance of copper-alumina (Cu-Al2O3) nanocomposites that have large applicability in electronics. This modification aims at determining the optimal weights of DN since they have largest influence on its performance. To achieve this improvement a new meta-heuristic technique named Artificial Hummingbird Algorithm (AHA) was used. The modified model was applied to predict the wear rates and coefficient of friction of Cu-Al2O3 nanocomposites that was developed in this study. Electroless coating of Al2O3 nanoparticles with silver (Ag) was performed to improve the wettability followed by ball milling and compaction to consolidate the composites. The microstructural, mechanical and wear properties of the produced composites with different Al2O3 content were characterized. The wear rates and coefficient of friction were evaluated using sliding wear test at different load and speeds. The developed model using AHA algorithm showed excellent predictability of the wear rate and coefficient of friction for Cu-Al2O3 nanocomposites with reinforcement content up to 10%.

Copper and iron based bimetallic nanocomposite: An enhanced and operative phenol sensor

The present manuscript describes the formation of oxide based nanocomposite of copper and iron oxide (CuFeO2NCNPs) nanoparticles. The nanocomposite nanoparticles (NCNPs) were processed via solution process with copper nitrate hexahydrate, iron nitrate nonhydrate and sodium hydroxide as a reducing agent. The chemicals were utilized to form a uniform solution and it refluxed at ∼80 °C for 60 min for the formation of CuFeO2NCNPs and analyzed well with various techniques. It reveals that the NCNPs are in range of 45–50 nm in size with clear spherical shaped morphology with good chemical characteristics. These NCNPs were utilized for to check their sensing performance against phenol, which is a hazardous chemical compound for the environment and human body analysed with glassy carbon electrode (GCE). The electrochemical observations were conducted with cyclic voltammetry (CV) from very low to high concentration range (7.8 μM–1000 μM in PBS) of phenol; effect of scan was analyzed from 5 to 100 mV/s with CuFeO2NCNPs/GCE electrode. The modified sensors reproducibly and sustainability were also identified for a longer period in presence of Phenol (62.5 μM). Based on the results and their discussion a possible mechanism was also presented.

Prominent bactericidal characteristics of silver-copper nanocomposites produced via pulse laser ablation

This paper reports the characterization and antibacterial performance evaluation of some spherical and stable crystalline silver (Ag)/copper (Cu) nanocomposites (Ag-CuNCs) prepared in deionized water (DIW) using pulse laser ablation in liquid (PLAL) method. The influence of various laser fluences (LFs) on the structural, morphological, optical and antibacterial properties of these NCs were determined. The UV–Vis absorbance of these NCs at 403 nm and 595 nm was gradually increased accompanied by a blue shift. XRD patterns disclosed the nucleation of highly crystalline Ag-CuNCs with their face centered cubic lattice structure. TEM images showed the existence of spherical NCs with size range of 3–20 nm and lattice fringe spacing of approximately 0.145 nm. EDX profiles of Ag-CuNCs indicated their high purity. The antibacterial effectiveness of the Ag-CuNCs was evaluated by the inhibition zone diameter (IZD) and optical density (OD600) tests against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. The proposed NCs revealed the IZD values in the range of 22–26 mm and 20–25 mm when tested against E. coli and S. aureus bacteria, respectively. The Ag-CuNCs prepared at LF of 14.15 J/cm2 revealed the best bactericidal activity. It is established that by controlling the laser fluence the bactericidal effectiveness of the Ag-CuNCs can be tuned.

Folded graphene reinforced nanocomposites with superior strength and toughness: A molecular dynamics study

• Folded graphene is designed and generated with the aid of hydrogenation and pre-compression. • Current molecular dynamics simulation model is experimentally and numerically validated. • The designed folded graphene leads to superior strength and toughness simultaneously in copper nanocomposites. • Pre-compressive strain of folded graphene further improves the strength and toughness of nanocomposites. • Nanocomposites reinforced with folded graphene with more wave and peak numbers exhibit better toughness. Toughness and strength are important material parameters in practical structural applications. However, it remains a great challenge to achieve high toughness and high strength simultaneously for most materials. Here, we report a folded graphene (FG) reinforced copper (Cu) nanocomposite that overcomes the long-standing conflicts between toughness and strength. Intensive molecular dynamics simulations show that the 10% pre-strain-induced four-wave-patterned FG (1.09 wt%) reinforced Cu nanocomposite exhibits simultaneous enhancement in toughness (∼13.59 J/m 2 ), ductility (∼32.38%), and strength (∼9.52 GPa), corresponding to 38.53%, 58.88%, and 2.26% increase, respectively when compared with its counterpart reinforced by pristine graphene (PG). More importantly, the mechanical properties of FG/Cu nanocomposites can be effectively tuned by changing the pre-compressive strain, wave number, and peak number of FG. The toughening and strengthening mechanisms are applicable to other metal materials reinforced by other 2D nanomaterials, opening up a new avenue for developing tough and strong metal nanocomposites.

Hardness and electrical conductivity of uncoated and silver coated carbon nanotubes reinforced copper nanocomposites

Hardness and electrical conductivity of uncoated and silver coated carbon nanotubes reinforced copper nanocomposites

Electrosynthesis of ternary nonprecious Ni, Cu, Fe oxide nanostructure as efficient electrocatalyst for ethanol electro-oxidation: Design strategy and electrochemical performance

Materials composed of various constituents with distinct physical or chemical features are named composites. Merging components in the composite structure leads to new properties creation or the intrinsic properties magnification of the components, or synergetic effects. Here, the ternary nanocomposite of copper, nickel, and iron oxides was electrodeposited on the glassy carbon electrode (GCE) surface to facilitate the ethanol electro-oxidation reaction (EOR) and overcome the electrode fouling problem while prolonging its efficiency. The GCEs were modified by three different procedures and activated by CV cycling in an alkaline solution, and their electro-catalytic activity was tested toward EOR. The ternary electrocatalysts prepared by two-steps electrodeposition of their components (Ni,Fe2O3/Cu and Cu/Ni,Fe2O3) demonstrated higher peak current and more negative peak potential (Epa = 476 mV, Ipa = 492 μA, and Epa = 510 mV, Ipa = 644 μA, respectively) than the binary electrocatalyst of Ni,Fe2O3 toward EOR. The best electro-catalytic efficiency was acquired for the simultaneous electrodeposition of nano Cu, Ni, and Fe2O3 on the GCE surface (Cu,Ni,Fe2O3, Epa = 530 mV, Ipa = 3179 μA). The physicochemical and electro-catalytic characterizations of the fabricated electrocatalysts were evaluated by various techniques. The fast and facile engineered design of the GCE modification with the ternary Cu,Ni,Fe2O3 components led to a high current density of about 101 mA/cm2 with increased tolerance against poisoning intermediates resulting in longtime stability for EOR in alkaline media. The synergistic effect between nano Ni, Cu, and Fe oxides provided promising properties for the EOR pursuing the construction of a powerful device with commercialization potential.

Facile synthesis and characterization of metal ions (Ce, Cu, Gd, Mn and Y) doped Nickel Oxide nanostructures for spintronic and photodiode applications

Multiphase hexagon and flower-shaped structures of NiO nanocomposites have been prepared with different metal ions (Ce, Cu, Gd, Mn and Y) using facile and low-cost co-precipitation method. The optical, structural, morphological, and magnetic properties of the synthesized nanostructures have been investigated. The XDR measurement reveals the coexistence of several crystal structures like cubic, monoclinic, tetragonal, and orthorhombic which unveils the formation of polymorphism in the nanocomposites with high crystallinity. A wideband has been located in the FT-IR spectra at around 600 cm−1 revealing the metal oxide (M-O) phase formation. DRS exhibits four large and intense absorption bands at 260, 380, 420, and 720 nm in the UV and visible domains assigned to the nanocrystalline phases of NiO, CuO, CeO, and MnO, respectively. SEM images of metal-doped nickel oxide nanocomposites show a white sponge, semi-spherical, flower-like, and hexagon-shaped particles of 15 nm size. TEM result establishes a smooth surface for samples grown from gadolinium and yttrium, contrary to other samples made off cerium and manganese demonstrate a rough surface. A ferromagnetic tendency has been located for samples prepared from copper, manganese, and gadolinium-based NiO nanocomposites with coercivities of 132, 113, and 26 Oe, correspondingly. Photodiode characteristics were also investigated on the developed devices. These outcomes signify their use in spintronic and optoelectronic industries.

Influence of N-doping on dielectric properties of carbon-coated copper nanocomposites in the microwave and terahertz ranges

Carbon-coated Cu nanocomposites (Cu@C NCs) consisting of core-shell nanoparticles and nanorods were synthesized by arc discharge plasma under an atmosphere of He and H2 gas, and the N-doping of them was achieved by a post-treatment process using ureal as the precursor. The concentration of N in the N-doped samples varies in the range of 0.62%–2.31 % (in mole), with a transformation from pyrrolic N to graphitic N when increasing the relative content of ureal. Dielectric properties of the NCs without or with N-doping in the microwave and THz bands were investigated. The N-doped samples achieve the enhanced dielectric loss in both microwave and THz bands. In the microwave band, dielectric loss was dominated by interfacial polarization, dipolar polarization, and conduction loss, while in the THz band, plasma resonance, ionic polarization and conduction loss are responsible for the dielectric loss, with a strong absorption characteristic dominated by conductive effect.

CuO and CuO-based nanocomposites: Synthesis and applications in environment and energy

Copper oxide (CuO) nanoparticles and nanocomposites have gained attention worldwide due to their unique characteristics and properties, followed by numerous applications in the field of environment and energy. Various synthesis techniques for CuO nanomaterials and their potential applications are discussed in this article. The traditional and green synthesis techniques are thoroughly studied, and the effect of reaction conditions on the fabricated nanoparticles is also investigated. Furthermore, the advantages and disadvantages of the synthesis techniques and how to overcome them are also discussed. In addition, the characterization and physicochemical properties are correspondingly studied. This review also focuses on the potential applications such as environmental remediation, including sensing, adsorption, and photodegradation of toxic contaminants, CO2 reduction. Furthermore, energy operations that include energy production devices like water splitting and fuel cells and energy storage devices, such as lithium-ion batteries and supercapacitors are discussed. Therefore, the upsurge of copper oxide-based nanocomposite and the journey will inspire the modern generation of chemists to modify and design robust nanoparticles and their nanocomposites that can effectively tackle substantial environmental challenges. This overview concludes by providing future perspectives on CuO research in synthesis and its various applications.

Buckling of functionally graded hydrogen-functionalized graphene reinforced beams based on machine learning-assisted micromechanics models

Nanocomposite reinforced with functionalized graphene is a novel class of high-performance materials with great potential in developing advanced lightweight structures in a wide range of engineering applications. However, accurate estimation of its material properties at different temperature conditions remains a great challenge as existing micromechanics models fail to capture the effects of chemical functionalization and temperature. This paper develops machine learning (ML)-assisted micromechanics models by employing genetic programming (GP) algorithm and molecular dynamics (MD) simulation to address this key scientific problem. The well-trained ML-assisted Halpin-Tsai model and rule of mixture can accurately and efficiently predict the temperature-dependent material properties including Young's modulus, Poisson's ratio, coefficient of thermal expansion (CTE), and density of hydrogen-functionalized graphene (HFGr) reinforced copper nanocomposites with high coefficients of determination (R2). Then, the buckling behavior of functionally graded (FG) HFGr nanocomposite beams is studied with the aid of the ML-assisted micromechanics models. A detailed parametric study is performed with a particular focus on the effects of hydrogenation percentage, graphene content, and temperature on the buckling performance of the FG-HFGr beam. Results show that bonding more hydrogen functional groups on the HFGr can effectively improve the buckling resistance of the beam.

Phytochemically stabilized chitosan encapsulated Cu and Ag nanocomposites to remove cefuroxime axetil and pathogens from the environment

Antibiotics have been a source of concern since they are causing resistance in bacteria that live in water and air. As a result, green technology was used to manufacture silver and copper nanoparticles, which were encapsulated with the biopolymer chitosan derived from the root extract of the Potentilla astrosanguinea plant. XRD, FTIR, TEM, EDX, and UV–Visible spectroscopy were methods used for structural and spectroscopic analysis. These nanomaterials have a roughly spherical 2–30 nm average size and a face-centered cubic (FCC) shape, according to the findings. The photocatalytic drug degradation and antibacterial properties of the produced nanocomposites were outstanding, with some resistance lasting longer than 180 days. The current study discovered that under UV light exposure, silver nanocomposites degrade drugs rapidly within 40 min, with an average rate of over 95%, while copper nanocomposites degrade drugs rapidly within 70 min, with an average rate of 84%. These nanocomposites have demonstrated exceptionally compelling antibacterial action against Gram-positive, Gram-negative, and fungal pathogens in addition to photocatalytic activity. The lowest recorded MIC values were 10.30 μg/mL and 10.84 μg/mL, respectively, whereas the lowest MBC values were 91.24 μg/mL and 99.50 μg/mL.

Magnetic Nanoparticles Supported Copper Nanocomposite: A Highly Active Nanocatalyst for Synthesis of Benzothiazoles and Polyhydroquinolines

A novel magnetically recoverable copper nanocatalyst was fabricated via the immobilization of a copper complex on the surface of silica-coated magnetic nanoparticles modified with a novel Schiff base ligand [Fe3O4@SiO2-bis(aminopyridine)-Cu]. FT-IR spectroscopy, SEM, TEM, EDX, VSM, XRD, XPS, TGA and AAS, ICP-OES techniques were applied to characterize the structure of the as-fabricated [Fe3O4@SiO2-bis(aminopyridine)-Cu(II)] nanocomposite. TEM and SEM analysis confirmed that the typical silica shell thickness was assessed to be around 20 nm. Catalytic studies revealed that the Fe3O4@SiO2-bis(aminopyridine)-Cu(II) nanocomposite is a highly efficient and green nanocatalyst for the synthesis of benzothiazoles and polyhydroquinolines. The [Fe3O4@SiO2-bis(aminopyridine)-Cu(II)] nanocatalyst could be easily recovered by a simple magnetic separation and recycled at least 6 times without deterioration in catalytic activity.

Biosynthesis of Bimetallic Cu-Ag Nanocomposites and Evaluation of their Electrocatalytic, Antibacterial and Anti-Cancerous Activity

Bimetallic nanocomposites have evolved into a significant smart material in the recent past. Owing to the growing interest, we herein report the biosynthesis of bimetallic silver doped copper (Cu-Ag) nanocomposites using green methods by utilizing aqueous extract of Carica papaya leaves. The optical property and the surface morphology of the nanoparticles were determined by using various analytical techniques like Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Analysis (EDAX) and Transmission Electron Microscopy (TEM). The redox behaviour of the bimetallic nanocomposites was studied using Cyclic Voltammetry (CV) with platinum electrode in 0.1M KCl solution at different scan rates and concentrations. The FTIR revealed the presence of active components of the leaf extract which played the roles of surfactants, stabilizing, capping, and reducing agents. Similarly, SEM with EDAX exhibited the presence of spherically agglomerated Cu-Ag nanocomposites and TEM images revealed a particle size of 20 nm. The gradual increase in peak current was observed in CV with increase in the scan rates and concentrations apparently. The bimetallic nanocomposites showed potential anti-bacterial, anti-cancerous activity and the reports are provided in detail.

Experimental and statistical investigation on the wear and hardness behaviour of multiwalled carbon nanotubes reinforced copper nanocomposites

In this experimental work the two parameter Weibull distribution statistical method is used to investigate the effect of fabrication process on the wear and hardness properties of multiwalled carbon nanotubes reinforced copper nanocomposites (MWCNTs/Cu). The MWCNTs/Cu nanocomposites are fabricated by the powder metallurgy processing route in two ways (i) MWCNTs/Cu nanocomposites without hot pressing (NHP-MWCNTs/Cu) and (ii) MWCNTs/Cu nanocomposites with hot pressing (HP-MWCNTs/Cu). The MWCNTs doping weight percentage (wt.%) include 0.0 (Pure copper), 0.5, 1.0 and 1.5. The MWCNTs/Cu nanocomposites are subjected to hardness and wear tests using micro-Vickers hardness tester and rotating type pin-on-disc tribometer, respectively. From the experimental results it is found that the MWNTs/Cu nanocomposites have higher hardness and lower wear rate than the pure Cu. Further, the HP-MWCNTs/Cu nanocomposites showed higher hardness and lower wear rate than the NHP-MWCNTs/C nanocomposites. From statistical analysis it is found that the HP-MWCTs/Cu nanocomposites showed more reliable and repeatable experimental data than the NHP-MWCNTs/Cu nanocomposites. Statistical analysis showed that the effectiveness of MWCNTs doping on the wear rate of Cu is more effective at lower sliding speed. Finally, it is observed form the statistical analysis that both theoretical and experimental results of hardness and wear tests showed good correlation.

Characterization and performance evaluation of Cu-based/TiO2 nano composites

Copper and copper alloys are used in industrial applications and food contact surfaces due to their desirable properties; copper metal matrix composites have been exciting researchers' attention in recent years since they can offer many valuable characteristics. The present study investigated the effects of the TiO2 nanoparticles addition with different weight percent on the hardness and corrosion behavior of copper nanocomposites. The powder metallurgy method was used to fabricate the Cu/TiO2 reinforced with different weight fractions of TiO2 nano particles up to 12 wt.%. The corrosion behavior of fabricated specimens is evaluated using potentiodynamic polarization curves and electrochemical impedance spectroscopy in different solutions. These solutions were 3.5wt.% NaCl, 0.5 NaOH and 0.5 M H2SO4 reflected different pH. The results showed that the addition of TiO2 nano particles improves pure copper's hardness. The hardness of pure copper increased from 53 to 91 HV by adding 12 wt.% TiO2. The corrosion current density (Icorr) of copper nanocomposites test specimens was higher than Icorr of pure copper in all test solutions. As TiO2 nano particles increase, the corrosion resistance of Cu nano composites decreased. All test specimens exhibited little corrosion current density in 3.5 wt.% NaCl solution as compared with other test solutions.

High performance of non-enzymatic glucose biosensors based on the design of microstructure of Ni2P/Cu3P nanocomposites

The transition-metal phosphides with metalloid characterics, exhibiting great application potential in the field of glucose detection that plays an important role in the treatment of diabetes, can achieve high sensitivity as a eletrocatalyst for nonenzymatic glucose sensors. However, it has the drawbacks of low detection range and difficulty in manufacture. In this work, a hybrid heterogeneous nanocomposite of copper and nickel phosphide (Ni2P-Cu3P) has been designed and successfully prepared by a mild one-step solvothermal method. Inspired by the porous characteristic of sponges, the mesoporous structure with a much larger surface area has been constructed by adjusting the reaction conditions and the element composition of copper and nickel to have more active sites, thus broadening linear range. The precisely designed heterogeneous nanostructure and the unique mesoporous morphology of Ni2P-Cu3P were confirmed and characterized by the XRD and TEM analysis. Electrochemical oxidation of glucose on the composite modified glassy-carbon electrode (Ni2P-Cu3P/GCE) was measured by chronoamperometry and cyclic voltammetry. At the optimal test potential of + 0.64 V, the Ni2P-Cu3P/GCE hybrid electrode possessed an ultra-high sensitive response of 4700 μA mM−1 cm−2 to glucose, in a broad linear range from 4 μM to 5 mM, and a low detection limit of 0.1 μM at an S/N ratio of 3. The electrode also exhibits excellent anti-interference properties towards other common co-existing electroactive distractions, such as ascorbic acid, uric acid, urea, dopamine, etc.