Background: The Arabic word "AlKohol," which meaning "a fine impalpable powder with which Eastern ladies paint their eyebrow, and used lately to refer to anything of highest perfection," is the source of the English word "alcohol" (Skinner, 1970). Aim: The current study aims to evaluate and compare the quality of life and coping skills of patients with alcohol dependency Pre and Post applying application of motivational enhancement therapy. Methods: This was a quasi-experimental study with pretest-posttest design with control group. The sample consists of 10 patients were diagnosed with alcohol dependence using a purposive sampling selected from the outpatient department of the CIIMHANS, Dewada, Rajnandgoan, India. Further these patients divided into two groups as experimental group (5) and control group (5). Tools used Brief coping and Quality of life questionnaire. Results: Result of the current study revealed that the experiment group of alcohol dependence patients improved in different domains of quality of life and coping after the application of motivational enhancement therapy treatment and exhibited enhanced quality of life and coping skills as compared to control group. International Journal of Scientific Research in Engineering and Management (IJSREM) Volume: 08 Issue: 02 | February - 2024 SJIF Rating: 8.176 ISSN: 2582-3930 © 2024, IJSREM | www.ijsrem.com DOI: 10.55041/IJSREM28829 | Page 2 Conclusion: Motivational Enhancement Therapy allows patients to have an optimistic attitude on life, accepts difficult events, deal with the present, and adopt suitable behaviors to cope with negative thoughts and feelings by enhancing psychological flexibility and improving self motivation. Key Words: Motivational Enhancement Therapy, Alcohol Dependence patients, coping skill and quality of life.