GWP (Global Warming Potential) and ODP (Ozone Depletion Potential) occupy an important place in global warming. This has led to the use of refrigerants with low GWP and ODP in cooling systems. Commonly used in cooling systems, R404A refrigerant has a very high GWP value despite having zero ODP. In this study, the exergetic performance analyses of the refrigerants, which may be alternative to R404A, in a theoretical cooling cycle were given comparatively. As an alternative to R404A refrigerant, R452A, R455A and R454C fluids are examined comparatively. COP and exergy destruction, for each refrigerant were examined separately and results were graphically analyzed. COP values of HFO group refrigerants were found as 2.472, 2.312, 2.632, 2.309 for R404A, R452A, R455A and R454C, respectively. In terms of exergy efficiency of HFO group refrigerants were found as 41.5%, 38.8%, 43.9%, 38.7% for R404A, R452A, R455A and R454C, respectively. As a result, thermodynamic properties, GWP and ODP values, energetic and external perspective; As an alternative to the R404A fluid, the best fluid selected is R455A, then R452A and R454C, respectively. The best choice for these alternative refrigerants in cooling systems is R455A.