Research Coordinators Research Articles

Meeting report of the seventh annual Tri-Service Microbiome Consortium Symposium.

The Tri-Service Microbiome Consortium (TSMC) was founded to enhance collaboration, coordination, and communication of microbiome research among DoD organizations and to facilitate resource, material and information sharing among consortium members, which includes collaborators in academia and industry. The 2023 annual symposium was a hybrid meeting held in Washington DC on 26-27 September 2023 concurrent with the virtual attendance, with oral and poster presentations and discussions centered on microbiome-related topics within five broad thematic areas: 1) Environmental Microbiome Characterization; 2) Microbiome Analysis; 3) Human Microbiome Characterization; 4) Microbiome Engineering; and 5) In Vitro and In Vivo Microbiome Models. Collectively, the symposium provided an update on the scope of current DoD and DoD-affiliated microbiome research efforts and fostered collaborative opportunities. This report summarizes the presentations and outcomes of the 7th annual TSMC symposium.

Implementing regional blue economy research and innovation strategies: a case study for the Black Sea

The Black Sea is a vital resource with vast potential to boost the societal value of the Blue Economy for its surrounding countries. Improved knowledge and enhanced infrastructure together with better coordination and alignment of research and innovation efforts are critical for the better management of the deteriorated Black Sea ecosystem to help restore and maintain its resilience and enable sustainable use of natural resources. In 2019, the Black Sea Strategic Research and Innovation Agenda (Black Sea SRIA), was developed by the Black Sea experts, in cooperation with European marine institutes and organizations, with the support of the European Commission. Black Sea SRIA presents the priorities and ecosystem-based management options needed for a healthy, sustainable, and resilient Black Sea. Since 2019, efforts focused on developing concrete actions under the Black Sea SRIA Implementation Plan (IP) to contribute to the national blue economy strategies, better structuring of the relevant funding mechanisms for solution-oriented implementation and the international and regional strategies, supporting the co-funding mechanisms. In this study, we present a transnational process that has led to the development of the IP which utilized a bottom-up, co-design and co-creation-based approach. The SRIA and its IP support better governance of the blue economy principles towards sustainable development and conservation of unique Black Sea ecosystems. The Black Sea SRIA and IP address the fundamental research challenges of the region, promote the blue economy, and also build vital support systems and innovative research infrastructure and capacity together with academia, funding organizations, industry, policy, civil society and local communities. The IP is a long-lasting guide to catalyze new ideas and innovations towards and with the Black Sea community with strong implications for other sea basins.

Reef Research Coordinating Institute Designation and Cooperative Agreements (DOC)

Reef Research Coordinating Institute Designation and Cooperative Agreements (DOC)

Barriers to Recruitment and Retention Among Underrepresented Populations in Cancer Clinical Trials: A Qualitative Study of the Perspectives of Clinical Trial Research Coordinating Staff at a Cancer Center.

Although US research agencies have instituted peer review processes to require participant diversity in clinical trials before funding decisions are made, the underrepresentation of certain populations (eg, racial and ethnic minorities) in clinical trials remains a persistent challenge in biomedical research. This issue has the potential to affect the generalizability of findings and impede efforts to ensure the provision of high-quality healthcare across all populations. In this study, we examined barriers to the recruitment and retention of underrepresented populations in cancer clinical trials from the perspective of research coordinating staff. Semi-structured interviews were conducted at a US-based academic cancer center and included 6 patient-facing staff (clinical research coordinators) and 6 non-patient-facing staff (regulatory and financial specialists). Interview data were subjected to thematic analysis. To provide additional organizational context, descriptive data were obtained on the characteristics of clinical trials undertaken at the cancer center. The following themes emerged from the staff interviews: 1) absence of a consistent structure for decision-making and problem-solving related to recruitment and retention, 2) staff shortages, 3) administrative burden, and 4) lack of resources. In addition, descriptive data revealed that nearly half the trials, 64/134 (48%), offered informed consent only in English, and only 3/134 (2%) offered participant incentives or reimbursement (eg, for transportation). These interrelated organizational issues were indicative of inadequate systems for ensuring diverse and equitable representation in cancer clinical trials. Results indicate that overcoming barriers to underrepresentation may require dedicated support from sponsoring agencies in the form of evidence-based guidelines, learning collaboratives to facilitate implementation, technical support, resources, and oversight. For progress to be made therefore, both sponsors and cancer centers may need to assume joint responsibility for the implementation of effective systems for ensuring diverse and equitable representation in cancer clinical trials.

The framework for action of the cross-agency One Health Task Force

The Cross-agency One Health Task Force, established by five EU agencies (EFSA, ECDC, EEA, ECHA, and EMA), has released its Framework for Action, aimed at operationalising the One Health approach across various EU regulatory science sectors. This initiative, originating from the 2022 ONE Conference, addresses the integration of human, animal, plant, and environmental health inspired by the European Green Deal. The framework outlines five strategic objectives: enhancing strategic coordination, promoting research, strengthening capacity building, fostering communication and partnerships, as well as joint activities. These objectives will align the agencies' efforts, improve collaboration, and promote a transdisciplinary approach to address health threats. Key actions for 2024–2026 include developing joint publications, research coordination, and One Health-driven training programs. The Task Force will coordinate its work through regular interactions, in close liaison with the European Commission, to ensure long-term interdisciplinary cooperation.

Re-engineering Agricultural Innovation in Southeast Asia (RAISE-Asia)

Feeding the growing global population and reducing poverty require innovative approaches in agriculture and food systems to sustain the planet’s health and food requirements. Sustainable development can be achieved by generating new knowledge and translating them into use through innovation process. A customer-oriented technology readiness level (COTRL) tool is presented to re-engineer agricultural innovation by systematically assessing new agricultural technologies with customer input and ensuring that the early design of the scientific research already has the end-products in mind. The COTRL methodology will integrate research, prototyping, and commercialization efforts and facilitate a disciplined and impactful innovation process. It will guide researchers and scientists, research managers and coordinators, funding agency program managers, policymakers, and other personnel involved in bringing scientific discoveries to market for societal impact. The COTRL framework can be used to strengthen the collaboration among academia, research institutions, networks of excellence, and the private sector in the ASEAN to create an effective ecosystem for manpower and structural capability development, knowledge sharing, and business development within and across member states.

Protecting subterranean ecosystems for the wellbeing of surface environments and humanity

Protecting subterranean ecosystems for the wellbeing of surface environments and humanity Stefano Mammola, a researcher at the Italian National Research Council and coordinator of the Biodiversa+ project ‘DarCo’, emphasizes the importance of better incorporation of subterranean biodiversity in conservation agendas. Beneath our feet lies a vast and intricate network of caves, aquifers, fissures, and other voids teeming with unique life forms crucial to both human life and the environment. Groundwaters, for instance, represent the largest unfrozen freshwater reserve, serving as the primary water source for over half of the world’s population. Despite their importance, subterranean ecosystems receive minimal attention in current biodiversity and climate change agendas – a concerning oversight that demands urgent action. (1)

Review article: A primer for clinical researchers in the emergency department: Part XIII. Strategies to engage staff and enhance participant recruitment in emergency department research.

Conducting research in ED is important and necessary to improve emergency care. Effective recruitment is an essential ingredient for the success of a research project and must be carefully monitored. Research coordinators are focused on optimising recruitment to research studies while also ensuring that the needs of participants and their families are met, and the research is acceptable to ED staff. In this paper, a group of experienced research coordinators from Australia and New Zealand have shared their strategies to engage staff and enhance recruitment of participants in emergency research. Although this paper is from a paediatric research network, the findings are applicable for EDs in general, both in Australasia and elsewhere.

Which stakeholders should be addressed to promote Geriatric Medicine among healthcare professionals, educationalists and policy-makers in European countries? – the PROGRAMMING COST 21,122 action experience

BackgroundGeriatric Medicine (GM), concerned with well-being and health of older adults, can play a crucial role in the alignment of healthcare systems to the needs of the aged populations. However, countries have varying GM development backgrounds. The goal of PROGRAMMING- COST 21,122 Action is to propose the content of education and training activities in GM for healthcare professionals across various clinical settings, adapted to local context, needs, and assets. Defining relevant stakeholders and addressing them on both an international as well as a country-specific level is crucial for this purpose. In this paper we are describing the methods used in the PROGRAMMING Action 21,122 to map the different categories of stakeholders to be engaged in the Action.MethodsThrough conceptualizing a model for stakeholders by literature research, and online discussion group meetings, a synthesis for the potential stakeholders was defined as a template, and pilot applications were requested from participant countries.ResultsThere were 24 members from 14 countries (6 males/18 females) of multidisciplinary professions involved in this study. A model for the list of stakeholders to be addressed was developed and, after seven online discussion meetings, a consensus framework was provided. Invited countries completed the templates to pilot such operationalization.ConclusionOur framework of stakeholders will support the research coordination and capacity-building objectives of PROGRAMMING, including the participation into the assessment of educational needs of healthcare professionals. Identified stakeholders will also be mobilized for purposes of dissemination and maximization of the Action’s impact. By defining and mapping multidisciplinary stakeholders involved in older people’s care specific to countries, particularly where GM is still emerging, GM tailored educational activities will be facilitated and optimally targeted.

Abstract C056: Improving Adherence to Cancer Care in Underserved Patients with Central Nervous System Tumors through the Integrated Cancer Care Access Network (ICCAN)

Abstract This pilot study investigates the impact of the Integrated Cancer Care Access Network (ICCAN) on treatment adherence for patients with central nervous system (CNS) tumors. Patients with CNS tumors often face significant financial toxicity due to a lack of ability to work, physical disabilities due to their disease, and cognitive changes due to treatment and disease. Patients were enrolled in the ICCAN intervention, a longstanding multidisciplinary patient navigation and socioeconomic resources facilitation program, where an initial essential needs survey was administered. The survey consisted of questions regarding food security, housing circumstances, monthly individual and household income, and transportation barriers that patients were facing. If patients could not complete the survey independently due to their disease, a caregiver helped answer the survey questions. The clinical research coordinator helped procure appropriate resources based on the needs expressed. Patient navigation services were also provided to facilitate patient engagement and adherence to treatment and appointments. Patients were provided access to the Memorial Sloan Kettering food pantry, gift card services, assistance applying for grants, and transportation assistance. Patients were followed at 2 months, 4 months, 6 months, and 12 months post the initial essential needs survey. Overall, the largest needs for the CNS tumor patients enrolled in ICCAN were housing, income due to lack of ability to work, food insecurity, and transportation barriers for appointments. Many patients expressed gratitude for the services provided and consistently followed up with the clinical research coordinator regarding any apparent new needs. There is a lack of research on the financial toxicity of patients with CNS tumors, and this pilot program provided proof of concept that patients with CNS tumors can be successfully enrolled in a patient navigation and resources intervention. Based on this data, we will expand this intervention into a randomized clinical trial. Citation Format: Cleopatra Elshiekh, Ashley Phillips, Ashley Rodriguez, Bharat Narang, Francesca Gany, Joshua Budhu. Improving Adherence to Cancer Care in Underserved Patients with Central Nervous System Tumors through the Integrated Cancer Care Access Network (ICCAN) [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C056.

Abstract B174: A unique partnership between the Office of Military Affiliated Communities and the UChicago Cancer Center leads to career pathways in clinical research

Abstract Background: The Clinical Trials Support Office (CTSO) priority is to recruit diverse individuals who are highly motivated and aligned with our cancer center mission and vision. Due to the competitive market, rates of internal staff turnover, and growing demand for clinical research professionals, the CTSO needed to find new ways to recruit talent but also look for ways to enhance workforce diversity. Goals: Increase exposure and skill building for clinical research jobs by identifying new populations with translatable skills. Create training and education pipelines (leveraging Community Outreach and Engagement (COE), Cancer Research Training Education Coordination (CRTEC), and Plans to Enhance Diversity (PED) to identify and hire the next generation of clinical research professionals. Hire, train, and retain a diverse, equitable, and inclusive CTSO team. Methods: The University Provost’s Equal Opportunity Programs launched the Department of Defense (DoD) SkillBridge Program through the Office for Military-Affiliated Communities (OMAC). This program connects servicemembers and spouses to partners who provide civilian work experience through specific industry training, apprenticeships, or internships during the last 180 days of military service with the goal of easing the transition to civilian careers. Many veterans, transitioning servicemembers and their spouses have experience in operations and logistics or have served as medical professionals in the military. We knew these diverse skills could qualify them for career opportunities within the field of clinical research which led to a partnership between the CTSO and OMAC. Through this unique partnership, the CTSO worked with OMAC to connect these individuals with opportunities in the clinical research space. This collaboration allows the CTSO to provide military servicemembers (and their spouses) with internship opportunities or a full-time position in clinical research roles. Outcomes: Since the launch of the OMAC partnership, 6 candidates (5 servicemembers, 1 spouse) were selected to take part in the CTSO internship program. Internships spanned across data management (2), clinical research coordination (1), regulatory (2), and finance (1). We successfully converted 5 of the 6 interns to direct hires and the CTSO is recruiting additional interns this year. Lessons Learned: This pilot partnership highlights the transferable skills of highly trained servicemembers. Essential skills for complex oncology trials include performing under pressure, accountability, adherence to protocols, health and safety awareness, leadership, teamwork, and integrity. The CTSO benefited from engaging skilled interns and was able to create a pipeline in the saturated Chicago job market. According to OMAC, transitioning from military service poses challenges for servicemembers and their families, including housing, food insecurities, and employment. This partnership allows servicemembers to ease transitional challenges, gain work experience, and get a head start on their next career after military service. Citation Format: Lauren Wall, Aspen Ward, Terrell Odom, Amanda Spratt, Sara Moellering, Camilla Frost-Brewer, Kristen Kipping-Johnson, Eileen Dolan, Russell Szmulewitz. A unique partnership between the Office of Military Affiliated Communities and the UChicago Cancer Center leads to career pathways in clinical research [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B174.

Understanding the Barriers to Clinical Trial Referral and Enrollment Among Oncology Providers Within the Veterans Health Administration.

Clinical trials are essential for advancing treatment options in oncology while providing cancer patients with innovative care; however, few cancer patients are referred to clinical trials. System-, provider-, and patient-level barriers to clinical trial participation have been described but have not been studied in the Veterans Health Administration (VHA). Although the VHA has engaged in several initiatives to improve Veteran's access to clinical trials, including the National Cancer Institute and VA Interagency Group to Accelerate Trials Enrollment program and VHA work on the White House Cancer Moonshot, further research is needed to understand the multifaceted challenges underlying limited enrollment for Veterans who receive care in the VHA system. This research aims to evaluate VHA oncology providers' attitudes toward and experiences with referral and enrollmentof Veterans with cancer into clinical trials, for the purpose of informing actions that could be taken to enhance Veterans' access to clinical trials as well as the VHA's contributions to clinical research. This research comprised the administration of an electronic 34-item survey and semistructured interviews among oncology care providers in the VHA nationally, between May 2022 and August 2023. The survey was introduced via a presentation at VHA Oncology Office Hours and aimed to capture VHA oncology care providers' perceptions of and experiences with referral and enrollment to clinical trials. The semistructured interviews explored providers' perceived barriers to clinical trial participation and recruitment bias, as well as inquired about potentially modifiable factors for improving clinical trial enrollment at the VHA, such as providers' concerns, motivations for and facilitators of enrollment of patients into clinical trials, and the manner in which they communicate about clinical trials with their patients. Thirty-eight oncology care providers completed the survey, and eight completed the semistructured interview, including 5 staff physicians, 1 fellow, 1 nurse practitioner, and 1 physician assistant. Thirty-four survey respondents identified their specialty as medical oncology, one respondent identified the specialty as radiation oncology, and three identified the specialty as hematology. Nineteen respondents identified as women and 14 as men; the remainder did not provide their gender. Three respondents identified as Hispanic or Latino individuals, 11 as Asians, 3 as Black individuals, and 17 as White individuals. Five interview participants reported holding an individual academic affiliation. Participants identified and described various barriers to clinical trial referral and enrollment at multiple levels, including lack of appropriate trials, strict patient eligibility criteria, difficulties in understanding and managing the referral process for trials outside the VHA system, challenges with obtaining information and identifying available clinical trials, Veterans' financial and logistical concerns, lack of trust in the medical establishment, lack of adequate social support, and Veterans' psychological and physical comorbidities. They also highlighted opportunities for system-level change that can overcome some of these barriers, including academic affiliations, patient support from internal and external nurse navigators, and dedicated research coordinators. The insights gleaned from this research can guide VHA in its efforts to optimize access to clinical trials for Veterans.

CICARE communication model and hierarchical responsibility nursing coordination in the application research of elderly patients with chronic heart failure.

The aim of this study was to evaluate the efficacy of implementing the CICARE communication model and hierarchical responsibility nursing coordination in managing chronic heart failure among elderly patients. From June 2021 to June 2023, 120 elderly patients diagnosed with chronic heart failure were admitted to our hospital. They were divided into 2 groups according to different treatment methods: the regular group and the observation group. Both groups of patients received nursing interventions for 3 months. Before and after the intervention, we assessed the levels of cardiac function indicators (left ventricular end-diastolic diameter, left ventricular ejection fraction, and B-type natriuretic peptide levels) and exercise tolerance (6-minute walk test) in both groups of patients. The time to clinical symptom relief, self-efficacy, and quality of life scores were compared between the 2 groups of patients. Before the intervention, there were no significant differences in cardiac function indicators between the 2 groups (P > .05). However, after the intervention, both groups exhibited improvements in left ventricular end-diastolic diameter and B-type natriuretic peptide levels, with the observation group demonstrating greater reductions compared to the control group. Furthermore, both groups showed increased left ventricular ejection fraction levels, with the observation group experiencing a significantly higher improvement. Although exercise tolerance did not differ significantly between the groups before the intervention, post-intervention analysis revealed a greater increase in 6-minute walk test distance in the observation group compared to the control group (P < .05). The time to relief of breathlessness and edema did not significantly differ between the groups (P > .05). Similarly, there were no significant differences in self-efficacy and quality of life scores between the groups before the intervention (P > .05); however, post-intervention analysis showed higher self-efficacy scores in the observation group. Application of the CICARE communication model and hierarchical responsibility nursing coordination in elderly patients with chronic heart failure can effectively improve the patients' cardiac function levels and significantly enhance their exercise tolerance, self-efficacy, and quality of life.

Construction of a competency evaluation model for Clinical Research Coordinators in China: a study based on the Delphi method and questionnaire survey

PurposeAs the number of clinical trials in China continues to grow, the assessment of competency of Clinical Research Coordinators (CRCs), who play a crucial role in clinical trials, has become...

Substantiation and Effectiveness of Remote Monitoring System Based on IoMT Using Portable ECG Device.

Cardiovascular disease is a major global health concern, with early detection being critical. This study assesses the effectiveness of a portable ECG device, based on Internet of Medical Things (IoMT) technology, for remote cardiovascular monitoring during daily activities. We conducted a clinical trial involving 2000 participants who wore the HiCardi device while engaging in hiking activities. The device monitored their ECG, heart rate, respiration, and body temperature in real-time. If an abnormal signal was detected while a physician was remotely monitoring the ECG at the IoMT monitoring center, he notified the clinical research coordinator (CRC) at the empirical research site, and the CRC advised the participant to visit a hospital. Follow-up calls were made to determine compliance and outcomes. Of the 2000 participants, 318 showed abnormal signals, and 182 were advised to visit a hospital. The follow-up revealed that 139 (76.37%) responded, and 30 (21.58% of those who responded) sought further medical examination. Most visits (80.00%) occurred within one month. Diagnostic approaches included ECG (56.67%), ECG and ultrasound (20.00%), ultrasound alone (16.67%), ECG and X-ray (3.33%), and general treatment (3.33%). Seven participants (23.33% of those who visited) were diagnosed with cardiovascular disease, including conditions such as arrhythmia, atrial fibrillation, and stent requirements. The portable ECG device using the patch-type electrocardiograph detected abnormal cardiovascular signals, leading to timely diagnoses and interventions, demonstrating its potential for broad applications in preventative healthcare.

Accuracy of Patient-Collected Vital Signs.

Introduction: Telehealth has emerged as an important clinical setting for managing acute respiratory tract infections (ARIs), potentially reducing emergency department and urgent care overcrowding, and reducing nosocomial transmission. Many current algorithms for ARI management incorporate information on patient vital signs. However, the accuracy of vital signs collected by patients using readily available home devices and techniques has not been studied. Methods: A cross-sectional sample of patients seen for urgent conditions at a hospital emergency and urgent care center were given instructions and low-cost, readily available devices to collect their vital signs. A trained research coordinator collected a parallel set of vital signs using standard hospital equipment, serving as the gold standard. We analyzed the performance of patient-collected vital signs compared with vital signs collected by a trained research coordinator. Results: A total of 300 patients completed the study. Patient-collected vital signs were highly specific for traditional levels of abnormalities (HR >100 beats per min, RR >24 breaths per min, temperature >100.4 degrees Fahrenheit, oxygen saturation <94 percent); however, sensitivity was poor for elevated heart rate by pulse estimation (25%) and elevated respiratory rate (60%). Heart rate and oxygen saturation by pulse oximeter and oral temperature had higher sensitivity. Conclusions: Vital signs measured and provided by patients are not uniformly accurate, particularly when using manual techniques rather than automated devices. Telehealth algorithms that rely on these values could provide incorrect triage and management advice.

Molecular tumor board: Real-world experience in a tertiary cancer centre in Singapore.

107 Background: Genomic profiling is increasingly employed to support diagnosis and treatment of cancer. Our Molecular tumor boards (MTBs) serves as a collaborative platform for a multi-disciplinary team of oncologists, pathologists, scientists, bioinformaticians, genetic counsellors and research coordinators to discuss and match patients to the most relevant therapies and/or clinical trials. We report here the evaluation of our MTBs for year 2023 with the aim of identifying challenges and opportunities for successful implementation of precision oncology. Methods: Regular monthly MTBs were conducted to discuss molecular profiles from predominantly advanced-stage patients enrolled to the IMPACT study (Individualized Molecular Profiling for Allocation to Clinical Trials NCT02806388). Next-generation sequencing was performed either in-house using Oncomine or commercial FoundationOne panels. Additional tests such as whole transcriptome sequencing (WTS), immunohistochemistry (IHC) and fluorescent in-situ hybridization (FISH) were also performed where indicated. MTB recommendations were documented for follow-up and analysis. Results: A total of 102 out of 611 profiled patients were discussed in MTBs in 2023, with an average of 8.6 patients per month. Top 3 cancer types were gastrointestinal (32%), breast (18%) and lung (18%). 65/102 (63.7%) cases had MTB recommendations, of which 21 (20.6%) had multiple recommendations. Overall uptake rate for recommendations was 23.8% (29/122). Conclusions: MTB plays an important role in identifying therapeutic opportunities by factoring in patient variables, available data and physician experience while at the same time provides an avenue for further investigation to gather cumulative evidence. Frequent reasons encountered for not adopting the recommendations include: (1) insufficient sample to proceed with further investigations, (2) limited access to off-label treatments, and (3) additional considerations to participate in clinical trials. To fully realize the value of MTB, we will focus on (1) defining the molecular tests for efficient profiling, (2) crafting a route for special access to treatments and (3) increasing awareness and understanding of clinical trials. [Table: see text]

Modeling Organismal Responses to Changing Environments.

Throughout their lives, organisms must integrate and maintain stability across complex developmental, morphological, and physiological systems, all while responding to changing internal and external environments. Determining the mechanisms underlying organismal responses to environmental change and development is a major challenge for biology. This is particularly important in the face of the rapidly changing global climate, increasing human populations, and habitat destruction. In January 2024, we organized a symposium to highlight some current efforts to use modeling to understand organismal responses to short- and long-term changes in their internal and external environments. Our goal was to facilitate collaboration and communication between modelers and organismal biologists, which is one of the major aims of the Organismal Systems-type Modeling Research Coordination Network, OSyM. Accompanying this introduction are a series of papers that are aimed to enhance research and education in linking organismal biology and modeling and contribute to building a new community of scientists to tackle important questions using this approach.

Palliative Care Acceptability for Older Adults with Advanced CKD: A Qualitative Study of Patients and Nephrologists

Older adults in the United States often receive kidney therapies that do not align with their goals. Palliative care (PC) specialists are experts in assisting patients with the goals of care discussions and decision support, yet views and experiences of older patients who have received PC while contemplating kidney therapy decisions and their nephrologists remain unexplored. We evaluated the acceptability of CKD-EDU, a PC-based kidney therapy decision support intervention for adults≥75 years of age. Qualitative study. Two trained research coordinators interviewed patients and nephrologists participating in the CKD-EDU study. Three coders analyzed the qualitative data using a thematic analysis approach to identify salient themes pertaining to intervention acceptability. Patients (n=19; mean age: 80 years) viewed the PC intervention favorably, noting PCphysicians' excellent communication skills, whole-person care, and decision-making support, including comprehension of prognostic information. Nephrologists (n=24; mean age) welcomed PC assistance in decision making, support for conservative kidney management, and symptom management; a minority voiced concerns about third-party involvement in their practice. Single-center study. Overall, patients and nephrologists generally found the PC intervention to beacceptable. Future testing of the current PC-based decision support intervention in a larger randomized controlled trial for older people navigating kidney therapy decisions is needed.

Leading impactful research: applying platform thinking to drive collaborative inquiry in the innovation field

PurposeThis study investigates the application of collaborative inquiry within innovation management, employing platform thinking to address challenges of generalizability and relevance. The aim is to integrate Collaborative Inquiry methods, characterized by participatory, diffuse, and reflective practices, to transform research into a tool for impactful change in organizations in the field of innovation management.Design/methodology/approachA longitudinal participatory case study approach focuses on the IDeaLs case—a research platform that collaborated with multiple companies over several years. The data gathered and analyzed comes from the research project within the research platforms over the first two editions and from the research platform management and coordination activities.FindingsThe study introduces the Collaborative Research Platform Approach (CRPA), demonstrating its effectiveness in addressing typical constraints of traditional research methodologies through a real-world application within the IDeaLs case. The findings highlight the CRPA's potential in fostering a dynamic, co-creative research environment that bridges theoretical knowledge with practical applications, thus enhancing both scholarly and organizational outcomes while pursuing a future change within the organizations.Research limitations/implicationsThere are two main research implications. First, it proposes platform thinking as a theoretical lens to read a multi-stakeholder phenomenon in the research domain, confirming its nature of value-creation mechanisms, using it outside the business model and strategic space. Second, it offers a methodological contribution by presenting the CRPA framework.Practical implicationsThe CRPA framework offers organizations a structured approach to managing collaborative research projects that align with both academic rigor and practical relevance. Companies engaged in the study reported enhanced ability to implement actionable insights from research, influencing real-time decision-making processes.Social implicationsBy fostering collaborative engagements across multiple stakeholders, the CRPA promotes a research culture that values inclusivity and practical impact, potentially leading to broader societal benefits through improved innovation management practices.Originality/valueThis paper contributes to the innovation management field by proposing the CRPA, which integrates principles of Platform Thinking with Collaborative Inquiry. This novel approach is designed to improve the applicability and scope of innovation research, offering a robust framework that enhances engagement and utility across academic and business domains. It uses platforms as a theoretical lens to read a multi-stakeholder environment in the research domain.