Coordination Networks Research Articles

NCOG-15. COMPARATIVE ANALYSIS OF GLIOMA INDUCED IMPAIRMENT MODELS

Abstract Speech is produced by the coordination of neural networks involved in language processing and motor control of vocal outputs, both of which can be disrupted by diffuse gliomas. Natural language is the instinctual written or spoken language profile that an individual has developed throughout his or her lifetime. Recent psycholinguistic analyses suggest that patterns of natural language may be an accurate measure for assessing clinical and behavioral conditions. One important feature of natural language is speech onset. Speech delays are common complaints among patients with glioma. Here, we assess the relationship between speech onset and histologic-molecular features of glioma. Speech onset was defined as acoustic measure of the interval of time between the release of the oral constriction in a stop consonant and the onset of subsequent voicing. Audio samples and video analysis of oral kinetics were analyzed from patients with newly diagnosed low- and high-grade glioma. Features were extracted by manual segmentation and aligned for each trial with high-density electrode arrays to record task specific responses from gliomas projecting to the cortical surface. A total of 1,120 stimuli (672 = picture naming (PN) and 448 auditory naming (AN) trials were presented. As expected, patients with glioblastoma had higher picture and auditory naming error rates (p < 0.001, Mann-Whitney U test) compared with diffuse low-grade gliomas. Assuming speech errors produce slower response times, we next measured only correct behavioral responses which demonstrated 7% slower speech initiation responses (p < 0.0001, Mann-Whitney U test) when comparing patients with glioblastoma and diffuse low-grade gliomas. Slowed speech responses did not require glioma infiltration into canonical cortical speech areas of the lateral prefrontal cortex and superior temporal gyrus. Finally, we identified electrophysiological biomarkers of speech errors. These results deepen our understanding of speech processing impairments, which are not based purely on coding errors.

On-surface synthesis of Au–C4 and Au–O4 alternately arranged organometallic coordination networks via selective aromatic C–H bond activation

Selective activation of the C–H bond of aromatic hydrocarbons is significant in synthetic chemistry. However, achieving oriented C–H activation remains challenging due to the poor selectivity of aromatic C–H bonds. Herein, we successfully constructed alternately arranged Au–C4 and Au–O4 organometallic coordination networks through selective aromatic C–H bond activation on Au(111) substrate. The stepwise reaction process of the 5, 12-dibromopyrene 3,4,9, 10-tetracarboxylic dianhydride precursor is monitored by high-resolution scanning tunneling microscopy. Our results show that the gold atoms in C–Au–C organometallic chains play a crucial role in promoting the selective ortho C–H bonds activation and forming Au–C4 coordination structure, which is further demonstrated by a comparative experiment of PTCDA precursor on Au(111). Furthermore, our experiment of 2Br-PTCDA precursor on Cu(111) substrate confirms that copper atoms in C–Cu–C organometallic chains can also assist the formation of Cu–C4 coordination structure. Our results reveal the vital effect of organometallic coordination on selective C–H bond activation of reactants, which holds promising implications for controllable on-surface synthesis.

Unidirectional Current in Layered Metal Hexacyanometallate Thin Films: Implication for Alternative Wet-Processed Electronic Materials.

Rectifying behavior of alternative electronic materials is demonstrated with layered structures of a crystalline coordination network whose mixed ionic and electronic conductivity can be manipulated by switching the redox state of coordinated transition-metal ions. The coordinated transition-metal ions can convey additional functionality such as (redox)catalysis or electrochromism. In order to obtain rectifying behavior and charge trapping, layered films of such materials are explored. Specifically, layered films of iron hexacyanoruthenate (Fe-HCR) and nickel hexacyanoferrate (Ni-HCF) were formed by the combination of different deposition procedures. They comprise electrodeposition during voltammetric cycles for Fe-HCR and Ni-HCF, layer-by-layer deposition of Ni-HCF without redox chemistry, and drop casting of presynthesized Ni-HCF nanoparticles. The obtained materials were structurally characterized by X-ray diffraction analysis, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy for nanoparticles, and scanning force microscopy (SFM). Voltammetry in 1 mol L-1 KCl and current-voltage curves (I-V curves) recorded between a conductive SFM tip and the back electrode outside of an electrolyte solution demonstrated charge trapping and rectifying behavior based on the different formal potentials of the redox centers in the films.

Nanocontainers with synergetic inhibition and corrosion protection abilities towards intelligent self-healing coatings

A new network structure of Ce (III) modified I-Ti3C2Tx (IT) (Ce@IT) was generated by covalent and/or coordination networks with a metal cation center of Ce (III) and imidazolium on the IT surface as a linker. The lamellar Ce@IT nanocomposites were formed with chemically bonded Ce-N bonds, which increased the crosslink density, ductility, and toughness of epoxy coatings, particularly by improving toughness and elongation at break. Furthermore, Ce3+ could be released from Ce@IT nanocomposites to form insoluble cerium-based oxide/hydroxide deposited on the substrate surface in the scratch areas and offer outstanding active and passive protection to epoxy coatings.

Single-Crystal Structure Analysis of Three Novel Iron(II) Coordination Polymers with Bridging 1,3,5-Tris((1H-1,2,4-triazol-1-yl)methyl)benzene

Three novel iron(II) coordination polymers, namely [Fe(H2O)2(ttmb)2](ClO4)2·4H2O (1), [Fe(H2O)2(ttmb)2](BF4)2·4H2O (2) and [Fe(NCS)2(ttmb)2] (3), were synthesized with the linker 1,3,5-tris((1H-1,2,4-triazol-1-yl)methyl)benzene (ttmb). The single-crystal structures show that all three compounds form a double-chain structure with the adjacent iron atoms being bridged by two ttmb linkers. The iron(II) ions are octahedrally surrounded by four N4 donor atoms from the 1,2,4-triazol-1-yl groups of four different ttmb linkers which form an equatorial plane and two trans-coordinated aqua ligands in 1 and 2 or isothiocyanato ligands in 3 in the axial positions. In view of the neutral bridging ttmb linker, there is a non-coordinated counter-anion in 1 and 2 (ClO4 and BF4, respectively), and a coordinated NCS anion in 3. Compounds 1 and 2 are isostructural. Interestingly, the ttmb linker only utilizes two of its three potentially coordinating triazole groups. All iron(II) coordination networks are colorless or have a light-yellow color, being indicative of the high-spin state.

GelMA-catechol coated FeHAp nanorods functionalized nanofibrous reinforced bio-instructive and mechanically robust composite hydrogel scaffold for bone tissue engineering

Critical bone defects complicate tissue graft-based surgeries, raising healthcare expenditures and underscoring scaffold-based tissue-engineering strategies to support bone reconstruction. Our study highlighted that the phase-compatible combination of inorganic nanorods, nanofibers, and hydrogels is promising for developing biomimetic and cell-instructive scaffolds since the bone matrix is a porous organic/inorganic composite. In brief, methacrylated gelatin (GelMA) was reacted with dopamine to form catechol-modified GeLMA (GelMA-C). The GelMA-C was nanocoated onto an iron-doped hydroxyapatite (FeHAp) nanorod via metal-catechol network coordination. The modified nanorod (FeHAp@GelMA-C) was loaded onto GelMA-based nanofibers. The nanorods loaded pre-fibers were electrospun onto GelMA solution and photochemically crosslinked to fabricate a fiber-reinforced hydrogel. The structural, mechanical, physicochemical, biocompatibility, swelling properties, osteogenic potential, and bone remodelling potential (using rat femoral defect model) of modified nanorods, simple hydrogel, and nanorod-loaded fiber-reinforced hydrogel were studied. The results supported that the interface interaction between GelMA-C/nanorods, nanorods/nanofibers, nanorods/hydrogels, and nanofiber/hydrogels significantly improved the microstructural and mechanical properties of the scaffold. Compared to pristine hydrogel, the nanorod-loaded fiber-reinforced scaffold better supported cellular responses, osteogenic differentiation, matrix mineralization, and accelerated bone regeneration. The nanorod-loaded fiber-reinforced hydrogel proved more biomimetic and cell-instructive for guided bone reconstruction.

Complex network-based analysis of inter-basin water transfer networks

Driven by water resources scarcity, inter-basin water transfer (IBWT) projects have emerged and evolved, thereby shaping the current water supply framework. As IBWT projects increase, they gradually acquire network characteristics, giving rise to IBWT networks. However, the impact of the development of IBWT networks on water-supply patterns remains unclear? Analyzing the spatial and temporal growth patterns of IBWT networks through the lens of complex network theory can help answer this question. This study established a framework for analyzing IBWT networks using complex network analysis (CNA). Within this framework, we analyzed the spatial and temporal development characteristics of the IBWT network by quantifying its global properties across three dimensions: efficiency, elasticity, and coordination. Six centrality indicators were employed to measure the significance of individual nodes. Finally, the Infomap method was employed for network community detection. The results demonstrated that the CNA-based framework effectively captured the comprehensive development of the IBWT network, which underwent six stages from inception to high-speed, near-term, and long-term Stages. IBWT network efficiency, elasticity, and coordination all showed growth, which was most pronounced in 2013–2022, where the scaled global efficiency, network efficiency, average node connectivity, and average betweenness centrality metrics all grew by a factor of greater than 4. Importantly, the total percentage of centrality greater than 0.2 in the Huang-Huai-Hai-Chang Basin was 63.0%. The 125 initial IBWT projects in the IBWT network contained 58 communities, while the subsequent construction of 57 projects added only 12 communities. Future new IBWT network projects will tend to joined existing communities.

Multi-Objective Traffic Signal Control Using Network-Wide Agent Coordinated Reinforcement Learning

The optimization of intersection signal control can improve traffic efficiency, reduce congestion degree, and improve traffic safety. Aiming at implementing the coordinated adaptive traffic signal control (ATSC) across large-scale arterial network, multi-agent reinforcement learning (MARL) has been widely concerned and lucubrated. Nevertheless, the existing MARL-based ATSC studies suffers from several limitations: (1) While most existing researches focused on the mobility performance of controlled corridor, there calls for a methodology that aims at combine multi-objective performance on traffic safety, efficiency, and network coordination simultaneously; (2) Most methods ignore the correlations between multiple agents, nor considers the spatial-temporal dependencies among the corelated neighboring intersections due to high communications requirements, which can hardly be achieved in real adaptive coordination control. To overcome the aforementioned difficulties, a multi-objective reinforcement learning model (NACRL) for network-wide coordinated signal control is proposed. Firstly, to enforce a coordinated network control with safety and efficiency considerations, a reward mechanism inspecting both traffic safety and traffic efficiency indicators was designed to achieve ideal performance in terms of mobility, safety and smooth. Secondly, the proposed NACRL conducted a centralized training-decentralized execution framework, this overcomes the critical limitation of data transmission in the field implementation while explicitly analyzing the traffic state over the entire network instead of examining each isolated intersection. Last but not least, the proposed algorithm utilized the attention mechanism to dynamically capture the sophisticated spatial-temporal dependencies over the complex arterial network, which aids the better coordinated control over multi-agents deployed at the intersections across the corridor. To testify the effeteness of the proposed algorithm, extensive experiments were implemented in both large-scale synthetic traffic grid and real-world arterial network. The experiment demonstrated that the proposed NACRL algorithm outperforms other state-of-the-art baselines with simultaneously improved performance in terms of traffic safety, traffic efficiency and network coordination, as well as improved algorithm convergence and interpretability.

Multiperiod channel coordination in franchise networks: The necessity of internal inventory trading and franchiser involvement

Facing consumers' growing demand for fast order fulfillment, it is important yet challenging for franchise companies to best incentivize frequent inventory sharing among their independent franchise retailers or dealers to achieve channel coordination. Past literature has only addressed such channel coordination for one‐time inventory sharing using contractual agreements, which unfortunately do not work for frequent inventory sharing. In this study, we consider multiple inventory‐sharing opportunities and propose a novel coordinating mechanism: internal inventory trading, enabled by disruptive IT platforms, such as the OneView platform's Inventory Management module (OVIM). On the OVIM, designed and operated by a brand (franchiser), every retailer (franchisee) can frequently access to all brand inventories virtually as they trade (buy or sell) inventory with one another and the brand. Using dynamic multiperiod games, we investigate how the brand should craft the trade rules and how the retailers should respond and trade periodically in equilibrium. We prove that channel coordination can be achieved in equilibrium, and the coordination requires both an internal inventory‐trading platform and the brand's proactive involvement in trading as the rule and market maker. Specifically, the coordinating trade rules require the brand to (1) only profit from the royalties (not from trading), (2) set the coordinating trade prices (CTPs) to respond to the real‐time channel inventory, and (3) let the buyer and the seller split shipping costs in any proportion, but not offering any subsidy. We provide a detailed characterization of the CTPs for each period, serving multiple purposes beyond simply removing double marginalization. When the channel inventory is high and imbalanced, the CTPs must include a trading reward to prevent retailers from strategically holding more or less inventory than the channel‐optimal amount to “manipulate” future trade prices. The good news is that these CTPs are intuitive (constant or market‐clearing) and can be automated into the trading platform ex ante. These actionable insights can guide franchise companies toward best utilizing their channel inventory and improving their profit and customer satisfaction.

What about Model Data? Best Practices for Preservation and Replicability

Abstract It has become common for researchers to make their data publicly available to meet the data management and accessibility requirements of funding agencies and scientific publishers. However, many researchers face the challenge of determining what data to preserve and share and where to preserve and share those data. This can be especially challenging for those who run dynamical models, which can produce complex, voluminous data outputs, and have not considered what outputs may need to be preserved and shared as part of the project design. This manuscript presents findings from the NSF EarthCube Research Coordination Network project titled “What About Model Data? Best Practices for Preservation and Replicability” (https://modeldatarcn.github.io/). These findings suggest that if the primary goal of sharing data are to communicate knowledge, most simulation-based research projects only need to preserve and share selected model outputs along with the full simulation experiment workflow. One major result of this project has been the development of a rubric, designed to provide guidance for making decisions on what simulation output needs to be preserved and shared in trusted community repositories to achieve the goal of knowledge communication. This rubric, along with use cases for selected projects, provide scientists with guidance on data accessibility requirements in the planning process of research, allowing for more thoughtful development of data management plans and funding requests. Additionally, this rubric can be referred to by publishers for what is expected in terms of data accessibility for publication.

Electrochemical proton-coupled electron transfer processes to form neutral radicals of azaphenalenes: pKa values of protonated radicals

Azaphenalenes are nitrogen substituted analogues of the phenalene ring system, and their radicals have attracted significant attention because of the novel electronic and magnetic properties. In the previous study, the neutral tris(tert-butyl) 1,3-diazaphenalenyl radical has been synthesized by chemical oxidation of the parent compound with PbO2. In this study, we focused on electrochemical proton-coupled electron transfer (PCET) process leading to the formation of neutral unsubstituted 1,3-diazaphenalenyl radical from 1,3-diazaphenalene (DAP) in solution. Additionally, this electrochemical approach was extended to study the redox behavior of newly synthesized 1,4,7-triazaphenalene (TAP) giving the access to the 1,4,7-triazaphenalenyl radical. Electrochemical oxidation potentials vs. pH plots (Pourbaix diagram) for DAP and TAP revealed that their one-electron oxidation to the corresponding neutral radicals occurred by a PCET process over a wide pH range. From the analysis of Pourbaix diagrams, the pKa values of the protonated radicals were determined to be pKa = 2.57 and 2.39 for the DAP and TAP radicals, respectively. Cyclic voltammograms of azaphenalenes in MeCN and MeCN/buffer solutions showed a characteristic ECE process, in which electrochemical oxidative dimerization took place following the electron transfer. The dimerization reaction pathway was rationalized by the digital simulations, DFT calculations and crystallization of a DAP dimer after chemical oxidation with PbO2. The spectroscopic properties of azaphenalenes and their dimerized products were characterized by in-situ UV–Vis and EPR spectroelectrochemistry techniques. The fundamental information about the pKa and redox potentials for a series of azaphenalenes (DAP, TAP, as well as 1,3,4,6,7,9-hexaazaphenalene, HAP) could be fed back into the molecular design of redox-active conductive coordination networks based on multi-interactive ligands.

Ultrasound-Induced Abiotic and Biotic Interfacial Electron Transfer for Efficient Treatment of Bacterial Infection.

Electron transfer plays an important role in various catalytic reactions and physiological activities, whose altered processes may change catalytic efficiency and interfere in physiological metabolic processes. In this study, we design an ultrasound (US)-activated piezoelectric responsive heterojunction (PCN-222-BTO, PCN: porous coordination network), which can change the electron transfer path at the abiotic and abiotic-biotic interfaces under US, thus achieving a rapid (15 min) and efficient bactericidal effect of 99.96%. US-induced polarization of BTO generates a built-in electric field, which promotes the electron transfer excited from PCN-222 to BTO at the PCN-222-BTO interface, thereby increasing the level of reactive oxygen species (ROS) production. Especially, we find that the biological electron transfer from the bacterial membrane to BTO is also activated at the MRSA-BTO interface. This antibacterial mode results in the down-regulated ribosomal, DNA and ATP synthesis related genes in MRSA, while the cell membrane and ion transport related genes are up-regulated due to the synergistic damage effect of ROS and disturbance of the bacterial electron transport chain. This US responsive dual-interface system shows an excellent therapeutic effect for the treatment of the MRSA-infected osteomyelitis model, which is superior to clinical vancomycin therapy.

Trust is personal and professional: The role of trust in the rise and fall of a South African civil society coalition

This article explores trust dynamics among a coalition of civil society organizations called Unite Behind that formed in Cape Town, South Africa, in late 2017. Unite Behind was established to demand more accountability from a state marred by corruption—and specifically for the resignation of then President Jacob Zuma. When Zuma resigned, the coalition attempted to transition to a social movement campaigning for social justice but declined as a coalition into an organization of sorts. Taking trust as a positive belief in the reliability, truth or ability of an actor or entity, this article argues that conceptions of political and social/generalized trust are of less importance in explaining the rise and fall of Unite Behind than a combination of personal trust in particular leaders, and a form of particularized trust, namely, trust in other organizations. This notion of organizational trust as a form of particularized trust is of potential wider importance to the analysis of civil society network co-ordination.

Study on the Influence of Network Configuration on the Accuracy of 3D Coordinate Control Network

Study on the Influence of Network Configuration on the Accuracy of 3D Coordinate Control Network

Sustainable humanitarian supply chains: a systematic literature review and research propositions

The purpose of this systematic review is to synthesise the body of knowledge related to sustainable humanitarian supply chains across disaster relief as well as those of logistics of development aid. The output of this paper is a set of research propositions that will help advance theory building and validation for the management of sustainable humanitarian supply chains. This systematic review identifies and categorises sustainable humanitarian supply chain management (SHSCM) themes, with a particular emphasis on theoretical development based on a categorical analysis of research articles. The thematic analysis reveals that sustainability in humanitarian supply chains encompasses a wide range of aspects, such as supply network configuration, coordination, and partnership, as well as performance measurement. However, theoretical studies typically do not integrate all sustainability dimensions. In particular, social sustainability factors are largely absent from current models of SHSCM, despite their inherent significance in humanitarian contexts. The categorical analysis explains how aspects related to the identified themes impact and pose opportunities for SHSCM. Insights from this systematic review can support humanitarian supply chain sustainability knowledge with policy-driven research directions. These policies can help achieve a greater level of sustainability in humanitarian supply chain management. The originality of this study lies in the development of detailed categories of sustainability studies, in its analytical focus on SHSCM theories, and in the development of research propositions to provide insights to researchers on how to advance theory and conduct impactful research on the topic of SHSCM.

Risk Contagion of Local Government Implicit Debt Integrating Complex Network and Multi-Subject Coordination

This article analyzes the risk contagion mechanism of local government implicit debt from the perspective of multi-subject collaboration, considering interaction effects among different influencing factors. On this basis, with the help of complex network theory and mean field theory, a risk contagion model of local government implicit debt is constructed, and then the evolution characteristics and control strategies for risk contagion of local government implicit debt are analyzed theoretically and simulated. The main findings obtained from the study are: (1) A scale-free network is not conducive to the risk contagion of local government implicit debt, while the opposite is true for a random network. (2) Information openness accuracy and information disclosure strategy both exhibit a positive “U” shaped relationship with the risk contagion of local government implicit debt. Debt management level, emotional tendency, risk preference level, credit policy robustness, accountability mechanism soundness, and perfection of laws and regulations are all negatively correlated with the risk contagion of local government implicit debt. (3) In order to effectively reduce the risk contagion intensity of local government implicit debt, local governments at all levels should continuously strengthen their debt management capabilities and information openness, and the central government should continuously improve accountability mechanisms, laws, and regulations. At the same time, financial institutions and the media should actively play the role of “stabilizers”. However, the local government implicit debt risk is an inherent risk, and its control focus should be on reducing rather than eliminating the risk.

Process evaluation of an intersectoral intervention for health equity in Munich, Germany

Abstract Background Intersectoral partnerships can help building sustainable urban environments for children and adolescents that decrease the impact of socioeconomic inequities regarding health and development. However, facilitators for implementing these kinds of public health interventions have hardly been researched. This study conducted a process evaluation of the intersectoral network Präventionskette Freiham that was implemented in a new residential development area in the city of Munich, Germany. Methods We collected data in four different sub-studies following a mixed methods design: (1) qualitative interviews and ego-centered network maps with the network coordinators; (2) qualitative interviews with local professionals from institutions engaged with or relevant for the intervention; (3) a focus group with representatives of the three municipal departments guiding the intervention; (4) an online survey with local network members. Results The intervention was able to integrate stakeholders from different sectors quickly at the start of the implementation process. However, the early development status of the area and the ongoing COVID-19 pandemic were a challenge for working processes within the network. Sufficient funding and resources, support from local politics and administration, transparent communication and perceived benefits for the individual members of the network were considered as facilitators for a successful implementation. Conclusions The early development status of the area was a challenge for building an intersectoral network. Availability of resources is a key factor for implementing a sustainable support infrastructure promoting health equity for children and adolescents. Key messages • This study increases the knowledge on implementing public health interventions in new residential development areas and helps to build better chances for disadvantaged children. • Implementing sustainable intersectoral partnerships for health equity in communities requires a long-term engagement by local stakeholders, especially in settings without established infrastructure.

Controlled chaos: examining collaborative response to the 2017 Hattiesburg tornado

Hattiesburg, Mississippi experienced two tornados within a four-year span (2013–2017). Community members who participated in response and recovery to both disasters were interviewed to understand how coordination changed between the two events. The purposive sample included representatives from a variety of organizational types, sizes, and missions. Four findings emerged detailing how organizations used collaborative management networks to respond to the disaster. Respondents indicated the importance of coordination, communication facilitation, identification, and experience. Lessons learned in 2013 did not have to be learned in 2017 when resultant network coordination and effective responses were retained by actors and made a part of their routine responses to crises.

Mixed-valence gold-porphyrin two-dimensional coordination networks for repurposing of chrysotherapy

Catalytic gold nanomaterials typically exhibit antibacterial properties, albeit significantly weaker than ionic gold in chrysotherapy. The inherent stability of gold nanoparticles prevents the release of gold ions, limiting their ability to achieve efficient antibacterial therapy. To address this limitation, we propose a novel sustained ionic gold release strategy through the construction of a mixed-valence gold-porphyrin coordination network (Au-Por). By adjusting the ratio of Au to porphyrin molecule, an ultrathin two-dimensional Au-Por nanosheet was successfully synthesized, which contains 85.9 % of Au (III). In addition, the remaining gold existed in the form of uniformly distributed ultrasmall nanoclusters on the Au-Por nanosheet. Notably, the Au-Por nanosheet exhibited a sustained release of gold ions. Thus, a multimodal antibacterial therapy was achieved by integrating the direct bactericidal action of ionic gold and lethal reactive oxygen species (ROS) generated through the peroxidase (POD)-like activity of gold nanoclusters and photodynamic therapy (PDT) using porphyrins. The innovative Au-Por exerted broad-spectrum bactericidal activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria mediated by bacterial membrane disruption and DNA damage. Moreover, in vivo studies demonstrated the synergistic effect of Au-Por on combating skin wound infections and facilitating wound healing. Comprehensive safety evaluations proved that Au-Por exhibited no hematotoxicity or hepatorenal toxicity, and it also displayed rapid renal clearance after treatment, indicating favorable biocompatibility. The repurposing of chrysotherapy has revolutionized the antibacterial strategy of nanoscale gold, resulting in a dramatic boost in antibacterial activity and valuable insights for designing highly efficient nanoscale antibacterial agents.

Ligand-Mediated Regulation of the Chemical/Thermal Stability and Catalytic Performance of Isostructural Cobalt(II) Coordination Polymers.

Regulating the chemical/thermal stability and catalytic activity of coordination polymers (CPs) to achieve high catalytic performance is topical and challenging. The CPs are competent in promoting oxidative cross-coupling, yet they have not received substantial attention. Here, the ligand effect of the secondary ligand of CPs for oxidative cross-coupling reactions was investigated. Specifically, four new isostructural CPs [Co(Fbtx)1.5(4-R-1,2-BDC)]n (denoted as Co-CP-R, Fbtx = 1,4-bis(1,2,4-triazole-1-ylmethyl)-2,3,5,6-tetrafluorobenzene, 4-R-1,2-BDC = 4-R-1,2-benzenedicarboxylate, R = F, Cl, Br, CF3) were prepared. It was found that in the reactions of oxidative amination of benzoxazoles with secondary amines and the oxidative coupling of styrenes with benzaldehydes, both the chemical and thermal stabilities of the four Co-CPs with the R group followed the trend of -CF3 > -Br > -Cl > -F. Density functional theory (DFT) calculations suggested that the difference in reactivity may be ascribed to the effect of substituent groups on the electron transition energy of the cobalt(II) center of these Co-CPs. These findings highlight the secondary ligand effect in regulating the stability and catalytic performance of coordination networks.