Helium (He) cooling requires large circulation power to remove high heat from plasma side and nuclear heating by high energy neutron in fusion reactors due to its low density. Based on the recent findings that the heat transfer capability of the light gas can be enhanced by mixing another heavier gas, this study adds CO2 to a reference helium coolant and evaluates the cooling performance of the binary mixture for various compositions. To assess the cooling performance, computational fluid dynamic (CFD) analyses on the KO HCML (Korea Helium Cooled Molten Lithium) TBM are conducted. As a result, it is revealed that the binary mixing of helium, which has favorable thermophysical properties but the density, with a heavier noble gas or an unreactive gas significantly reduces the required circulation power by an order of magnitude with meeting the thermal design requirements. This is attributed to the fact that the density can be highly increased with small amount of a heavier gas while other gas properties are kept relatively comparable. The optimal CO2 mole fraction is estimated to be 0.4 and the circulation power, in this case, can be reduced to 13% of that of pure helium. This implies that the thermal efficiency of a He-cooled blanket system can be fairly enhanced by means of the proposed binary mixing.