Convulsions In Childhood Research Articles

Ultrastructural Analysis of the Large Neuronal Perikarya in an Injured Dentate Nucleus Using an Experimental Model of Hyperthermia-Induced Convulsions: The First Qualitative and Quantitative Study.

Background: Febrile seizures are a common form of convulsions in childhood, with poorly known cellular mechanisms. The objective of this pioneering study was to provide qualitative and quantitative ultrastructural research on the large neuronal perikarya in the cerebellar dentate nucleus (DN), using an experimental model of hyperthermia-induced seizures (HSs), comparable to febrile seizures in children. Methods: The study used young male Wistar rats, divided into experimental and control groups. The HSs were evoked by a hyperthermic water bath at 45 °C for 4 min for four consecutive days. Specimens (1 mm3) collected from the DN were routinely processed for transmission electron microscopy studies. Results: The ultrastructure of the large neurons in the DN affected by hyperthermic stress showed variously pronounced lesions in the perikarya, including total cell disintegration. The most pronounced neuronal lesions exhibited specific morphological signs of aponecrosis, i.e., dark cell degeneration ('dark neurons'). In close vicinity to the 'dark neurons', the aponecrotic bodies were found. The findings of this qualitative ultrastructural study correspond with the results of the morphometric analysis of the neuronal perikarya. Conclusions: Our results may constitute interesting comparative material for similar submicroscopic observations on large DN neurons in HS morphogenesis and, in the future, may help to find potential treatment targets to prevent febrile seizures or reduce recurrent seizures in children.

Has the Incidence of Febrile Convulsions in Childhood Changed During the SARS-CoV-2 Pandemic?

Introduction: SARS-CoV-2 infection in children is usually asymptomatic or only mild symptoms are typical. The aim of our study was to assess the incidence of febrile convulsions in our own patients with COVID-19. Patients and Methods: In our retrospective study, we reviewed the data of children who presented at our University Hospital from March 2020 to March 2022 with febrile convulsion. The control group were children admitted to the hospital because of febrile convulsions from January 2018 to January 2020. Results: During the coronavirus pandemic, 51 patients were examined with febrile convulsions. The majority (86.3%) of children had their first febrile convulsion during this period. We diagnosed simple febrile convulsions in 40 cases and complicated ones in 11 cases. The family history of febrile convulsion or epilepsy was present in 12 (23.5%) patients. In addition to febrile convulsion, SARS-CoV-2 infection was confirmed by laboratory testing in 4 cases (7.8%). Three of them had febrile convulsion during the Omicron variant period. Conclusions: During the coronavirus pandemic, the number of children examined because of having febrile convulsions was not higher than in the control period. The coronavirus is unlikely to increase the risk of febrile convulsions.

Assessment of knowledge and belief towards prevention of childhood convulsion among women attending infant welfare clinic in selected primary healthcare centers, Ibadan north local government area

Childhood convulsion is one of the most common neurological disorders contributing to high mortality and morbidity rate among children. This study assessed the level of knowledge and belief towards prevention of childhood convulsion among women attending infant welfare clinics in selected primary health care centers, Ibadan north local government area. This study adopted a descriptive survey design and a multi-stage sampling technique was used to select one hundred and fifty-one mothers and data was collected with a structured questionnaire. Two research questions were raised and two hypotheses were formulated and tested at the level of 0.05 significance. Hypothesis one was tested using student chi-square while the second was tested using PPMC. Data was collated, collected, and analyzed using Statistical Package for The Social Sciences (SPSS) 25. The results from the study revealed that the majority of the participants had above average knowledge of childhood convulsion 102(67.5%) x2 = 82.475a; p=0.001< .05), there is a significant relationship between respondents’ knowledge and their belief on childhood convulsion (r = .334; p=0.000 < .05), that there is a significant relationship between respondents’ knowledge and preventive practices on childhood convulsion among women attending infant welfare clinic at selected PHC (r = .210; p=0.000 < .05). The majority of the participants demonstrated a high level of knowledge on the causes of and preventive practices towards childhood convulsion but misconceptions about orthodox medication persist, it is therefore recommended that health providers educate mothers on alarming signs and symptoms, care, and proper home management of childhood convulsion.

Acute dizziness and mental alteration associated with Moderna COVID-19 vaccine: a case report

BackgroundDue to a rising number of COVID-19 cases, the Indonesian government implemented public health programs to lower the rate. Since January 2021, one of the government’s primary policies has been the COVID-19 immunization program. Recently, the Moderna messenger ribonucleic acid (mRNA) vaccine is one of the COVID-19 vaccines used in Indonesia. Based on some research, Moderna has possible side effects throughout the body, including neurological symptoms.Case presentationWe describe a 39-year-old female with uncontrolled hypertension who showed behavioral change, communication difficulty, social withdrawal, and a confused state within 7 days from getting her first dose of the Moderna vaccine. The patient had a history of febrile convulsion in childhood. An increase of neutrophil-to-lymphocyte ratio (16.9) and C-reactive protein level (31.75 mg/L) indicates ongoing inflammation. Head CT scan shows no abnormalities. She received ceftriaxone, citicoline, and methylprednisolone. The patient was discharged on the seventh day and completely recovered 1 week later. This study is the first case report of encephalopathy following the administration of the Moderna COVID-19 vaccine reported in Indonesia up to our knowledge.ConclusionEncephalopathy related to the Moderna COVID-19 vaccine should be acknowledged as an adverse effect of the Moderna COVID-19 vaccine.

Analysis of clinical and genetic characteristics of epilepsy associated with chromosome 16p11.2 microdeletion

Objective: To investigate the clinical and genetic characteristics of epilepsy associated with chromosome 16p11.2 microdeletion. Methods: The patients (n=10) with 16p11.2 microdeletion found in children with epilepsy treated in Beijing Children's Hospital Affiliated to Capital Medical University from January 2018 to January 2021 were collected. The clinical manifestations, gene variations and prognosis were analyzed retrospectively. Results: A total of 10 children's data were collected, including 5 male and 5 female. The onset age of epilepsy was 4.5 (4.1,5.0) months. Regarding the seizure types, 7 cases had focal seizures with secondary generalization, 2 cases had generalized seizures, and 1 case had tonic seizures and spasms. Nine cases had cluster seizure attacks and 3 cases had status epilepticus. Seven cases had focal or multifocal epileptiform discharges in interictal electroencephalogram (EEG), 3 cases had borderline or normal EEG. Brain magnetic resonance imaging showed polymicrogyria in 1 case, paraventricular leukomalacia in 1 case, delayed myelination of white matter in 3 cases, and no obvious abnormalities in the other 5 cases. The patients were followed up for 0.5-3.5 years, with 1-3 kinds of antiepileptic drugs taken orally. The case with polymicrogyria still had seizures, however the other 9 cases had seizures controlled. The age of the last seizure attack was 8 (6, 12) months. There were 6 cases with mental and motor developmental delay before epilepsy onset. During the follow-up, 7 cases were retarded to varying degrees, while 3 cases had normal development. Regarding the genetic detection methods, 7 cases underwent whole exome sequencing, 2 cases underwent whole genome copy number variation detection, and 1 case underwent whole genome sequencing. The length of the 16p11.2 deletion in 10 cases ranged from 525 to 951 kb, and all contained the PRRT2 gene intact. Six cases were de novo variants, 1 case was inherited from the mother who had a history of convulsions in early childhood, and the source of variant was not verified in 3 cases, none of whose parents had relevant phenotype. Conclusions: The epilepsy associated with 16p11.2 microdeletion is mainly induced by the heterozygous deletion of PRRT2 gene in this region, however the phenotype is usually severe, and often combined with developmental and epileptic encephalopathy. Detection of copy number variation should be emphasized in children whose etiology is considered genetic but second-generation sequencing result is negative.

TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures

Febrile seizures (FSs) are the most common convulsion in infancy and childhood. Considering the limitations of current treatments, it is important to examine the mechanistic cause of FSs. Prompted by a genome-wide association study identifying TMEM16C (also known as ANO3) as a risk factor of FSs, we showed previously that loss of TMEM16C function causes hippocampal neuronal hyperexcitability [Feenstra et al., Nat. Genet. 46, 1274-1282 (2014)]. Our previous study further revealed a reduction in the number of warm-sensitive neurons that increase their action potential firing rate with rising temperature of the brain region harboring these hypothalamic neurons. Whereas central neuronal hyperexcitability has been implicated in FSs, it is unclear whether the maximal temperature reached during fever or the rate of body temperature rise affects FSs. Here we report that mutant rodent pups with TMEM16C eliminated from all or a subset of their central neurons serve as FS models with deficient thermoregulation. Tmem16c knockout (KO) rat pups at postnatal day 10 (P10) are more susceptible to hyperthermia-induced seizures. Moreover, they display a more rapid rise of body temperature upon heat exposure. In addition, conditional knockout (cKO) mouse pups (P11) with TMEM16C deletion from the brain display greater susceptibility of hyperthermia-induced seizures as well as deficiency in thermoregulation. We also found similar phenotypes in P11 cKO mouse pups with TMEM16C deletion from Ptgds-expressing cells, including temperature-sensitive neurons in the preoptic area (POA) of the anterior hypothalamus, the brain region that controls body temperature. These findings suggest that homeostatic thermoregulation plays an important role in FSs.

Pre-hospital management of childhood convulsions in Ilesa, South-west, Nigeria

Convulsion evokes a lot of fear in mothers and caregivers whenever it occurs. They even think that their child is dying. Many interventions are often carried out because of anxiety and limited knowledge. The aim of this study is to examine the interventions instituted by caregivers for children with convulsions before presentation in the hospital for treatment. We prospectively studied all the 276 children that presented to the emergency room with convulsion over a period of seven months and the care administered at home before presenting in the hospital was noted. One hundred and nine (39.5%) of the children had water poured on them during convulsion. Substances administered orally were; salt 32 (11.6%), onions 14 (5.1%), palm oil 3 (1.1%) and herbal concoctions 13 (4.7%), of which two contained cow urine. Metal spoons were used as mouth gag in 41 (14.9%) of subjects while 29 (10.5%) children had intramuscular (IM) injections given by health workers at home (eight) in various health centres (15) and hospitals (6). Other interventions were scarifications and drinking of their mothers’ urine. While 40 (14.5%) children had more than one treatment given to them before their arrival, 99 (35.9%) had no treatment given before their arrival. Caregivers continue to carry out various interventions at home for convulsions in children. Majority of the interventions are not beneficial while some are harmful. There is, therefore, need to continue to educate caregivers on the appropriate prehospital interventions of convulsions in children before presenting in the hospital. Key words: Convulsion, pre-hospital interventions.

Increased levels of NLRP3 in children with febrile seizures

ObjectiveFebrile seizures (FS) are the most common convulsions in childhood. Interleukin-1beta (IL-1β) is proposed to play an important role in the development of FS, from in vitro data and data from peripheral blood samples. IL-1β secretion is needed for activation of the NLR family, pyrin-domain containing 3(NLRP3) inflammasome. However, whether NLRP3 play a role in the development of FS remains unknown. This study aimed to investigate the role of NLRP3 in FS. MethodsThirty-two FS cases and twenty-two matched controls were included in this study. Control samples were collected from children with febrile illness without seizures. We detected their levels of IL-1β and NLRP3 by Enzyme linked immunosorbent assay and Western blot, respectively. ResultsSerum IL-1β levels weresignificantlyhigher in FS patients (Median = 301.64 pg/ml) than in fever only controls (Median = 159.48 pg/ml) (P < 0.05). Additionally, NLRP3 protein levels of peripheral blood mononuclear cells (PBMC) were significantly higher in typical FS than in fever only controls (P < 0.05). Moreover, serum levels of IL-1β were significantly correlated with levels of NLRP3 protein (r = 0.787, P < 0.001). ConclusionsIn this study, our results firstly indicated that NLRP3 protein was significantly up-regulated in the typical FS children compared in fever only controls. Increased NLRP3 can mediate IL-1β secretion that is responsible for the occurrence of FS.

Effectiveness of video-assisted teaching on febril convulsions among primary caregivers of underfive children

The occurrence of febrile convulsion in childhood is common in 2 to 5% of children younger than age 5 years with a peak incidence in the second year of life. Recent evidence that suggests a small subset of children that present with fever may cause febrile convulsion. So appropriate parental action is necessary to prevent Febrile Convulsion and reduce complications. This Study is to Assess the effectiveness of video-assisted teaching on febrile convulsions among primary caregivers of underfive children at Sedarapet, Puducherry. Quasi Experimental one group pre test and post test design was used, in which 60 Primary care givers of Underfive children were assessed the KAP and video assisted teaching was administered and after a week Level of KAP was assessed using same structured Interview Schedule. Study revealed that, Video assisted teaching programme on febrile convulsion was found to be an effective, appropriate and feasible mode to develop Knowledge, Attitude and Knowledge on Practice of Primary caregivers of underfive children regarding Febrile convulsion at p>0.05.

Hemiconvulsion-hemiplegia-epilepsy syndrome in Niger: A retrospective case series

ObjectiveTo report the demographic, clinical and paraclinical characteristics as well as the outcomes during follow-up visits of HHE syndrome in Niger. Patients and methodsIt was a retrospective study conducted at the Neurology Outpatient Clinic of the National Hospital of Niamey (Niger) between May 2003 and May 2018. ResultsDuring the period of study, 882 patients with epilepsy aged 20 years or less were seen in consultation among whom we collected 22 cases of HHE syndrome with a hospital prevalence of 2.5%. They were 14 men and 8 women (sex ratio = 1.75) with a mean age of 3.76 years (range: 1 and 20 years). At the time of diagnosis, 81.8% of patients were aged under 6 years. The antecedent of febrile convulsions in childhood was found in only 31.8% of cases. The mean age of onset of hemiplegia was 1.9 years (range: 9 months and 5 years). The mean age of onset of epileptic seizures was 2.94 years (range: 1 and 8 years). The mean interval between the onset of hemiplegia and onset of epileptic seizures was 9 months (range: 1 month and 4 years). 31.8% of patients had a delay of acquisitions at the time of diagnosis. 95.5% of patients had drug-resistant epilepsy. ConclusionHHE syndrome is still seen in the countries of Sub-Saharan Africa. The high morbidity and mortality in children with HHE syndrome highlight the need to improve emergency care for febrile clonic seizures in childhood and the early and adequate management of infectious diseases in the child.

Evaluation of the Anti-Diabetic Activity of Polysaccharide from Cordyceps cicadae in Experimental Diabetic Rats.

Cordyceps cicadae is a medicinal fungus used in treating night sweat, childhood convulsions, vision improvement and pain. This study was designed to evaluate the anti-diabetic activity of the crude polysaccharide (SHF) from the mycelium and body portion of C.cicadae. Diabetes mellitus was induced in the rat with a single intravenous injection of alloxan monohydrate (150mg/kg). In other to evaluate the anti-diabetic effects of C.cicadae polysaccharide in alloxan-induced diabetic rats, the crude polysaccharide (SHF at 100, 200 and 400mg/kg body weight) and glibenclamide were administered orally to diabetic rats for 30days. Blood glucose level, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphate (ALP), creatinine (CREA), urea, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH) were determined. SHF showed significant reduction in blood glucose in diabetic rats. Treatment of diabetic rats also resulted an improvement in body weights, increased HDL, SOD and GSH, as well as decreased TC, TG, LDL, MDA, urea, CREA, ALT, AST and ALP. These results suggested that C.cicadae polysaccharide displayed anti-hyperglycemic, anti-hyperlipidemic and antioxidant activities and could be a promising therapeutic source in managing diabetes mellitus and its associated complications.

The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures.

Febrile seizures are childhood convulsions resulting from an infection that leads to an inflammatory response and subsequent convulsions. Prenatal stress has been shown to heighten the progression and intensity of febrile seizures. Current medications are costly and have adverse effects associated with prolonged use. Quercetin flavonoid exhibits anti-inflammatory, anti-convulsant, and anti-stress effects. This study was aimed to investigate the therapeutic effect of quercetin in a prenatally stressed rat model of febrile seizures. We hypothesized that quercetin will alleviate the effects of prenatal stress in a febrile seizure rat model. On gestational day 13, Sprague-Dawley rat dams were subjected to restraint stress for 1 hour/d for 7 days. Febrile seizures were induced on postnatal day 14 on rat pups by intraperitoneally injecting lipopolysaccharide followed by kainic acid and quercetin on seizure onset. Hippocampal tissue was harvested to profile cytokine concentrations. Our results show that quercetin suppresses prenatal stress–induced pro-inflammatory marker (interleukin 1 beta) levels, subsequently attenuating febrile seizures. This shows that quercetin can be therapeutic for febrile seizures in prenatally stressed individuals.

The Effect of Simple Febrile Seizure on Attention Deficit Hyperactivity Disorder (ADHD) in Children

The Effect of Simple Febrile Seizure on Attention Deficit Hyperactivity Disorder (ADHD) in Children Bahman Salehi1 ; Parsa Yousefichaijan 2 ; Samira Safi-Arian3 ; Somaieh Ebrahimi4 ; Abolfazl Mohammadbeigi 5 ;Mona Salehi6 1Department of Psychiatry, School of Medicine, Arak University of Medical Sciences, Arak, Iran. 2Department of Pediatric Nephrology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. 3School of Medicine, Arak University of Medical Sciences, Arak, Iran. 4Department of Psychology, Islamic Azad University of Arak, Arak, Iran 5Neurology and Neurosciences Research Center, Department of Epidemiology and Biostatistics, Qom University of Medical Sciences, Qom, Iran 6School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Abstract Background Febrile seizure is one of the most prevalent childhood convulsions. There are controversy about possible relation between febrile seizure and Attention Deficit Hyperactivity Disorder (ADHD). The aim of this study was to find the effect of simple febrile seizure on ADHD in children. Materials and Methods In a case-control study all children of 3-12 years old with febrile seizure referring Amir-Kabir hospital, Arak-Iran. Among these children, 103 of them with no corporeal or psychiatric disorders were compared to 103 children of the same age and gender admitted due to disease other than febrile seizure utilizing DSM-IV criteria for ADHD. Data were analyzed using SPSS 16. Results This study shows that the hyperactivity disorder in the same order were 34.3% and 16.7%, respectively, which also denotes a significant relation between simple febrile seizure and hyperactivity(P<0.05). The frequency of consanguineous marriages was 26.2% in parents of children with simple febrile seizure, and 9.7% in the control group (P<0.05). Conclusion A significant relationship observed between FS with HI and CT of ADHD among children. In addition, hyperactivity has a significant relation with febrile seizure in male gender, making further investigation in these children prudent for early diagnosis and management. Keywords: ADHD; Children; Febrile seizure

Comparison of Relation between Attention Deficit Hyperactivity Disorder in Children with and without Simple Febrile Seizure Admitted in Arak Central Iran.

Febrile seizure is one of the most prevalent childhood convulsions with the most common age of onset at 14-18 mo old. Fever decreases the brain threshold for seizure. Attention Deficit Hyperactivity Disorder (ADHD) is also a neurologic-behavioral problem defined by attention deficit and hyperactivity according to DSM-IV criteria in which the child must have these signs in two different environments. There is controversy on the possible relation between febrile seizure and ADHD; while some studies approve a strong relation, some exclude any relation and some attribute ADHD to the side effects of other reasons. This descriptive-analytic study enrolled all children of 3-12 yr old with febrile seizure (according to Nelson Pediatrics Textbook diagnosed by the pediatrician in charge) referring to Amir Kabir Hospital, Arak, central Iran in 2010-2011. Overall, 103 of them with no corporeal or psychological disorder (like depression, anxiety, schizophrenia and other CNS maternal disease) were compared to 103 children of the same age and gender admitted due to disease other than febrile seizure utilizing DSM IV criteria for ADHD. Data were analyzed using SPSS version 18. The hyperactivity disorder in the control and case group was 34.3% and 16.7%, respectively, denoted a significant relation between simple febrile seizure and hyperactivity. Hyperactivity has a significant relation with febrile seizure in male gender, making further investigation in these children prudent for early diagnosis and management.

Na+/Ca2+ Exchanger 3 is Downregulated in the Hippocampus and Cerebrocortex of Rats with Hyperthermia-induced Convulsion

Background:Na+/Ca2+ exchanger (NCX) plays a crucial role in pentylenetetrazol-induced convulsion. However, it is unclear whether NCX is critically involved in hyperthermia-induced convulsion. In this study, we examined the potential changes in NCX3 in the hippocampus and cerebrocortex of rats with hyperthermia-induced convulsion.Methods:Twenty-one Sprague Dawley rats were randomly assigned to control group, convulsion-prone group and convulsion-resistant group (n = 7 in each group). Whole-cell patch-clamp method was used to record NCX currents. Both the Western blotting analysis and immunofluorescence labeling techniques were used to examine the expression of NCX3.Results:NCX currents were decreased in rats after febrile convulsion. Compared to the control group, NCX3 expression was decreased by about 40% and 50% in the hippocampus and cerebrocortex of convulsion-prone rats, respectively. Furthermore, the extent of reduction in NCX3 expression seemed to correlate with the number of seizures.Conclusions:There is a significant reduction in NCX3 expression in rats with febrile convulsions. Our findings also indicate a potential link between NCX3 expression, febrile convulsion in early childhood, and adult onset of epilepsy.

Anticonvulsant effects of ethanol stem bark extract of Lannea barteri (Anacardiaceae) in mice and chicks

Ethnopharmacological relevancePreparation of Lannea barteri is used in the treatment of epilepsy, gastritis, childhood convulsions among other uses in northern Nigeria for many years. The popularity of its efficacy is well established among the Traditional Medical Practitioners. Aim of the studyThe present study aimed at screening the ethanol stem bark extract of Lannea barteri for possible anticonvulsant action. Materials and methodAnticonvulsant screening was carried out using pentylenetetrazole (PTZ), strychnine (STN) and picrotoxin (PTC) induced seizures in mice while Maximal electroshock (MES) test was carried out in day old chicks. Preliminary phytochemical screening of the extract was performed on the extract. The intraperitoneal median lethal dose (LD50) was carried out in mice. ResultsThe intraperitoneal (i.p.) LD50 of the extract was estimated to be 567.70mg/kg in mice. Lannea barteri (160mg/kg) significantly (p≤0.05) delayed the mean onset of seizures induced by PTZ when compared with normal saline treated group. Similarly, the extract at 160mg/kg significantly (p≤0.05) prolonged the latency of convulsion induced by STN. Lannea barteri (40mg/kg) significantly (p≤0.05) delayed the mean onset of seizures induced by picrotoxin in mice. The extracts at all the doses tested showed no observable effect in decreasing the mean recovery time of convulsed chicks in MEST. Flavonoids, alkaloids, tannins, saponins and glycosides were found present in the stem bark extract. ConclusionOur findings revealed that the ethanol stem bark extract of Lannea barteri contained bioactive constituents that may be useful in the management of petit mal epilepsy and supports the ethnomedical claim for the use of its stem bark in the management of epilepsy.

Evaluation of Clinical Features of 238 Cases With Febrile Convulsion

Febrile convulsion (FC) is defined as a seizure triggered by fever in children between 6 months and 5 years of age without an underlying central nervous system infection. It is the most common cause of convulsion in childhood, and 3% to 4% of children experience …

Protective effect of carnosine on febrile seizures in immature mice

Febrile seizures (FSs) are the most common type of convulsions in childhood and complex FSs represent an increased risk for development of temporal lobe epilepsy. The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice. Injection of carnosine significantly increased the latency and decreased the duration of FSs in a dose-dependent manner. In addition, histidine had similar effects on FSs as carnosine. The protective effect of carnosine or histidine was completely abolished by α-fluoromethylhistidine (α-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice. Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus. These results indicate that carnosine can protect against FSs in mice pups through its conversion to histamine, suggesting that it may serve as an efficient anti-FSs drug in the future.

Hippocampal volume in childhood seizures

Article type Review article Many children with hippocampal sclerosis underwent surgery for treatment. Early childhood convulsion occurs in 2 to 4% of population and its prognosis is good in majority of cases. It seems that hippocampal anomalies are common in patients with neocortical epilepsies. The theory of hippocampal sclerosis association with temporal lobe epilepsy has been proposed 100 years ago. Recent studies demonstrated that there was a correlation between memory impairments and prolonged febrile convulsion (PFC), which might be a result of hippocampal injury. Transient hippocampus swelling might happen in complicated early childhood epilepsy or status epilepticus and result in hippocampal sclerosis.

Indigenous Knowledge, Practices, Beliefs and Social Impacts of Porcine Cysticercosis and Epilepsy in Iringa Rural

Porcine Cysticercosis (PCC) and Human Cysticercosis (HCC)/Neurocysticercosis (NCC) are a burden to the community owing to the reduced value of animals, associated costs of treatment, decreased labour productivity and social discrimination. There is limited knowledge on the management and prevention of PCC and epilepsy in Iringa rural. Therefore, the present study aimed at assessing indigenous knowledge, practices, attitudes and social impacts of PCC and epilepsy in Iringa rural district. A total of 588 people participated in the survey whereby 306 were pig farmers, 223 non-pig farmers and 59 families with epileptic individuals. It was found that 49.8% (χ2 = 0.003, DF = 1, p = 0.954) of pig keepers were aware of PCC, whereas the remaining 50.2% were not aware (χ2 = 25.5, DF = 1, p < 0.001). The prevalence of late onset epilepsy was significantly higher (62.7%) than that of those who manifested seizures and convulsions in childhood 37.3% (χ2 = 3.814, DF = 1, p = 0.51). People in Iringa rural believe epilepsy is caused by evil spirits, witchcraft and/or inheritance. It was concluded that there was limited knowledge on T. solium cysticercosis and epilepsy. This ignorance is the cause of poor practices, negative beliefs and attitudes that negatively affect the social life of People with Epilepsy (PWE) in communities. This study recommends that health education to raise awareness on cysticercosis/taeniosis and epilepsy should be one of the intervention measures for elimination of cysticercosis and epilepsy in Iringa rural district.