Floods have been projected to increase due to climate change and informal settlements in developing countries will be the most affected. This study presents results of using Local and Indigenous Knowledge in selecting indicators for mapping the vulnerability of people to flood hazards in an informal settlement context. Using Quarry Road West informal settlement, the study employed a convergent parallel mixed-methods approach which involved a household survey (n = 359), interviews with key informants (n = 8) and a focus group discussion (n = 1). The study findings reveal that flood vulnerability in the study area is not only a result of the proximity of the houses to the Palmiet River, the M19 freeway and Quarry Road, but also as a result of the nature of the soil and the type of materials people use to build their houses. Furthermore, findings reveal that using both Local and Indigenous Knowledge possessed by community members, a minimal number (sixteen) of context-specific indicators for mapping flood vulnerability in the study area were selected. The study also finds that flood vulnerability in the study area is a result of physical, socio-economic and institutional problems. Therefore, using Local and Indigenous Knowledge to select indicators for mapping flood vulnerability helps to provide a better understanding of flood vulnerability in an informal settlement and this gives decision-makers and other stakeholders a glimpse of adaptive measures that can be implemented to increase people's resilience.