This issue of Arts and Humanities in Higher Education focuses on innovative initiatives which are emerging in different Latin-American university contexts as well as a few other experiments in traditionally established universities. Sometimes these initiatives are newly created higher education institutions that are rooted inside indigenous regions, in other cases conventional universities start to “interculturalize” their student population, their teaching staff, or even their curricular contents and methods. Despite certain criticisms, community leaders frequently claim and celebrate the appearance of these new higher education opportunities as part of a strategy of empowering ethnic actors of indigenous or afro-descendant origin. After an interview to Boaventura de Sousa Santos, Laura Selene Mateos Cortés, and Gunther Dietz, analyze the different ways in which the Mexican intercultural education subsystem conceives “interculturalidad.” The next article, by Guillermo Williamson, also “expresses interculturality polyphonically from the Latin-American perspective” and reports “the nature and condition of the academic reflection on interculturality carried out in universities, in supposedly intercultural contexts.” Then, Carlos Octavio Sandoval brings the focus back to Mexico and the Intercultural University of Veracruz; in the article that follows, Isabel Dulfano explores the relationship between antiglobalization, counterhegemonic discourse, and indigenous feminist alternative knowledge production. She bases her article on the autoethnographic writing of some Indigenous feminists from Latin America that questions the assumptions and presuppositions of Western development models and globalization, while asserting an identity as contemporary Indigenous activist academic women. Christine D. Beaule and Benito Quintana’s article adds to the topic of this special issue with the argument of interdisciplinarity bringing together both an archaeological and anthropological perspectives of indigeneity to the higher education classroom. And finally, Catherine Manathunga focuses on the issue of intercultural doctoral supervision.