ABSTRACT Aim The present study to assess and compare the clinical and antimicrobial effects of sodium chlorite based toothpaste and mouthwash in periodontitis patients along with combination of nutritional dietary supplement of CoQ10 with conventional based toothpaste and mouthwash without sodium chlorite. Materials and methods A total 100 generalized chronic periodontitis patient between the ages of 18 and 55 years were enrolled in the study and divided under four categories. Clinical and microbiological parameters were recorded prior to phase 1 therapy; and subjects were put on different oral hygiene regime with chlorine dioxide based and conventional dentifrice and mouthrinse. CoQ10 was also provided in both the groups as nutritional dietary supplement. At 2nd and 4th month post-phase 1 therapy subjects were re-evaluated. Results The results of this study showed that there was significant decrease in clinical, and microbiological parameters from baseline to 4 months in both the groups (p < 0.01). The subjects under groups using sodium chlorite based toothpaste and mouthwash with dietary supplement of CoQ10 showed a highly significant reduction to all the parameters as compared to subjects under groups using a conventional dentifrice and mouthrinse. Conclusion Thus, we can conclude that long-term regular use of chlorine dioxide based products along with nutritional supplement of CoQ10 is more beneficial than conventional toothpaste and mouthrinse. How to cite this article Mani S, Mani A, Saini R. Clinical and Microbiological Evaluation of Chlorine Dioxide Based Mouthwash and Toothpaste in Periodontitis Patients along with Combination of Nutritional Dietary Supplement of CoQ10. Int J Experiment Dent Sci 2013;2(2):98-103.